| Entrez gene ID | | 56632 |
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| Official gene symbol | | Sphk2 |
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| Full name | | sphingosine kinase 2 |
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| Aliases | | C76851,MGC102297 |
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| Gene summary | | This gene encodes a kinase that phosphorylates sphingosine into sphingosine-1-phosphate, which is involved in cell differentiation, motility, and apoptosis. The encoded protein plays a role in maintaining cellular levels of sphingosine-1-phosphate. The gene product also enhances apoptosis in different cell types and suppresses cellular proliferation. In mast cells, the encoded protein is necessary for influx of calcium, protein kinase C activation, and cytokine production and degranulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq] |
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| Location | | Chromosome: 7 Locus: 7 B4 |
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| Gene position | | 52973372 - 52964833 Map Viewer |
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| Gene orientation | | minus |
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| Gene size | | 8540 bp |
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| Gene sequence |
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