| Entrez gene ID | | 5641 |
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| Official gene symbol | | LGMN |
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| Full name | | legumain |
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| Aliases | | ,AEP,LGMN1,PRSC1, |
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| Gene summary | | This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined. These two variants encode the same isoform. [provided by RefSeq] |
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| Location | | Chromosome: 14 Locus: 14q32.1 |
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| Gene position | | 93215047 - 93170152 Map Viewer |
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| Gene orientation | | minus |
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| Gene size | | 44896 bp |
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| Gene sequence |
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| OMIM ID | | 602620 |
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