| Entrez gene ID | | 5602 |
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| Official gene symbol | | MAPK10 |
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| Full name | | mitogen-activated protein kinase 10 |
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| Aliases | | ,FLJ12099,FLJ33785,JNK3,JNK3A,MGC50974,PRKM10,p493F12,p54bSAPK, |
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| Gene summary | | The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kianse 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq] |
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| Location | | Chromosome: 4 Locus: 4q22.1-q23 |
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| Gene position | | 87281375 - 86936276 Map Viewer |
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| Gene orientation | | minus |
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| Gene size | | 345100 bp |
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| Gene sequence |
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| OMIM ID | | 602897 |
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