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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for PRKACA (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID5566
Official gene symbolPRKACA
Full nameprotein kinase, cAMP-dependent, catalytic, alpha
Aliases,MGC102831,MGC48865,PKACA,
Gene summarycAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is a member of the Ser/Thr protein kinase family and is a catalytic subunit of cAMP-dependent protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq]
LocationChromosome: 19   Locus: 19p13.1
Gene position14228559 - 14202500  Map Viewer
Gene orientationminus
Gene size26060 bp
Gene sequence
OMIM ID601639