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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for PRKAB2 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID5565
Official gene symbolPRKAB2
Full nameprotein kinase, AMP-activated, beta 2 non-catalytic subunit
Aliases,MGC61468,
Gene summaryThe protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. It is highly expressed in skeletal muscle and thus may have tissue-specific roles. [provided by RefSeq]
LocationChromosome: 1   Locus: 1q21.1
Gene position146644129 - 146626685  Map Viewer
Gene orientationminus
Gene size17445 bp
Gene sequence
OMIM ID602741