| Entrez gene ID | | 5565 |
| Official gene symbol | | PRKAB2 |
| Full name | | protein kinase, AMP-activated, beta 2 non-catalytic subunit |
| Aliases | | ,MGC61468, |
| Gene summary | | The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. It is highly expressed in skeletal muscle and thus may have tissue-specific roles. [provided by RefSeq] |
| Location | | Chromosome: 1 Locus: 1q21.1 |
| Gene position | | 146644129 - 146626685 Map Viewer |
| Gene orientation | | minus |
| Gene size | | 17445 bp |
| Gene sequence |
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| OMIM ID | | 602741 |
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