| Entrez gene ID | | 55615 |
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| Official gene symbol | | PRR5 |
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| Full name | | proline rich 5 (renal) |
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| Aliases | | ,FLJ20185,FLJ20185k,PP610,PROTOR1, |
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| Gene summary | | This gene encodes a protein with a proline-rich domain. This gene is located in a region of chromosome 22 reported to contain a tumor suppressor gene that may be involved in breast and colorectal tumorigenesis. The protein is a component of the mammalian target of rapamycin complex 2 (mTORC2), and it regulates platelet-derived growth factor (PDGF) receptor beta expression and PDGF signaling to Akt and S6K1. Alternative splicing and the use of alternative promoters results in transcripts encoding different isoforms. Read-through transcripts from this gene into the downstream Rho GTPase activating protein 8 (ARHGAP8) gene also exist, which led to the original description of PRR5 and ARHGAP8 being a single gene. [provided by RefSeq] |
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| Location | | Chromosome: 22 Locus: 22q13 |
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| Gene position | | 45064593 - 45133561 Map Viewer |
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| Gene orientation | | plus |
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| Gene size | | 68969 bp |
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| Gene sequence |
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| OMIM ID | | 609406 |
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