| Entrez gene ID | | 550 |
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| Official gene symbol | | AUP1 |
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| Full name | | ancient ubiquitous protein 1 |
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| Aliases | | ,-, |
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| Gene summary | | This gene encodes a protein that contains a domain with homology to the ancient conserved region of the archain 1 gene and a domain that may be involved in binding ubiquitin-conjugating enzymes. The protein encoded by this gene has been shown to bind to the conserved membrane-proximal sequence of the cytoplasmic tail of integrin alpha(IIb) subunits. These subunits play a crucial role in the integrin alpha(IIb)beta(3) inside-out signalling in platelets and megakaryocytes that leads to platelet aggregation and thrombus formation. This gene overlaps the gene for mitochondrial serine protease 25. [provided by RefSeq] |
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| Location | | Chromosome: 2 Locus: 2p13 |
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| Gene position | | 74756974 - 74753775 Map Viewer |
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| Gene orientation | | minus |
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| Gene size | | 3200 bp |
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| Gene sequence |
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