| Entrez gene ID | | 54476 |
| Official gene symbol | | RNF216 |
| Full name | | ring finger protein 216 |
| Aliases | | ,TRIAD3,U7I1,UBCE7IP1,ZIN, |
| Gene summary | | This gene encodes a cytoplasmic protein which specifically colocalizes and interacts with the serine/threonine protein kinase, receptor-interacting protein (RIP). Zinc finger domains of the encoded protein are required for its interaction with RIP and for inhibition of TNF- and IL1-induced NF-kappa B activation pathways. The encoded protein may also function as an E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes and transfers it to substrates. Several alternatively spliced transcript variants have been described for this locus but the full-length natures of only some are known. [provided by RefSeq] |
| Location | | Chromosome: 7 Locus: 7p22.1 |
| Gene position | | 5821292 - 5659678 Map Viewer |
| Gene orientation | | minus |
| Gene size | | 161615 bp |
| Gene sequence |
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| OMIM ID | | 609948 |