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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for POLG (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 5428 Official gene symbol POLG Full name polymerase (DNA directed), gamma Aliases ,FLJ27114,MDP1,PEO,POLG1,POLGA,SANDO,SCAE, Gene summary Mitochondrial DNA polymerase is heterotrimeric, consisting of a homodimer of accessory subunits plus a catalytic subunit. The protein encoded by this gene is the catalytic subunit of mitochondrial DNA polymerase. The encoded protein contains a polyglutamine tract near its N-terminus that may be polymorphic. Defects in this gene are a cause of progressive external ophthalmoplegia with mitochondrial DNA deletions 1 (PEOA1), sensory ataxic neuropathy dysarthria and ophthalmoparesis (SANDO), Alpers-Huttenlocher syndrome (AHS), and mitochondrial neurogastrointestinal encephalopathy syndrome (MNGIE). Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq] Location Chromosome: 15   Locus: 15q25 Gene position 89878026 - 89859536  Map Viewer Gene orientation minus Gene size 18491 bp Gene sequence >POLG:complement(4825063..4843553):Length=18491 GCGGACCGGCCGGGTGGAGGCCACACGCTACCCCGAGGCTGCGTAGGCCGCGCGAAGGGG GACGCCGTGCCGTGGGCCTGGGGTCGGGGGAGCAGCAGACCGGGAAGCACCGTGAGGACC GAGGTTTCCGGCGGGGTCGGCGGCGGGGAGGCCGGGTCGCTGAGCGACGGCGCGGCCCCT CCCTCTCCAGTCAGGGAGCGAGGCCCGGAGCAGGGCGGCGGCTAGTCCCAGGGCGCACCG CGGCGCCTCTGCCGGGCGCAGGCGGGCGGCGGGGCGCACGGGGGTGGCCGCCGACTCCTC CTGCAGGACGCTCTCGGCCGGGTGGGCCGTGGTCCGGGTGTGGGTGTGGGTCCCGGGGGA CGGCGGCCCACCCTGCGGGTTCGAATCCGGGCGCTGGCACCTCTCGACGCTAGGCCCGCG CCGGTCGCGGTAATGGCAGCCACCATTTGCCGAGCGCTTGCCAAGAGCAGGGCCGCACGA CATAGGCGCCCTGTGTCCCCCAGACAGCAGCCCGGTGTGACAGGCAGAATCCGTAATCCC ATTTTACAGAATAGGATATCAGGGCCTAAGGAGCTTTGCCCAAGGTCACACAGCTCGAGA GAGCCAGAAGCGGGGTTCAAAACCGCGTCGCCCTACTCCAGATACTGCTCTCTTACTCGC TGCCCTCGGCTTCCCCACGTGGGTTCACTGACGAAGTTGCGTGGACCCCGGTTCCCCCAG GAGGGGTATTGACGTTTCCCAAGTTTTGAGGCTTAACGGAAAATGCAACTGAAGCGCCTG GCACAGTGTTGGGGACGCAGTAAATGCTCAAGGAATGATGATTATGGATACACCTATTAC ATATATGGTAAAATAACGCTTTATATCATCTGTCTCCTTTAGGATTTGGGGTGGAAGGCA GGCATGGTCAAACCCATTTCACTGACAGGAGAGCAGAGACAGGACGTGTCTCTCTCCACG TCTTCCAGCCAGTAAAAGAAGCCAAGCTGGAGCCCAAAGCCAGGTGTTCTGACTCCCAGC GTGGGGGTCCCTGCACCAACCATGAGCCGCCTGCTCTGGAGGAAGGTGGCCGGCGCCACC GTCGGGCCAGGGCCGGTTCCAGCTCCGGGGCGCTGGGTCTCCAGCTCCGTCCCCGCGTCC GACCCCAGCGACGGGCAGCGGCGGCGGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAA CAGCAGCCTCAGCAGCCGCAAGTGCTATCCTCGGAGGGCGGGCAGCTGCGGCACAACCCA TTGGACATCCAGATGCTCTCGAGAGGGCTGCACGAGCAAATCTTCGGGCAAGGAGGGGAG ATGCCTGGCGAGGCCGCGGTGCGCCGCAGCGTCGAGCACCTGCAGAAGCACGGGCTCTGG GGGCAGCCAGCCGTGCCCTTGCCCGACGTGGAGCTGCGCCTGCCGCCCCTCTACGGGGAC AACCTGGACCAGCACTTCCGCCTCCTGGCCCAGAAGCAGAGCCTGCCCTACCTGGAGGCG GCCAACTTGCTGTTGCAGGCCCAGCTGCCCCCGAAGCCCCCGGCTTGGGCCTGGGCGGAG GGCTGGACCCGGTACGGCCCCGAGGGGGAGGCCGTACCCGTGGCCATCCCCGAGGAGCGG GCCCTGGTGTTCGACGTGGAGGTCTGCTTGGCAGAGGGAACTTGCCCCACATTGGCGGTG GCCATATCCCCCTCGGCCTGGTAAGTAGGGGCAGGGTTGGGGACATAAGCAGGCATGGGG GCCCAGCTTAATAGTTTGTTTCAGTGAACATTTTCTGAGGTCCTGTTACGGGCTGGGTGC TCACGTAGGGAGCGCTGATGTGTTGAATTAGGACTAGACCCCTGTTTATGTGGGACTCAC TTTCTGGTGGGAAGATCACAGGCAGTAAGCAAATACCCAAGTAAATGTCAGGCAGTAAAG GCCACGCAGAGAATCACAGTAGAGCGCTGTACATGAGACCTTCGGGAGGCCACTTAAGAT CACGGTGATTTGGTGCCTTTACCCCCTCTCCTAATAGCGTCATGAGAAGTTAGTCTGAAA AGTCATTTGAACAGTGTTTCTATTTGGGGAGCTATTAATTATTTTGGGCGGTAGAAAGCT CCCTTTTGTGGGACTGTCCCAGGCAGTATAGGACATTTAGCATCCCCAGCCTTTCCCATA AACGCCAGACCAACACCCCCCCGCCCCCCTGCCCCCGCCGGCAACGTTTCCAGACGCCCC CTTGAGGTGGCATCTGGTTGACCACCCCTAGTTGAGAAACATTGCTTCCTTCCCCCAGCC TTCCAAGCAGGCATTTTGGTCCCAAACAAGTATATCCAATCTCTCTTTTCTTTTTAAATA ACTTTCTAAGTGCTACCCAAGTTTCTTTTTCAAACAATGATGGCAGTACTGTTTCTCCCC TTTTTTTATTCTTCATTCCAGGATTAAAATACTATTTACAACCTTAATGCTTTCAGGCAT GGCCAGCAAAAAAGTTGGCAGTTTCTTTATTCCTATTGGAAGCTACATCTTTGTAAAGAA AGCTGCGAAATGTTAAATATGCAGTTGAAAATGGTGAAAACATGGCTAAATAGATAAGGT AGGCATTAATGGCTGAAAAGAGCAAAACTAGATGATTCTGCATTGATTGAGTTCCAGTTA CAATGAGAATCACACTACTTAGAATATGTAACTTGATGGTCAAAGTAAAGGGGAATATCG GCCATCATTTGAAAAGATAAAGTAGGCTTTGGTGGCTGAAAGAAAATTAGGAAACCAGTG ACAAGAAAGATTTGTTTTTTGATCTGTCGGTCATTTTAGGCCAAATTACCTCAAGTCCCC TTTTCTTTTCTCTTTCTCCTTCTTTCTCTCTTTTTACCTCTCCTTTCCCTCCCTGTCCTT CCCTGCTCTGCCCTCATTCTCATTCCATTCTTGCCAGTGGTACTCGGGGCATTGCTTAGT TGACCTGATGGCAGAAGTCACTGTTAAGGCCTGGGCTCATGCTGGGACCTTCCTCCTGGG AGTCTGACTGGTGGGTGGGGGTGGGTGCCACATGGTGCCCTAATAGCGGTCCACTTTGAA CCTGGGCATGCCCCTGCCCCTTAGCTGAGTAACATTAGGTACCTGACCAGCCCACAATTT ACAATGGGAGGAGAAGCGGTAGTCAGCTATGAGCCTCCCACAGGGCAGCTTCTTCCCAAA GGGTGTTGGTAAGGGCTTCGGCCATCAGGCTAGAGGGACGTCTCTCTGGCCATCAGCATT TTTCTAAGATTCACAGTAAAACTAGTATTAATGGCATGGATCCCTACTCATCTTAAATTT GGCTTGTTTCTTTTTAATCACTAGTTTATAATATGGCTTCATGCACAGCTGCAGAGCTGC ATCTTGACACCAGTGTGGCTTTTTACTGTAACCAAAGTTCCTGTTACCACCATGGCCTCA AAGATTTGGCATTCTTTAGCCTTTTTGTCTGCGTTGTTTTAAGGGCTTTGACATGCTGAA TTAAAATGTGGGGGGGTGGGGATTTCTTTCAGTCCCTTGGCTTATTTTCACCATTTGGAG TATGAGTTCGATTTTGTCAGGTTTAAAACTAGGAACCTCTTTTTGCTTTCTCTTTGAAAG AAGTTAGTTTTATGTGTGTTGAATCTGTTGAGGCAGATACTCCCTTTTTCCCTTCCATAA AGGTTGCAAGGAGCTCCTTCGCAGCTGTGTTGTCCACACGTGGCCTCGTCACTCACTTTG ATGCTGAGTGGGCCTTGATTGTTTAGAATAATCTGTGGCTTGCAACAGGCATTTCCTCAG TGGCCATTCCCCTACACCTAGCCTTGTGGATCTTGAGCAAACTGCAGCCTTTTCCTGAAT CAGTGTCGGGCCCCCAACAGGCAGCACTCATCCCCTATCCCTCCCACCCCAACCCTGTCA CATACACATACATTTTCTCATTCTGGCACTTTCCCTGGTTCTCACTGAGGGTGGTTGCTT CTCCAAGGTGTGTGATTTGCTCTTTGTCCCCCAGAATCTTTTCAGCCGTGAGATGATTCA TCCTGTACATGTGTGCAGCAGCATTTGTCATTTTTTTTTTTTTTGCCAATTCAATTAAAT CTCCACCTTGGGTTCTGTTATTGTCTATCTCCTTTACTAGTACTTTGAACAGTAGCTGGT TTGTGCCTGTAGACGTGAGGGGTTGATAATGTTCATAAAACCTCAGAGCTAGATGCAGAC TCAGTGAACGCTGGGCCTAGCAAACACCTTGATAGCCCAGGCTGTAATAGAATACCTGCA CGTAGGTCTAATAGCCCAGTAGTTCCATTTTTATGTGCAGAAGTTTAAAGAAGCTTTTGT AGCTCTTGCCCGCCAGCACACACACCCACCCTGCCACACCTGACCTGTAGCTGTTTGAGT TAGGAGCACCCTTTGGTCTCACTTGTGTCCCCAGCTGCCAATGCACCATCTGGCATGTGG CGGTAGGTGTGCAGTGGTTGTTGTGGAGTGGAAGTTTAATGTCTCCATGGTGAACCTGCC TGCCTCTCACCTCCCTCAGGTATTCCTGGTGCAGCCAGCGGCTGGTGGAAGAGCGTTACT CTTGGACCAGCCAGCTGTCGCCGGCTGACCTCATCCCCCTGGAGGTCCCTACTGGTGCCA GCAGCCCCACCCAGAGAGACTGGCAGGAGCAGTTAGTGGTGGGGCACAATGTTTCCTTTG ACCGAGCTCATATCAGGGAGCAGTACCTGATCCAGGTAAGGTTCCTGGGGCCAACTGCAG GTTCTGGCATGGGATGGGCCAGGAGCCCTAATCTCAGTGGTTAGGGGAGGTACTCCTTTC CTGGCACGTGTCTCTGTTGCCTTTGCTGAAGCCGCAAGGCGCATCTGTTGACCAGCTGTG CCTCTGGTCTCTGTGCCTAGCTGTTGTATGTCCCCGGGAAAGCCTGGTATAGGACCTAAG TTGTCACAAAGTAATAATGGCCTTCGTCTCTGTGGCATTTTAGAGCTTAGCATGGGTCTT GAAGGTTTTGAGCCACAGCCTGGGCTCACTTCCTGCCTTAACCACCGATGACTACTGTGA GCGCCTTAACATCTCTAAGTCTTAGTTTCCTTTTTTATAAAAAGGCAGACATAACAGAAA TCTCATAGGATTAATAGGAGGGTTGGAACAATGCCTGCATGTCAAACACTCAGCACTCTG CCTGGTGTATAGTAGTGGCAATTCTTAATTTTATGAAAAGTGTTTTTTCACTGGATCTTC ACAACAGCCCTAGAAGATAGGCCAGGCAGGGGAGAGCAACCTTACCCTATAGCTGAGGGT GCTGAGGCTCAGACAGCCTTGTTGACATGCTCAGGGCCACAGAGCTTTTGAGTGGCAGGG TTGGGGCCAGACCAGATAGCCCTGAAGGCTTTATTTTGGCCACTCTGTATCTACGTTGCT CAGAGCTATTGTTGGAAGCTGAGAAGGACTTGCACATTGGGATTGAGCCAGGCCTGCATC TTAAAGGGTGGCTAGGATTTGGGAAGGCAGGCCCCTTACAGGTGATGGGGCAAGCATGAA CAAGCATGAGGATTCTGTATTTGGTGTTGAAGGCTGTGTGCTGGGAGGGGAGGCTGTTTG AGGAGCTGAGGTGGGGCTGGAGGTCCACACCACCAAGCAGTGGTGGGCTGGCCCCACAGT TGCAGCCTCCCTCCTTCCCTTCCCTTTTCTCCTCCTCCTCCTCAGGGTTCCCGCATGCGT TTCCTGGACACCATGAGCATGCACATGGCCATCTCAGGGCTAAGCAGCTTCCAGCGCAGT CTGTGGATAGCAGCCAAGCAGGGCAAACACAAGGTCCAGCCCCCCACAAAGCAAGGCCAG AAGTCCCAGAGGAAAGCCAGAAGAGGCCCAGCGGTGAGAGCACACTGCCGGTGGGCAGGA GCATAGTGCTTGGGACCCCCTCTCACCAGCCCGTCTGGCCCGAGGCCAGGCTGATCTGCC ATGTCCCTTGCTCTGGTTCCCCAGATCTCATCCTGGGACTGGCTGGACATCAGCAGTGTC AACAGTCTGGCAGAGGTGCACAGACTTTATGTAGGGGGGCCTCCCTTAGAGAAGGAGCCT CGAGAACTGTTTGTGAAGGGCACCATGAAGGACATTCGTGAGAACTTCCAGGTATGGTGC TGGAGGGGGCTCTGGGGACATGGGCTGTGGCACACCCCTAGCTGCACTTGGGGAGATGCA GCTGCCAGGCCTGACCCTGAGAGCTGGTGGTGGTAATGGGATGGCTGCCCACCTTGCGCC TTCCTGTCACCTTGTGCCAGGACCTGATGCAGTACTGTGCCCAGGACGTGTGGGCCACCC ATGAGGTTTTCCAGCAGCAGCTACCGCTCTTCTTGGAGAGGTGAGGGGGAGCCCATGTGG GAATCTCTGGGGGTCAGTGTGTTCCTGGTACCCGGGCCCACTGTAATCAGGTGGCGCTGG TTCTATCTCAGGTTGGGGACCTTAGCTTTTCTAGGCTGAAAGAATGGAGCCCTTCTGTTC AGTGGTGTCCATCTGGGCCCTGGACTCTGGATTTGACAGAGGCCCTGAAGGGGAGGGCCA TGGAGTTGTGCTTGTGTGTCATGTGCACGGTCCTGGTTTACTGTGCACCTTCTCTAACTA GATCCTTAGCCAAGGGCTTCACATACAGCGTGGTTATGTTTATTAATGAGTCTGTCTTAT GAAGTGACCCTTGTATGCTGAAAATTCAGGTATATTTGTACCAAAGATATGGAAAGAAAA AAGAAGGGAGGAAAATTTGGGTGTAACTTTTGACTCCCTCAGAGCTTAACTACTAATAGC TTGCTGTTGGCTAGAAGCTTTACTGATAACATAATACATATTTTTTATGTTATACGTATT ATATACTGTATTCTTAAAGTAAGCTAGATAAAAGAAAATGTATTAAGAAAATCATGAGGA GAAAATATGTTTACTATTCATTAGGTGGAAGTGGATCATCATAAAGATATCTATCCTTCA CGTTGAGTAGGCTGAGGGCGGGGGTTGGGCTTGCTGTCTCGGGTGGCTAAGGCTGAAGAA AATAAATGTGTAAGTGAACTTGCACGATCCAGACATGTGTTGTTTAAATGTCAGCTGTAT TTTACCACCCAAGTTGTGAGGTTCAGGCATGATGTTTTTCATGTATGGGATTATTAGCAC AGTGCCTGGCACAGAGTCATTACTCCACGTGTGGCAGCCATTTTCACTTTTGCCATCTAT ATTTCCCACATTACCCCTGAGGATGGGATGATATTGTTCCCATTTTATAGATGAAAGAAC TGAGGCTCCGAGAGATGGGGTTGCTTACCCAGGGATGAGTAACAGTAGAGCTGGGATTTA ATGCCGTCTGACTTTTGAGCTGTGCCATGTCAGTGGCTGGGTTGAGGCTTGCTAAACCAG CTCAGGGATTGGGCCAGTCTTGCCTCCTGTGGTCATTTATGGCAGCTCCTGGTGTTTGCC TCCAAGGTGTCCCCACCCAGTGACTCTGGCCGGCATGCTGGAGATGGGTGTCTCCTACCT GCCTGTCAACCAGAACTGGGAGCGTTACCTGGCAGAGGCACAGGGCACTTATGAGGAGCT CCAGCGGGAGATGAAGAAGTCGTTGATGGATCTGGCCAATGATGCCTGCCAGCTGCTCTC AGGAGAGAGGTAGCCAGGCCTTGGGTGGGCAGGATCTAGGCAGGGGACTGGCAGGTGGGC GGCCTAGCCTTCGGCTTAGCCTTAGCCCTGCCCTAGTGGACTGGCTCTGTAGGTACAAAG AAGACCCCTGGCTCTGGGACCTGGAGTGGGACCTGCAAGAATTTAAGCAGAAGAAAGCTA AGAAGGTGAAGAAGGAACCAGCCACAGCCAGCAAGTTGCCCATCGAGGGGGCTGGGGCCC CTGGTGATCCCATGGATCAGGAAGGTGGGGAGCATGGGTGGGAGGTAGGGTAGGGTAGGG GTTGTCTCTGGGAAGGTCCTGTGATTGAGGGGGTCCTTCGAAAGGATTGCTCCAGCCTTC TGGAGATGAGCGGGTGGGAGCAGATCTTATTGAGAGTTCCTTCTCCTGCTCCTGATTGTC TTCCCCCACCCTCACAGACCTCGGCCCCTGCAGTGAGGAGGAGGAGTTTCAACAAGATGT CATGGCCCGCGCCTGCTTGCAGAAGCTGAAGGGGACCACAGAGCTCCTGCCCAAGCGGCC CCAGCACCTTCCTGGACACCCTGGGTGAGCCCTGCCCACCCCCAGCAGTGTATCTAGAGT CTACCCTTGCTCCATTCTCAGGACAGCCCTGGTCTGGGTTCTGGCACAGAGGCATCATGC ACATGTATACTTATTGACCTGCTGCCATTCAGTCACACTGTCTTCCAGTCCTATTCTCAT TTGCTCACTCTGGACCGGCTCACTGGACTCATTCAGCACAGTGTTGTGAGCACCTGCTGT GCAATGGCCCGTGGCAGCCACCGGGTGTACACACTGGAGCATAGCTCCTCCTTTCCAGTA GTTCTTTTTCCTAGGAGGAGCCAGGCACGTAGACCAGCCAGTGCAGCTAGTGTCCATAGG TAGAGTTCTGACTCTGCCTCGGGAAATAAATCAAGAAGGCTTCCTTGAGAAGGTGCCCCT TCCTTTGAGCCTCATAGGGTGGCAGAGATGAGAAAAAGGGCAGCCAGGGTGAGCAGCAGG GTGCCAGCTTTGCACCTGCAAGACCCTGAGAGCAAGTGTCCTGAGTGCCTTGCTAGTCTC ACCCTGGGCTCAACTCTGGTGAACAGCCTGCAAGAGAGCACCCAGAAGGACTGGTGTTTC TCTAGAGGGGTGGGGAGGGCAGATCTGCTCCCTCCTCTGGTCAGTTACCCTGGATGAAAT GGAGCTTGGGAAGGAGCCCTGCCCTGGGTCAGGGTATGCTTTTGTGTCCTGGCTTCTGAC TAGTCCAGTGGGACTGACTTAGTGTCTTTGCTTTTGAAATATTCTTCTAGAGGATTCCAT GGGGGTCCTGGCTAAAGCATCCCAGAGGAGGGGATGGCGGCTGTAGGCTGGGGTCACCAG AAAGCCCCAGGGCTTTGGAGGGTGGGTGGGGACATTGTGAGAGAGAGAACCTTCCCCCCA ACAACTGCCCTTACCATCGTGACACTGCTGTCTTCCTGCTGGGACGTAGATGGTACCGGA AGCTCTGCCCCCGGCTAGACGACCCTGCATGGACCCCGGGCCCCAGCCTCCTCAGCCTGC AGATGCGGGTCACACCTAAACTCATGGCACTTACCTGGGATGGCTTCCCTCTGCACTACT CAGAGCGTCATGGCTGGGGCTACTTGGTGCCTGGGCGGCGGGACAACCTGGCCAAGCTGC CGACAGGTACCACCCTGGAGTCAGCTGGGGTGGTCTGCCCCTACAGGTAAGGCTTAGGCC CAGGGGAGGAAGGGGCTGGAGCCTAGGGACCCCTTCCCCTGGCTGGTCAGCTCAGGCTAG TGGAAAGAGTTTGGGTTCAAGAGTCTGGGTTCAGAAGAAGGGAAAACAGGAAAAAAATTA ACACACACACACACACCCTCTCTCTCTCTCTTTCTCTCTCTCTCACTCACTCACTCACTC TCTCTCTCACTCACTCACTCTCTCACTCACTCTCTCACTCACTCACTCTCTCACTCACTC TCTCACTCACTCACTCTCTCACTCTCTCACTCACTCACTCACTCACTCACTCTCTCACTC ACTCTCTCACTCACTCACTCACTCTCTCTCACTCTCTCACTCACTCACTCTCTCACTCAC TCACTCACTCACTCACTCTCTCACTCACTCACTCACTCTCTGGGTTCAGGTTTTTTCTTC CATGGCTACCCTTACCCTCTGGATCTCAGAGCTCTGGGAGGGAGTATGTTGAGATGTTCA CAGTGGGGAGGACTAAAGGCCCTACTCTTGGGCCCAGAAGCATAGCTGCCTTCACAGGAA CATGCGGAGGGCTGTTACAAGTAGCAGGGAGATGGGCTTTTAAAAAAGTGTGTGTATATA ATTTGAGTGATAATTATGGGCCAAGCAGTGCTTCCCTTATTTGTTCCCCAAGGAGTCCCA TGAGCTAGAATGGTTATCCCCATGTTGTAGTTGACAAAGGCTTGGTTGACTTAAGATCAC AGACCCTGAGCTTTAGGCAGGCAGGTGTTGGGGAGAAACTTACAGTGGCCCAGAATTAAG AGTCCTGGCTCTTCAGGGCAGCCTGAGTCTCTTATGGGGCCATGGGACCAAAGGGGATAA CACTGGCCTTGCTCCTTTGAGCCCGAGGGTAGGTGAGCGGACAGGAGCCAGCCTGCAGCT GGGCCTTGGGTCCTGTCCTCCCGCTGCTGTGCTCTCAGAACTTCTCTTGAGACGGCAGCT CTGTAGTGTAAGAGGAACTTGGATTTGAGTGAGACAAGGCCTTGAACCCCAGCCTGCTGC CAGGGTGCTGTCATTTTCAGTTTGTCAATCAATCCCTGTCTAAAACCCGGGAAAGTGCTA TCTGGTTCTGCCTCAGAGCTGATTCTGAGGACTAAACAAAGGGAATTGTGGAAGGCACTA GCAAGCTGCCTGGCCCAGAGTGGGCATCTGGTAATCAGCGGCTGCTGCTGCTACTGTTCT CTGCCCAGAGCCATCGAGTCCCTGTACAGGAAGCACTGTCTCGAACAGGGGAAGCAGCAG CTGATGCCCCAGGAGGCCGGCCTGGCGGAGGAGTTCCTGCTCACTGACAATAGTGCCATA TGGCAAACGGTGAGGGCAGGCTCTGAACCTGAGCTTTGGGGAGGGGAGGTCTCTGTATTC CACCCAGGGAAGGGGCAGCCTTTGGGTGGGAGGCTGGCACTGGTGGCTCACCCCAGACTG GCCTGCAGTGTCTGAGTACCATGCAGGGAGGGGCTGGTGGATTGGGGCCTACCCAGTCCC CTGCTTCACTACTTTGGTCCTTGGACTGCTCCAGGTAGAAGAACTGGATTACTTAGAAGT GGAGGCTGAGGCCAAGATGGAGAACTTGCGAGCTGCAGTGCCAGGTCAACCCCTAGCTCT GGTGAGCAGTGCGCCGGCTTGGGTTCTCTAGGTGGGTGCTGGGTGGAAAGGGCTTCCTCT TGCCCACCTAGTTCTTCCCAGCCAGAGTTCCCTAGGTCTTAAGGGGGTTGGAGATGCCAC CCTGCCCCTGGGAGGCCCCACACGTGTTGGAGCAAGGAGAAAGCCTGGGTGAGACCTCAT GGCCATCTTGTCATTTCCCAGCTGATGACGACAGTTTCAGGCCCTTTTCCCACCCCCTAC CCCATGGCCCTTGCTGAATGCAGGTGCTGGAGCAGGGCCTGATATAGGTGTGTGGCCCTC ACAGACTGCCCGTGGTGGCCCCAAGGACACCCAGCCCAGCTATCACCATGGCAATGGACC TTACAACGACGTGGACATCCCTGGCTGCTGGTTTTTCAAGCTGCCTCACAAGGTGTGTCC TGGGTCATGGCCTGTCCTGTGGTGTTTCCTCATTCTGCTCAAGGCCCACAGCAGGCCTTC AGAGTGACACACCTGAGACTTTCCTTTTTGTGGGAATGACTAGTAGTGGGACAGAGTGTG ATTTCAGGCACATACTGTCATCTCTCAGCTTTTGTTTTTCTAATGAAAGTCGGGTGGCAA GGGGCATGGTGGTGGAATTAAATGACATGGGGCACGTCGTATGTTTGGTACGACATCTGG TACGTGATAGGTTTTTCCGATTTGTTATTATGCAGGGAGCCAGGTTTGCTTGTGTCTGTG TGTCTTAGGGGGCATGTGTGTGCACGTGTGTGTGTGCGTGCGCGCGTGCGCGCGTGCGTG ATACAATCAGGGATTTGCCTCAGACTGCTGAGGTTCTGGGCTCAGTGTTGGGAGGAGTGC AGGTACTCACGTTGGTTCCCCACCCAGGGGTCTGCCACCTGCCTCCAGCCCCTGCTTCCT TTGCTCTGTCCAGGATGGTAATAGCTGTAATGTGGGAAGCCCCTTTGCCAAGGACTTCCT GCCCAAGATGGAGGATGGCACCCTGCAGGCTGGCCCAGGAGGTGCCAGTGGGCCCCGTGC TCTGGAAATCAACAAAATGATTTCTTTCTGGAGGAACGCCCATAAACGTATCAGGTGGGC CACCATGGGAGGAGTCCTGGGATGCCTTTCCCCTCTCTTCCCACCCAGGGACCCCTGACT AACCCTGGATTCCCACAGAGGGCCAGCCTGACTATGGTCTAGAGGCCTGGCTACTTTTGG TCCTGGTGCCATGGACCTTGGGCAGGTCTCCCCTCTAGCTTCAGTTTCCCTGTTAATGTA AAAAGAATGGTGCTGTAGGACCATGAGAGCCCTTCGTAGCTCCAACAGAACTTCTTGGTG TAACTGCTGGAGCCGTGGGCTATGGCTGAGGACCATGGAGAGCTGGTGGCCTGTAAGCCC TGTTGGGGGCTGGGAGCTGGGTCTTCTAGTCTGGAATGGCAAATGTATTCATCTTGAAGG CCATTTCCAAGGTGGTTGTGGCCATCAGCACACTGGCGAGCAGAGTGGGTGTTGGGATGG TGAAGTCTGCCTGTGTGTAGGAAGAGGCATTGGTGGAAGGAGCGCCTCATGGATGCCCCC CGGAGAGGAGCGGAAGCTCGCTCGGAGGCCTGGCCGGTTCCCAGATGGTTTATGCTCTTG ATTGGTGTATCATAGGGCCCCAGTTCTTGGCTGAGCCAGGGCTCACCTTGAGTCCAGTTA GTGAGGCTGGGTAATGGAGTATAGCAGTCCTGGAGGTGGGCAGGTGAGGGCCATGGTGGG ATGTGGGATAGATTCTGCTTCCCATGGCTGTGCTGAGCCTCACGTTGTCTGTCCCCACAG CTCCCAGATGGTGGTGTGGCTGCCCAGGTCAGCTCTGCCCCGTGCTGTGATCAGGTATGG TCTGCTGAGTGGTTGTAGGGATAGGAGAACTGAGGTGAGGTGGTAGGTCCTAAGGCCAAA GCACCCTGCTAAGACCCATTTCCTTCCCCTGCACCCCACCAGGCACCCCGACTATGATGA GGAAGGCCTCTATGGGGCCATCCTGCCCCAAGTGGTGACTGCCGGCACCATCACTCGCCG GGCTGTGGAGCCCACATGGCTCACCGCCAGCAATGCCCGGGTATGTGACCTCTGTACCTC TGGCCCCTGCTCTTCCTCTCCCAGGTCTGTAGAAACTGGGCTCTGAGGGCCTTTAGGTAT TTAGTGAGGATCATGAAAAGGACCCTGTGATCTGGGTCAGGCAGGACTCTAGTCAAATCT GGCTTCATGATTTCTGTCCACTCCTTCAGTAAATATGTTCTGGGCACCTGCTCCTGGCCA GACCGTGACAGGCGTAATAGCTACAGCTCTCATGGAATTTAGATAGGACCGTGTAGGTGA GGGGTCTGGCATAGCGCTAGGCATAGAGTAGATTCTTTACCTGTCACACCAATTGCTGAT AGGTGGCCATCTCTGGAACTGTGGAATTTCAGCAGTGCTGTCTGGCATTCTCTAAAGCCA TCCCCTCAGGAAAGGCTCTAGCTCTTTCTCAGTCAACTCTGGCTCCAGGAATGGGGTAGG AAGAGTCTCATTTGGGTATCTCACTCTTCCCACAGCCTGACCGAGTAGGCAGTGAGTTGA AAGCCATGGTGCAGGCCCCACCTGGCTACACCCTTGTGGGTGCTGATGTGGACTCCCAAG AGCTGTGGATTGCAGCTGTGCTTGGAGACGCCCACTTTGCCGGCATGCATGGTGAGCAGG AGCCGGGGTTGGGGCAGCCCAGCCCCTCAGCATATTGACAGTTCTGATGAACATTGGGCA GAATGTTCCTGAGCTGCTTTTCTCACTCCTGCTTGTCTTCCAGGCTGCACAGCCTTTGGG TGGATGACACTGCAGGGCAGGAAGAGCAGGGGCACTGATCTACACAGTAAGACAGCCACT ACTGTGGGCATCAGCCGTGAGCATGCCAAAATCTTCAACTACGGCCGCATCTATGGTGCT GGGCAGCCCTTTGCTGAGCGCTTACTAATGCAGTTTAACCACCGGCTCACACAGCAGGAG GCAGCTGAGAAGGCCCAGCAGATGTACGCTGCCACCAAGGGCCTCCGCTGGTGAGGGTCC CTCTCCCATCCACTTTAACACCCAGGACCCGAGGCCTGCTTTACTGTCCTTTAGTACTAC CATCTGTTCTATCTCCTGCCCATTACTTGAACTCTCACCTAGCCCCTCTCCTTCCACACC TGTGTAACCTGGTTCCAGGATGATTTGTCCTATTGTGACATTTGGTTGCTTTATAGTCAG CCTTAAACAGTTTTTCCTCATGGGAGTAAAGCTATACTTTTGGTATACTGTTACCAAGTG GTAGCATCTTGACAATTCTGATTATGCTGCATAATCAATAATACAGGGGTTGCAAACTCA GATGCCTACAGGGAATGAGAGCAAATGGAGTGGGTGGAAGACAGGAGTTGACAGGAGGGC GCTGTGGCAAACTGGAGCATGTAGGCTGATGTTGATACTGGAGAAAGCATTACCAGGCCT CCAGGTTACTTAGCCTAGCTCTCCAATTTGTTTCCTCTGATCGTACTGCATACTGTGTGC TCAGGGCCTTAGCAGACTCTCTGCAGGGTTCCAAAAACATTGAGGGAAGAGAGGTACAAC TTCCTGAGGTACAGTACACTGTCCACATTTAATTAGCTGGCTCATTGTGGAAACTTCACT TTCTCGTCAACAACTAAAAGTTAAGTATGTGATAAATGATATAGTGGTTGATGACTATAA ATGCAGGGAAGGGGAGCTGAGTATCGTCCAGTGGATAAAGTGAGGTCGGGTAAGGCTCAT ACCGTGAGCAGCGTGTGCTGGTGGAGGCGAGAAAGGTGGTGGGGCTTTAGTTGTGGACAC CTTTGAAAGTGTCACAGGAGTTTGGACTGTGGGTGCAGGTGGTGGGGAAGCCATTTATGC GAGTGACGTGTCTCTGGAGCCTTCAGGCGACAAGCCTTGTGAGGTCTGCAGGTTAGATGG AAGCTGGGAGTTGTCTAGGGTTGTGGCAGTTGAGAGGGGTAAGCCAGGCCTGGCTGTTGT GTTTTCTGCTTCAACAAATGCCCCCTCCCCTTCAGGGAGTAGCCTATTCTTACCCCTATC CCCCCAAATCTAGAGTGATGGCCCTTGCTGCCTCCTGAATAAAAGGCCCGTGTTGGTCAT TGGGCAATTCAGTGTCTAAAGAAACAGGACAGTAGGAATAGTGGTGCCTCCTGTGCTGGA GTCTTTGTCCTTTATTGGGCTACCATGGGGTGGCCCAGGCTTTGGGGCTACAAAAGCCTG GGCTGCATCTCTTTCTAGCTCCATGATCCTAGGCAAGGCACTTAGCCTCTCTGAGCCGTT TCTTCCTCTGAATAAAAGCCTTTAGGGGACTGGCATGATGTCAGTGTTTTTAAAAGTTGA AGTGATATGTGAACATTCCTTGCCAAGGCACTAGCGTGGCACAGGAAGCACTCCCGTGGA ATGATGGTGATAACACTGCCCCCAGGTATCGGCTGTCGGATGAGGGCGAGTGGCTGGTGA GGGAGTTGAACCTCCCAGTGGACAGGACTGAGGGTGGCTGGATTTCCCTGCAGGATCTGC GCAAGGTCCAGAGAGAAACTGCAAGGAAGTAAGAACCTTCTTTGTGTTAAGGATGGAGGG AGGGGTCTGGGCTTGCCCCAGAAGAGCTTGGATGCTTTGTTTTTTAGCTTTGAGATGCTG AAAGACAAAGTCTGCCCTCTGTTTCTGGTCCCTTAGGTCACAGTGGAAGAAGTGGGAGGT GGTTGCTGAACGGGCATGGAAGGGGGGCACAGAGTCAGAAATGTTCAATAAGCTTGAGAG CATTGCTACGTCTGACATACCACGTACCCCGGTGCTGGGCTGCTGCATCAGCCGAGCCCT GGAGCCCTCGGCTGTCCAGGAAGAGGTATCTTGCTACCTTTGGAGCATGGGCAGAGGGGC CCCAGGGAGGGCAGGGCAGAGCTCCCTGTGGACCTTACCAATGTTTGTAGGTAGGGCCAG AGTGAAGCTTCTCTTGGGGCTTCTACCCTGGAGTTAATTGGTATGTAGCATAGCCCCTTT CACCTCTGCCCACCTTCCCTTCCCAGTTTATGACCAGCCGTGTGAATTGGGTGGTACAGA GCTCTGCTGTTGACTACTTACACCTCATGCTTGTGGCCATGAAGTGGCTGTTTGAAGAGT TTGCCATAGATGGGCGCTTCTGCATCAGCATCCATGACGAGGTTCGCTACCTGGTGCGGG AGGAGGACCGCTACCGCGCTGCCCTGGCCTTGCAGATCACCAACCTCTTGACCAGGTATG CGGGGCCCATGGCCTCTAGCCTGGCCATGTGCTCCTATGTGGGGCTTTGGGTGAGCGTTC CTTGGGCCAGACTGGTCAGTTTTGACTTTTCATCCCCCTAGAAGTGAATGTTTCAGCTTA TTTATTTATTTCTAATTTTTAAAAAGTTGTAGAAGTCCTAAAAAGACTAGCCTCAATTCG TAAAAAAAGAGTTATTGGGTTTGAAAATGTGAAATACCAAGACTGATCATTGAGGGAAGC AGTGAGGTTAGGGGAATTGTTCCGAAGGGTGGTACTCACGCTTTTCTATTTGGAAAATCA AATGACAGAAGCCTTTTCTCATTTCATAGAAAATTGAGATGTTTGTTTTTCTTTCTCCCA TAAATGTTTTCTTTCTTAAGTAAGTGCCAAAAGTTTGTTATTTGACTGCTAACAGAAAAC ACTGTTAATGGGGACACTCAAATGTGATTTTTAAAAATATCTTATATATTTTATATATTG AGTTGTATTTTCTTGTAGTAAAATTCCTAGTTCATATGGATGAATTAAATATTACCGTTC CATGTTGATCTGCCACTCAGAACCAGTTTGGGAACCATGATCTATCCTGATTATTGGGTA AATAACAGATGTTTACAATATTCAACATTGTTCCCATTGCCCTCTTAATCATCATCTCCG GGAGGTTATGCTTAACAAAGCTAAAAGTCCTCATTTATGCTTCAAACTCTGGCCCAATTG GAAGTGATTTCGTATATTAATTAATAAAGTGTACCAAACTGGGAAAAAAAAAAAAAGTAT GTTGAGTCCATAATTGCATTTCAGTATCTCAGTGGGAGGTTAGGCTGCTGGATGGAAAAC AGTGCTGGACCTTCACCTTTCTTGACTTAGCTAAGTGAACAGATGGGGTGTTGGTCCAGG GGAAGCCCTGCTCTAAGGGGTGTGGGGTCATTGCTCCAGGAGTGATGCATCTGTTCACAG GAGGGGCATGACTGTGAGAGTAGATTGGGTCTCTTTCAGGTGCATGTTTGCCTACAAGCT GGGTCTGAATGACTTGCCCCAGTCAGTCGCCTTTTTCAGTGCAGTCGATATTGACCGGTG CCTCAGGAAGGAAGTGACCATGGATTGTAAAACCCCTTCCAACCCAACTGGGATGGAAAG GAGATACGGGATTCCCCAGGGTGAGCACAACACATTTGTTCCTCATTACACATAGGATCT GAGGTGGACTAGAAAGTGGGTCTTGGAGAACAGGAAACTTGGGGCCCCAGAGAATCCACT CTTGACTCAGGCTATATTCTAGGCTAATTTCAGTTTATAAGGTGCCCTGTGTCCAGAGTG AATGTGATATGATGTTTCAGAAATGAAGGCAGCAGAGCTTCAAATATTCTACCTGTACCT GTCCCCTACTTCAACCACAGAAGAAATGTTTAAAGATAATTTATTCTATAGAGTGCATTC TTGCACTCTATAGGTGACAGAAAAACAAACTGTGCTTTAAATACCAAACAAGTAAATCAG AAAGCTTATTTTCTATTTAAAATATATCTAAGACACACTTATATAAAAAGAAAACAGACC CTCCTAACATGTAACATTACCGTTCGTGGCAATTGTTCTCAACCTTTCACTCTCCTTTTG ACCTTAGCATTAAGCTCCTTTGCTCACTTCTGAGCTCTCAGTTACAGTTCTTGAGGTGGC ATCCTAACCAATTTGCACTATCTTTCAGGTGAAGCGCTGGATATTTACCAGATAATTGAA CTCACCAAAGGCTCCTTGGAAAAACGAAGCCAGCCTGGACCATAGCACTGCCTGGAGGCT CTGTATTTGCTCCCGTGGAGCTTCATCGGGGTGGTGCAGGCTCCCAAACTCAGGCTTTCA GCTGTGCTTTTTGCAAAAGGGCTTGCCTAAGGCCAGCCATTTTTCAGTAGCAGGACCTGC CAAGAAGATTCCTTCTAACTGAAGGTGCAGTTGAATTCAGTGGGTTCAGAACCAAGATGC CAACATCGGTGTGGACTACAGGACAAGGGGCATTGTTGCTTGTTGGGTAAAAATGAAGCA GAAGCCCCAAAGTTCACATTAACTCAGGCATTTCATTTATTTTTTCCTTTTCTTCTTGGC TGGTTCTTTGTTCTGTCCCCCATGCTCTGATGCAGTGCCCTAGAAGGGGAAAGAATTAAT GCTCTAACGTGATAAACCTGCTCCAAGGCAGTGGAAATAAAAAGAAGGAAAAAAAAGACT CTATCTTCTCA OMIM ID 174763