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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for PLAT (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 5327 Official gene symbol PLAT Full name plasminogen activator, tissue Aliases ,DKFZp686I03148,T-PA,TPA, Gene summary This gene encodes tissue-type plasminogen activator, a secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Tissue-type plasminogen activator is synthesized as a single chain which is cleaved by plasmin to a two chain disulfide linked protein. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding; decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq] Location Chromosome: 8   Locus: 8p12 Gene position 42065194 - 42032236  Map Viewer Gene orientation minus Gene size 32959 bp Gene sequence >PLAT:complement(29890382..29923340):Length=32959 ATGGCCCTGTCCACTGAGCATCCTCCCGCCACACAGAAACCCGCCCAGCCGGGGCCACCG ACCCCACCCCCTGCCTGGAAACTTAAAGGAGGCCGGAGCTGTGGGGAGCTCAGAGCTGAG ATCCTACAGGAGTCCAGGGCTGGAGAGAAAACCTCTGCGAGGAAAGGGAAGGAGCAAGCC GTGGTAGGTCGGGTTTCTGTACCTTGGGGTCTGTCTCCTCTTCTTTCTCTTAAAAGTCTT TCCAGCAAGCTGAGCCAGTGAAGGAATGCTTTAACCAAGGGACCAACTTTGTAATTCAGG CAACTAGAGGATCCGCTAGAATCCACTCCAGAGGGGAGATGTCTGTTTGCATTTGCATGT GATTGGGATAGGCTGGAGTGTTTTGGAGGGGAGAGGCAGTCGGGGAAAGGGAGACTAGGG AGGTTGCATTCATTGGAGAAGCCTCTGCTGACAGAGTAAAGGGGAAAGTGAAAAGAACGA TACAGAAAAGCCCCAAATAGCCTATGGGAGTACCTCAAGACGAGCAAGCAATAAAAGCAA AATCGGCTGCCTTGGGACACGTGCCTGTGACAGCTGGGAGGGCCCGCTGGGTCCCCTAGT TTCCTCCCTCCCCCGATGAACCCCCAGAAAGGAACTGAGGCTGTGGATGGGGCAGAGGGG GACTTACTTCCAGAGCACTATTTGCTAGGTGCTGGGAGAGAGAAGCAGGTGGCTTTCACA CCCCACATTACCCCGTGGGATAGAGAAATGCCTCTGATCTCCCTAGGTGCCACCCCTACA AGTCTCCACAGGTCAGTTTGGCCCTCTGGCTTTTTGCCCAGGGTGCATCAGTCAAGTGTG CAGTCCTCCTTAAAGGACATTTTAATTACAGGGGAAAAAACTGACATTAATGTCTTTTAT TCCTAAAGCACTCTGCAGGAAGCATGTGGGGTTCTCCAGATTTTCACTGTTATTATCTTT ATTTTCTTAACCTCACAGGGAGGGAGAGAGGAAGGGAGGGAGGGAAGACGAAAACACGCC GAGGTCCCAGGTAACTAATGACAACTCAAGCTCAAAGAAGTGTGGTAACAAGGATGTGTT TGGTGGCCAATTGGGAATAATATGGTGGTCTCCTGTAGCTGCTTGATGACAGAAAAAATG TCGTGTGTGTGTGTATGCGTGTGCATTGCAGTCCCGGGAAGGGGTCTTGCAAATACCATT GTCAGGTGGAGTCCCCTCAAAGGTGACTTCCTAGCAGTACTTGCTGTGGCAAGAACGCTC ATTCTGGGATCTAGACTCAATCCATGACGGTCAGCATGAGCTGCTGGGTGCGTGCTTCCT GTGCAGGCAGAGTCGGACTCCAGCACTGGCAGGGACACTGTGAGTATTGAGATATGAATA GCTCCATCCTGCCCACCCATTTATTCCACCTAAAATGTTCTCAAAGATGCAAGCCTCCAA GCTCTGGATCAAATGATAAAGCCCCAGATCAAAATCTCAGGAGCAAATGAAAGCTGCCCT TGTCTCCAAAATGCTCCTTCTCTGCCCGACTCCCCAAGACCAGCTTGGTTTATTTCACAA TGACTCGCGTCGGATTCTCCCAGTGTCTGCGGCTCCCCCTGCTTCATCACAGGCCTGGGA CAGTCCAGGCAGCCAGGGAATAGCTGGGAATAGCAGTTCCCCTTTGTTGGTTTTTGAGTT CACTGAGGCTTTGATTTCCCCCAGGGCCTGACGTTGCTGAGCAGAGCCAGCGGCCAGTAG ATTTCAAAGGATTCCAAAAAACAGTCAGGCACTCCTTTGTGAACCCAAAAGTATCTGAGA CAGGTCTGTCAATTTAGAAAGTTTATTTTGCCAATGTTAAGAACACACATGTGACACGGC CTCTGGAGATCCTGAGGACATATGTCCAAGGTGGCCAAGGTATGGCTTGGTTTCATACAT TTCAGGGAGACATGAGACATTAATCAATGTATGTAAGATGTGCACCGGTTCGGTCTGGAA AGGCAGGACAACTCGAAGTAGGGGCTTCCAGGTCATAGGTAGATAAGAGAAGGCTTCATT CTTCTGAGTCTTTGTCAGCCTTTCACTGAATACACAATTTACATATGAGAGGGGGGCAGA GGAAGAGTCACTTATGCCTTAGTTGGCTCAGTGAATCTACTTTTTTTTTTGAGACGGAGT TTCACTCTTTTTGCCCAGGCTAGAGTGCAATGGCATGATCCCGGCTACTGCAACCTCCAC CTCCCAGGTTCAAGTGATTCTCCTGCCTCAGCCTTCTGAGTAACTGGGATTACAGGCGCC TGCCACCACACCTGGTTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCACCATGTTGGC CAGACTGGTCTTGAACTCGTGACCTCAGGTGATCCACCCACCTCGGCCCCCCGAAGTGCT GGGATTACAGGCATGAGCCAACATGCCTGGCCTGAATCTTCATTTTTACAAAAACAATAG GGCAGAGGAAGCAATCAGATATGCGTTTGTCTCAGGTGAGCAGAGGGATGACTTTGAGTT CTGTCCTTTGTCCTGTACCCATTTGCATTGCCAAGGTGAAGTTCAGCAGAACTGTTTTAG GGTAAAGATCTTGAAGTCCACAAGGAGTTTCCTTGTGGGTAAATTGTGAGAGAGGTATGT AGCCTTTTATCTTTGTAGCCGTCTTATGTAGGAATAAAATGGGAGGCAGGTTTGCCTCAT GCAGTTCCCAGCTTGGCTTTTCCCTTTGGCTTAGTGATTTGGGGGTCTTGAGATTTATTT TCCTTTCATACCTTGGTAGTGTCACTTGAAGCCACCACGCCCGGCTAATTTTTATATTTT TAGTAGAGACAGGGTTTCACCATGTTGATCAGGCTGGTCTCGAACTCCTGACCTCGTGAT CTGCCCTCCTCCTCCAAAGTGCTGGGATTACAGGCATGAGCCACCATGCCCGGCCAATTT TTCTTTTCTTTTTTTTTTTTTTTAAGATGGAGTCTCGCTTTTTCACCAGGCTGGGGTGCA GTGGCACAATCTTGGCTCACTGCAACCTCCACCTCCCAGGTTCAAGCGATTTTCCTGCCT CAGCCTCCCAAATAGCTTGGATTACAGGCGCCCGCCACCACACCCAGCTAAGTTTTCACC ATGTTGGCCAGGCTGGTCTTGAACACCTGACCTCAAGTGATCTGCCCGCCTTGGCCTCGC AAAGTATTGGGATTACAGGCGTGAGCCACCATGCCCAGACAGGTTTTTCTTTGATTATTT GGCATTATGCACCTGCAGTCTCAGAATAAATTTTTTACTTTCTCTGAGTGATTTTCGCTT CTGCTTTGATGAGATTGTTGGGACGGACAATAAGGGACCAGTGCATTCTGCTCATTCCTT CTTGGGGCCATTTCTTTTGTATATACGGGAGAAAATGTCTGTCTATAGTGTCAGGCTATA AACCTCGTCCTAGTCAAGCAGCTCACAAAACCATATGGTGGGTCTCACATCAAACCAGGT AAAAGAGTGAGGATGATTTAGACTCAAAGAAAATTAGAGCTAGAAATAAATTTAAAGCTC ATCCACCCTGCTCCAACCCTAAGTCAAGCCACATGGTCTTCCGATAGTGGCTCAGTTTTC TACTTACATAAAAAGACAGCACATTCTCTTAGCAATATGTGTTTGTATGTGTGTGTGTGT GTGTGTGTGTGTGTGTGTGTGTGTATATATATATATATATATATATAATTTAGAGACAAG GTCTGACTCCATCACCCAGGCTGGAGTGCAGCAGTGTGATCGTAGGTCACTGAACCTTCA AACTCCTGGGCTCAAGTGATCCTCCATCTCAGCCTCCCAAGTAGCTAGGACTACAGGGGC ATGCTGCCATATCCAGCTAATTATAAAATTTTTTTGTAGAAGCAGAGTTTTGCTTTGTTG CCCAGGCTAGTCTCAAACTCCTGGCCTCAAGCAACCCTCTTGCCATGGCCTCACAAAATG CTGGGATTACAGGCAAGAGCCACTGTGCCCAGTCCCTCTTAGTGATATTTTGCATATTAT ATATTCAAAAAATATTTTCTATGTATGCCACTTGGGAAACTTCTGTAGAATGGGATAGAG GGACAGATAAACCCAATTCTTGATCCACTCAAAAATAACACCTGTGACAGAGTGAAGATG AAACAGGTGCTGGGCACACAGCAAGTGTTTTAGAAACATTTTTGAACTCAACTTTGCCTG AGTTGTGGTGCTGATCATGGCTGCCAGGAAATGCTAGCCAGCTGTTCTTCCTATACAAGT ATATGACTGGGTGTCTGCAGCAGCTGCCCGGCTGTGAATTGCACACACCAATGGCCAAGA CCCAGCAGCGACTTGGCTAACAGGCCCAGCCGATGTGCATGGGTGACCACGCGATGCTCC TGACACACGCACTGGTGGCTTAGGGAAGTTTTTTTGAGGATTGATCAGAAGATCTGATTC CACCTGGAGCCTCTGAAGTGATCACTTCCAGGTTAGGCTGAACCCAGATACCAGGAGACC TGTGTATTGAGAGCCTTTTGTTTTTTTTATGTAGTCACAACTATTCCATTAACATACAGC TAGGCATTAGAGAATCCATGCTGGACTCCTACAAAGGCCCCTAGATCCTTAGAACACTCA GAGATTCCAAAGCACACGTCCTCCCAGGACACCCTGGCAGAAGAGCCCGGGGGCGACTGT CACCTTTGCCTGCTGTCGGGAGCTGTGCTGATGGGTAGGGGGCTCTGTGCTTGCTGTGGC CCAGAGCCAAGCCGTGGGGATGTGCTCTGTCTGGAGCAGACCCCTTCACTGTCTGCCTAA CTCCTTCGTGTGTTCCCGGAACAGCTTCTGTGTTATGCATTCCAGAAAGCCTGCCTGACC ACCCCAACCTCAACAAGCCTGGGATGGACAACCTCCTCCACATTCCACTCCAAGCCCACC CCCGTCCCCACCCTGCTGCGTGGTATGGCGCTGCTCTGCTGTACCCTGAGTGTCTAGTTA TTCATCAGGCCCCTTCCTAACTATGAGCTCTTTCAGGATAAGAGCTGTGTCTTTGCATCA CCAGAGCCTGTGCCAGGGCACGGCTGGTGCTCCATACACGTTGATGGTGAATATATAGCA TGGGTAGATCATTGTCTGTGAATGCTTAACAGAGAAGCAGCTCATGTGGGTGCTTGAGGG CTGGGGGGGCAGGGTGGGGGTCTGGTAGGCGCTGGGAGGAGGACATCCCTGCAGCTTCTC CAGCCCCATAGATGGGACTCTTGATGTGGGCAGTTTTTATTTCAGCTGAGTCTCCAGAAG GCAGGGGACAGGGACTGGGAGGGGATGCTAAACCCGATAACCCAGTATGGATGAGCTAAC AGAGGCCGGGCACACAGCTCCTGCCTGTAATCCCAGCACTTTGGGAGCCCGAGGTGGGCG GGTTGCTTGAGCCAAGGAGTTTGAAACCAGCCCGGGTCTTGAACATAGCGAAGACTCTGT CTCTACAAAAAAATGAAAAAAAAAAAAAAATTAGCCAGACATGGTGGCACGCACCTGTAG TCCCAGCTACTTGAGAAGCTGAGGTGAGAGGATCACTTGAGCCAGGGAGGTTGAAACTGC AGTGAGCTGTGATCACGCCACTGCACTCCAGTCTGGGTGACTGGGCGAGACCCTGTCTCA AAACAAATAAATAAGAAAGAGAGACTACTGGTCAACTTGATTTCTGCTGGTTATTCTCTT TCTGTCATGTTCACCAAAAAGAGAAACCCGTTGTATTTTATCTTGTTGTAGCAAGAGCCG GTGTCTAACACCTGGGCTACTGAGAGAAAGCGAAGGGTTTTTTTCTGGGAAGCTCCAATT TCCTTATTTCTCTCACATGATGCCTCTGACTTTCATAGTGTGGCTTGGTCAGATGGGCCT TATCAATAGAGATGGCCTGATGTCTCAGCTGTGTCATCTCAGCTGCTAGTTCTGGCTTCT GCTGGGAGTCCACAGTGGCCTCTGCATGCATGGTGTGGGAAAGGCAAATAAAAAAGCAGA TTAAAAACCAGATTAAAGACATCACCCTGTATTCAGGAAATAATGGCTCCTGTTGATACT GTTCTACGAACACAGATGAAGGCACAAAATTCTACATCAATTGCAGAGAATTGGTTATAG GCTAACACAGGTGGTCGGATGATCTAGGAAGCAGGATTCAGTATTAACGGGGATCCATGA GGACCCCATGAAGCGTGGCATCTCTTCTGCATCAGCAGCTTCAAGTTGTTCCAGGGAGAA GCGGGAAGCCTCAGTGCTTTTGTTGAGGAAGGATGTTCATGACAGTAGGTGCAGGTCGCT CCTGCCGTGCACCCAGGTGTGGGGGAAGGACTTTCCTGCTTCTTTTCCAGTTACCTTACA ATTCAGCAAGACGGAAATGATTAGCCCATGACAAAAACCAGGAAACAGGCTCAGAGAGAG TGAGTTGCCCACACAGAATGTGTGCTGTAAATGCAGTTAGATTTCCAGGTTGAGAATCCA GTGACCACGCCCCTTCTTTGTGGCATTCTGCTGTCGTATACCATGTGGAACACATTAAGA ACGTTATGGCCAGGCGTGTTGGCTCACGCCTGTAATCCTAGCACTTTGGGAGGCCAAGGT GGACAGATCACCTGAGGTTGGGAGTTCGAGACCAGCCTGGCCAGCATGCCGAAACCCTGT CTCTACTAAAAATACAAAAATTAGCCAGGCATGGTGGCACACACTTGTAATCCGAGCTAC TCGGGAGGCTGAAGAAGGAGAATCGCTTAAACCCAGGAGGCGGAGGTTGCAGTGAGCTGA GATTGCACCGTTGCAATCCAGCCTGGGCAACAGAGTGAAACTCCATCTCAGAAAAAAAAA AAAAGTTACAATTGGGTGTCACATAGACAGTGAGGAGTAGTGGAAAGAGTGTTAGATTTG GGGTAAGAGAACTGTGTCTCCTGGGCTTGAGTCCTGATGCCAACTCTCACAAGATGTGTC ACCGTACAGCACGACGCTTATACTTTTTTTTTTTTTTTTTTTGAGACAGGATCTTGCTCT GTCTCAAGCTGGAGTGCAGTGGTATGATCACAGCTCACTGCAGCCTCAAACTCCCAGGCT CAGGCCATCCTCCCACCTCAGCCTCCCAAGTAGCTGGGACTACAGGCATGTACCACCATG CCCAAATAATTTTTTGTATTTTTTTGTTGAGATGGGGTTTTGCCATGTTACCCAGGGAGG TCTCAAACTCCAAGGATCAAGCCACCCACCCTCCTTGGCCTCCCAAAGTGTTGGGATTAC AGATGTGAGCCACCACACCTTGCAAATTTTTGTATTTTTTGTACAGCCGAGGGTCTCCCT ATGTTGCCGAGGGTGATCTTGAACTCCTGGGCTCAAATGATCCACCCTCCTCAGCCTCCC AAAGTGTTGGGATTACAGACGTGAGCCACTGCTCTCAGCCCCTTACACTTTTTTGAAGTT CAGTTCTCCCATCTGTAAAAACGAGGTAATAATATTGCCTCAAATGACTTAATGGATGTG AAAGGGTTTAGTAAACTCTGTGCCTGGAAAGGTAGAAGCTACTCAAATATCTGTTGAGTG AGTGGCATTCATCCATGTGTACATTTCTCAGGCAACAATAATGTCACTTTCACCTAAGGC CAGTAAAATGTGGGTAAAGTCATATAATGATACAATGAAAGTTTCTGATCAGTATTTCCT AATTCAAGTGTGTTGAAATGTGGAGTTGGGCTGGAGAATTGTCAAATCATTGCGTATTTA ATTACCTTGTGGTGATGTTTGCTTTAGGGAGTGGAAGGAACATGAGGAACGAACGACCTT CATCACGGAAGATGACATTCATTTCGATTCACTTTAGATTTCAGGGCTTGTTTAGATGCA GACTTTGCAGTTAACATTTTATTGCACTGACTGATTTAGTTTTCACCAGGTGGTCCTTGT GTTTGCTTCAGAAGGATCTAAGTGTATTAGGACAGGGTTTCTTCTGTTTTGATTGTGGGA GGAGGCGGGATAGACTTCTGTTTTCCTAGACCCACAACCAAAATTCCCCACTCCTCCAAA TAACCGGGATTACCAGGCAGAGGGTGGAGCATTGAGGAGATGACAGCTGGACATGCCTGC TGTAGCTTTTTCTGAGTTTAATTCCATATAGCTTAGACACAGGCCATATGCCTACATTTG GAAGATGTTTTGGAGAAAATTCTGCTCTGATGGGTGGGGGGCAGGGTCTGCCAGGAAAAT ATTCTATTCTTTTGAAGACATGGGGTCTTGCTATGTTGCCTAGGCTGGTCTTGAACTCCT CGCCTCAAGTGATGCTCCTGCCTCAGCCTCCTGAGTAGCTAGGACTACAGGTGCAAACCA CCACACCCAGCTCTGAGAGGATGCTATACTCTTCACTTCATTGGAATTGGTGAAATTAGA TAAGAAACAGACTCTTCCTCTCTTCTCCCCTAGTTATAAACAGTTCTGTTAAGAGAGGGA AAATAACCATTTAGCCTATAGAAAATCACCTTTTCGAAAAGTTAAGAATTACTTATGTGA TGGTAGTTTTTGAAAGTGGTTTTTATTCTGAGATCATGGCCTCTGTACTATGCAGGGCCT GGAGAAGTGGGATGAGAGCTACCAGGCTCAAAGCTCCTGTCCCGAACAAAGGGTTGCTTT CGTGGGAGCACGCCACCCTTTCCAAGGCTAGTTCCTCTCCCAGCATCTCACTTCAGCTCT CGTCCTGCTCTAGAAACGTGCCTTTGCTGGTCCAAGGAATCCTGGCCGTTTCTTTTCTTA ATTGTTGGCATTCATCTGGGCTATGGTGGTTGTGGCGGGGGTGGCAGTGGAGAGTGTGTT GTTTTAAATCCATGAGTCATTTTAGGGTATTGGTACTCTTGAAGACTGACTTTCTCTTGC TCAGGTTTTCAGAGAGACCTTTTGCTAAGCAACAATAACCTAAGAATCTCCTTGACCAAA GATAAATGTAGCAAACTTTGCACATGGTGCAACATTTGATAATAGTATCAATTTACGTTT GTCTTTCCCTTGCAATTTCCCTCCTCCTCTAGCTTGCTCACGTTTCTGCCTTCTTCTTGC TGGCAAGAGTACAGACTATAATTCTCCAGTTCACTAACATCTGGAGCGACTGCACTGTTT GCAATTTCATTGATTGACTACATGTGTACAGTTCCTTTATTGCAAGTCACTTTTCTGTAT AATCTTTTTTGAGACGAAGTCCTGCTCTGTCGCCCAGGCTGCAGTAGCGCAATCTTGGCT CACTGCAACTTCCGCCTCCCGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCTGAGTAGCT GGGATTATAGGCGCCCGCCACCATGCCCAGCTAATTTTTTTGTATTTTTAGTAGAGATGG GGTTTCACTATGTTGGCCAGGCTTGTTTTGAACTCCTGACCTCAAGAGATCTGCCAGCCT TGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACTGTGCCTGGCCATATAATCTAT TTTTAAAATGTTTTTATATGAAAATAAACAGAGACAGAGTCTCACTGTGTTGCCCAGGCT GATCTCGAACTCCTGGGTTCAAGTGATCCTCCCACCCTGGCCTCCCAAAGTGCTGGGGTT ACAGGCGTGAACCACCTCATGTGGCCTCGCTTTCCTATATAATTTAAACAATAGAACTAT AGTGCCATTTGTAAGAGTTTCCCAGTTTATACTGCATGTGACACTCCCCATGTCGTATGT TCTCACAACAGAACAGAAACCGCAGGATGTCAGCACCGGAGGCAACCTTGGAGCATCCAG CCCACTTGGTTTTGCATTGCTGGCAGGAGATTTTATGCCTCAAAATATAGATGCTTTTTG GAAGGACAGCACATTAATTATTTTTCAGTCATTTTTACCTTATGCGAACAAGCTGATTAG TTCCTTTCCTAGGAGCTGGTTTTTATGGAGGGAAGATGGGGCCGGTAGAGGCAGATAGAG GGGGATGTAATACACAGGCACTGAGACAGCACCCCACTGACTTTCCCCTGTCCCTCCTCC AGCTGGCCTCCTCCTTTCCAGGGGCTGTGCCCAATCCAGAATCAGTTACTCACTGGTGCC CATCGACCATCATTTCCCCATGTGGCCACCAAAGAAATGAACACCACCTTTCTGGTTGGC ATGATCATCAATTTCTCAGCCAAAACGGCATGCATCCTTGGCTCTGGGAAACAGTACATC TCCCAGGAAAGTGAGCTTACAGCACGGTACCCCACTTCCTGGTTACCAGACTATTGTTCC CGTTTTCCCCAAGAACAGTCATCATTCACAGGTTGTTTGGCAGGGCCCAGGAACAGAGTC ACTCTGGTTGCTACAGCCAACAGACCAAACACGGCTTCCAGGCAGGAAGGTCAGAGCTGC TCTGCAGGATGCACATGCAGGTTGGAAGCAGACAGGGCTGGCCGAGCACAGATATGCTGG CTGTGTCCTACACACAGGTGCCTACACACACATCCTTCAGATCCGGGCTGCACTCTATCA GCCAACCCACGGACTCTGTTTTTTCTAATTTGCACAGATTCTTTGTCAACCTGCCATGCC CTGAGACTGCTGAACTTCATCCAACAGAGAGGGTACCTTTTGCAAATCTGCAAAAATCAA CTTTGTGTGCTAGGGTGGCCTGACAGGGCTAGGCCTTGGGGTCTTGGGGACCAGCATTCC ACCTCTCCTCTCATACAGTGATTCTGGATTCCAGCCCAGCAAAAGTCAGCCAACCTTGGG GCCTTCCTTTCTTTCATCCTTTCTTTTTTTTCCTTTTCTATCCTTCTGTGCCTCCCTTCC TACCCCCTTCCTTCCTTCTTCTCATTTGCCTTTTTTTTTTTCAGTTCTTTGATGATCCTG AGAAGCTACTAAATATAGCAAAAGGGAGATAACACAGAACAAAATTAGAAGTCTATTTAT AAAAATGAGCCTCTTCCATCCCTTCCGCCAATGTCATCTCTCACCCGGGTCTCGCCAGAG CACTCATGGACCTCCCTTTGGTGAGGCCCAAAGTCCATCCCAGCCACGCCCTGCGGTCCC GAGTCTGAGTCCATTGTTCTGGCTTTCACTCTGCTCTGCATCCCGTCACTGGCCCCAGAC CTCGACGCCCACCTCTTCAGCGAAGGCGAAACAAGGACTCATTTTTCCTCCCTCTCTTCG CTCTTTCTTGTTTTCAGACTGCACTGTTTTTCTGCTGGCCGGATGACTCATTTCTTTGTC ATCTCTTACCCCACTTGGCCTTTTCAGCTGCTCGAATCGCCTCTGTGTGATGCGGACAGA GCTATCGCCCTGCTGGGGTGAGATTCACTTGCATTGAATCAGCTCAAGGCGCAGGAAGGT CCAGGGAAGCCAAGGAAGAGAAGAGACAAGTCTCCAACTCTCTCAGGAGCAAAGACAAAA ATATGCTCCTGCTCTCTTATCTCTTATTCAGACCGTTCAGTTGCAAAAGGGTTGAACATG ATGCAGCGGGTGGTATGTGTGGACCAGCCCTAGGTCGTGCTTCTCCTCCATCTGGTCCCC CCACCCCTAGTTATCCAGAAAGGGGGATGTTCCCAGGCAATGCCAACATGTCCATACTGC ACTCTTCACATTGCAGTTTCCCGGCATCTGGGATTGCATTCCTTTTGGAAGGACTTTGAG TTCTTGAAATAAAGAAGTAACTTGGTGGGCATCTGGAAAAAACACCCAAACTGTATCCCA GGCTGGGGTGCAGGAGCCTATCGAGAGGGCTGGGTGGTGTGGACAGCGTGATGAAGAAGG TCAAGTTCCTTGTACTCACTCGTTTGCTGTTTCATTCACAATTCCTGTGAGGTGGGAGCT CTCACCATCCTTGGGTCTTGCTTAAGAGTAAGGAGTGGGGCAACCTAGAGATACATGAAC ATCAAGGAGAAATGGGGAGGGAGTTTCACATGAGCTATTTTTACAAGATTAAGTAATGGG ATAAAATTTAAAAGGGGAATTTAAGAGGAATTTTGGGCAGTTTTGAGAAACAGGAAATTT GAGGAAAGCTGAGAAAGAGAAGATCTGGAGTAAGTCTCTGTGATGAGAAGATTCCACCCC GCACTCCTGTTCTGGGTGGCCTTGGCTCCTGACTCCCTTTCTTCTGAAACTGCCTGGAGC CAGGGAGTAGCACAGCTGCTTCCTCCCGGGGAGAAAGGGACACCCAAAGAGCGCACTCCA GGGAGACCTTGGGCACTGCGGGCTCAAAGGCTGGAGATGGCACTTCTGTTCCCTCCTGAT GGGACAGGTGCAGGGAGGCTGAGAGGATGCCACGCTGGCGAGCCTCCCTCTGAGCTGTGT TTTCTCATTGGAATTGCTGTACCCGGAGCCTCCTGCAGGTTTCCCTCGCCCTCTCCCTAA GCTCCTCTGCCTGACACAGGAGCCCGGGGAGAATCTGTCAGGCATGAAATGTAGCGAGGC AAGGAGGGTGATCAGCACCTCCCACGGGGGAGTTCGTTTCGAAGTAACAATCAAAGATCC AGAGCCGGACCCAGGCAGGGAGGCAAGGCCTGGAAGCCCCTGTGCCTCCAGGCCCCTAGG ACGCTCGGGGGAGGGGGAGGGGGAGGGTGGGACCTGAAGTTGTTGTGACCGAAGGGAAAT GAGTCAGGGAAAGAAATGCCATGCTTTAATTTTTGTGGATGAAGGAGGGAACAGGCCGCC AGACCACAAAATAACACCCGGCCGACTAACCTACTTTTAGCTGCCGAGGGCAGGATCACA GAGGAGAGGCAGATGGAAACTGGGGCTCTGGGGTCCAGGAAGATCTGAGTCTTCCGACCA AACATCATTTGCCTCCCCTCCTTCCTGCAAATATGCACATTGCCGGATCTGCTGCAGTCT ATGAAAAAGGAGACAGATGTTCTGGCAGAGCGGTGGGGGGGGTGGGCGTGGAGGTTGGGT TGGGGGGCCTCTGCTTTGTGGGGAGAACCTCAGGCAGGGGAGTAGGCTCCATCCTGCGTG GAGGAACCTGAGCAGTCTAAGGCAGGCTGGCTCTATGATGTGCTGGCAATAAAATCCCAA TGGCTTCCGCTGCAGAAGTCCAAGAGGACATGACTGCGGCTCCATCTAGTCAAGCCCAGG GCAGGAATTCCCTTCCAGGAAACCAAGCCAGAGCGCTGTGGTCTCTGGGCTGCCAAGATG TCTCAGAAATGGTCTAGCCCTTCAGCCCACAGAAATCTCTGGGCAAAATTATCTCCCAGC ATTGACAGACGAATGGATAAACAAAATGTGTTCTATCCCACAGTGGAGTATTATTCAGCT TTAAAAAGGAAGGAAAAATGCTGGGCGCGGTGGCTCACGCCTGATCCCAGCACTTTGGGA GGCTGAGGAAGGAGGATCATTTGTGCCCAGGAGTTCGAGACTAGCCTGGACAACATAGAG AAACCTTGTCTCTACACACACACACACACACACACACACACACACACACACACACTCTCT CTCTCTCTCTCTCTCTCTCTCAGCCAGGCACAGTGGCACATGCCTGAAGTCCCAGCTCTG GGAAGCTGAGGCAGGAGGATCTCTTGAGCCTGGTGGGTCAAGGCTGCAGTGAACCATGTT CATGCCACTGCACTCCAGTCTGGATGACAGAGCGAGACCTAGTCTCAAAAAAAAAAAAAA AAAAAAGAAAGAAGAAAGAAGAAAGGAAAAAGAAAAAAAGGCAGCGGGGGCGCGGTGGCT CACGCCTGTAATCCCACCACTTTGGGAGGCCAAGGCGAGCGGATCACGAGGTCAGGAGAT CGAGACCATCCTGGCTAACACGGTGAAACCCCGTCTCTACTAAAAATACAAAAATTAGCC GGGCGTGGTGGCAGGCGCCTGTAGTCCCAGCTACTCAGGAGGCTGAGACATGAGAATGGC ATGAACCCGGGAGGCGGAGCTTGTAGTGAGCCGAGATCACACCACTGCACTCCAGCCTGG GCGACAGAGCGAGACTCCATCTTAAAAGAAAAAAAAAAAAAGGACATGCTACAGCATGGA TGCACCTTGAAGACATTTGCAAAGTGAAACAAACCAGTCGCAAAAGAAGAAACACTGTCT CATTCCACTTCTAGGATGTATGTAGAGCAGTCAGGTTCATACAGACAGAAAGTAGCAGCG TGGCTGCTGGGGAAAAGGGGAATGGGGAGTTATTCTTTAATGGCTACAGAGTTTCAGTTA GGGGTGATGGAGAAGTTCTGGAGATGGGCGGTGGTGACGGCCGGCCGCACAGCAATATGA CGTGCTTAATGCCACTGAACTGTGCACTGAACATCGTTAAGGTGGTAAATTTTGTGTTAT ATATATTTTGCAACAATAAAAAATATGTAGTTTCTAGAATCCTCTTCTAGATGCATGTCT GGCGTTTCTGCCGCGGGGCTGGCACTGGAGGAAGCCAGACAGGACAACATTGCGGCTTAT CCTCCTCTGTTGCCATCATGGACCTCTCGCACCCCGTGATCAAGCTGTTTTTTCTCTCCT TCCAGAATTTAAGGGACGCTGTGAAGCAATCATGGATGCAATGAAGAGAGGGCTCTGCTG TGTGCTGCTGCTGTGTGGAGCAGTCTTCGTTTCGCCCAGCCAGGTTGGTGTGCAGGATCC CTGTGTCCCGCCCCTCAAGGCTGTGATGCTTCCGGAGGCTCCAGGGGTCTGTGTCCATCT GGGCCACGGAGGTTGGAATGCTGTCAGGGAGCAGAGAGGCACAGGGACGAGGGGCTGGCA TTGCTGTGGAGCACACAGCACACACTCCCTTCTGTACAGCAAACTCTGTATTTGGGGGCC CAGTGTGTAGCTGGGCCCTAGGCACTTATTTTGACCTGAGTAAGCGGAATTAACATGCCA CTCCCTGCCTGTGACTGCCTTTTTTTGCAGCTGTTTTTAAAGAATGTATTCAAATTAATC CATAAAGTACAGTTGTCCCTCATATCTATGGGGTATTTGTTCCAGGACCCCCAAGGATAC CAAAATCCAGGGATACTCAAGTTCCTCATATAGAATGGTGTAGAGTTTGCATATCCTATG CACACCCTCCTGTATACTTTAAATCATCTCTAAATTACTTATAATACCTAGTACAATGTT AATGCTATGTAAATGGTTGTTATAAGGTATTTTTTAATTTGTGTTATTTTTATTGTTGTA TTATTTATTTATATATTTTTTGGAAACAGGGTCTCACTCTGTCACCCAGGCTGGAGTGCA ATGGCACAATCATAGCTCACTGCAGCACCAAACTCCTAGGCTTAAGCCTTGGCCTCCCAA AACTCTGGGGTTACAGGTGTGAGCCACAAGCCCAGCTTATATTATTATTTTTTATTTTTC TGTTTTGGTTGAATCCACAGATATGGAACCTGCAGATATACAAAGTGGACTGTATTTATA AAAGACAATGCAGGACAGGGCACAGTGACTCACACCTGTAATCTCAGCACTTTGGGAGGC CGAGGTGGGAGGATCGCTTGAGCCCAGGAGTTGGAGACCAGTCTGGGCAATATAGTGAGA TGCTGTCTCTACAAAAAATTTAAAAATTAGCCGGGTGTACTAGTATGCACCTGTGGTCCC AGCTACTCAGGAGGCTGAGGCGGGAGGATCGCTTAAGTTCAGGAGGTTGGGACTTCAGTG AGATATGATTACGCCAATGCACTCCAGCCTGGGTGACAAACTGAGATCCTGTCTCAAAAA AAAAAAAAAAAAAAGAAAAAGGCAATGCAAGTGCCATGAGCCACAGCAGAGGCAAACTGC CCTCATGGTGCCTACTCTCTAGCTGAGATGGAAGCGCTACACACACTCTCTGAAAATGCC TAGCAATAAAGGGCCTCACGGAAGTCCAAACTAACCACACCTCTCCCACAGGACCCTACA GCGGGGAGAGCCAGGTGACTGCGTGGAGTAGACAGCCAGCTGCAACTCCATTGCCCAATA TGGTGGCCACTTACCTTGTGCAACTGTTTAAATTTAAAATAATTAAAGTTAAAAATTGTT TCTCAGTCCCACTGGCCACATTCAAAGCACTCGGTGGCCCTGTGTGGCTTCTGTCGTGGA CAGCACAGACAGAAAACATTTCCACCAAGCAGAAAGCTCTTCTGGACAGAGCCAGTCAGG AAGGAGAGGAAGAATTGGACTAGAAGGCAGGAGATGGACTTTCACTTGGGCCAGTTACCC GAGGGGGTCTCTGAGCAGAGGTATCTGGCCGGCAGGTTCACATGGGCTTCTGGGTTGGCC GCCTTTACTCTTAGTACACCTGGCATGTGCTGATCCTTCCTCCACCTCTGGTTTCTTCGC AGGAAATCCATGCCCGATTCAGAAGAGGAGCCAGATCTTACCAAGGTCGGGTGAAGCTGA GGGGTGCATGGGGTCATCAGGGAGGGAGGCAGGGCGGGGTGCAGGGTGCATCACCCACCC ACCACCTGCCTTCTTCCACCCACCACCTGCCTACGGTGTGACAGTGCCATTGCAGCATGA TTCTACAGAGATGCCTGTGTCGGCACCATTCTCCCATCAGCTGCGGCCACTGGGCGGGTT CTGATTCTGAGGGGAGCAGAAACAGGTGTTCCCCCCCAAGGAGCCAGGCTGTCAGGGATC ACAACCTAGCGGGGGCTGGGGGGGGCGGCCACTGGCCCAAGGTCCTGGTTATACAGATCA AAAGGCAGAGCCCAGGAGAGAGCAAGTGGCTTGCCCAGGGTCACACAGCCGCCAGCAGCA CGGCCAGGGCAGTCACAGCCGAGGCCAGGCCCATGCTCTGGGTCTCATCCTAGGCTGTGA TCCCACCACAGTGCACCGGCAGCTTTGGTAACAACATCCCTGTGTATCCATTTCCCTCTG TTGATCCAACCGGGATGTCCCAACTGGGATGTCCCACCCAGGCAACCCCTCGACATGGTG GGGTCTCTAAGTCCACATCTAGAGTTGACTCTAGAAGGCTGAGGAATGCGAGGCCCAGCT TCAGGTCCAAAACTACCAACTTAGGCCCTCGATTTCCCTCCTTCACGACCCAGTTCCTTC GAGTCTGGAAGACTCTGCAATACCCTTTGTGAAGGTGTTAAAAAGGGTGACTCACTCCCC AGAGCGAGTCACACCTGGACTCTTAATGCCTTCGTTGTTGGATGGCATCCTGCTTCCTAC CAGGTTATCCTGGCCTCAGTGACCTCAGAAGCAGCAAGGGTCTGACTTACAGTGGGCACG TGCTACTTCTTTAATTAATTGAAAGTAAAGTTGTTGTTTTTTAAGTTGGCATTCTGGCTT GAAAACAGAAAGATGGCATGAAAATATTAATGGGAGTACTTCAACTATTTTCATTATGCC AAAAATACTTGGAGAAGTAGCACATTTTCTGCAAAGTCTAAAATGTCAATTTTCTTTGGG GCCAAAAATGCATCATTTCTGTGTGGTAATACTTATGTGGATAAAAAACTCTGGTAGACA GTTATGCATATATATATTTTTTGGTGAATTACAATGAGAAAAAGTCCAGGTGCAATGGCT CACATCTGTAACTCCAGCACTTTAGGAGGCGGATCCAGGAGGATGGCTTTAGCCCAGGAG TTCAAGACCAGCATGGGCAACATAGTGAGACACCTCTGCCTCCCCCACCCCACCCCGCCT CTACAAAAAAATTTAAAAATTAGCTGGGTGTGGTGGTGTGCACCTGTAGTCCCAGCTACT TGGGAGGTTGACGCAGGAGGACTGCTTGAGCCTGGGAGGCAGAGGTTGCAGTGAGCCAAG ACAGCACCATTGGACTCCAGCCTGGGTGACAGAGACCCTCGAAAAAAAAAAAGAAAAAGA AAAGAAAAGAAAAAATTAGGCTGGGCACGGTGGCTCATGCCTGTAACCCCAGCACTTTGG GAGACCGAGGTGGGTGGATCACTTGAGATCAGGAGTTCGAGACCAGCCTGTCCAATATGG TGAAACCCCGTCCCTACCAAAAATACAAAAATTAGCCGGGCATGGTATCGGGCACCTGTA ATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCACTTGAACCCAGGAGGTGGAGGTTG CAGTGAGCCGAGATTGTGCCACTTCACTCCAGCCTGGGCGACAGAGTGAGACTTTGTTTC AAAAATAATAATAATAAATAAATAATAAATAAATAAATCATATGAGAAGATACTCAATGG CACTCAGAAAAGAAATGCAAATTTATTTTATTTTATTTTGAGATGGAGTCTTGCTCTGTC GCCCAGGCTGGAGTGCAGTGGTACAATCTCGGCTCACTGCAACCCCCACTTCCTGGGTTC AAGCAATACTCCTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGGCACCTGCCACCATGC CTGGCTCATTTTTGTATTTTTAGTAGAGATAGGGTTTCACCATGTTGGCCAGGCTGGTCT CGAACTCCTGAGCTCAAGTGATTCACCCACCTCGGCCACCCAAAGTGCTGGGATTACCAG CATCAGTCACCGTGTTTGGCCAGTATTCATTATCTTGTTGTCTTCCAGTTGTGTCTCTTC AATAAGGGAGTATGCAATGGAGTCTATAGAAAGCAAGTGAGGGAGTTTTCTCAGTAGGTG CAAGGGTAGTGAGGCATTTCATTTTGAGTCATACTCTGATGAGGCTGGCCTGTCTTTTCT CATAGTGATCTGCAGAGATGAAAAAACGCAGATGATATACCAGCAACATCAGTCATGGCT GCGCCCTGTGCTCAGAAGCAACCGGGTGGAATATTGCTGGTGCAACAGTGGCAGGGCACA GTGCCACTCAGTGCCTGTCAAAAGTATGTACTGAGGCTGGGAGGTGGTGCATGCCTGTGA TCCCAGCACTTTAGGAGGCCAAGGTGGGAGGGTCGCTGGAGCCCGGGAGTTCAAGACCAA TCTGGGCAAACATAGCAAGTCCCCTGTCTCTACAAAAAATAAAAAAATTAGCCAGACCTG GTATGTAGTCCCAACTACTTGGGAGGTTGAGGCAGAAGGATCACTTGAGCCCAGGAGTTG GAGGCTGCAGTAATCTACGATTGTGCCACTGCATTTCAACCTCAGTGACAGGGCAAGCCC TCACCTCTAAAACAAAACAAAACAACACAAACAAAAACAAAAACACAGAAAAGCCCAGTA CAAATCGACTTCAAACTGAGACTTCGAGTTCAGGGGTCCAGTCATGAACCCTGTCTTTCA TGGTCCCCGGAAAGTTCAAATCTTCAAAAGGAGCCTCCAGGCCTGTTCGGCCTTAGGCGG AGGTGAAGGTACAAGCAGAAAAGGGAGCAAGACCAAGTGACCTTGGGCAAATGCCCGCTT GCCTCAGTTTCCTCATCTATAAAGAGGTGGGAATAACAGTACACACTTCATGGTTTGCTG TGAGGATTAAATTAGCTAATTTTTGTAGACTGTACAACAGCGCCTGGCACATAGAGCACA TTCTTAATATTTTAACTCACATCATCCTTGGAGCTGCTTTGAAAATACAGGGGACCCTTG AACAACACTTGTCTGACCTGCAGGGTCCACTTATGTATGGATTTTTTTCAACCAAAGGCA GGATGAAAACAGTATTTGTAGGATGCAGAACTGGTATACGCGTGTTCCACGCTGCAGGAC TTGAGTGTGTGTGGATTGTGGTAGACAGGGCTCCTGGAACCATGGCCTGAGCACACAGAA GGAGGCTGTCATTAGGGGCTTCCTTTTTTATACTTGACAGGTTGCAGCGAGCCAAGGTGT TTCAACGGGGGCACCTGCCAGCAGGCCCTGTACTTCTCAGATTTCGTGTGCCAGTGCCCC GAAGGATTTGCTGGGAAGTGCTGTGAAATAGGTGAGTAGGTGAGAGCACGTGAAACGAGC TGAAATCCCACCTCTCCAGTCTCCCCCGCCCCCGGAAGGAAAGGCAGGGTGCGATGGCAG GGCCAGGGGTGGGGGCCAGGGACAGGGAAGGCGCTTCTGCCATGGGTCAGGAAGCACAGT GCCACACAGCAAGCAGAGCCTAGGTGTGACCCTGAATCCAGGCTGGCACCCTTGCCACCC AGCCTGTGGCTTCCGAGCCAGCCTGCATCAGGCCTGGGGGAGGACGGGGCAGAGAGGGGA GCCTCCTGAGGGCTGAATGAAAGGGGACTCCCATGTGAGGCATCCATGCCCTGCTCTCTG TCAGATACCAGGGCCACGTGCTACGAGGACCAGGGCATCAGCTACAGGGGCACGTGGAGC ACAGCGGAGAGTGGCGCCGAGTGCACCAACTGGAACAGCAGCGCGTTGGCCCAGAAGCCC TACAGCGGGCGGAGGCCAGACGCCATCAGGCTGGGCCTGGGGAACCACAACTACTGCAGG TGAGGGCACATCCCCAAGGAGGGATTCCCCCTGTGAGAAGCTGCTACAGCTGGGGAAAGA TTCTGTCAGATCCGTCAGGGTTCTCCCAAGAAACATAACCAATACAGGATGGATAGATGG ATAGATGATAGACAGATAATAGATGATAGGTGATAGATGATAGATTGATAGATGATAGAT GATAGGTGATAGATTAGATAAATAGATGATACATACATGATAGATAGATGATAAATAGAC GGTAGATGGATGACAGATAGACAGATGATAGGTGATAGATAGATGATAGATTGATAGATG ATTGATAGATAAATAGATGATAGATACATAGATGATAGATGGTAGATAGATGATAGATGG ATAGATGATAGATGATAGGTGGTAGATGATAGACAGATGATTAGAAAGATAGATGATAGA TACATAGATGATAGACACATAGATGATAGACAGATTGACAGATGATAGATGATTGATAGA TGATTAAATAGATGATACATAGATGATAATGATAAATAGATGATAGATGATAGATGATAG GTGATAGATAGATTGATAGATGATAGAAGATTGATAGATGATAGATACATAGGTGATAGT AGATGTAAGATGATAGATGATAGATAGATAGATGATAGACAGATTGATAGATGATAGAGA GATAGAGATAGAGAAAGAGGAGAGAGAAATAGAGAGAGAGAGAGAATGTGTGTGAACCCA AAGTATCTGAGACAGGTCTCAATCGATTTAGAAAGTTGATTTTGCCAAGGTTAAGGACAC CCCCGTGACACAGCCTCAGGAGGTCCTGAGGACATGTGCCCAAGGTTGTCAGGGCACAGC TTGCCTTTAGACGTTTTAGGGAGTCATGAGACATCAATCAACATGTGTGAGATGTACATC GGTTTGGTCGGGAAAGTTGGGATAACTCGAAGCAAGGGCTTCCAGGCCATAGGTAGATAA GAGACAAAAGGCTGTATTCTGAGTCCTTGATCAGCTTTTCACTGAACACACAATTGAGTC TGGCTCAGTTCATCTGCATTTTTACATAAAAAATAGGGCAGAGGAAGCAATCAGATACGC ATTTGTCTCAGATGAGCAGAGGGATGATTTTCTGTCCTGCACCTGGGAAGATAAGCTATC CATTTACAATGCCAAGGTGAAAGTCAACAGAACTGTTTTAGGGTAAAGATCTTTAGGCCT GCAAGGAATGTCCTTGTAGAGAATTAAAAAAAAAAAAAAAAAACTTTGCAGCTATCTTAT TGAGGAATAAATGAGAGGCAGGTTTGCCTGACGTAGTTCCCGGCTTGACATTTCCCTTGG CTCATGACGTTGGGGTCCTGAGATTTATTTTCCTTTCACACTAGATAGATAGACATTTAT GTTAAGGAACTGGCTGACAGGATCGTGGGGGCTGGCAAGTCCGAAACATCTTGGTAAGCC AGGCTGGAAGTGCAGGCAGAAGCTGAGGCTGCTCTCTTAAGGCAGAATTTCTTATTCAGG AAACCTCATATTTGCTCTTAAGGCCTTTAAGTGATTGGACGAGGCCCAACTACATTATCT AGGACAATTTCCTTTTCTAAAGTCAACTGGCTGTAGATATTAACCACATCTATAAAACAC TTTCACAACTCCTAGATGAATGTTTGGTTAACTGACTGGGTGCCACAGCCTGGCCAAGTT GACATATAAGACTATTCCAGTCCACACCTTGTCAATTTGGCACCCATGTGCATCTCCTTA AACCATCCTTCACCTCCAAGTAAACACAGGAACAAAATCATACTCCTGCCTAACATGATA GAACTACCAGTGTACAACCAAAAACGCACTCCCGGCTGGGCGTGGTGGCTCACGCCTGTA ATCCCAGCACTTTGGGAAGCCAAGGCAGGTGGATCACCTGAGGTCAGGAGTTCAAGACCA GCCTGGCCAACATGGTGAAACCCTGTCTCTACTAAAAATACAAAAATTAGCCAGGCATGG TGGCAGGCACCTGTAATCCCAGCTACTCGGGAAGCTGAGGCTGAAGAATTGCCCAAATCC AGGAAACGGAGGTTGCAGTGAGAGGAGATGCGCCGCTGCACTCCAGCCTGGGATAAACAG CGAGACTCTGTCAAAAAAAAAAGCACCCCCCATTCCTCCAGAAAAGGATACCAAAGTCCT TGGGTCCTAAAGGAGAGGCTTCACCTTTGACCTACCCTGGCCCTTCCCTTGGCTGATTTT TCAGAAACCCAGATCGAGACTCAAAGCCCTGGTGCTACGTCTTTAAGGCGGGGAAGTACA GCTCAGAGTTCTGCAGCACCCCTGCCTGCTCTGAGGGTAAGTGGCAGCCACCCCGCCTTT CCCTGAATGTCCCTGGGGGAGGAAAGTCCAGGAGGACAGGCCGATAGCCCTCCTGCACCT GAGGGGAGAAAGGGGGAGGCCAGGAGTGAGTCATTTTGGTTGCAGAGGGAAGAAAGACAG GACTTAGGTCTGTGCCTGGGCTTGGCCTCTGACTGGCTATTTGTCTGACCTGGAGCTGAT CTCCTCACACTCTGACCCTCAATTTCCTCCTCTATGGAGGAGAGGATGGGGCTGAATCAG TGGTTTTCAGTCCTTTTGAGAATGAATGGAGATTCTCCCTTTTTTGATTAATGGGTGAAT GGGGCTTTGTCTCTCTTTCGCTCCCTCTCAAACTTTTTAATGCAAAAAAAAAAAAAAAAA AACTTCCAAGATTGAAAAAATATATATTAAGTTACAAGACCAGGCACAGTGGCTTATGCC TATAAACCCAGCACTCTGGGAGGCTGAGGCGGGCGGCTCACCTGAGGTCAGGAGTTTGAG ACCAGCCTGGCCAACATGGTGAAACCCTGTCTCTACTAAAAATACAAAAATTAGCCGGAT ACGGTGGCAGGCACCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATTGCTTGA ACCTGGGAGATGGAGGTTGCAGTGAGCCGAGATCATGCCACTGCACTCCAGCCTGGGTGA TAGAACAAAAAACTGTTTCAAAAAAAAGAAAAAAATGAAATGCTAAGTTACAGAAAGGTA CTATGAATTCAGTGGTGCTTATACAAATCATTACGTTACTTATCACATTTATCACAGCAC TATGAAAGATTTTTTTTAAGTTCTAAATATATATAGGGCCAGGTGCAGTGGCTCGTGTCT ATAATCCCAGCACTTTGGGAGGCTGAGGCGGGAGAACTGCTTGAGCCCAGGAGTTTGAGA CCAGCCTGGGCAACAAAGTGAGACTCCATCTCTACAAAAAATACAAAAATTAGTCAGGTG TGGTGGCTTGTGCCTATGGTCCCAGCTGCTTGGGAGGCTCAGGTGGGAGGATCGCTTGAG CCCAGGAGGTTGAGGCCACAGTGAGCAATGATTGTGCCACTGCACTCCAGCCTGGGTGAC AGTGAGATCCTGCCTCAAAATAAATACATAAATATGTGTGTGGGTGTGTGTATATATATA TGTAATACACATATATTAAATTTATATATGATATATATAAACACGCACCAGCTATATGCA TTCAGCACCCAGGTCCACGGGTGATGCCTGTGACTCTGAAGACTTTACAGTCACTCTACA ATATCCTCCCCATCCCCCATGGTCTGGTCTAAATGAGGACTCGCAGATCTAGATAATCTT GAAAATCCCTTCCATTTATGGTATTTATGTATAGAGGTATGCTTTGTCAGTTTCAGGTCG GGAGAAAAAAATGGAAAAATGGGGGAAATAAATGAAAACAGGCAGCACTCCACGGCTCAT ACCCTCCTCCTTCCCAAGCCCATCATCAGATCCTCAGGACACTGGCAGACACAGTCCGAG AAATAACCCCCACCCCAGCCCCACTGAAGCACGTTGGTTCACTGCAGCCTGTTAAGTAAC ACAAGGAAACCCCTACTGGCTTTCAAAGCAGCTTCAGAAACAGCCCCCACTCATGGAAGT GGTTCTTCCTGCTGAACCTGAAGATGTCCCCAGACTCTCTCTCAACATAGCAATCTAGGG AGCCACTTCCGGTGGAGATGAAACCCCCTTGCCATCTCTAAGTAAAAGGACTCAAAGAGG GGGAAAAAGGCTCAGGCCGGGCGTGTTGGCTCACACCTGTACTCCCAGCACTTTGGGAGG CTGAGGCGGGCAGATCACCTGATGTTAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAA ACCCTGTCTCAACTAAAAATACAAAATTAGCGTAGCATGGTGGCGCATGCCTGTAACCCC ACCTACTCGGGAGGCTGAGGTAGAAGAATCGCTTGAACCCAGGAGGTGGAGATTGCAGTG AGCCAAGATCGCGCATTGCACTCCAGCCTGGGCAACAAAAGGGGAAGTGTGAGGTGTTAC ACTCTTCTCAGTGCCGGGCTAGCGGCCTCCAGCTTCCTCGACCGGCAGCTCCGCTTCAAG CCCCAGCCCTGACTTGCGTGCTTCAGAATTTGTTTTTGTTTCAGTTTGAGAATTCTTTTC TTCTAGGAAACAGTGACTGCTACTTTGGGAATGGGTCAGCCTACCGTGGCACGCACAGCC TCACCGAGTCGGGTGCCTCCTGCCTCCCGTGGAATTCCATGATCCTGATAGGCAAGGTTT ACACAGCACAGAACCCCAGTGCCCAGGCACTGGGCCTGGGCAAACATAATTACTGCCGGT AGGTAGCACAGGGGTGGGGGGTTCAGGTCTTGGCAGAACGTGGGATTAGGGTGTGAGACG GGGGAAGATCCAATGTCTCAAGTTGCATGACAGACCCAGTGCGTGGGAAGCACCCATGGA TATTATCTAATCCAACCTCTTCACTTGCTAGAATAACACATATTGTGAAAAGCAAGGTCT ACCAGTTTTCCAACCTAAATCCCAAGTTAAGGGTCCTGGCCTGTAACCATTTAGTCCTCA GCTGTTCTCCTGACATCTTTATTGCAATGATTTGTAAGAGTTCCGTAACAGGACAGCTCA CAGTTCTGTCTGACAACCCTATGAGATTAGAACACTACATTACTGACTGGGTAACAAAGT TAAAGAGAAGTTCTCCTAGGGTGGGGGTGTGCTGCAAGGTCAAGATGAACTCGGTGTCCT CCCTCCCAGCTCAGTGGTTTTCATTGGTTGACTGAGTCTCCTTCTACTCTTACATGGCCT GTGATGTGGCTGAAAATGGGATTGAAAATCTTAAACTCCTGGCCTGGTGTGGTGGTGCAT GCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGAGGATTGCTTGAGCCCAGGAGTTC AAGACCAGCCTGGGCAACATGGCAAGACCCCATCTCTACAAAAATTAAAAAATAAGAAGA TAAAAAGGAAACCTTAAACTCTCTTATCATTTAGGAATCCTGATGGGGATGCCAAGCCCT GGTGCCACGTGCTGAAGAACCGCAGGCTGACGTGGGAGTACTGTGATGTGCCCTCCTGCT GTAAGGGCTGGGCCCCGGCTGCCTCCCTGCACCTGGTCTCCCTTCTTCACCATCTCCTCG CCACTTTCTAGGCCTTCATGGCTGTCTGGTGCAGACTGTGTGCCTACCAGACTTCCAGGC TGGGTGGGGAGGGGGCTTCCATGACTGAAGCCACGGTGGGTGGGCGGGTGTCCATGACCC ATGCATGGGGGTGGTGGGGAGGGGCAAGAAGAAAGAAAAGAACACAGCAACCTCTCTGAG AAGTCAGTAGGCTCTACCCGGCTCTCTCTAGACGCCTCTATTGGTGTTGCTGAGAGTAAT GGGGAATGAGGAGGAGGCCTCGCATGCATGGCTCCTTAGATAATAAAGTGCCTTCACCAC ATTTGTCCAACAGCGTGGTGGAGGTGGTCTTCCTACCTCCAGTTTACTGAGTAGGAAGCA GTCTCCCAGACGCCAGGTGGCCTGCCCAAGCTCGCTGGGCACCGGGAGGTAAAGCTAGGG CCTGCCCTCATGCCCTCTGACCCCAATGGCATGTACTTCCACTGTGAGATCTTCCACGTT TCCTGTTGACCTATTTCACACAGGGGAGCTGGCTCATGATGTGGGTGAGAGATAGGAGAT TCAAGTTGGTGCATATTGCTAAAAAATGAAACTTTAGTTTGGAAATGGCCAGAGAGTAGG TTATTAATCACCTCCTGTGAACACAGATCAGCCAGAATGTTCCCCAAGGAACACAAGTCC AACTGGGACGATGAGACACAGACCACCAGCTAACTCACACCCAAGGGCATTAGTGTGAGT CCTCAGTGGTCCGTGTCCCTAAGCTCCTCAGAGCTGAGCAGGTGGGGACGTCAGGAAAGC TTTGCGAGGAGGCAGGATTGCACCTGGGCCTTGAAGCATGGGTAAGGTTGGACAGATGGA AAAGAAATGAGCAGACATTCCACAGAAGGAAGCTGCAATTCTTCATTTCTTAGGCCAGGA AATGGCTGTAGGAAAACATTAGAAGGAATGAAGGATGGCAGATCCCCAGTTTTGGAGTCA AACATACTTGGGAACTAATCCAGGTGCCATTGCAACCTTGGGCAAAAACGTCTCCGCCTC CTGAAACTTATCGCTGTGGGAACTAAAGAGAATGTATGGACAACATTCGGCATGCTGATC CCACCAAGTGAAAGTTGTGGTTTTACAGCCATGCTGATGGCCTCCTCACTCTACCTACAC ACGTGCAGGAGGCCTGTGGGACTGACTGCCTCCTCGTCCTTTCCTCCCCAGCCACCTGCG GCCTGAGACAGTACAGCCAGCCTCAGTTTCGCATCAAAGGAGGGCTCTTCGCCGACATCG CCTCCCACCCCTGGCAGGCTGCCATCTTTGCCAAGCACAGGAGGTCGCCCGGAGAGCGGT TCCTGTGCGGGGGCATACTCATCAGCTCCTGCTGGATTCTCTCTGCCGCCCACTGCTTCC AGGAGAGGTAGGGGCTCGGAAACCCAGTTGGTTTTTCCACCCTCTAACGCCTAGAAACCA AGCCCTTTAGGGGAAATCCCACAGCAAAAAAAGCATTCTAAGGCTGTTTCTCCACCAGGT TTCCGCCCCACCACCTGACGGTGATCTTGGGCAGAACATACCGGGTGGTCCCTGGCGAGG AGGAGCAGAAATTTGAAGTCGAAAAATACATTGTCCATAAGGAATTCGATGATGACACTT ACGACAATGACATTGGTAAGAGCTCGTCATTCCCGGCTCCAGTTCATACAGATCACACAA CACACCCACATGCACTCACCTATGTTTACACACACGGGCCTCCTCCTCCAGCCCCTGCCC CTCCTGCGTGTTCCTCCCCTCCCGGGGACGCGGCCCTCACGCCAGCTCACTCCTCCTTTC TCCCTCCCAGCGCTGCTGCAGCTGAAATCGGATTCGTCCCGCTGTGCCCAGGAGAGCAGC GTGGTCCGCACTGTGTGCCTTCCCCCGGCGGACCTGCAGCTGCCGGACTGGACGGAGTGT GAGCTCTCCGGCTACGGCAAGCATGAGGCCTGTAAGTGGAAGGAAGTCTCGGCCCCATCC TGTCTGCGGGACAGCAGGGGAGGCTGCGGTCCACCAGAGGAAAATGGGGTCAGGAGACCG AAGTTCCAGCCCCGGGTCAGGCACTGACGCCAGTCCCGTCTCCCTGTGTCGTGGGGGCCC GTCTCTGCTGTCTCTGCCTCACAGGGACACTGCAGGCCAGGAAAGGACACAACAGTATGA GGGCCTCGAAGTGCTGCAGGTGTTGGGAAGGTTCTGAGTAGGAAGTGGAGTACAGTCGCT AAGCGTGTGGGTTCTGGGAAGCTGGAGTTACAAAGACCCGATTTCAAATCCCACTTGCTG AGCTGTGTGACCGTGGACATGGATTTTTATTTTGAACTGCTCCCAGCCTCAGTTTCCTCG TTGGTAAAGTGGAGATAGAACTATCTCCCTAATTAGATTAGGAGGGTTAAATGAGATAAT ATTGAACGAATGGATGTCAGCTGGGGTGATTTTGTCCCCCAGGAAACGTTTGGCGAGGTC TGGAGACGTTTTTGGTTGTTACAGTTTAGGGTGAGGGTTAACGCCGGCCTTCAGTGAGTG CAGCCAGGGATGCTGCACACTGCAGGGCTCGGGACTGTCCCCATCCCCCACAACAGGGAC CTCCCTGGTCCGAAGCATCAGCAGTGCCACTACGGAGAGGCTGTGGGTTCAATCCCGGAA TCCTGCTGTTTTTGTGGGTCAAAACGATAAAATACCAGCAGTGTCATAGGATTCGACCTA ATACATGTTGAATCTTGATCAATGTTAGCTATTATTGGAAAATTTGGCTTTCTCTTTCAA AAACGTTTATAAATAACTTTCCCTAAAACCATATGATGGTTCTCCCCTTTCAGTGTCTCC TTTCTATTCGGAGCGGCTGAAGGAGGCTCATGTCAGACTGTACCCATCCAGCCGCTGCAC ATCACAACATTTACTTAACAGAACAGTCACCGACAACATGCTGTGTGCTGGAGACACTCG GAGCGGCGGGCCCCAGGCAAACTTGCACGACGCCTGCCAGGTAACCAGGAGTGGCGCGCC CATGCTGGGCACAACCCAGGGGAGAATGCCCCTGGGACAACAGGTTCTTCACCAAAGAAA AAAGTTATCACCAGAGTGGAGTGATTTCCTCTTAGTGATACCCCTGGGGATTCTAGATGA GGGCCTCACAGAATAAAGCAACTGGAGGAAGATCAAAGTCACCTAAACCTAAGAATTCTA AACTGCAGGAAATTTCCCCAGGATCTGCACAGGCAACTCCACCTGTACAGGATTTCCTTT CAGCCCAGGCAATTGATTGACTATTGAAGTGATGGAGAGAGCCACACAATTAAGAAACGT TTGCCTCAGCCTGGTGTGGTGGTTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGT GGGAGGCTCACCTGAGGTCAGGAGTTCGAGACCAGCCTGACCAACATGGAGAAACCCCAT CTCTACTAAAAATACAAAATTAGCCTGGCATGGTGGCACATGCCTGTAATCCCAGCTACT CAGGAGGCTGAGGCAGGAGAATCGCTTGAACCCGGGAGGCAGAGGTTGCAGTGAGCCGAG ATCGCGCCATTGCGCTTCAGCCTGGGCAACAAGAGCGAAACTCGATCTCAAAAAAAAAAA AAAAAAAAAAAAGAAAGAAATGTTTGCCTCTGTTGGCACTAGAGAATTGGAGTCTGCTTT GTAGAAGGAGAAGGAAGAAAGGCAACTTACTGGGAAGCAGGATCTAGATGATGTGAGAAA GAAGTTTTCAAAACTCACATTCAGCCCTAATACCCTGGGAAAGCACACTATTTGAGGTCC TTTGTGTGGGCATCCTTATCAGAATTAGTACTTATATTTCATGATTAGCCAGATACTGGG GTATGGGAGGACAGGCCAGCCTGCTGGTATTAAGACCTGCACAGAGCCAAGGAATTGATC TTCCTCAGACATTTCAGTGCCTGCAGCGTGCGAAGCTCTCCTTTAGGGGCTGGGGGTAGA AGAGATACAAAGAGAAGTGAGGCCAGGCTCTGGTGCTGAAGGATGTGTGGGCTTTGTTTT CGCAAGGCAGTCATATCGGCGGTTTCCCCTCTGATTCCCTGACAGGATTTAGTTTCTTTT TGAATGGTTTCTTCAGCAACCTCAGCTGTACCAGCTTACAGTCCAGAAACAAAAAGGTTG TACCAAAGTGAAACCATTATCTATCTGCAAGCTTAGTTAAAAGCAAAACCAAATCATTTT AATTCAATATAAGAACAGCTAACAATTACCAAGAGTTTTACTAGATGTCTTCCAGTGCTT TTCATGCATTCTTCTACTGAATGCCATAACCACTCTATGGGTAGTATGAATATTATCTCT ATGGTACAGATAAGAAAACCAAAGCATGGTTAGTCTAAGGCCATCAGCTAGTAAGTGATG GAGCCAAGCCAGGGTTTTTGAGGCCTGAAACGTTTGAGTAATTAACTCTACTTTACCAGA ATAGATACAGCCTAATCCTCCATGGGACCAAGATAACTGAGATACAATCTACCCACTCTT CAGTAAGTCTCCACTTAACAGCATGCCTGGAAAAAATAGGTTCTTAGAAACTGCAACTGT AAGTGAAATGACGTATAACAAAACCAATTTTACCACCAGCTAATTGATATAAACAAGAGT TGGTCAGGTGCGGGGCTCATGCCTGTAATCCCAGCACTTTGAGAGGCTGAGGAAGGCAGA TCACCTGAGGTCAGGAGTTCGAGACCAGCCTGGCCACCATGGTGAAACCCTGCCTCTACT AAAAACACAAAAATTAGCCAGGTGTGGTGGTGCGTGCCCATAAGCACGAGAATTGCTTGA ACCCCGGAGGTGGAGGGTGCAGTGAGCTGAGATTGCGCCACTGCACTCCAGCCTGGGTGG GTGACAGAGTGAGACTCTGTCTCAAAACAAAAAAACAAAAAAAAACAAAAAAAGAAGAGT GAAGTTCTTGTGGCAATATTTCTAGTCATAAAAACATCAGCAAACTTCTAAATAAAGACC CAAAACACTTCTAACATTCAATATTGAAATAAATGTGAGCTATACAACATTTAAGAAAGG TTAATAAAAACAAACATGGTATTTATTTACCCAATTTTTGGAGAATAAGTGAATGATGGC GGCCATAATAGTGGTGGGTTAATTCAGGGAATAAATGTTTGCAAAGCAAAAATGGTAAGG AACACCTCTTACTACCATGAAGTTCAAAAACAATCACAAATAGGGCAGGCTCCCTGACTG CCTCCACACCTCACAGTTTATCATGCATTCGTGTATTTAGCACAGACTAGACAGATTTTT ACTTTATAACACTTTGTATTCATTCATTTTCCAACGTGCTTATTCCGGTTCAGGGTCTTG GGTGGGGGTGGCCAGAGCCACCTGGCAGCTCAGGGCGCCAGGCGGGACCAGCCCTGGACA GACGCCACCATCCTATTGCAGAGCCACTAACACCCACACTCACTCAGACTGGGCCCACGT AGATACATCCTCAGTTGGCTTAATGTGCAAGCTTTGGGATGTGGAAGGAAACCGGGGTAC CTGGACAAAACCCAGGCAGACAGTGTCCCCAGACAGGAATTGATTTTTGTTTTCCTCATC AAAGTTATAATGAAATGACACTGAATGGAATATTATTGAAGGGCCTGCTGTATTTTGAAG ATTACGATGTTCATGCTACACATACTGACTTTCTCCAGATAGTCTGCTTTTTTTGCAAAC GCCAAACCTGCTATCTCCTTTGCAGGGCGATTCGGGAGGCCCCCTGGTGTGTCTGAACGA TGGCCGCATGACTTTGGTGGGCATCATCAGCTGGGGCCTGGGCTGTGGACAGAAGGATGT CCCGGGTGTGTACACCAAGGTTACCAACTACCTAGACTGGATTCGTGACAACATGCGACC GTGACCAGGAACACCCGACTCCTCAAAAGCAAATGAGATCCCGCCTCTTCTTCTTCAGAA GACACTGCAAAGGCGCAGTGCTTCTCTACAGACTTCTCCAGACCCACCACACCGCAGAAG CGGGACGAGACCCTACAGGAGAGGGAAGAGTGCATTTTCCCAGATACTTCCCATTTTGGA AGTTTTCAGGACTTGGTCTGATTTCAGGATACTCTGTCAGATGGGAAGACATGAATGCAC ACTAGCCTCTCCAGGAATGCCTCCTCCCTGGGCAGAAAGTGGCCATGCCACCCTGTTTTC AGCTAAAGCCCAACCTCCTGACCTGTCACCGTGAGCAGCTTTGGAAACAGGACCACAAAA ATGAAAGCATGTCTCAATAGTAAAAGATAACAAGATCTTTCAGGAAAGACGGATTGCATT AGAAATAGACAGTATATTTATAGTCACAAGAGCCCAGCAGGGCCTCAAAGTTGGGGCAGG CTGGCTGGCCCGTCATGTTCCTCAAAAGCACCCTTGACGTCAAGTCTCCTTCCCCTTTCC CCACTCCCTGGCTCTCAGAAGGTATTCCTTTTGTGTACAGTGTGTAAAGTGTAAATCCTT TTTCTTTATAAACTTTAGAGTAGCATGAGAGAATTGTATCATTTGAACAACTAGGCTTCA GCATATTTATAGCAATCCATGTTAGTTTTTACTTTCTGTTGCCACAACCCTGTTTTATAC TGTACTTAATAAATTCAGATATATTTTTCACAGTTTTTCCAAAATCAGAGTGGAATGGTT TTGTTATAGATGCTGTATCCCACTCTTTATTCATGTTCACATTTTAAAATCATTTGGAAT TCTGCTTCACTCGCTTAACATATACACAACACCTGTAACATACAAGGCAATGGGCTAGGT GCTCCAGACCGGGAAAAGGAGGGACAGGAATGCTTGGTCTGATGGGCTAATATGGCATTT AGAGAAGTACCAAGGTACAGTGGAGCCGGTCACAAAAGGGCAGACTTGTAGTAGAATTCA GTTGCAAGAGGGATTGGGGAATCTTAAGGAAAAAATAGAATCTTAAGGAAAAAATAACTG GGTGAGACGTGGACTGTGGACAGGTGTGGAAAAGGCACTCTCCATGGAGGTATGAATATG TAGAGGGCCAAGAGAGGGGAGTACAGGGAGAAATGAGTTGAGCTTGTCTGAAGTGAACTT CAGGAAGAGGAACATAGGCTGGAATTTAGATTATGGGGGCTCTGAACACCAAACTGAGTT TGGACTTAATTGACTTCTG OMIM ID 173370