| Entrez gene ID | | 5196 |
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| Official gene symbol | | PF4 |
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| Full name | | platelet factor 4 |
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| Aliases | | ,CXCL4,MGC138298,SCYB4, |
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| Gene summary | | Platelet factor-4 is a 70-amino acid protein that is released from the alpha-granules of activated platelets and binds with high affinity to heparin. Its major physiologic role appears to be neutralization of heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. As a strong chemoattractant for neutrophils and fibroblasts, PF4 probably has a role in inflammation and wound repair (Eisman et al., 1990 [PubMed 1695112]).[supplied by OMIM] |
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| Location | | Chromosome: 4 Locus: 4q12-q21 |
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| Gene position | | 74847715 - 74846796 Map Viewer |
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| Gene orientation | | minus |
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| Gene size | | 920 bp |
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| Gene sequence |
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| OMIM ID | | 173460 |
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