| Entrez gene ID | | 51776 |
| Official gene symbol | | ZAK |
| Full name | | sterile alpha motif and leucine zipper containing kinase AZK |
| Aliases | | ,AZK,MLK7,MLT,MLTK,MRK,mlklak,pk, |
| Gene summary | | This gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq] |
| Location | | Chromosome: 2 Locus: 2q24.2 |
| Gene position | | 173940565 - 174132737 Map Viewer |
| Gene orientation | | plus |
| Gene size | | 192173 bp |
| Gene sequence |
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| OMIM ID | | 609479 |
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