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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for UPB1 (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 51733 Official gene symbol UPB1 Full name ureidopropionase, beta Aliases ,BUP1, Gene summary This gene encodes a protein that belongs to the CN hydrolase family. Beta-ureidopropionase catalyzes the last step in the pyrimidine degradation pathway. The pyrimidine bases uracil and thymine are degraded via the consecutive action of dihydropyrimidine dehydrogenase (DHPDH), dihydropyrimidinase (DHP) and beta-ureidopropionase (UP) to beta-alanine and beta-aminoisobutyric acid, respectively. UP deficiencies are associated with N-carbamyl-beta-amino aciduria and may lead to abnormalities in neurological activity. [provided by RefSeq] Location Chromosome: 22   Locus: 22q11.2 Gene position 24891251 - 24922553  Map Viewer Gene orientation plus Gene size 31303 bp Gene sequence >UPB1:4281820..4313122:Length=31303 GTCTGGGAGCGAGAGTAAGAGATAAAGGCAAGGGCGCCTGACCGGGCCTGGGCACCTCCT CCCACTGCGGGCAAAGGGCAGGCAGTTCGTGCGCGGACACAAGCACTGGCGGACCGTGGC CATGGCGGGCGCTGAGTGGAAGTCGCTGGAGGAATGCTTGGAGAAGCACCTGCCGCTCCC CGACTTGCAGGAAGTGAAGCGCGTTCTCTATGGCAAGGAACTCAGGTCCGCAGCCAAGAG GCTAAGCTAATGGGGTCTTGGGGCCACAGAGTGTGGGTCTGGGGGAGCAGGCAGGGAGGG CCTCAGGGTCTGAAGGGCTCAGGGGAGGCGGTGAGAAGTCCTGAGTTGGCGGGCAGAGAC CATAGTAGGTCTTGATGGGACGGCCCCGGGGTCCTTGGGGGTTGCAGAATCCTGGCGTGA CCTTTACAAATCTCTTCTCCCCCACGTTGCCCAGAACCGGAAGGAAAAGGACGGGATTTT ACTCTCCAGGGCTTTCTCTGTGGCCATCCCAACCCTCCTCCCCGGAGCCGGGCTTGTCTT CTGGATGTCTGGCTGGATCACTGTCTCCAACCAGAGCACCCAGCAGGTGTACTGATTGTC CGGCCCCAGACCATCCTTCTTGCGGTGACCCGACCTCTGGCTGACCCTTGGAAATAGAGG CTGTCTGCATTTAGTTGGCGAGGGAACCTTTCCCACTGGCAAGCCATGGGCGCTGGTTTT TCCACTCCCTGCAAGCTTGTGCATCACCAGGACTTTCTGAGGGCTGTATACTGCTGGACA CTGTGTCCACAAAGCTGAAAAAGACACTTCCTGGCCGGGCTCACACCTGTAATCTCAGCA CTTTGGGAGGCCAGGGCTGGAAGATTGCTTGAACTCAGGAGTTCGAGACCGGCCTGGGCA ACATAGTGAGACACCCATCTCTATAAAGCATTTAAAAAAATAGCCAAGCATGGTAGCATG CATCTGTAGTCCTAGCTACATGGCAGGCTGAGGCGGGAGGATCACTTGAGCTTGGGAGGT CGAGGCTGCAGTGAGCCAAAATCTCTCCTCTGCACTCCAGCCTGGGAGTCAGAGTGAGGC CCTGTCTCAAACACACACACACACACACACACACACACACATACACACACACACACACAC ACACGTCTTTGGATTTGGAGCTTACTTGGATAATCCCGGATGATCTTATCTTGAGATCCT GACCTTAATTACGTCTGTGAAGACCCTTTTTCCAAATAAAATCACAATGACAGGTTCCAG GTGTCAGGATGGAGACACAGCTCAACCTGCTACAGTAGCTTCAGGGTCTGCAGGTGGAAA TAACTCAGGGGCTATTTGCTATGTGGAGGTGGGCCTCAGGTGGGCGAGGCTGGGCTTGTT GAGCTGCCCTGGAGATGGTCATTCCAGGTGAAGGAGGAGCAGGTACAAAAGAGGGCGCTG GAGAGAATGCTGGAAAACCTGGATATTCAAGGGGTCAGAGAAAGAGACTTTGTGGGAGAT TCTGGAGGTGAGGACTCTGGGGCAGGACAGGAAAGAAGCATCAGATGGCTCAGAAATGTC TAGCGGGTGAGGACAGCAGGAAGTCTGCTGGATTTAGCCATGATAAGGCTGTTGGCAGTT CCTGAGATGGGGCCAGGAGGTAAGGCCTGAGCTGAGGGGAAGCATGTGTGGAAGCTCCCT AGGCAGCAGGGAGAGACAGCAAGTGAGTAAACACATGGACATATGTGGAACACTGTCCCT CTTTCTCTTTCTTCCTCACCTTCTCTCCCCCCTATCTCCCTTCTGTTTTTCAACGGGAGA GACTCTTTAACAGCTTCAGTGATGGATGTGGAGGTCTGTAGGTACTAGTGGAGAAAGATG TCCAAGCTATGTGTATTAAGTGAAAAAGGCAAGTTGAAGAACAGAAAATACAGAATGATA CCATTGTATTTGTAATGCATACACGTAGGAAAATAGGAAAGAGACATAAAACATTGTTAA GAGGGGTTGCCTCTGAGTTTTGGGACTAGGGGTGGGGTAGAAAGGGGAATGTATGTTTCA TTTTATACCCTTTCCCACTATTTGATTCACCCCCGCCATGAGCACATGTCTCTTTTGTAA CAGAGCTCTAGTTTAATGATTTAAAGTGCTGGTGGTAAAGAGCCATCAGACATGGAAAGA TGAAGTTCCAGAAGTGAGAGGTTGCTGAGGAGGCAGGAACTTGGTGTCCTCTGGCAAGGT CTGCCTGACCCTGGGTGGGAGAGGTGGGGGCCCTGAAGGGCATGGTGGGGCTAGGATGGG AAGTGAAGGGCTTTACTCCTTGAAGTTTGAAGGGAAGCCCTGAGTGGGGAGGCCTCAGTA GCAGGGTGAGGGGTAGAGGGTCTGAAAGCCAACTACAGGGACCAGGGCAGGCAGTGGCAG CAGGAGGCCGTCTGTGAGGTTATGGCTCATTTGCTGGTCTTGTCCTCCTGGGCAGTGGCT GATTGATGTTTTAGTACTTTTGGGCTACTATAACAGAATACCAGACTTCCCTGTACTTGT GGGCAATCACAGGGAGAAAAAGGAGAAGGGTCTGTGTGTCTGTTTCCCCAAAGGTCTGTG GGCCTGGTAGCTGGACAGCCCTTTGGGAACGTCCTAGTGAACACTGTCCTCAGCCTGTGG TCTCACACCAGGAAGAAGTCAGGTGGCAGAGCTCTTGTCTGAGTGTGCAACCCTGGCTGT AACCAACATCTGGCTGCGGTCTCTTTCCCCATCTTAAACCACATGAATTTATTCCTCACA GTTCTGAATGCTATGAAGTCCAAGATCAAGGTGCCACAGCAGATCTGGTGTCTGTTGAGG GCCCACTTTCTGGTTTTTGATGGTGCCTTCTCACTGTGTTCTTACATGGTGCAGGAAGCA AGCATGCCCTCTTGGTCTTTTAAAAGGACTCTACCCTCATGACCTAATCACCTCTGAAAG AGCCCTATCACATTGGAGATTAGGATTTCAACATATGAATTTGGGGCAGACATAAGCATT CAGTCTGTCTCAGTGTTCCACTGCATCTCCTGTACCAGGCCTTTCGGTGGGCACAGCACA TGGTCATTGACTGCGTCTACACAGGGTATGGCTTGAGGATTGGTTAGGTTCTCCAAGATG AAGCTGTGTAGGATGTGGTAATGCACCGCCTTTGATAATGGGAGGGCAGAGAGGCCTTAC AGGTACTGCCCAGATAGTAGACAGGAGTGGCTGGGAGGAGGTAGAGCCCCAAAGGTGGCT GTCCTGGAGGGTGGAGCGGCCTCTCCTGTATTACCTTGGCTTAGAATGAGCTCGCAGGGA GCTGGGGATAAGGAGGTGGGCAGCCTCAGGGCTGGCTAGGCGGAGGCATCACTTGGGGGA AGAAGGGTAGGTAATGGAGGTTGTGCATGGTGGGAAGATGAGGAGAGAGACTTCAGCCAG GTGGTGGTTACAGCCATGTTTCCACACCCAAGACGAGCTCTTCACCTGACATTTTCCTGG TGTGAGACCACAGGCTGAGAGGCCAGGCAGGGTTCACCAGGACACTCTGAAAGAGCTGTC TGGCTCCCAGGCCCACAGGCCTTCGAGGGAATAGACACATAAGCCTTGCTCCTTTTTCTC CTGGTGTCTGCCCACACCCATATCCTGGAAAGCTGCGTGATTTATGTCCACCAGAGGGGA TTTGCTCTGAGGCTGTGGCCTGCAGGAGCGCCCTTCCGCTGGAGGGTGGGAGGACTGTCT AAGGCAGTCACAGCAAGGAGAGGCACGGTGTGGGCACTGCTGCTATTTCTAACCTGCTGG AGTGAAGGGAACCTTGACTACTTGAAAAGCAGGCTGATTGTCAGGGGCGGAACCGAACTC AGAGCTGTCAGGGCCGTCACATGGAAAGTGCCTGGCAGGGGGCGGCGACAGGGGGCTTGG GCTGACAGGGCTGTGATTTTGAAAGAAACGTCTCCAAGAAAGTGATTTAAAGTAGGAGAG AAATATTATTATTAGATAATGGCTGTCAGGTTATTTTTTGATGTGTTTTCTGAGTATTTC ATAATCATCTTGCGCTTAGATGGTAAGCCCTTCCTGGCTAGGGGCCGTGTCCCATCCCAT GCCTCTGTGGCTTTCACCTTCGGGTGTGCAACAGGTATCAGGAGGTATTTGCTGTTTGGC TAATGGTCACTTCAGTGGAAGGTTTTATAACTAATTCTCTAGCCTTGGTTAATAAACTAC AAATGTGGATGAGCACTTAGGGCTTCCATCTGAACACCTGGGCCCCTCCAAGCCCACCCA ACACCAGATGTAGAACTGGCCTCCCCCAGCAGGAGCAGCAGGACAGAGTGGCCAGGGTCT TTATTCACCATAAGGCCATCCATGTGATCCCAGGTCATGGCCTCTCCATCCAACCTGTCT CCTGAGCCCCATTTTCCAAGCCCCTCGGCTCCCACAGCCTGCCTCACACCCTAGGCTCAG CATAGCCCTGATTCTGGTTCAGAAACACTTTTGAGAATCTGTTCCCTCCTTTCTGTGCTG ACTGCCAGGACTTTAATTCCTACCGTGATTTCAGCAACTCTAAAACACCAACCTCTTAAC TGGCCTCCCCATTGCCAGGCCTAACCGTGCTGACTCTGCTGAGGTCTCCCTGCCAATTGC AGGTAAAGTCCAGGTTCAGTGTAGTGTTCTGTCATGGCTGGACCCCACTGCTCGCCAGCT CCCTTGGGCCCTGGCACTGAGCGCCTTCTAGCCAGGACATCCTCACCTCTTTGGCTGATA AATAGCTACAAGAAATGGGAGAGAGATTTTAAGTGGAGCAGACTGCATCAAAATCCCCTT CCCTCTTTTTTCCTGCCCATCTAGGAAGCTTGATCTGCCCAGGGAAGCTTTCGAAGCTGC CTCCAGAGAAGACTTTGAACTGCAGGGATATGCCTTTGAAGCAGCGGAGGAGCAGCTGAG ACGACCCCGCATTGTGCACGTGGGGCTGGTTCAGAACAGAATCCCCCTCCCCGCAAATGC CCCTGTGGCAGAACAGGTGCAGACTCTTTTGACCATAATAAATACACAAACAGGGTTGTG GCCTGCCCTTGGAGCACACCTGCAGGCCCTGGCTGGCCGCATACTCCGGGTCTGCAGGCT TGGGCGCCTCAAGCAGTAGCAGAGGCGCTTCTGCCCTGGCCTCCCCACATCCCTCCAGCC TGCATCTCTGGCTCTTCTGTCTTCCTGTTCTTATTCTGTCTCTCCCTCCTCCTCACTGAT CTTTCCACTTCTCTCCAGCTATTGATCTGAAGCTCCATTTACCAACCGGGAGGGTGCCCT TTTGGCCTGCTCGTGCTCTCCACGGGACGCTGCCTCTCAGCTGCCTGCCAGGAGGCGGCC AGCCAGCACACGCTGGTTGGGACCGTCTGTCCGTGTGTTCTTCTGCCTTAATCCTCAGGG CGGGGACTCGCTATACCCAGAAGTCTGTCAGTTGTGGTGCCTACAGGATTACGGGAATAG ATAGGCATTCGCTTATGACCTCAGAGTTAGTAAATAAAGGTGACAGCATCTTGTATCTCC CTAAAGAAACATGTTGTCACAGGCGCAGGTGGTTTGCTTTATACACTTCTCCACAGCATT CCTCCAGCTGCTCAAACTTTCAGGGATTTTCCTGCACAGGTTTCCTCAGGATACGGCGTG TTTGAGGATTCTTAGGGATTCTGGAGAAACCTAAGGCCTCTTGGATTCCAGGTTTGGTTC TGCATCATCATTCACATTGGTCCTTCCTTTGCTTTTGTTGGATTCACAGATGTCTGGTTC TCAGTTCTCTCACTTTTTGTATCAGGATTTGTTTTTTGTGGATATGTCCCCTCTATCATC CCAGACTGTCAAGTCATAGGACCAGCTATGTTTTTTTCACGTGCACAGGGCCTAGAAGTA TGCTTTGCGTTTTGCTAACACCAAGCAAATGTGTGTTTGCGGGGCTGATGCTGTCAGCAA ATATCCACAAAGCCATGGGGTGCACAGCCTCTCAAAGGAGGAGACTATAGGCCTTGTGGA GAGTTTGTGCGCTCTGGGTTTTCAGCCTGGTTCCTTTGGTCTGTCTTTGAACAAACGCTT TTGAATGTCTCCTGGGAGCCAGGCATTGTGCCAAGGACAAGCAGACAATGAGGATGCTTT CTTCCTATCCCCAAGGAGCCTGTGGGGTCCTGGGAGTGACAGACAGCAGAGGAAGAGTGG CACACAAAGCAGTGGCACACAATGGCTCCCGAAGGCCAGGGGATGCTGAGTTACCTTGAC ACTTGGCCCATAGCTGTGAGAGCCTGCAGAGGCCCACAGAGGGGTGACATGTGACATAGA TAACACCTCCAGGAAGATTAGGTGGGAGGAGGGAAGTACATTCCTGGCCCAGGGCACAGC ACACACCAAAGCACGGGGATTTAAAAGAGCCAGAGAGGCGAGGCATTCCATGATAAGATG CACACAGGATAAGTAGGATAAGTGTGGAACCAGGCTTGCCTCTGAAGGCAGGAGAGTGGG GAGCGGAGTCCCGGGCCAAGGGGGTGGCTGACCTGGGAGATGGGTGTGAACGTGGGCCCT GGACCGGAAGCAGCACCATCCTCATCCCTGCCTCTCAGCAACCCCACAGGTCAGGTGGCA GCCTCCCCATTACCAGGTGAGGAAACTGAGGCAGTGTCCAAGTGTCTGACCCCAGAGCCT CTGCACCTCCAGCTTTTCATGCAGATTTTGGACATCAGGAGATAACCAAATATAGAACCT CCCCACCCTACTCCTCATACCTGCCCAGGTGGGCATTGATTTTTCCATATGCATTAGGAT GAGATCCTAAAAATTGCCTTACCAATAGAACTAAATGGATTCTAATCCTTTTTAAATTCT CAGGTCTCTGCCCTTCATAGACGCATAAAGGCTATCGTAGAGGTGGCTGCAATGTGTGGA GTCAACATCATCTGTTTCCAGGAAGCATGGAGTGAGTCTTTTTTATGGTGCTTTCTCTGC TGCCTTCAAACAATTGTGTATTCTCTCCATGTTGCCAAGAGTGTCTGCTGCCTGACTTTT AAAGAATCTCCTTTGTTTCCTCATCCATGGAAAGTTCTCCGTCCACATCACCAGGAACCC CGGCCTCCCTGCTGTTACGCACCGAGCTGTTGTCTGATTCCTTCAGTTTTCCCACATCGT TCTGAATCCATTCGCTCCTCTCCATCTCTCTACCACCACCTGGTCCAAGCCCCTGGCAGC TCACCTCTGGCTTTTGTAATTCCCTCCAGCTGGTCTCCTGTGCCCTCCTGACCAGGACTT CTTTACCTTCAGATCTCAGCCCAGAGCCAGCCCCCCCATCTAAACATCCTGGTAGTATGT ACCTTTGTGGTTTTTATTTTTATCAGAGTTTTACATGCTCATGGTTTAGAGTCAGATGGG TGTACAAGGTCTGTTACCAAAAAATAGCTATTATCCCCAGCATCAACACTGAGCTAGTTC CTTTGGAATTTACCTTTGTTAGTGTTGCTACTTCCTAATTTTTTAGTTTTGCATCACCTA TTGACTTCCCCCTATGGAAGATGTCAGTGTTAGCCCTTTCTTGCCTCCTCCTGGCCCTTC GACATACATGTGTCCTTGTTCTATCCCCCCAGCCCATTTTGTCAACTTTGATTCCTTTTC TTTTTTTTTAAGACAAGGACTTACTCTGTCACCCAGGCTTAGAGTACAATCACAGCTCAC TGCAGCCTTGATCCCAGGCCCAAGCAATCCTCCCACCTCAGCCTCCCAAGTAGCTGGGAC CACAGGTGCACACCATCACGCCCAGCTAATTGAAAAAAAAAAGTTTGTAGAGATGGAGAT CTCACTATATTGCTAGGCTGAACTTTGATTTCTTTTCCTGAATTATTTTCTGTTTTCCCT AGAGTTTGCTTTGTTTTCTACTTGCCACGCATTCAACCCCAAACTTTCTATCAATTCCTA AATCTCCCTTAATGTGTTTTAGACGCATCAAACAGTCTATCAGTTTCATCTCCTCCAAGG AATCTGCCCCAGAGCCTTGTGACTGCTGTGGTCTGAATCAGGTGCCCCCTCTGCTGGCCA CACAGTTATTGTCCTGGGATCCCCCCTCATCATCACCCTGGGGAATCCCTTTGCCTTGCT CTTGTGTTTCTCTGTTCCCACAGCTTCCTCTTTCTTGGTTTATACCCTTATTTTAGTGGA GTGGTGTAGTGGATCCTTATAGATTTATGTTGCCTCGGCATCCATGTTGAATACAAGTTT AACTCTCTCATACCAGCGGCAGGGCTCGGTCACGCTGGACACAGTTTCCAGATCTACACC ACACCGAGATGGCTCAAGCCAAGTGGCCAGAGGTAAGAACTTAAGAGGCCTCTCTCCCAC CAGCAGACTGGGCTGCCCACTTTCCTGCTGCTTCCTTTAAATGGACCATCCAGGCATTTG GCCATTAACTTAAGGTGACCACATCTTAGTCATTATGTGTACTGCTAGTTGCCCCATACT CTCTCTGACTCTTCATTTCTCCCTCATCTGACCTGGGGACAGAGGACTGCCCTCCTGACT CATGGCACTCTCCTTGCCCAGGATCTGTAAGTAAAAAAATCTTTAAACTTGTTTCCTATT GCGATTGTGTGTTGAATTTGCACCTTCCATGAGAAGAACCAGGGGCTGCCCCAGGCTGGG TTTTCCTTGGGATACCGGTGGAAACACAAAGTTGGGCTCCTAGGGCCAGAGTGGTAGTCA GGCAGGGACAGGTCAGGCAAGAGCTGCCACACAGCATGTGCCAGTATAAACAAGTTTCAC GTATGAGGGACCCCCTGGTCACGGGTTGGACAGACAGGCATTAGGCTGTCCACCATGTAC AAGATGTATCCTGTGAAAGGCACACTGTAGAGACCACATCCAGCTCCCTTCATTTCCTGT TAGTGCTGGGTTGCCAACCGCTCTGGTACTGGAGCCCCCATTTAGCTAGGGACTCTCAGA ACAAGTAGTTCCCTGAGGAAGAACACATCAGAGGTAAACTTTTTGAGGCCTTGCCCATCT GAAAATATGTTCCTTCTACAATTTTCTTGATAGTTTGGTTGAGCATCAAATTTTAGGTTA GAAATCATTTTCCTTCAGAAGTTTGAACACATTGTTCCATTGTCTTCTAGTTTTTTGGGC ATTGTTGAGTAGTCCACAGCCATTTTAATTTGTGACCCATTGTCTATGACTTGTTTTTCT CTGGAAGACTGTAGGAGTTTCTCTTTTTCACCAGTACTCTACAATTTCATAATGATATTC CATTGTGTATATCTATTTTAATCCACTCTAGGCACTCAGTGGGTTCTTTTAGTCTAGAAA CTTGGGTTCTGAAGCTCTAGGAAATGTTCTTGCATTATTTCATTCATTATTTTCCCCTCT TTTTTTCTCTTTCTAGACAGTCCTACTATTAGGATGTTGGAACCCTGGACTAGTTCCCTA ATTTTGTTATGTATTTCCTCCTTTTTTTTTTTTTTTTTTTTTTGATACGTGGTCTTACTC TGTCACTGAGGCTGTAGTGCAGTGGCACAATCACAGCTCACTGCAGCCTTGACCTCCCAG GATCAAGCAATCCTCCCGCCCCAGCCTCCTGAGTAGCTGGGACCATAGATGCATACCACC ACACCTGGCTAATTTTCTTGAATTTTTTTTTTTTTTTTTTTTTGTAAAGATGAGATCTGT GTTGCCCAGGCAGGTCTCAAATTCCTGGGCCCAAGCAATTCTCCCACCTTGGACTCCCAA AATGCTGCAACTATAGGCGTGAGCCACAGGGCCCAGTCACCACTTTGTCTTTTTGCTCAA TTTTCTGGTGGATTTGATCTGATTTGTCAGTCAGCCCTCCTATTCAACCTTTCATTTCTG CTGTCAAATTTTGAATTTACTAGTGTTCTTTTGGTCTGAAAGTCCCTGTTGTATTACATC CTGTTCTTGCATCATGGTTGCGATATCTTCTCTTACCTCTAAGGATACTAATATTAAGTA AATTTTGTTTTCTCTCTTATTCCAAGAGTCCTTATTCCAAGTTGGACGCTTTGTTTGATT GCTCATATTTTAAGAATTGGGGATTAAAAATCTGTGAGCTCTGAGTTTGTAGTAGGGGCT CACCCACTGAGCTCCATTATAGGGTGATCTGATTTAGTGGTAATTCCCAGGTAATCCCAG TGTTAGTATCTCTGGGTCATTCTTTTCAGGCTGGTCAGAGTCCCCAGAGATTTTTCTGCC CTTGTGCCAAGAAGGGAAGGAGAACAAAGGTTCAGCATGCTGATGTTTACTCAATCCCTC TGTTTTGACACTTCACTTGCTTTCATCTGCCCTGCTCCAAAGCCAGAGAGCCTCTGCTGA ACCATCTCTGGAGGATGAGCCTCTGGCCTTCTTCTGGGGTAGATGGGGCAGGTCCCAGCC TCTTGGTGTGGAGAAAGGACCTGGATTTCTAACTGCTTCTTTTTTTATTTTTATTTTTAT TTTTTTTTGAGGTGGAGTCTTGGTCTGTCACCCAGGCTGGAGGGCAGTGGCGCGATCTCA GCTCACTGCAACCTCTGCCTCCTGGATTCAAGCGATTTTTCTGCCTCAGCCTCCTGAGTA GCTGGGACTACAGGCCCGTGCCACCATGCCTGCCTGATTTCTGTATTTTTAGTAGAGATG GGGTTTTGCCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAGGTGATCCACCCACC TCAGCCTCCCAAAGTTCTGGGATTACAGGCGTGAGCCACCGTGCCTGGCCCTAACTGCAT TTTTTTTTTTTTTTTTCAGACGGAATCTTGTTCTGTCACCCAGGCTGGCATGCAGTGGCG CATTCTCAGCTCACTGCAACCTCTGCCTCCTGGGTTCAAAAAATTCTCCTGCCTCAGCCT CCTGAGTAGCTGGAATTACAGGCCTGTACCACCACACCCAGCTAATTTTTGTATTTTTAG TAGAGACCAGGCTTCACCATGTTGGCCAGGCTGGTCTCGAATTCCTGACCTCAGGTGATC CGCCCACCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGCGCCCGGCCCC TAACTGCTTCTTAAATAGACCTTTGACCAGTCCTTGTTTATCATACTTCCCTGCTTCCCC ACCTTCAGAGGTACCTGGTGCCCCTGGGTCCTGAGCTTTGGATAAGCAGGAGATCTTCTC TACTGCTAGCGGGACTCAGTTTTCTCTGATCTGCTGAGAGATTTGCCTGCATCTTTCCGC CTTCCAGCTTCCCGTGTTTCCGTGCCTCAGTGCACCATCCTTGTTGGGTATATGCCTTTG CATGAACATTGCTTTCCTGTCATGTTAATGGGGTTTCAGGAAAGAACACGTGTCTGTGTC CCAGAAGTTCATGTCGTTTTCCTATTTTTGTTACCTTTGTACTCTCACTCTTCATTAGAC TATGAGCTCCATGAGGATAGTATCTGTGTTTGTTTTTCCCAACTCTCCACCCACCCCTGT TTCATCTTTAGTGGCAAGAATAATCCCTAGTGCATGACAGGCACTACAAATTAGTATTGG CTGGATAGTTGAACTAACATCTCCCCTTTCTTGGATCTGGAACTCCCCCTCATTTATCAA AGTCTAGCACAGGTACCCCTCCTTTGTGGGGCCCTGGGGACTCCCCCAGGACTCCCCCTG ACCACTCTGTATTGCCAGGTTGTGTGGCCGCACCAGGTTCTAATTCATCTCCTTCCCTCT AGGCTGGCAGTTCCTGAGGGCCAGGTGTTAGGTCAGTGCATGTGGAACCTCGTCCCCTCT AGTTGAAGAACTGTAGTTGGGACTTTGCAGCCAGCCTCACCCAACCTCACTTCCACATCC TTCTTTTGAAAGTGTGTTTACATTAGAGTGGTTGTGTAAACAGGAAAAGAAGCTGCTTAT TCTCTGGGGGCACTTGACTCACTCCTAATGCTCTGAAAGCTGAGAATTAATGGTCATTAA GGAGCATTTGTGTTTTCAACAGCTTTTCTGTTGGCTTCCTTAAAATAATTCATCTCTCTT CACAGAAGGCGAGCCTGGGGAGCCTTGAGCCTGCTACCAAGGCCCCCAGGACTGTTGCTG GCAGTGCCTGCCGCCTGCTTGGCAAGATGGTGGTGGTGCCATTGGCGGGATATTTACTGT GGTACTCTCTTAGGACCAGGCTTCCTGGGACCGGAAGGAATTGAGAGGCTGAGGCTTCTC TTCCTTCTCTGTGAAATAAAGGGGGTGACACCAGCTTAGGGATGTTGGAGACGATCTGCC TATTACGAAGATAGGAGTTATAAAGAAATACTTTTTAGGCAACTAGAAAGGAGTAAAAGG AATAAAGGAGTAAAGGTTCTCAGTGGAAATTTTCCTGTAATAAGAAGCAACTCCTGAACC ATTTCTTTTCTAACCGAAAAGGCGGCTTAAAGAGCCAGGCCAGCAAGCTTTGATATGCAA ATGTCGGCAATTAGAAACTAGGTCCACCCAACATGGCAATTCCTGCCCTCTTCTCCTTGT CACCACCTGTGCCAAGTGTCATGACCGCCTCCAGATAACTCATACATGTTCAGGACATCA TGGCAGCTCACGTTTGCATATTAAAGGGCTAAGGTGGGAGGGCTAGATTTTTTGCGGGCT ACTTGAATGTCACACCTGGTCAAACCAATCCCCTGGGCCCTATGCAAATCAGACCCCACC TCCTCCAGCCCCCCAATATAACCAACCACTTTTCCGCTGCACACCGGATTTCTCTTGGTT CAGACTCCCCTGGCCCCCTCCGCCGTATGGGGGAGCTGTTTTCTTCTTTCTACCAGGCAC CATGCTTCACATATGCCTGGCATTTAGGAGATACTGTCTACAATTGTTAATTCTAAAGGG GTCTTAAGGCCCTCGCAGAGGCCAGTTAAACACTGCCCCATCACATCACACAGCTTCCTG CACACCCCCCTCAAGTTAGTTCAAAGTAGCTGGAACAATAGCAGACAACTGGAAACTTCT GTTAGGCTAATCCCTCTAAAAGTAATGGACTTGGGGCCAGATGTGGTGGCTCACGCCTGT AATCCCAGCACTTTCTGAGCCTGAGGTGGGCGAATCACCTGAGGTCAGGAGTTCGAAACC AGCCTGGCCAACATGGTGAAACCCTGTCTCTACTAAATATACAAAAATTAGCTGGATGTG GTGGCGGGCACCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCGCTTGAACC CAGGAGGTGGAGGTTGCAATGAGCCAAGATCGTGCCACTGCACTCCAGCCTGGGCAACGA GAGCGAGACTCCGTCTCAAAAAAGAAAAAAAAAGAAAGAAAGAAATGGACTTGGGCTGGG TGTGGTAGCTCATGTCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGCTGGATCACCTG AGGTCAGGAGTTTGAGACCAGCCTGGCCAACATGATGAAAACCCATCTCTACTAAAAATA CAAAAAAAATTAGATGGGCATGGTGGTGGGCTCCTGTAATTTCAGCTACTTGGGAGGCTG AGGCAGAAGAATCGCTTGAACCCAGGAGGTGGAGGTTTCAGTGAGCCAAGATCGTGCCAT TGCACTCCAGCCTGGGCAACAAGAACAAGACTCCATCTCAAAAGAAAAGAAAAAAAGAAA GAAATGCACTTGGGTTATTGTGAGGTGGGAGATCTACAAAGTATACTGAATTAGTCCAGA CAAGGATTGAGTTCTCCACATTGAGAAAGAAAAAGACGAATAGCACAGTAGGAAATAGGC AAAGGGTATGAACAAAAAAATGTAGGGGAGGAATCCAGACTGGCCAGTGAATGTGTGGTG AGGGGTTCAGCCTCACCGGGGATATGGGAAACATTTACTCACAGTGAGGCACCGTTCACA CCAGCAGACTGGCAGGTACTAAAGGTAACTCCATGCACTGCAGATATTCACGTGTGGCTG GGCTGTAGAGCAGCATTAGGCACATAGCCAAAGGTCCCAAGGGCCCACCCCAGCGGAGTC CCCTCCATCCCCTGCATAGGAGACTGCTCTGAACTTGGTGTGCATGGAGATGACCAGTAT CTTTGAACTGTTAATCTGTGTGTATGTACCTACTGTTTGAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAGCAAAAACCAATGAGTCGAATGAAATTTCCTACTGAATTAGCTCCT AGGTGGGGCCTGGCCAGAGATCATGAGAATAAGAGCATTAATCCTTGCAGATGTTCATCC TGTCCAGTGGTTCCCAAACTTTTTGTGGGATCATTAATGAGTAGCTTTTCTTATTTCTGA AGAAGCCTCCTTGTCACTAGGAGGAGGGGGGGTCCCAGTGCCATCCCCAGCAGCCTTCTG ATACTTTCCCCAAGGAGTCAATGGAGCTCCTGCCACCCTGCAGATTGGCCAACAGCATGA GATCTGCTGGTTGGGAACTTTGGCAATTTAAAACTTTTTGTGTGTGTGGCATATAGATAT ACATTAACAATATTTACCATTTTAACGTGTACAGTCTGTGGCATTAAATACATTCATGTT GTGCAACCATCATCACCATGATCTCCAGAACTTTTCTCATCATTCACAATTGGACACCTC TACCCATTAAACAGTAACTTCCCATTATCCCCTCTTCTGGCCTCTGACAGCTATTCTACT TTCTGTCATTAAGAATTTGACTACTCTAGGCTGGGCGTGGTGACTCACACCTGTAATCCC AGCACTTTGGGAGGCTGAGGTGGGCGGATCACCTGAGGTCGGGAGTTCAAGACCAGCCTG ACCAACATGGAGAAACCCCATCTCTACTAAAAATACAAAATTAGCCAGGCATGGTGGCGC ATACCTGTAATCCCATCTACTCGGGAAGGCTGAGGCAGGAGAATTGCTTGAACCTGGGAG GGGGAGGTTGAGGTGAGCCAAGATAGTGCCATTGTACTCTGGCCTGGGCAACAAGAGCAA AACTCCATCTCAAAAAAAAAAAAAAAAATTTGACTACTCTAAATACCTCCTATGAGTAGA CGCCTACAGTATTTGTTTTGTGTCTTAGCATATTCTTAAAGGTTCATCCATGTAAGCATG CATCAGAATTTCTTCCCTTTTTAAAAGAGAGTTGACTGATATTCCATTGTGTATATATAT ATACCACATTTTACCTATCAGTTCATCTGTTGATAAGACACTTGGGTTGTTTCCATCTTT TGGCTATTGTGAATAATGTTCCTGTAAACATGAGTGTGCAAATATCTGTTCAAGTCCCTG CTGCAATTGTTTTTAAGACTTTGGGAAAGACATTTGGCCCAGCCCCTTGTTTTGCCATGA AGCCCAGAGGTAAGGGCTGCCCACAGCCAGGAACAGGACCCAGAAGCCAGGCCATGGCAC TCCTGAGACTGTATTCTTTTGCAGTGACTTCCCGCTGCTGGGCTGAGGAGCCCCCCTCAG AGGCTGTGCATGTTGGATATAATTCTGCCCTTTCTCCTATTTATAGCTATGCCCTTTGCC TTCTGTACGAGAGAGAAGCTTCCTTGGACAGAATTTGCTGAGTCAGCAGAGGATGGGCCC ACCACCAGATTCTGTCAGAAGGTAGGACATTAACGGTGCCTCTGGCAGCAGCTGCCAAAT ATGTGCAAGTCACAGAGCATGACCACAGCTGCCGGGTTTGGCCTTTCACCATGGAAAATG CACCCATTTGGTGCTTGTTTTGCCAGATAAGATTAGATAAGACTATCTGCCACTTTTTTT TTTAGCGTACTCTTAGAATTGGGGCGTGTAAGGCTCCAGAAGGGCCATTAGCTTTTTCAG GCAAGGGAGCTGCAGCCCAGGGAGGGTGGTCGGAGGTGACTTTTGTAGCAAGTCCCACAG CTGGCAAGTGGCAGAGCTGGCATTCAGGGACCAGAGAAGCCAGTTTCTCATCCAGAGCTC TGCATGCTCCACTGCAGTTTGCTTGAGTCACAGAAGCTTCGATGCATGGCCTGTGTCTCA TCAGCATAGAAATTGGTTTTGATTTTTCTTCATTAAAACCTTATAATACATATTGTATGA TCCCATTTATATAAACTGTCCAGAATAGGCAAATCCATAGAGACAGAAAGTAGATAAGTG GTGGCTAAGGGCTGGGGGTGAGGGAGGAAGGGAGTGACTGCTAATGGATACAAAGTTTCC GTTTAGGGTGATGAAAATGTTCTAAAATTAGATAGTGGTGAAGGTTGCACAACTCTGTGA ATATCCTGAATACTACTGAATTGCACACTTCAAAAGAGTGACTCCTTGTTCTGCTGTTTC CCACCTCTCGCTACTGTACTTGACCAATCTTAAAGTGAATCTTATGCTCTGTGAATTATA TATATATATATATATATTTTTTTTTTTTTGAGATGGAGTCTCACTCTGTTGCCCAGGTTG GAGTGCAGTGGCACGATCTCGGTTCACTGCAAGCTCTGCCTCCTGGGTTCACGCCATTCT CCTGCCTCAGCCTCCGGAGTAGCTGGGACTACAGGCGCCCGCCACCATGCCTGGCTAATT TTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCGTGTTAGCCAGGATGGTCTTGATCT CCTGACCTCGTGATCCGCCACCTCGGCCTCCCAAAGTGCTGGGATTATAGGCGTGAGCCA CCGCACCTGGCCTGAATTATATCTTAATAAAACTGTTATCAGAAAACCCATGAGGTGACG AATGGTCATTTATCCTTATTTTCACCTCTAACACAATAACTCTTTTCATTTCTTTGTATT CTCTTTCAGGTTTTATACATATACTTAGGGGCTTTTGGGGCAGAGCTATAATCATGGTGA CTTTATCAATACTCAGTTGTGATTCCAAACATCGATGTTCTCAGGCTGTAGGGGAAAAAA AAAAATCTCTCATTCACCAGGTTGTTGATTTCTTGCTATGGAAAAAAGAGGAAGGAGACT GGTTAGGGGACTTTTGCAGATGATAAGTCTGAGCCAGGGCTGGAGGAAGAGTGTGAAAGA GAGCTGGTGCCAGAGACACTCCGCCTCCACAGGGACCTGAGGCTGCCCTTAGCATGGCTC CTAGTGTTGCCTTCTGAGCATGCCTCTCCCCTATCCTGTTGTTAAGGCCAGAGATCATGA CAGCTAATTAGAGTAGAGGACAAATGACCCGCTGGGCTGCTCATCCTGTGGTCACCAGGG ACTGATGTTCTTACTTGAGACAAAAGGAATTTGATGCCAAAGAAATTTATTTTTGGCATA GATAAGTCGTTTGATTATTATTTTTATTCTTTTTTCAAGTGGTAAAATATACATATAAAA TGTACTATTTTAACCACTTTTAAGTGCACAGTTCAGTAGTGTAAAGTATATTCACACTGT GCGGATCTCCAGAATTTTTGCATCTTGCAAATCTGACTCTGTCCCATTAAACAATAGCTC CCCATTCCCCCAGCCCCTGGCAACCACCGTTCTATTAATATTATAGTTTCCATTTCTGTG AGTTTGACTACTCTAGATACCTTACACAAGTGGAATCATACAGTATTTGTCTTTTTGGGA CTGGCTTATTTCATTTAGCATAGTATCATCAAGGTTCATCCATGTGTAGCGTAGAACCGT GGCATCTAAGGCTGAATGATACTCCATTGTATGGATGTGCCATGTTTCATTTATCCATTC ACCCATTGATGGGCACTTGGTTGGCTCCCACCTCTTTGCTATTGTGAATAATGCTGCAAT GAATATGCGTTTGCAAATCTCTTCTGCTTTCAATACTTTTGGATATATACCCAGGATTAG GATTGCCAGATCAAATGGTAATTCTTGTTTAATTTTTTGAGGAACTCCCATATGGTTTTC CAGAGCAGCTGCACCATTTTACTCTACCACCAACTGTGTACAGGACAATGTGATTCTTAT TTAGCAAAGCATGGACATCAGGGTATTTAGTGTTCCAAACAACAAATGCAAGTGGTTGCT CTGACCCAAGCCTATTGATTTAGTAGGATCATTCTTCTTTGATAAAAAACTACAACAATT GGTTTATAAGTGGGACTCTGCCATATTTATCATTTTTCCAGCTGGCGAAGAACCATGACA TGGTGGTGGTGTCTCCCATCCTGGAACGAGACAGCGAGCATGGGGATGTTTTGTGGAATA CAGCCGTGGTGATCTCCAATTCCGGAGCAGTCCTGGGAAAGACCAGGAAAAACCACATCC CCAGAGTGGGTGATTTCAACGAGGTGAGCCACCCATAAGATAGATAACCAGCCCTGCTCA CTTGCCCCTCTGTATGTTGTAGATCTCTGTGGGACTTTCTGTGGGGAAGTTCTGTGCAGG ATCATACTCCATGTCACGTACACTCCACGGGAGCACAGTGTGGCTGCAGTGCTCAGAGGG TTACCTGACATTGCCCTATATCACACAGGCAGACAGGATTCAGGCGGGACTCTCAGAGGA GTCCCAAACACCTTTAGCACAATGGGGCATATATTTTTTTAATACAACCTGATTTGGCCT CCTGAATTCTTTGAAGTAAGTGGTATATAAATTAAAACCAAAACTAAATATTGCACAAAC ATGAAATGATTCCTGTGGCCCCTTTCAGGCTCAGAGCCTAGCACGCCACAGCCCTGTCCT TGTTTGGAGCATGGCATTCCTTGTCTGTGGATCATGGGGGGGTCTGAGGTGGCCCATGTT TGTGTGTCAGGTGGCAGTAGGCAAACATGCATGTCTGTATACTGTGCATTATGTGAAGTT TCATGTGCCCATGATCAGGGCATAAGTTGGGGGGGCCATTTTGGTTGGTTAATGCCAACC CCTGGGTGGGTAAGATGGGAGCGGTGGATGTTTGAAGGAGGGAAATGACCTCTGCCTAAT GCCTAAGATGTTAAATCTGAACTTGATTTGCCATTAATGCAGTTGTTCAGGATGTGATGT CCCCAGTTCTCTCTCCATGAATGTGGGGGTCCTGGCCGTTCTCAGGCTGGTCAGGCAGAT AAGAAATGGCCTGCAGAGCTAGAGGAGGTTTCCCAGGGAGAAAGAAGAACCCAGCGTTTC TCAGTAACAGCTGGAGGTGGGGGTGGGAAGACGCGCCCCTCACCTGTTTACCCTGGGATT AATCTTTAGCTCCCTGCAGATAGCACAGGGCTTGTCTCAGCACAGCAGGATCTGCTCCGG TGTTCACCACGTGCACACATCCTGGTTGCTGCCTGACCCTGGCCAATTTTGATGGCCAGG ATCAGGAGGAGGTGGAAGGCTCCTGGAGCAGATCTGTTTGGGACCCTGATTTGCCCTCTA GCTTCCCTCAGTGCTGTCCAGGACAGTGTCCCTGCCCTGGCACCCTTAGGAGCAGACAGA GAAGCAGGGATGGGAGGATGGGGTCTGGTCCGCCTGCCCCACAGGGACCTCCTTAACCCT AGGCAGGATGGAGAAGGTGCGCTTTCAGGGTGTGGGTTCCACTAGAAGCTTTGGCCTTAA TCATTTGGGCGAGCTATGCCCCCTCAGGAAGCAGCTTTCTCCTCTGACCAGGGAGAGAGT TGCTTGGATGTGCTCCAGGTCTCCGGGCTCCACCGTTCTATATAATGACATGTGATTGCT GAGGGCATTGACCAACTCGTGTTAATGCCAACCAAACCCGAGCCTTGAGTTGGACCATAA TTGAAACCTCACCAGAGTTTGAAATAGTGTGGAACGTCATTGTGGGGATTTTTGTGACAT GTCAGAAAGGAGACTGGGCAAATGCTTAAGCCACTGTGATTTCCCCCGGGGGCTGGCTTA TTTGGTGTCAGGGTTTTTTTGTGTGTGTTTTGTTTTTATCATATTGAAATTCTGGAACTT AGAGTCACACTCAGGAGTGTAACCACCTCTGGACTATTGGTGATATTTCAGTTTTTCTGC TGAGTCTAAGGAAATCTTGAAGGTCAGAGGCATCAGTATATGGCCCTTTGCTTTTCAGTC AACTTACTACATGGAGGGAAACCTGGGCCACCCCGTGTTCCAGACGCAGTTCGGAAGGAT CGCGGTGAACATTTGCTACGGGCGGCACCACCCCCTCAACTGGCTTATGTACAGCATCAA CGGGGCTGAGATCATCTTCAACCCCTCGGCCACGATAGGAGCACTCAGGTCACTCAGTTG GTGGGGTCTGGGGGGCTTCCTGGGGCCCAGCCAGCTAAAGCCCAAGGCTGGGCTGTGGAG CTCCAAGGTGGCAGCAGGCAGGCGCAGCCACCAGGATGTTAACAGAGCTGAGCCCCCAGG ATTGCATGTTGTACATGTGACCAGCTTTTCAGTGAAAAGAATCCTCAAGATGGCAATGAG CAATCCCCCACCCGCAGCAAGAGCTGCTCTACAGTAAAACACCAACCTCTGCTGTGATTC TGAACACTGAGATGAAAATAATTCCCCCCTTTCCCTGTAGTCAGCAGGGGGCTTCAAAAA GCCCCACATTGGGCTGAGCTCGGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCCG AAGCAGGTGGATCACTTGAGGTCAGGAGTTTGAGACCAGCCTAGCCAACGTGGTGAAACC CTGTCTCTACTAAAAATACAAAAATCAGCCAGGCGTGGTGGTGTGTGCCTGTAGTCCCAG CTACTCGGGAGGCTGAGGCAGGAGAATCACTTGAACTTGGGAGGCGGAGGTTGCAGTGAG CCAAGATGGCACCACTGCACTCCAGCCTGGTGATAGAGCGAGACTCCATCTCAAAAAATA AAACAAAACAAAACGAAAAAACAAAAAAGAACCCCCACATCTAAGTCCTTGGAGCATAGT AGGTGCCTAGCCAGCATTGGCTCTTGGATGGGGAACTGTGGATTCCTAGTCCTCACATCT GCAGCATCCTGCACAGGCAGGACAGACATCTGGACAAGAGAAGCTGCAAATGAGGGAGTT GGAGATCAGTCGAGGAAACTTGTCTTTAACCAGAGAAGGGTTTTATTTTTATAACACATA ACAAGTGTTTCGGTGTTAGCCTCACCCCTAAACAGATAGAACTGCCCTTGTCAAGGCAGG GCTGGGGGATGAGGGGAGGGTGGCCCCGGAAGCCCGAGAACTGGGCAGTACCCCACCCCT GGGGCCCCTCATTTAGGAGGGGCATCCAGCGAGCTGATCTGACTGCATGACTCTGCTGCT GCTGCCTCTCTCTTCCACAAAGGCTGAGCATTTGGGTGGTTTCCAGTTTTGCATCACTAC AAGTAACAGAACTCTAGGAATTTATGTGCAAATACTTTTCTCCCCAACTCACTTCTTTCC AAGCAGGATTCCTGCAGCAGGAGGTGCTGGCTTTCACTTTCTGTGGTCTTGGCTGCCAGT GTCCCCAGCAGGACAGGGGTGTGCCCTGTCCTGCCATGGGTGGGGAGCAGGGGGAGTTCT GGTGGGTGTGCAGCTTTAGTCTCTGTCAGCCTGCACTTGTCTCTCTTGTCCTCATTCTTG ACTAAATTTCAGTTGAATTTCTTCTTTTTTTTTTTTCTTTGAGACGGAGTCTTGCTCTGT CACCCAGGCTGGAGCGCAGTGGCGCAATCTTGGCTCACTGCAAGCTCCGCCTCCTGGGTT CACGCCATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGACTGCAGGCGCCCGCCACCATA CCTGGCTAATTTTTTGTATTTTTCGTAGAGATGGGGTTTCACCGTCTTAGCCAGGATGGT CTCGATCTCCTGACCTTGTGATCCACCCACCTTGGCCTCCCAAAGTGCTGGGATTACAAG CGTGAGCCACTGCCCCCGGCCAAATTTCAGTTGAATTTCTTCTAAACGTCAGGGTGTGAC ATTTACCTTTTCTTTTCATACAGTGCCCCTTTCTCAAGAGTAATATCCCCTCCCCATTCA ACATTTATTTACATAGCAGGTTCCTTCTGGAGCCAGAATGCAACCCCTCCTCTGTTACCT CAGGTCTACCACCCTGCCCATGTACCTGGAGGTCTGGTCCATGTCCAGGAGGGGTACTGT TGGGTAGAAGGGGAATATCAGGCCTCCATCTCCCCTCAGAGAACATACTGGAGTCTCATG GTGGTCAGATCACCAGTGATAGCATTCATTGGTGGTTGTCAGTAGGGTTTTTACTGGTCA TCCAGCTACCAGGCCTGGGCAGAACTTTGGGGCCACCCCCTAAAGCAGCCCCCTCTGCTG GCTCTGGGTAAGACACTTGGCAAGCTCCATCTTCCCACTGGGGTCCCTAGAGGAACCCGA AGCACTAGGGCATCTGGCTTCTGGGCCAGGGCAGACAAAGTTGTGGCTGTGGACTCAGAT GGCTCCTCGCCTTGTGTGTGCAGAGGCCCTCCCTGACCCTCCTATCTCAGGCTTTTATTG GCTCCAGTTAGGCAAACAGAAGCACCCCAGTGTAATATGCATATAATTGCTATGTCCTCA GCAGCCTATTAGGCTTATTAAAAATGATTGATTTTTCTTTCCTCAGCCAAGAATCATCCA ACCCTTGGCTTTCCAGGGTGTGGTGAGGCTGGCAGTAAAAACTAACAGGTCTTTTGGAAA GCAGTATGTTTCATGAGCTCCTAAAATGCTCATGCCCTTTGGCCTGATAATGATGCTCCT AGAACTGTAGCCTGAAGAAACAATCTAAAAGAGGAGGGAAGGCCAGGCACAGTAGCTCAC ATTTGTAATCCCAGCCCTTTGGGAGGCCAAGGCTGGCGGATCACTTGAGGTCAGGAGTTT GAGACCATCCTGGCCAACATGGTGAAACCTCATCTCTACTAAAAATACAAAAATTAGCCG GGCATGGTGGCAGGCACCTGTAGTCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCGCT TGAACCTAGCAGGTGGAGGTTGCAGTGAGCTGATATTGCACCACTGCGCTCCAGCCTGGG TGACAGAACAAGACAGAAAAAAAAAACAGGGAAAGGCAATGCATGTGAAGGTGCTCACAA CAGCTTACTTACAATAAGGGAAAAGCTGACAGCGGGGGAAGTGTCTGAGCTAAGCACATT ACAGCCCACCTCTTCCACAGGTTATTGTACAGCCACTATAAAGAGTCATGATGAAGGTAA TGCAAAGTGATGAAAGCCTGTGAGCAAGAAAAAGACGTGTTCAGGCTGTGGTCAGAACTC TTGGAAAAAAAAGGAAAAAAAAGTTTGCCTATGGATGAGGATAGTCATGGAGTGTGGATA AAAGGCAACAGGTGGTTTATTAAGATGGTAGGATCCTGGCTTGTTTTCTTAAAATGATGA ATGATGGAATTGATAGTGTTTTTCAGCATAATGCTGGGCAAATCCCCACCAGCATTGGAT CACAGCATCCAGAACCATCCATCCCCTTTTCTGGCACCTTCTGCCGCCTGTATTAGAGAC AGACATACACATGTGCATGCACACACATGGGTCAGCAGGGTGTCCTCATTCATTTTTGAG TCCCACAGTTCTAAGTACATAGTAGTGTCTGAATGCTTTTGATTAGGTTATCCTCATAAT CCAAGGATGTGTCCCTTACAGCTTGGGTGACCAAAGATTTCTACCACCTGTGTACATTCA TTGGCAAGTCACCATCCTATCCTCTTGCTGCATCTTGCCTTTCCACTGCGATTATTTTTA GGGGTGTGTGTGCACCGCGCTGGGAATATGGCAAACGTCCCCACTCCCCATCAGACGTCA TGATTCCTGCACACACTGGGCTCTCACTAACCCCAGCTTCCTTTCCCCTGGTGGTTTTGA GAGCATAAATTTTATTTCCAGCTGTGGGTTTGGGTCCTATGCAGAACACCTCCCTGGAGA ATTGCAACTAAGATGTTTATGGCAATCGCCCTGCAAGTGTCTATTTAATTCCTGAAAATG TCATTTACTGGTGTGTTTCTGTAAAAATCATTTCTGAAAAGTTTTGTCAGCTTGGCTTAG CAGCTGGGGGAAAAAAGCAGCAAAATGAGTCCCCTCAATCAAGCCTGTGATTTTTTATTT TTTCAGACTCATGAATCCTCCTGAGAATTAGGCTTATGACAAGCACCCACCCCCTCCACC TACTCCCTGGTTTAAACCAGGTGCCTGCTGACACGAAGGAAGATTCCGGGGCATTTTGAT CCTAGTCACACAGTGTTTCTAAGTGGGCATTACTCCTGTCAATCCACAGTCTTAAAGATG TTCCTCAGACAAAAGATAATTAGTGACAAGAAGGCCCACTAGATTCCATGTCATATCTTA GTTGGCGGGCCAGAGAAGGACAGGGTCTCTGGTTGGGGCCGTGTCTCCCATCGCATTCTC CCTTTGCAGGTGCTGAAGTGAGGAAGGCCCACAGCTCAGCCAAGCACATGGGGTGCCTCC CTCCTGGGCCACTAGCCCACTGGCCAGTAAGAGAACCAGGGAGCCTTTACTTAGAGACTC AAGGTTCAGAAGAGGGAAATGGGAAGTCACTGGGAAATGGCCCAGCTTGGAGGAGGTGAC CCTGCTGCCGAATCTGACCCCTTATCCTATTACCTAAGTTCCTTTCTTGTTTACTGGCCC TGAAATCACCCGCTTTGGAGATTGCCTTGCAAGGCAGCATAGCAGAGTAGGAGAGTTAGG GTAGGGCAGGTACAGCCTGTGCTCAGCCCTCACAGGCCCTGCACAAGCCCACCAGGCCCC CGGCTCCCTTCTGGCATTCACCAGGAGAGGTTCTGCCCAGCCCAGCAGGTGGGTTCCAGG AGAAGGGATGGAGGTGGGAAGTGGTGGTTATGGAACTCCTACCACTTGGATCTTCACCTG CATGGTCATTCAGTCTTCATAGTCTTCTTTTGAGGACATTTCAGAAAAGGAAACTGAGGC TCAGGATGAGGATTTGATCCAGGGCTGCTAATTCTTCTGACAGAGCACAGCCACGTGGCT TATGCCTGCAGCAGGCCCTTCCCAAAGGCTGTTCAGGCCAGGGCAAGGTGCTGAGGACAG GCTGGCCTGGTTGCAGGTTTGGGGTGTGACCGGTGAGTCTCCTGGTTGTCCCCACCACTG GCCCAGGAAAGCCTGCAGCCAGGCCAGGCTCTGTCCCCACCACTGGCCCAGGAAAGCCTG CAGCCAGGCCAGGCTCAGGGCTGAGCATCCACTGAGTCTGCCTGGAAAGTCGGCAACCTG GTTCCTCTTGGTCCTCTCTTACAGCGAGTCCCTGTGGCCCATCGAGGCCAGAAACGCAGC CATTGCCAATCACTGCTTCACCTGCGCCATCAATCGAGTGGGCACCGTAAGTCCCGAGGT CTGGCTGGGGAGAGGAGCCACCACCTGGTGGCTCTGGTGGGGACACCCCGTTCCCTCTGC ACACATGCCACAAATCCTAGGGTCCGGAAAGGGGTAAAACTGGCTTGGTCCGTTACTTTT CAAGATATCTCTGTCCTCCTGTTTTTTCTGTTTTTGTATTTGGCTGAAGCCCTTTTGAAA AGATCTTTGACATGGCAGTTCTCACCCTATCACCTCCAAGTATCCAGTTTATTTTCCCCA TTGACCCCATACACTTAACAGTTTTGACTGCCAAACAGAATGCACTTATTATATCTCTTC CTCATCCTTATTAATCAGATAGCAAACTCTAATCAGAAGATCTTTTCAGTCTGAGATAAC CAAGGTTTCTACACTAAGTCTATCTGACTTCTAGCAGCATAAAGAAACCTGATGTTTTGG CTGGGTTTGGTGGCTCATGCTTGTAATCCTAACACTTTGGGAATCCGAGGCTGGCAGATC ACCTGAGGTCAGAAGTTTGAAACCAGCCTGGCCAGTGTGGCAAAACCCTGTCTCTACTAA AAATATAAAAATTAGCAGGGCAGGCTGGCACGTGCCTGTGATTCCAGCTACTCAGGAGGC TGGGGCACGAGAATAGCTTGAACAAGGAGGCAGAGGTTGCAGTAAGCCAGGATCGCGCCA CTGCACTCCAGCTTGGGTGACAGAGTGAGACTCTGTCAAAAAAAAAAAAAAAAAAAAGGC CAGGTGCGGACGCTCATGCCTGTAATCCCAGCACTTTGGGAGACCGAGTCGGGTAGATCA CCTGAAGTCAGGAGTTCCAGACCAGCCTGGCCAACATGGAGAAATCCTGTCTCTACTGAA AATACAAAAAATTAGCCGGGCGCGGTGGTAGGCGCCTGTAATCCCAGCTACTAGGGAGGC TGAGGCAGGAGAATTGCTTGAACCCGGGAGGTGGAAGAGCCGCGGTCGCATCATTGCACT CCAGCCTGGGCAACAAAAATGAAACTCCGTCTCCAAAATAAATAAATAATTAAATAAATA AATAGAAAAGAAACCTGATGTTTTAGTTAGCCTATGTAACCCCATCACAGGTTGATGTAC AGTTTCCATTAGGTTCTGGAGGAAATACTGAAAGCAGTGTGTGTACCTGCCCACTGCCTT CACACACCCCGGCCTGGGGTTTTAATTACTTCAAGCAGGCCAGCCTCAGGTGCCCACAGC CCTGAGAACCAGTCTGTGCCCAGTTTCTTTCTCTTCTCTCAGATTATGAACTCCCCAAAG GCACCATCCAGGTTTTTACCCCGCTTGTCAAATTCCCCTCTGGCCCAGGGCTGGCTGCTC AGCAGGAGTGTTTAATAAGCACTTAATTGCCCGGTGAGTACAGACCATTCCAGCTCACCT TAACTGTTTCCTGGCTGACTCGCCTCTCGGCCTGATTGCCCTGCTCATCTGGCTGAGTGA GCTGGAATGAGTGTAGTGGTAGTGCCACCTATAGGTTCCTCTTACCTTGGTCTTATTTCA CAGGAGCACTTCCCGAACGAGTTTACCTCGGGAGATGGAAAGAAAGGTATGTCCCATGAA CCATGGTGGCTGCAGTTGAGGAGTGGGCCTTCCTCTCCCCTTCTCTGTCTGCTTCCTCCA GTCAGGATCTGCCACACAGATCACATCTGCATGCCTGGCACCTAGGAGGAGGCGCCAATT CCTCTCTGCTTTATTGCCTGCAGTGTGGGAATCGGGCTGTGGCTGGGGTGTGGATAGGCA GTCCTGAGCTTGAGGAGTGGGTTGGACTCCATCCATTCCCCGGGACTGGTGTGAAGATGA ACCAAGAGGATGTGGGGGATCCTCTGTGAGCTCTCTGAAAGGGAGAGGTGCTCTCATCCA GCCCATAGATCTCCCTTTCCACTTTCCTTTGTCCTTGTCCCCCCTCCCCTTGCCCAAACC AGCTGTACTGATGCCACAGGGCATTGGCATGGATGGCCCTGGGTTTCTAGAGTCCATGGC TTGTTTTGATCCAAGGGCATATACCACCTCACCTCTGCTAAGAACCCTAAAGACTCCTTT CCCATGTCTCTGGCCAAGAATGAGGGAGGTAGGGACTGCCCCCCTCACCAAGGAGGTATC TGAACCTTGGTGAGGTAGCTTGGACACTTGGAGGTAGCTCAGAGTGTCCTCTAGAAAGCC AGGAGGAGGCCAGGCATGGTGTCTCATGCCTGTAATCCCAGTACTTTGGGAGGCTGAGGC GGGCGGATCACCTGAGGTTGGGAGTTTGAGGCCAGCCTGACCAACATGGAGAAACCCAGT CTCTACTAAAAAAAAAAAAAAAATACAAAAAATTAGCCGGGCATGGTGGCCCATACCTAT AATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATTGCTTGAACCCAGGAGGTGGAGGTT GTGGTGAGCTGACATCGCACCATTGCACTCCAGCCTGGGCAACAGGAGGGAAATGCCACC TAAAAAAAAAAAAAAAAAAAAAAAATGCCAGAAGGGGCTGAGCGAGTCTGTTTTCCAGGA AAACACTTCCTGAAAGGGTCCCAGATGCCGCCATTTCAGGTCCCCCGACTTCTAGAGTCC CTGATCCTAGTTAACTTACTGCAAATAGAGATGCAGAAAGGGCAGGGGAATGAGCGTCCA CTGGGTGCCTGCTGCATCTGGGCCATGCTAGGCCCTGCCCAGCCCCACCTGCTCCTTACA CATGTGTGGGGTGGCTGCTAGTCCTCCCTGACTGGTGAAGGGACCAAGGCCTGGAGGGAG GATAAGGGTGACGCAGCTGGCAAGGCAGATGAAGGCAGAGCCTCCAGCTCACTGTGAGGG CCCCCATAGGAAGCCCCCAGAGTGTGACTTTCTGTTTTCCTTAGGCTGTGGGTAGAAGTG ACACCTCTCAGAAGGGTGACATTTAGACATTTCCCCAGGGGCAAAGGGAAGCAGCATAAG GGGGCCATTTGCAGCAATTTGCTGGGCCTTCAGGCCTGAGATGAGAGACAGGCCTTTTGG GCCTCAGCATTTGGCAGACACTGGGGAGGATGGCATGGACTCCGTGTCCTGGGCCTGCCT CAAGGTGCCTGACCCTCTGTGGAGCCCACAGTGCATCTACACAAGCTCACAGATGTGTTT CTTTGTTCCTTTAAAGCTCACCAGGACTTTGGCTACTTTTATGGCTCGAGCTATGTGGCA GCCCCTGACAGCAGCCGGACTCCTGGGCTGTCCCGTAGCCGGGATGGACTGCTAGTTGCT AAGCTCGACCTAAACCTCTGCCAGCAGGTGAATGATGTCTGGAACTTCAAGGTAGGTCCC CAGGACCCCTGTTGTTGCCTGCTCCTCTGCTTTGGCCCTCATCCTGCTCTCAGGAACTGC TGTTGCGGGGTTGCCCATGGCAGCATGAGGTACCAGCTCCCACCTGAGGGCTCTGTGTGA GCTGAGGGCTGAATCTCTGCCTCCTTGCTGGCTCCCGGGAGGAACAGTTGGGTCAAACAA TGTACAAGCAGCAGGCTGCAATAAATTCTCCTCTCATCTGATTTAGATTCTGGGTGCCTT CAGACAAATTAATCTCAATTTCATTTGTCCAGAGAATAGAATGGATTGGCTCCTCTAATC CTTTTTCCTTTCCAGGCATTTGCACTTATCACAAGATAAATATGCATGTCTGGTTCTGCT TGTGGCCAGTCCCTGCAGTCTAGGCCTTGACGATAGCAGGAAATGGGTCATGCAGAGAAA TGGAATCTAGGCCTGGCTCTGCCACAGCCTTCCTTCCTTGGTCACCTTAATTAAGCCCCT TGTGCTCCCAAGCCTTAGTACTCCCAGTTGTAAAATACGGGGCTTAACTCGAAGGTCCCA TGCTGGCTTTGACACCTAATGCCCTGTGATGTCAGGAGTCAGAGGAATGGAGATGTCTGC CCTCCTGGGATGGGACTCCACCCTAGAAAGGCTCACAGCTTCAGAGTTTGCTGTATTAGT GTCCGAAAGTATTTCCACCAACTCAGCACCCCTTTTTCTTTTTTGGTGGAGTAGGGGGCA TGGAGACAAGGTCTTGGCTCTGTCATCTAGGCTGGACCAATGGCACAGCCATAGATCATG GCAGCCTTGACCTCCTGGGCTCAAGCCATCCTCCCACCTCAGCCTCCCGAGTAACTGGGA CTATAGGCGTGCACCACCACCACACCCAGCTAATTTTTAAAATTTTTTATAGAGACCGAG TCTCACTATGTTGCCCAGGCTGGTCTTGAACTCCTGGCTTCAAGCAATCCTCGCACCTCG GGCTCCCAAAATACCAGGATTATAGACATAAGCCACTGTGCCCTGCCTCAGCAACCTTTT ATAAGCAAATTGTATATGCAAATGTCCATTGTTATAACTGACTTTGCCCGGTGTGACTAA AAGACCACCAGGGCCTCTAATCCACCCAGACATGGGCTTTTGGCCTTGATCCTGTTTTCT GAGCATGGGTTCCTCAGTCTCGGATCCTTGTCAGACAAACAAGGTATTGGGCATGAGAGA GTCTCCTGACCTCTCTCTCCTCTTCCTGGGCAACTAGGATGAATGTAGGATTCCACCCAA ATCAGAAGGGAGCCAAGAATGCTGGCCAACTCTTTTTAATAAGTATCCCAGGAGCAGTAA ACCAAATGTTTTCTCATTAGACACTTCTTAGAAGCAGAAGCCTTCCCAACTTTGGTAATG GGCCTGAGCTCCTGTCAAGGCTTTTGGGAGTAATCCACCTTGGGAAAGGAGGGAGGGAGG GAGGGTGTGCTGGGTGTGAGCACTGTGGGTGGGCTTTCCAACTCCACCAGCCTCTGTATC CACGATGAGATGCCACATGGAGTAGACAGAACTCCAGGCCCATCCAGGAGCCCCTGGTTC AAATCCCAGCCTTTTCTACAACTGGCTAGTGACCTGGAGCAGGTCACTCCTCTCTGGGCT GTAGGATGCTCTTCTGGGGAGCAACAGGACCACGGGACTCCCCTTCTCCATCCTGCCTCA GCAGACCACACTTTCTGGATAGACAGGTCGAAGGGGTCACAGCAGCCAATGCTGGGCTGT ATGAGTCATTGTAGCATCTGTGAACTTTGCCACAGTACTAGAATCAGTGCCAAGAGGTCA CTGTCAACGAGCCTTCCTGATGCGTTCCTGCCCCATGACTGCCCTCCAGTGGCAAGAGGT GGTGGCGTGTAAGTGATGGGGATTTATAAAACCAGAACCTCTAAAGTACATCTGTGTTTT GCTTTCAGATGACGGGCAGGTATGAGATGTACGCACGGGAGCTCGCCGAAGCTGTCAAGT CCAACTACAGCCCCACCATCGTGAAAGAGTAGCCGGCTTCAGTGCCTGCCTTGGGGTGAG GAAGACACCTCTGCCCCAGTGGATTAGCAAGTGTGGCAGGCTTAACATGTCCAGGTTCTC CCCAATAACATTGTCCAGGTTGGTTTTAAAATTCCCAGGCAGGGGGAGAGTGGCATGGGG AGTGACTTCTTAATGGGTAAGGGGCTGCTTACTTCTGGGGTATTGGAAATGTTTGGGGAC TAGGTAGAGGTGAATGTACTAAATGCCACTGAATTTGTATACTTCAGAATGTTTGTTATG TAAATTTTACCTCAACTAAAAAAAAAAATGCCCAGGTACTGCTTGTGCAGGTGGATTTGA GGTTAGGCAGATGATGCTGTCCATCCCGTACACCAGTGGGAAGAGGGTGAGGGCTGATCC AGAGACCCTGAGCCTACAGCAAGGCTGTGGTGGGTCGGATGGTCTTTGGATGTGTCAGCT TAGCTAGGCCACAGTCACCAGTAATTCAATCAGACACTAATCTAGGTATTTCTGTGAAGG TATTTTGTAGATGTGACAGAAGTCCATTCCCAATTGACTAAGTAAGTGAGATTATCTCAG ATAATCTGGGTCAGCCTGACCTGATTAGTCAGAAGGCCTAAAGAACAGAGCTAAGGGTTT CCCTGAGGAAGAAATTCTGCCTGAGGACAGCAGCCCAGTGCTTGGCGAGAGTTCCTGACA GTCTGCCCTTCTGATAGCCTGCCTCACAGAGTTTAGACATGACTAGCCAGCTCCTACAAT CACTGAAGTCAATTCCTTGCAATAAATCTCAATATATCCCCTA OMIM ID 606673