| Entrez gene ID | | 5142 |
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| Official gene symbol | | PDE4B |
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| Full name | | phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila) |
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| Aliases | | ,DKFZp686F2182,DPDE4,MGC126529,PDE4B5,PDEIVB, |
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| Gene summary | | This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. Cyclic nucleotides are important second messengers that regulate and mediate a number of cellular responses to extracellular signals, such as hormones, light, and neurotransmitters. The cyclic nucleotide phosphodiesterases (PDEs) regulate the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. This gene encodes a protein that specifically hydrolyzes cAMP. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq] |
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| Location | | Chromosome: 1 Locus: 1p31 |
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| Gene position | | 66258193 - 66840262 Map Viewer |
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| Gene orientation | | plus |
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| Gene size | | 582070 bp |
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| Gene sequence |
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| OMIM ID | | 600127 |
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