| Entrez gene ID | | 5110 |
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| Official gene symbol | | PCMT1 |
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| Full name | | protein-L-isoaspartate (D-aspartate) O-methyltransferase |
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| Aliases | | ,-, |
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| Gene summary | | Three classes of protein carboxyl methyltransferases, distinguished by their methyl-acceptor substrate specificity, have been found in prokaryotic and eukaryotic cells. The type II enzyme catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to the free carboxyl groups of D-aspartyl and L-isoaspartyl residues. These methyl-accepting residues result from the spontaneous deamidation, isomerization, and racemization of normal L-aspartyl and L-asparaginyl residues and represent sites of covalent damage to aging proteins PCMT1 (EC 2.1.1.77) is a protein repair enzyme that initiates the conversion of abnormal D-aspartyl and L-isoaspartyl residues to the normal L-aspartyl form.[supplied by OMIM] |
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| Location | | Chromosome: 6 Locus: 6q24-q25 |
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| Gene position | | 150070831 - 150132557 Map Viewer |
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| Gene orientation | | plus |
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| Gene size | | 61727 bp |
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| Gene sequence |
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