| Entrez gene ID | | 50964 |
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| Official gene symbol | | SOST |
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| Full name | | sclerostin |
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| Aliases | | ,VBCH, |
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| Gene summary | | Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease. [provided by RefSeq] |
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| Location | | Chromosome: 17 Locus: 17q11.2 |
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| Gene position | | 41836156 - 41831099 Map Viewer |
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| Gene orientation | | minus |
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| Gene size | | 5058 bp |
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| Gene sequence |
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| OMIM ID | | 605740 |
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