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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for PCBP1 (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 5093 Official gene symbol PCBP1 Full name poly(rC) binding protein 1 Aliases ,HNRPE1,HNRPX,hnRNP-E1,hnRNP-X, Gene summary This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 have paralogues (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly(rC)-binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. [provided by RefSeq] Location Chromosome: 2   Locus: 2p13-p12 Gene position 70314585 - 70316335  Map Viewer Gene orientation plus Gene size 1751 bp Gene sequence >PCBP1:49136472..49138222:Length=1751 GAAAGCGGGCTTCCCGCCCCGCCCAGACCGCCGAGGCTGCCGCCGGAGTCGCCACCGCCG CGCCCTCGCCCACCCGCCCGCCCGCCGCTCCCGGCCCCGCTCGCCCCCTCCGCCGCCGCC GCCCGCCCCTGCGACTACGCTGCGGCCTCCCGCCCGCTCCCGCTCGCTCCCGCGGCCCTC GCTCGCCTCGCGCCGGCAGTTTTGGGCCTACACCTCCCCTCCCCCCGCCAGCCGCCAAAG ACTTGACCACGTAACGAGCCCAACTCCCCCGAACGCCGCCCGCCGCTCGCCATGGATGCC GGTGTGACTGAAAGTGGACTAAATGTGACTCTCACCATTCGGCTTCTTATGCACGGAAAG GAAGTAGGAAGCATCATTGGGAAGAAAGGGGAGTCGGTTAAGAGGATCCGCGAGGAGAGT GGCGCGCGGATCAACATCTCGGAGGGGAATTGTCCGGAGAGAATCATCACTCTGACCGGC CCCACCAATGCCATCTTTAAGGCTTTCGCTATGATCATCGACAAGCTGGAGGAAGATATC AACAGCTCCATGACCAACAGTACCGCGGCCAGCAGGCCCCCGGTCACCCTGAGGCTGGTG GTGCCGGCCACCCAGTGCGGCTCCCTGATTGGGAAAGGCGGGTGTAAGATCAAAGAGATC CGCGAGAGTACGGGGGCGCAGGTCCAGGTGGCGGGGGATATGCTGCCCAACTCCACCGAG CGGGCCATCACCATCGCTGGCGTGCCGCAGTCTGTCACCGAGTGTGTCAAGCAGATTTGC CTGGTCATGCTGGAGACGCTCTCCCAGTCTCCGCAAGGGAGAGTCATGACCATTCCGTAC CAGCCCATGCCGGCCAGCTCCCCAGTCATCTGCGCGGGCGGCCAAGATCGGTGCAGCGAC GCTGCGGGCTACCCCCATGCCACCCATGACCTGGAGGGACCACCTCTAGATGCCTACTCG ATTCAAGGACAACACACCATTTCTCCGCTCGATCTGGCCAAGCTGAACCAGGTGGCAAGA CAACAGTCTCACTTTGCCATGATGCACGGCGGGACCGGATTCGCCGGAATTGACTCCAGC TCTCCAGAGGTGAAAGGCTATTGGGCAAGTTTGGATGCATCTACTCAAACCACCCATGAA CTCACCATTCCAAATAACTTAATTGGCTGCATAATCGGGCGCCAAGGCGCCAACATTAAT GAGATCCGCCAGATGTCCGGGGCCCAGATCAAAATTGCCAACCCAGTGGAAGGCTCCTCT GGTAGGCAGGTTACTATCACTGGCTCTGCTGCCAGTATTAGTCTGGCCCAGTATCTAATC AATGCCAGGCTTTCCTCTGAGAAGGGCATGGGGTGCAGCTAGAACAGTGTAGGTTCCCTC AATAACCCCTTTCTGCTGTTCTCCCATGATCCAACTGTGTAATTTCTGGTCAGTGATTCC AGGTTTTAAATAATTTGTAAGTGTTCAGTTTCTACACAACTTTATCATCCGCTAAGAATT TAAAAATCACATTCTCTGTTCAGCTGTTAATGCTGGGATCCATATTTAGTTTTATAAGCT TTTCCCTGTTTTTAGTTTTGTTTTGGGTTTTTTGGCTCATGAATTTTATTTCTGTTTGTC GATAAGAAATGTAAGAGTGGAATGTTAATAAATTTCAGTTTAGTTCTGTAATGTCAAGAA TTTAAGAATTAAAAAACGGATTGGTTAAAAAATGCTTCATATTTGAAAAAGCTGGGAATT GCTGTCTTAAA OMIM ID 601209