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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for PARN (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID5073
Official gene symbolPARN
Full namepoly(A)-specific ribonuclease (deadenylation nuclease)
Aliases,DAN,
Gene summaryThe protein encoded by this gene is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mRNAs. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. This protein is also involved in silencing of certain maternal mRNAs during oocyte maturation and early embryonic development, as well as in nonsense-mediated decay (NMD) of mRNAs that contain premature stop codons. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
LocationChromosome: 16   Locus: 16p13
Gene position14724124 - 14529558  Map Viewer
Gene orientationminus
Gene size194567 bp
Gene sequence
OMIM ID604212