| Entrez gene ID | | 4907 |
| Official gene symbol | | NT5E |
| Full name | | 5'-nucleotidase, ecto (CD73) |
| Aliases | | ,CD73,E5NT,NT,NT5,NTE,eN,eNT, |
| Gene summary | | Ecto-5-prime-nucleotidase (5-prime-ribonucleotide phosphohydrolase; EC 3.1.3.5) catalyzes the conversion at neutral pH of purine 5-prime mononucleotides to nucleosides, the preferred substrate being AMP. The enzyme consists of a dimer of 2 identical 70-kD subunits bound by a glycosyl phosphatidyl inositol linkage to the external face of the plasma membrane. The enzyme is used as a marker of lymphocyte differentiation. Consequently, a deficiency of NT5 occurs in a variety of immunodeficiency diseases (e.g., see MIM 102700, MIM 300300). Other forms of 5-prime nucleotidase exist in the cytoplasm and lysosomes and can be distinguished from ecto-NT5 by their substrate affinities, requirement for divalent magnesium ion, activation by ATP, and inhibition by inorganic phosphate.[supplied by OMIM] |
| Location | | Chromosome: 6 Locus: 6q14-q21 |
| Gene position | | 86159302 - 86205498 Map Viewer |
| Gene orientation | | plus |
| Gene size | | 46197 bp |
| Gene sequence |
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| OMIM ID | | 129190 |
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