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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for NPR2 (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 4882 Official gene symbol NPR2 Full name natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B) Aliases ,AMDM,ANPRB,ANPb,GUC2B,GUCY2B,NPRB,NPRBi, Gene summary This gene encodes natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. Both NPR1 and NPR2 contain five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain, a helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. The protein is the primary receptor for C-type natriuretic peptide (CNP), which upon ligand binding exhibits greatly increased guanylyl cyclase activity. Mutations in this gene are the cause of acromesomelic dysplasia Maroteaux type. [provided by RefSeq] Location Chromosome: 9   Locus: 9p21-p12 Gene position 35792406 - 35809728  Map Viewer Gene orientation plus Gene size 17323 bp Gene sequence >NPR2:35782406..35799728:Length=17323 ATGGCGCTGCCATCACTTCTGCTGTTGGTGGCAGCCCTGGCAGGTGGGGTGCGTCCTCCC GGGGCGCGGAACCTGACGCTGGCGGTGGTGCTGCCAGAACACAACCTGAGCTATGCCTGG GCCTGGCCACGGGTGGGACCCGCTGTGGCACTAGCTGTGGAGGCTCTGGGCCGGGCACTG CCCGTGGACCTGCGGTTTGTCAGCTCCGAACTGGAAGGCGCCTGCTCTGAGTACCTGGCA CCGCTGAGCGCTGTGGACCTCAAGCTGTACCATGACCCCGACCTGCTGTTAGGTCCCGGT TGCGTGTACCCTGCTGCCTCTGTGGCCCGCTTTGCCTCCCACTGGCGCCTTCCCCTGCTG ACTGCGGGTGCTGTGGCCTCTGGTTTTTCGGCTAAGAATGACCATTATCGTACCCTGGTT CGCACTGGCCCCTCTGCTCCCAAGCTGGGTGAGTTTGTGGTGACACTACACGGGCACTTC AATTGGACTGCCCGTGCTGCCTTGCTGTACCTGGATGCTCGCACAGATGACCGGCCTCAC TACTTCACCATCGAGGGCGTCTTTGAGGCCCTGCAGGGCAGCAACCTCAGTGTGCAGCAC CAGGTGTATGCCCGAGAGCCAGGGGGCCCCGAGCAGGCCACCCACTTCATCCGGGCCAAC GGGCGCAGTGAGTGTGGCCTGGGCTATTTTAGGGTCATGGGAGGAGGGTCGCTGTGTCCC TAAAGCTCAGCACTGGGGAACTGTAGATGGAGATAGGCATTGAGCAGCTGTATGTGGTGG TTGGGATCAAGAAGCACACGTGGACAGAGCACCTGTGAGAGGGCCAAGGCTTCATCATGG GAGCTTGTGAACACCCTAGGCAGATGCAAACAAGGAAGAAGAGAGCATGAGGGGTGAAGC CTTGTATCAAGGTGGAATGTGAAAATGAGGGGATATTAAGTTTCGGGAGCAATGTTTGTG CCCTAGAGTAGTGAATGTGATTGATAGCCACTCTGAAATGTGCCCTGTCTGTGATCAGAG CTACCACCCAGACTGGGCGCCAAGACCCCTTGGTGGTGTAAAAATAATGAGGGCTCCATG AACGGACTCAGGGCTCAGCAGATTTGGGAAAGACAGATAAAGCTCATACTGAGAAATCTG TGCTGTCTGTGCCTTTGAGCCCAGGGAAGGGCAGGGAAGAGTCAGGGAGCAGGCCGGTTG GGTGGGGAGCAGCAAGGGAGGCTCTGGGAAAGGGAGGGGCTTGAGAGTGACAGCTCCCTT CCTCTGGGGTCTGGACAGGCTCTGACTTCTGCCAGATGGTCCATATGGCCCCAGGGTACT TATGGTGGACTCCAAGAGGGGTGGGCTGGGGAGCATCTGCTTTGGGGTTGATAGGTTAGG GCACTCTCTTTCTTGCTGAAGAGGGACATCCCAGTGATTCAGAGAGGGGGCTGTGTGGGG GACCTGGATACCTTCTCAGGGTGCTCCTCTGTCATGTACCTGCTCCCAGTTGTGTATATC TGCGGCCCTCTGGAGATGCTGCATGAGATCCTGCTTCAGGCCCAGAGGGAGAATCTGACC AATGGGGATTATGTCTTCTTTTACCTGGATGTCTTTGGGGAGAGTCTCCGTGCAGGCCCC ACACGTGCTACAGGCCGGCCCTGGCAGGACAATCGCACCCGGGAACAGGCCCAGGCCCTC AGAGAGGCCTTTCAGGTATCATTTGAGCCAAATCTGAAGGAGGAGGGGGAAGAGGTGCTT CGCTGGAAATTCTCTCTCACAAGACCCTAAAGAAACCCTAGGAACCAGGCAGGAATTGTG AGCCACAGGAGTAAAATGAACAGAGGCATTCTGAGTCTAGTGTCACCCTTTCTTACTTCT CTACTTTTGTGACTCTTAGTGTGCTTGCTGCCAAGACTGACTTTGGCTGCCTCCAAAATC CTAAAACACTGACTTTCCTAAGTGCCAGTAGTAGGCTATATTGTGGGGGAGAAAAGTTCA GGAAGAGATCTGATCCTAGCCCTTGGGTGGGCTTCCACCCTTTATGGAGAGGTGAGGCAT CGTTCTGGTACAGTCAGACAAAGTTTGAGAAAGGATATGATTATGTGTCCTGGAACAGAC ACTAAGAACTTTAGTGGCTCAGAGGAGGAAGAGTCAGTGTGGGCTGTGTTTAGGGAAGGC TTTTACACAGGAAGTGAGACCGTATTGTGACTTTAATGATAGATGTCATATTCATAGTCA GAGTGGGAGAGGAGATCCAAGCATCCTGAGCAAAGAGAAAAAGATAGGAATGGGCGTGTT TGAGAGACCAAGAAGATACTGACCCGACAAGAATGAGGGGTTCACTTAAAGGAGATACAG GAAATAAAGTTGCAAAGGTAGAATCAGATTAAGGAGAGCTCTAAGTCTTAAGGCACTAGG ACTTGAATTTGGGGTCCTTGACTTTTTGTGTGTGTGTGTGTGTGTGTGGAGATAATTATA CAGTAGTGACAGAATTCAGGATTAGAAGAGGGGGAGACCTGGGGCAGTGAGACCAACTGT AACAGATTAGAAGGGGGTGAGGTGATATAGCTTGAACTAGTGTGATGATAGCAGGAATGG AAAGAAACGCATTTCAGATTTCAGAAAATTTGTGGGGAATGTTGGCATGACTCTGTTCAT TTCACTCCTGCTCAAAACTTTCAGTGACTTGTGTTCTAGAGAATAAAATCCTGACTCCTT ATTGTGACATTTAAGACCTTCTGCAGTCTGTTCTCAAACCACTTTTTCAGTCTTACCTCC TGGTACCCTCATGCTGAGAACTGCAGCCTACCAGGCCTCTGAGTTCCCCCAACCCCAGGG CCTTCCTGCCCCTGTGCCTTTATGTTCTTTTTCCTTTTGTCTGGAATGCTCTTCCTTCCC TCATCCCAAATATCTGCCTCTCAAAATCATACCCATGAATCTTCCCGATTCCCCCGCCAC TTTTTTACTAACCGTGCATATAAGTGTTTCCCGTGTATTTATCCATATCCCTCCTTTTTT CCAAGAAGGATTGGAGGTGGCTTATGGGATAACCTTAAAGTCCTTTAAACTCTGGGATTA TTTGGTTCGAAGTAGCTGTGTATAAGGGCTGGACCTGGGTGGCCATTCTTCTCCAATAAG GTTTTATGTGGCTGTGATTATATATTTGGTTGCGACTGACGAGTGTGTGTCTGACTGAGA ATGACATAGCTGTTTGCATGCCTGAGAATGAGTCTGTGACTGTCACACTTGAATATGGGC AGTGGCAGGGCAGGTTTTGTTTATGCCATAATGTTTTCCTAAAACAATCTTCTCACCTTT GTCTGGGTAATGCTTCCATATTCTTTAAGACTCATACCAGTTATTTTCCTTTCTAGGAAA TGATCCCAGAATCCCTAAGTGGGACTGAATTTCCTACTCTTTTGCTTAACTCCATCTACC ATAGAACTAACCATATTATTCAGTCTGTGTTTGATTTATTTGAAGGCTGACTCATTTCAT TAGTATTTACTGAGCACCTATCATGTCCAGTCACTGTGCTAGGTACTGGTATACAAGGGA GAGCATAACAGACTTTGTTCCTGCCTTTTTGGAGTTTACATTTGGTAGGATGGGCAGGCA ATAAATAAGTAAGCAAATAAATACAAATGTAGGAACATATTGTGATGTGTTACTAAAACA TAAAGAGGAAAGGAATAGAGTGTTATGAAAAGAGAAGAACAAGGGGATTGTACTTCAGCT GGTGTGGACTGCAGAAGATCTGTGACCCTCTCAGATGGGAGCACTCCATAACCTTCCTGG TTATATCCTTTTTCTTTTTGAGACAGCTCTGTTGCCCAAGTTGGAGAGCAGTGGTGTGAT CACAGCTGCTCACTGCAGTCTTGACCTCCCAGGCTGAAGCAATCCTCCCACTTCAGCCTC CCGAGTTGCTGGGACTACAGGCATATGACACCATGCCCAGATAATTTTTTATTTTTTATA GAGATGGGGTCTTATCATGTTGCCCAGGCTGGTCTCGAACTCCTGGGCTCAAATGATCTT CTTGCCTTGGCCTCTCAAAGTGCTGGGATTACAGGCATGAGCCACTGCGCCTTGCTGGCT GTATTCTATTTGTGGAAGAAAAGCCTCACTTTCTTCTGTGAGCATTATTGCCCAGCCAAG AGTCCCCAGCATTAAGGGTAGCTAGAGGAGGGATCTAGTCATCCAATAATCAGTTATATC AATTAACTCTCAGTTCTCCCCCTCACTGTGGGCATTATTCAGACAGAGAAATAAAGAGGG AATCTTTGCTGCAACACAAGAGAAGGGAACTAGGCACCAGGAATATGCTGATGGGAAGGT CAAGGCTTTGGGTAGGTGGGGCTGAGGGGTGATAAGGTGCCCCGCCCCCCACCTTCCAAT GGGGAAGCAGGGGAGAGTCTGAGGGAAGTTGGGCAGTTAGCTACAGCCAAGCAAGGATGA AAGAGCACAGAGCCTTTCTCCCAGAGACACTGGCCCTCTGAGGTCCCAGACCAGGCCAGC CTGGAAAAGGTGGCAATAGAGGAAAGGAGGCCTTGACACAGATGCCCACAGCTTTTCCAG GAGGGTATCATGCTCAAGGAAAGGCCTTAGCTCATGCCGTATCGATACTGGCTACTAGGG AGAGAGCTCTGAAATCAAGTATGTTGATATGATTTTTCTCTCCCATTTAGCCACTAGCTG CTCCAGGGCAGGGATCATGCTCATCTTCATATTCCATATGTCTAGCATGTAGTAGGTGTT TAACACATATTTGCTGAATTGAATTAGGGGTGTGTTGGGGAGAGGGGGATAGGATGAGGA ATTCACCTAGACAGGAGTAGAGCTGGCAAGTAATGTAAACTAGGTGATCAACCAGGATAG GGAAGAAAAGATTGAGTGGAACTAAATAAGCAATGACCAGGCTCTGAGGATCCAGAAGCC CAGGCTGGTCAATGGAGGACTACAGGGTTAGAAACCCAGGCAGAGGTCACAACCTACATG ACCAGCATGAGATTGGGTTACACACAGGGAGCACCAGCGGCAAGAATGGAAGAAAGCACT AAACCAAGGGCTTGGAGATCACTTGTCTCATTAGGCCACTGTTGACCACTCTCCAGTTGG CCAGGGCAAGTCTCAGTGGGCGGGTCCACAGATAGAGGCAGGTGCCTCCTGAGGGTGCAC ATTTCCTAGGTGTGCTCCTGGCACCCACCCACCACTGCACCCATTTGTGGCGGACTTTGC TTGTTTTTTCCACCTGGGGTCCACTGTGAAATGGGACACAATTATCCTCCTTCACTTTCT CTCAAACCCCTGAGCAAGCACAGAAACTGTTTGAGGTTGGGTTTTTTTTTTTGGTTTGGT TTTTCATTTTTGTTTTTTGGTACTACAACTACAACTAGTAACCACAGCAAAAACAGTTCT AGCATAGCAGTTTAGGGGGACCATGGGGTCAAAACTATTTAAAAATAATACAAAGATCTT ATCTGCTTTGTCACGCTTGTTCTTTTGTGATTGTGTAGGGAAGTTTTCCAGAGGTTACAT GGCATGATGATGTCATCACTTGGACAGCTATGGAAGGTGTGCTTGTGTGTTCTTGCGTTT TCAAAATTTATCAGTTTTAATTTCTAAGATGGTCAATATTGATAGATATAGTCCACATAA ACAAACTTTATTTGGGGTCCTTAATAATTTTTAAGAGTATAAAGCGATTGTGAGACCAAA AGTTTGATAACTGCTAGCCTAACAAACTAGCCAAACTTAGTGTTGAGAATTAGTGTTTAA AATGTGTTAAAAACCTATCATCAGCCTTTATTGAAATATAAATTGTGTTGAACCTGATCT TTTCTCGCCCTTTTCCTGACTTTTTACATTGCTTGTCAACAATATTCTACCTCTTTATTT TATTCTTGGAACAGGTGCTACTGAATGAACTATTTCAACCCTTTCCTCAATTCCCTTCTC TTTTTAAAAAAATTTTACCTGAGACTGGGAGAATGTTAGAAGTGTGTAATCAGGCAGCTA AATGCTCTAGTAAGAATAATGATATCTTGAGGCAAGCTGCAGTCTAATATAATATAATGA ATGCATATTAGAAATCGACTTTATTATTTCCTATCTCTAATGAATTGATACATAATAGGC CATATGTGATGTGTCTAGTGCAGCGTATCTCTATGGTCCACATGTACTTTCTATGACAAG AATAAACAAAACTGGGAGAAATGACCGGATTTTAAATTATCATTTCACAAAGTCATGTTT CATAAAATATATTGAACTGAAGTCTTTCCTTGAAGTTGTGATGCCAGTTTCCTGTTGGAG CAGAAGTTGGTCTCAGTGACTATGTGGCCTGAGGCAGGGCCTGAGACTGGGAGGTCCAGC AGCTCAGGAAGGGGAAATGTGTGAGACTAATGGGAGCCAAGCAGGCACTTTGGTGAGAGA CAGAGATGCTGACTCATGCGCCAGTGAGATGTGTGCATGTCTGAGATCACATGTGTCATT TGCTTACCTGTGAAATGTGTGTGGGCATGTGACTGTGTGTTTGTCCCTGTGACACATCTA TTACTCAGTAAGCAGGACAGTGCTGTTTGTGGTAGGTGTTCCACACATTAAATGGATGAG CACACAGCTTTTCACAGGTGGAATCACTGTCTCAAAGTATTTCCCTCAGTTGTCATAGGG CCTGAAATCTCTCTAATTCACTGGGCGGAGACACTGTGTTCAAGTGGCCGAAATGACAAT GTTAGTATTTTACTGATGACATTAACAGTGATTAACATCTCAGAGAGGAGCTGTTAGTGG GTGTTGTCCTTGATCATAAGCAGATACCCAGAAAGCATGGGACAGAGGAGCCGTGTGAGC TGTGGTGGCCTGGCAGGAACCTGGATGCTGGAAGGGAGCTCTGGAAGATGTTGGGCTGGG CTTTGGGGATGGGGTTGACTATTATTTGCCAGTTTCCACCTTCCCAGAACCAGTCCTATC TACCTTTCAGGAGGAGTGCCACTCCCTCTTCCCAGATGTATGCAACACAACACACACACA CACACACACACACACACGCACACACACACGCAGAGAGAGAGAGGTTAGTAGCCCTTTCAA AGCCTTCAGACTCACCTGTGTATATTTTATATCATGTATATTTTACCAAGTTTCCCTGTC CTGCATCTTCTCTTCCCATAATGCCTATCTTGAATCCTGTTCACTCTTCCCCATATGCTG CTGGTACAGACTGTATTGGTGATCACGTACCGAGAACCCCCAAATCCTGAGTATCAGGAA TTCCAGAATCGTCTGCTGATAAGAGCCCGGGAAGACTTTGGTGTGGAGCTGGGCCCTTCC CTGGTAAGTAGATCTCTCCCTTCCTGAGAGTCAGGTCAAGCTTTGGGGAAGGGCTTCTCT CCCAAACTCAGCATCAAGTCTTGGCTGTGGAGCAAGCCCAACTTTGGGGGGTCTCCGCTT CTGTCCAGGATTTTTCCTTCTGCCCTATGGAGTAGTTAGGAAGGGATGGCACTTTAGGAA TAAGAGGGAAGAAAGCAAACCAGAAGAGAGAATAGGTAGAAGGGAGACCCCAGAGAGAGG GGAAGGGGCCTTGCAGGACATTTGGAGAGTACTGCTGAAGTTGCCACCCCCAGATGAACC TCATCGCTGGCTGCTTCTATGATGGGATCCTGCTATATGCTGAAGTCCTGAATGAGACAA TACAGGAAGGAGGCACCCGGGAGGATGGACTTCGAATTGTGGAAAAGATGCAGGGACGAA GATATCACGGTAATGAAGAGGGGTCAATGGGGGTCTGAGGGCTGATGTCAGGAATAGAGT GGGCTGAAGAAGAAACAGATGTCAGGATCACCACAGCTTTAGTGGGGGTTAGTGAATATG GCAGAGTTGCCCACACCTCAAGATCGGGGAAGGGTAGACTCTGAGGGAGCCGTAGGCATG AGTGAGTGGGAGAGGAGCCCAGGGTAGACCTCAAAGAAAGGACACTCTTTTCTGTCTTAG GTGTAACTGGGCTGGTTGTCATGGACAAGAACAATGACCGAGAGACTGACTTTGTCCTCT GGGCCATGGGAGACCTGGATTCTGGGGACTTTCAGGTGATGGAGGAGGAGGCAGGGAAGA GAGTGTGGCCCTGCAAAATCCAGCTTTCAAGGGTTCAGTCGGGGCAGAACCAAAACTACT AGATGAGGGATTTGTTTTCTCTGCTGGCACTGCATCCTGGCTGGGTGGTAGGCTGGGGAG AAAAGCAGCGAAACAGCTGGGGTCTGGGGAGGAGGCTGGTGGGAGCAGGCCTGTGGGCCC AGCTTTTTGCTTCCTTACAGCCTGCAGCCCACTACTCGGGAGCTGAGAAGCAGATTTGGT GGACGGGACGGCCTATTCCCTGGGTGAAGGGGGCTCCTCCCTCGGACAATCCCCCCTGTG CCTTTGACTTGGACGACCCATCCTGTGATAAAAGTGGGTGTGTGCAGGGACTGGGAGCAG CTTTCCTCCCTTTGCTTTCCATTCATGGCCTCCACCCTCACTGACCCTCCACTCTTAACT GTGCTTCTGCCTTTACGTCTGCATCCCTCCCTCCTCATTTCTTCCTACTCCCAAGGAGTC TGTCTATGCACCTATGCACCCCGTTCTCCATTCTGCCAAGTCCGCACACAGTCTTCCTCA GGGTCTCTATTTCCCCTTCAGCTCCACTTTCAACCCTGGCAATTGTGGCTCTGGGCACAG GAATCACCTTCATCATGTTTGGTGTTTCCAGCTTCCTAATTTTCCGGTGAGTTCTGGGTT TCTTGCTGACCTACTCCCTGCCCCCATTGCCACACAACCTCTGGCTGAAGCCAGGTGGTC CCTATAATGTGGGATAGGGTAGTAGGTTTCTTAATTTGCTGGTTGTCTCTTAGATCCAAC AGCGTCTTCCTCTCTAGCCTTTCTCTTTAGTTGTCGCTTAGCCTAGGTGTTTGTTCCACT TTTGGTCCTAGACTGGATATACTAACTAGTGTTTTTCAGTGGGGTTAAGATCAAAGGTGA ATTTTCCATTGGTCTTCTTTTAGGAAAGAACTTTCACCCCCAGTCTCTGTGTTTGTTAGT GAGCATAGGGCATGTGCCAGATATGCCGAGAATGCAGCCTTATCTTCCAGCCCTGTCTCT CAGGTGTAACAGTTGCAGCTTCAGGAGCTGCAGGGAAGCCCCTGCAACCCTGCTGTTGGC TTGGGGGTGGCAGGATTCGGCTTGCCAGTCAACTGAGGTGTGCAGTCCTTACAGAAAGCT GATGCTGGAGAAGGAGCTGGCTAGCATGTTGTGGCGTATTCGCTGGGAAGAACTGCAGTT TGGCAACTCAGAGCGTTATCACAAAGGTGCAGGCAGTCGCCTCACACTGTCGCTGGTGAG CCCTTGTCTCAGCTGTTCCTCTGCCTCCCTCTGAGTTCCTGTCCCTTCTTACCCTGGATC TCTCCCAGCACATTGGCTTGTAATGATAGCCCCTGCACTACCACCATCATCTAATGTTCC TTTCATCCTTCCGCCTCCATGTTGCCCTTGGCCCCAGCGGGGATCCAGTTACGGCTCGCT CATGACAGCCCATGGGAAATACCAGATCTTTGCCAACACCGGTCACTTCAAGGTGAACAG TCATTTGCTTGTTCTGGTCCCCACCATTTCATCCTGTCTCATCCCCATCTGCCACCTCTG CCCCTGAACCTCTGTCCCTCATACCCGACTCTCTGTGCCCAGCTGAGCTCCTGGGTGCTT CCACTGCTCTCTAGCATTTCCTTGTACCCAGAACTTCTGATATTCACTTTCCTTTCCCCT TTCACTCCCACCATCAGGGAAATGTTGTCGCCATCAAACATGTGAATAAGAAGCGCATTG AGCTGACCCGGCAGGTTCTGTTTGAACTCAAACATGTATGTAACAGAGGATGGACTCTAA CATGTATGTAATGGAGGAGTGGGGAAAACTATGAAATAGTAAAATTGGCTAGATGGGCAA GGGGTTGATTTATAAATGATTTTAAAATCGTAGATACAACTAAGAGAAAGGTCCTCTTAT GTAGTGGTAAGTTTCTGTATCTAATTTTTAACTCTTTCAATTTTCTTATCCTTCCCATTG TTTTTTTCTGCCAGATGAGAGATGTTCAGTTCAACCATCTCACTCGCTTCATTGGCGCCT GCATAGACCCTCCCAACATTTGCATTGTCACTGAATACTGTCCTCGTGGGAGTTTACAGG TGAGGGATAGGTGTAGGAGATTATGGCAGGGGTGGGAAGGATAGACCCAAAGTTATACTG ACTCTATGCTGGGTGATAGCTGGTGGGACCAGGACAGACAGTCTATTCCATGTCACTTAC CAGGATATTCTAGAAAATGACAGCATCAACTTGGACTGGATGTTTCGTTATTCACTCATT AATGACCTTGTTAAGGTGAGTCTTCCCCACTCCTTAAAAGTTCATCCACTTTAAATCACT TCCACTGTTCTTTGATTGTGGTTTTTCTCCTTCTAGTCCTCTGAAGTCCTGTTCTCTCAT CTCCCCTTATTCCCATGGTCTGGTAATAATGGGTAAACAAGGAGTCTGGGGCTTATAACT GGGACAGTGAGTTTTACCTGCCACAAGGAGTCCTGTGCCTGTAGAGAGTTTCTATCTTTC TGTCTTAAATATCTCAGGTCTCTTTCCATCATCTCTTTTACCTCTAAGAACTCATAAAAT GAGTGGAGTCTCTGAACATATTTTTTTTTTTTTGAGACGGAGTCTCGCTCTGTCGCCCAG GCTGGAGTGCAGTGGCGGGATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCACGCCA TTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGACTACAGGCGCCCGCCACTACGCCCGGCT AATTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCGTTTTAGCCGGGATGGTCTCGAT CTCTTGACCTCGTGATCCGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAG CCACCGCGCCCGGCCTGAACATATTTATCTCTTGTTTTTCCTCTCATTATTTTACTCTCC GAACATATTTATCTCCTGTTTTTCCTCTCATTATTTTACTCTCTGACCAATATTTGGCAT GTCTGCCCTTTTGTTCAGAAAACTGAAATTTAAAAAAGGAACATTTACTAGTAGAACTAA GAGAAACCAAGGAAGATTGTACTAAAAACCTTTGGTACTCTTCTGTTATACTAGGTTTTA GCTATGTTCAAATGACTCAGAGGCCCATGGATTTGTGGAGCATAAAATAGAATCTTGCAT GAGTTGGACAGGTTTTCTGAAATAAGTCTCATAGCCAATGAGCATCCCAGTGGATCACCC CACACTGTATCTGAAACTAGCTTTGGTTTTCTGCTGAATTCTCATGAAGTTATTTAAAAA GTATTTTTTTGTGTGTGAAAATTTGCTATCAAATGAGAGATAAAAATATTAGTAAAGCCA ATGTCATGCTCAACTAGAGGTGTGATGATAAACATAAGACACGACTCTTGAGAGAACAGT GATTTGGTGGAAAAGTGATTTACAACAAAGCCAGAAGCCTAATCCTGTGATTGTTGAAGG CATCCTTTGCACAGTTTCCACACAAGTAAATTCACAACTTCAGAGATTCCCAAAAGTTTT GTTGATACCAAAATAAATAAAAAGGAAGAATTCATAGAGATTAGAGTTATGAATTAAGTC CAGAGCTAAACATTTAGACAGAAATGTTTTTTGTTAGCATATTGAACCTTGTATCCTCTT TCTGTCTCACCTGAACTGACTTGGGTGGCTCCTAGGGTTTCATTTTTGGGGAGCATCATT AAGACTTTTTTTTTTTTTTTTCTGAGACAGGGTCTTATTCTGTCACCCAGGCTAGAGTGT AGTGGCTAGGTCACTGCTCACTGCAGCTTCGACCTCCTGGGCTCAAGTGATTCTCCCATC TTAGCCTCCTGAGTAGCTGGGACCACAGCGTGTGCTGCAGTGCCCGGCTCATTTTTATAT TTTTGGTAGAGGTGGGGTTTCGCCATGTTGCTGAGGCTGGTCTTGAACTGCTGGGCTCAA GCAATCTGCCAGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGAGCCC GGCCTTTAAGACTGTCTTTCAGCTCCTCGGAGGCAAAGGTTTTTCCCTCTCTGGACCCAC AGAGCCAGCAGTTTTAGGCTTCTGCACTGGCTTAGCAGATTTTGTCCATTTTCCAGGTTT ATGATGTTCTGCACTTTCTCTCTGATCCAGCATTCCCTCTAGTAGATCTTGTTCCTCCTC TACCCCGACTTGCCCACCTCCCTCTAGTAGATCTTATTCCTCCTCTACCCCGACCTGCCC ACCTCCCTCTAGTAGATCTTGTTCTTCCTCTACCCCGACCTGCCCACCTCCCTCTAGTAG ATCTTGTTCCTCCTCTACCCCGACCTGCCCACCTCCCTCTAGTAGATCTTGTTCCTCCTC TACCCCGACCTGCCCACCTCCCTCTAGTAGATCTTGTTCCTCCTCTACCCCGACCTGCCC ACCTCCCTCTAGTAGATCTTGTTCCTCCTCTACCCCGACCTGCCCACCTCCCTCTAGTAG ATCTTGTTCCTCCTCTACCCCGACTTGCCCACCTACGCCTGGTTATGCATTAAAGTTTAC AACTGGTCTTCCTTGGTATATCCAGCTACTCTTGATACCTGGGTCTCAAGTCATGTCTTC CTAATTAGTAGCCAGGTATCTGAGGCCACCATGGGTGTTATATCATTTTGGTCTTCACCC AAGTTCTGTTCTCTTCACTAATCAAGAAGATTGACTGCCCTCTCCAGGGTAGTCATTTGT AGCTCCACTTATCCCTCTTTTTAAGCATTTTCCCTGTCCCTGGTGGCTGGGTGCCTGTGT CCTGCTTATGATACCAGGAACAGATGACTCTTCTGTTCTTCCTGCTTCCTTGGGTGGAAA CTGCAAAGGATGCCTTCCAAAATCAGCTTATTATTTTTGTGGACCCAAGATCTGTAGACA GCTAGCCAGTGCCCATCTCATGGAGAGAGGGTATTCTAAGCCAGATATGATCCAATCCCA TGACTTGATCTGTACCCTGCAGGGCATGGCCTTTCTCCACAACAGCATTATTTCATCGCA TGGGAGTCTCAAGTCCTCCAACTGTGTGGTGGATAGTCGTTTTGTGCTCAAAATCACAGA CTATGGCCTGGCCAGCTTCCGATCAACTGCTGAACCTGATGACAGCCATGCCCTCTATGC CAGTGAGGCCCACCCCCACAACCCACTTTTTATATTGCTCCTCTTTCCACCTAGGGATGG TGGGAGAGGGAGGTGGAGTGACAGTAATATAGGGATGAGCCCAGGTGGGCTTGGGGGTGC CCCATTTCGGGGGACCTGGCCAGCCGGTTTCCTCTTTTCAGAGAAGCTGTGGACTGCCCC AGAACTGCTCAGTGGGAACCCCTTGCCAACCACAGGCATGCAGAAGGCTGACGTCTATAG CTTTGGGATCATCCTGCAGGAGATAGCACTTCGCAGTGGTCCTTTCTACTTGGAGGGCCT GGACCTCAGCCCCAAAGGTAAGAGTCAATCCACTACCCACAGCCTCTTCTTCCTGGGGGA ACTCTGTTCTTCATCCAAACCTTTGATCACCCTCAGAGATTGTCCAGAAGGTACGAAATG GTCAGCGGCCATATTTCCGGCCAAGCATTGACCGGACCCAACTGAATGAAGAGCTAGTTT TGCTGATGGAGCGATGTTGGGCTCAGGACCCAGCTGAGCGGCCAGACTTTGGACAGATTA AGGGCTTCATTCGGCGCTTTAACAAGTGAGAGGGCATTATGGGGCAGGGGCTTCCCAGGG ATAGAAGACTCATTAGTCCTAGTGCATGAAGTGGGGCAGGTGGGACCAGAGGGTGGGTTG GATAGGAAGTCCTGGGAATCTTCAGAATCTTAGAGCAAGTGCCTTATCCTGGCCTCCCTC TAGGGAGGGTGGCACCAGCATATTGGACAACCTCCTGCTGCGCATGGAACAGTATGCCAA TAACTTGGAGAAGCTGGTGGAGGAACGCACACAGGCCTATCTGGAGGAAAAACGCAAGGC TGAAGCTCTGCTCTACCAAATCCTACCCCAGTGAGACTTTGTCCCCCTTCCTGTATTTTC TTTTGGGATTCTGCTCTGTTGGGCTCTGCCTCATCAGGCACCTGAGAACTCGCCTCCCCA CCCTCAGAACCCTGCTGGCCACAGGGAGCACCCCTGCTTATAGATTATTTGCTGTCATTC TGTCTCCACATCAGCTATGCTGCCTTCTTACTGGCTGCCCATCCCTTCTTCTTAAGACCC TGCTCTACCACACCCTTGCTTCAGCAAGTGTATGTAAAACAGTCCCAACTTGAGACAGCT CCCATGCACAGGGATTCCCCTCAAACCCCCCCGCCACTTGTGTGCCTTACCTTGCATTAG ACTGTAATGTCTTCCCAGCCACTTTCCTCCCTCCCACCTGAAAAGCCTAGCTTTCTTGTT ACAGCTCATCTCTGCTGCAGCCACATACACTTTCCCTCTCTCTTCCACTCCTGCTCTCTT GGAGTTTGGCTCATACGGCACCCTTGCTTCCTAGTTCAGTGGCAGAGCAGTTAAAACGGG GAGAGACTGTACAGGCTGAGGCCTTTGACAGTGTTACCATCTACTTCAGTGACATTGTTG GCTTCACAGCATTGTCAGCAGAGAGCACCCCCATGCAGGTGAGAGCCATGGGTGAGAGGT GGCGGGTGGGGTTGGGTGGGTAGGGACCTGGGGAAGCCTCATTGATAATAGGAAAGATGA GTTTGTTCTAGAGTTCCCACATCTTTTGATGGCTTGTGGGTTAAGAATTCTTAGAAAATT GGGCACAAGTCTCAGGGCCTCTGCTTTTCTATCCCTTTTAGGTAGTGACACTTCTTAATG ACCTGTATACCTGCTTTGATGCCATAATTGACAACTTTGATGTCTACAAGGTGAGAGCTG GGGCCGCTGTTCAATAGAAGACCCTTTAATAGAGACCCGCTTTGAAACTCAGTCTCCCTG AACCCCACACACCTTACCCACCCCATGATCAGTTTTCCCTCCAGGGTACTCAGCATCCTG GTGCTGGAGTGTACTTCGTAGACAGATGTAGCTCCAGCACTATAATTGTACACTCCAGTC GAATTTCTTGTGAATCCTTTGACTTCCCTAATCAGAACCATCATGAGATTTAGCTCCTAT CTTCCTGGAGTATAAATACAGCCTATCCAACATTTCTCTCCAGTCCTCTCCAGACATGGA AGAATCATATAGGATGTGGGTCCAGACTGATTTAGTGGGGTGAGGGAAAATATATTTTAA AAAGTAAAACTTTTTGTTGAAGTTATTGAGTTGGATTTATTGTCCTTGGGAGTAAAAATC ATCTGGATTTGAATATTGGCTTGTTGCTAACTGTGTGGCCTTAGGTAAGTCACAGAATCT CCCTGAGCCTCAGTTGTTTTATCTGTAAGATGGGAATAATAGATTCGTTGTATGGAAAGT ACCTAACATTGTTTGGCATGTGGCAGACTACTATTTAGGGATAACTACTTTATCCCTAAA TACTTAGTGTGTATTTCCTAAAAACTTCACTGTGTATTTCCTTAAAACAATGGCATTTAT TCTCTTACATAGCTTTGGCACAATTACCAAAATCAAATGCCTGCTTTCCTCCTCTCTGAC AGTTTGGGCTGTCAGGTCCATTTCACTGGGCCTGCTTTACCTCCTCACCAGCCTCTGTCC TCTTGAGTTACCGTTTTCTTGCTTCCCATTTCCTGATGGCAGAGCCTATTTGTCCATGTC CTGCTGCAGACAGGGTGTTCATTCATTCCGCAAATGTTTACTGAGTATTCACCAGGTGCT GGGTGGAGAAAGAAGACTTAAAGATTCCCTAGACATCTCCTCTCCCCTAGACTCAGGACC ATGGCACTTATTTTCTAGTCAATATTCTGGTCTCCAGCATGTCAGGATGATTAATGATGG TGTCAAGCTTGTCTCCCTCTACTTTTTCCCATCCCCATGGATATAAATAGAGGTGACCTT TTAATCCCCCTCTCAATCAGGTGGAGACGATTGGGGATGCTTACATGGTGGTATCTGGCC TCCCAGGCCGAAATGGTCAACGCCATGCACCAGAAATTGCTCGTATGGCCCTAGCATTAC TAGATGCAGTTTCTTCCTTTCGCATCCGCCACCGACCCCATGACCAGCTGAGGCTACGCA TAGGGGTCCATACTGGTAAGGCTGACTCTCACTCCAGCCCTAGTCTCCACCTTTCCCAGA CTCTCCCAACCTGTTTCTTCTCAAAGGGCCAGTCTGTGCTGGGGTTGTTGGCCTGAAGAT GCCCCGTTATTGTCTTTTTGGAGACACAGTGAACACTGCTTCTCGAATGGAGTCTAATGG TCAAGGTAAGACATTAGCCCTCAACCCCACTGTTGGCCTCAATTTATCTTGCCCTTTTCT TCTTTTCATAATCCCTCCAATTTCTTAATCTGAGAGACCACAGTTCCTTAGTGTCGCATC CTCGGGCATATTTTGGTTCTAATAGATATGCATTGGGAGGTTGGGCATATTTTGGTCCTA ATAGATATGCATTGGGAGCTTCCCAGGGATGGTTGGTCGGGCACGGTGCTATACAGTATC ACCAATTATTTGATTGCCTTTTCTTTGATTCCTCATTCCACCATCCTCCCCATTCCACCC ACCCCAGCGCTGAAGATCCATGTCTCCTCTACCACCAAGGATGCCCTAGATGAGCTAGGA TGCTTCCAGCTAGAGCTTCGGGGGGATGTGGAAATGAAGGTGATGGCAGGCCATGGGGAG GGGGGCATGGAAAGGGAGGGTGAAAGTGATTATGGGAATCATAGGGAAAGAGAGGGAGAC AAAGGGACTAACATCGAAGCATCTGAATCATGTCCACTCTCCCACTTCCAGGGAAAAGGA AAGATGCGAACATACTGGCTCTTAGGAGAGCGGAAAGGACCTCCTGGACTCCTGTAAACC CCCATTCTTTCCAAGTCAGATAGTCTTCTGCTGCTGGTACCTGGGTGGGCAATGGCCACC ATGTCTGCACACACCAGAAATGGACATTTTCATATGCAATGGAAAACAGCCACAAAAAAA CCTACCTTATATGGAAGTTGTAGCCCTCTGCAGCTCAGCCCTGTACATATACCTGTCCCT CTCTGGCTTGGTCCCCTTCCTCCCTACTTTCTGTAAATATCTGTATCTAAACCAGAATAT TTTGGTCAAATATAAAACAATAATAAAAAAAGTTCTGATGTCA OMIM ID 108961