| Entrez gene ID | | 4799 |
|
| Official gene symbol | | NFX1 |
|
| Full name | | nuclear transcription factor, X-box binding 1 |
|
| Aliases | | ,DKFZp779G2416,MGC20369,NFX2, |
|
| Gene summary | | MHC class II gene expression is controlled primarily at the transcriptional level by transcription factors that bind to the X and Y boxes, two highly conserved elements in the proximal promoter of MHC class II genes. The protein encoded by this gene is a transcriptional repressor capable of binding to the conserved X box motif of HLA-DRA and other MHC class II genes in vitro. The protein may play a role in regulating the duration of an inflammatory response by limiting the period in which class II MHC molecules are induced by IFN-gamma. Three alternative splice variants, each of which encodes a different isoform, have been identified. [provided by RefSeq] |
|
| Location | | Chromosome: 9 Locus: 9p13.3 |
|
| Gene position | | 33290418 - 33371155 Map Viewer |
|
| Gene orientation | | plus |
|
| Gene size | | 80738 bp |
|
| Gene sequence |
| |
|
| OMIM ID | | 603255 |
|
|
