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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for NFKBIB (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 4793 Official gene symbol NFKBIB Full name nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta Aliases ,IKBB,TRIP9, Gene summary NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008, or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664 or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).[supplied by OMIM] Location Chromosome: 19   Locus: 19q13.1 Gene position 39390615 - 39399534  Map Viewer Gene orientation plus Gene size 8920 bp Gene sequence >NFKBIB:11658833..11667752:Length=8920 CCGGCAAAGCCCAGCTACAGGCGGGCGACTGCGGGGGGCCCCTGAGGCGGCGGGGGCCAT GGCTGGGGTCGCGTGCTTGGGAAAAGCTGCCGACGCAGATGAATGGTGCGACAGCGGCCT GGGCTCCCTGGGTCCGGACGCAGCGGCCCCCGGAGGACCTGGGTTGGGCGCGGAGTTGGG CCCGGGGCTGTCGTGGGCTCCCCTCGTCTTCGGCTACGTCACTGAGGATGGGGACACGTG AGTGAACCTTAGGCTGCCAAACGGAGCCCTAGGACCCGGCGTCACATTCCTCATTAATCT CTGATCCCTGAGGCTTCCTAACCTCATACTCCTAAATCTGACTTCCGATGCTGAACTTCC TGACCTCTAACCCCCGAGTCCTAACTTTTAACAAAACCAATCTTCTATCTAGCTATGATC CTAACCCAATCATTTCTTACCTTCTTTTCTTGAACTATGATTCTCAGCTCCTGGAATCCA CATTGTATCCACTGATACCCAAACCTGACTCCAGTCCTGAGACTTCTGTTAGAACTGTGG CTTCTCCTGACTTCTAACCTCCAAATATGATCTTTGATTCTTAGTTCCCGATTTGAGCCC TAGAGTTTGATTTCCGAAATTAATACTTGGTCCCTGACTCTAAGATCCTGTCTTCTGAGC AGTGTTCTTCAAATCTTAAATTCAAAGAGAGAGAATGTAAGCTCTTCTATGTTGAATTCC TAATTAAAGTAAAAAAATAGGAAAATTAAAAAAAAGAATGTTAGCTCCATGAGACCAAGG ATTCATCTGTTAAACAAATATTCTTTACACATTACCACGTTCCAGGCTCCGTTTAGGTGC TAGTGATAAAGGCAGTGAAGAAAACAAACAAAAACTTAAGCCCTTGTGGAGCATACATTT TAGTGGAGCTAAATAAACAGATTGATAAGACCACAAGGAAGGAAAGAAATGGAAAGACAG GAAGAAACAAAGAAAGACACGCAGAAAGAAAGAAACATAGAAAGTAAGAAAAGGAAATAA AGTCAGAGGTAGTTAAGTACTTTGGAGAAAAATAAAGCAGGAAAATGAGGCAATAGATAA ACAAGATAAGAGCATTTCAAGGAGAAGGAACTGCAGTTGCAAAGGCCCAGATGAGGGATT GTACTGGGTTTTTTGTCTGTTGTGTTTACTGCTGTATGCCCAGTGATGCAAGCAGGGCCT GATCCAGGAGGCACTGAATATTGATCTCAACCAGCTTTATAGTCTCGTTAATTTTCATTA AATTTCATTAATTAATTTTGGTTTCATTAATTTTTTTTTACTTTCTATTCAATTGGTCTC TGTTCTGACTTTTTTTTTTGAAACGAAGTCTCACTCTGTCGCCCAGGCTGGAGTGCAGTG GCATGATCATGGCTTACTATAGCCACAACCTCCTGGCTCAAGTGATCCTTGCACCTCAGC CTCCTGAGTAGCTGGGACCACAGGCACATGCCACCATGCCTGGCAAATTTTTAAATTTTT TTGTCCCCCTATGTTCTCAAACTCTTTTTTTTTTTTTGAGACAGAGTCTTGTTCTGTCAC CCAGGCTGGAGTATAGTGGCACTATCTCTGCTCGCTGAAACCTCTGACTCCTGGGTTTAA GCAGTTCTACTGCCTCAGCCTCCCAAATTTGGGATTACAGGCACGTGCCCCCACACCTGG CTAATTTTTGTATTTTTAGTAGCAACAGCAGTTTCACCATGTTGGCCAGGCTGGTCTCAA ACTCCTGACCTCAGGTGATCCACCCGCTGTGGCCTCTCAGAGTGCTGGGATTACAGGTGT GAGCCACTGTGTGCAGCTGTGGTCTCAAACTCTTGAGCTCAAGCATTCTTCCCACCTTGG CCTCCCAAAGTGCTGGGTTACAGGGATGAACCACTGTGCCCAGACAGTCTCTGCCTTTTA ATTAGTGTTTAGACCATTTACATTTAATTTGATATTGATATGATTGTGTAAATTTATCCC ATGTCTATTATATATATTCTACTTACCTATGTTTTCTTTTTCCTCCCTCCTTTTTGCCTT TTATTGGGTATAGTTTTTGTTACTTTTTTTTCAATCCTGCTCCTTCTGTATAGTGTTTTT CATTTTATTTCTTTTTTTTTTTTTGAGATGGAGTCTCGCTCTGTCACCCAGGCTGGAGTG CAGTGGTGCAATCTCGGCTCACTGCAAGCTCCGCCTCCCAGGTTCATGCCATTCTCCTGC CTCAGCCTCCCGAGTAGCTGGGACTACAGGCACCTGCCACTTCGCCTGGCTAATTTTTTT TGTATTTTTAGTAGAGACGGGGTTTCACCGTGGTCTTGATCTCCTGACCTTGTGATCCGC CCGCCTCGGCTTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGCGCCCGGCCTCATT TTATTTCTTTTGTTTGCTTATTAGATATTCCTCTTTTTGTTATGTTAGTGGTTGCTTTAA GGTGGGGGTTGGCAAACTATGGCCTCCAGGCAAAATCTAGCCAGCCATCTGCTTTTGTAT GGTTGTGAGCTAAGAATGGTCTTTACATTTTTAAACAGTTTCTAAAAATCAAAAGAATAA TAATATTATATGGCTTTTGTATGGTTGTGAGCTAAGAATGGTCTTTACATTTTTAAACAG TTTCTAAAAATCAAAAGAATAATAATATTATATGGCAAGTGAAAGTGTATGAAATTCATA TTTCAAGCTCCATAAATAAAGTTCTTTTGGAACGCAAGCAAGCTCACTCATTTACATATT GTCAGTGGCTGCTTTTGCACTGACACAGCAGAGTCGAGTAGTCAAAAGAAACTGTATGGC TGCTGGGCTCAGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGCCAAGGCGGACAGAT CACAAGGTCAGGAGATCGAGACCATCCTGGCTAACATGGTGAAACCTTGTCTCTACTAAA AATACAAAAAGTTAGCTGGCAGTGGTGGCGAGCGCCTGTAATCCCAGCTACTTGAGAGGC AGGAGAATCGCTTGAACCCGGGAGGCGGAGGTTGCAGTGAGCTGAGATCACGCCACTGCA CTCCAGCCTGGGCAGCAGAACGAGACTCCATCTCAAAAAAACAAAACAAACAAACAAAAA AAGAAAAAGAAAAACAAAACCAAAAAGAGAAACCATATGACCTACAAAGACTAAAATAGT TATCTGGCTCCTTACAGAAAAAGTTTGCTGACTCCTGCTGTAGGGTTGATAGTTTACAAC TTTAGGTTATCATGGGCTACCTTAAAGTGATATTATGCCATTTCACATAGAGTAAAAGAA ATTTATTTTATTTTATTATTATTATTTGAGACGGAGTCTCACTCTGTTGCCCAGGCTGGA GTGCAGTGGCACGATCTCAGCTCACTGCAACCTCCATTTCTCAGGTTCAAATGATTGTCC TGCCTCAGCCTCCTGTGTAGGTGGGATTACAGGCGCATGCCACCATGCCTGGCTAAATTT TTTTTGTATTTTTTGTAGAGACAGGGTCTCATCGTGTTGGCCAGGTTGGTCTCAAACTCC TGACCTCAAGTGATCTGCCCGCCTTGGCCTCCCAAAGTGCCAGGATTACAGGTGTGGGCC ACCGTGCCCAGCATAATGAACTGTTTTAATATTCTTGTTTGCAAATTCTAACATCTCTGT CATTTCTGGGTCAGTTTCAATTCACTGATGGTTCCTATTATGGATCATGTTTTCCTGCTT CTTTACATGCCTGATAATCTTTGGTTAGGTGCCAGACATTGTGAATTTTGCCTTGTTAGT CTGGAGAATTCTGTATTCCTATAAATATTCTTGAGGCCGGGCGCCGTGGCTCACACCTGT AATCCCAGCACTTTGGGAGGCCAAGGCGGGTGGATCACGAGGTCAGGAGTTCAAGATCAG CCTGGCCAACATGGTGAAACCCTGTCTGTACTAAAAACTGCAAAAATTAGCCAGGTGTGG TGGCACGCACCTGTGGTTCCGGCTACTCGGGAGGCTGAGGCAGAAGAATCGCTTGAACCC AGGAGGTGGAGGTTGCAGTGAGCCACGATCGTGTCACTGCGCTCCAGCCTGGGCGACAGG GCAAGACTCTCTCTCAAAAAATAAAAATTAAAATAAATAAATAAATAAATAAATAAATAA ATATTCTTGAATATTATTCTGGGATGGAGTTAAATTACTCGGAAGTAGTTTGAGTCTTTC CAGTTTTGCTTTTATGATTTGTTAGGTGGGTGTTGAGCAGTGCCCCATCTACAGTTAATT ATTCCCCACTATTGAGGCAAGACCTTCCTGAGTATCCCACCCGATAGCCTGTGATGATGT TTTTCCAGCCTGGCTGGTGGGAACACTCACTATTCCTGGCCCTGTGTGAGTAACGAGCAC TTTTCTGAAATCCTTTTGGATGGTTTTCCCATCCCCACAGACTCACAGGCATGGCTGATC CGTATTCTCCGGAATACACAAGAGAACCTCCTGCAGTTCCCCAGCAATCTCTCCTTTGGC AACTCTGTTTTGTACTCTGTCCTGTGACTCTAGCCACGCTGGCCTCCACAGACTCTTCCT CCATATCCATCTCCTGACCTCAGACAACCTGATGCGCTCTGCTTGGATTCCCCTCTCTGC ACCGTGGCTTTGAAACTCTCTCAAGACAATAAGCTGTGGCAGTCAAGTGTGGGGCCCACC TCGTGTTTCCTGTCTTTCAGGGGTCACTGTGATTCATTGCACGATGTCCAGTGTCTTCAA CACTGTTGCTTCATATACCGTATTTCGTCTGACTCTTGTTTGTTTGTTTGTTTGTTTCAC GTGGGAGTGAATTCTGGTCCATGTTACTTCATTTTGGGCAGAAGTGGAAATCCCACTGAA TAAACATTGATTCCACGAATTTGCTGATGAAACTCTGACCTCTGACCTCCCAGATAGCTG ACAGGGGGTTCCAGAACTGTGGTCACAAGGCCTAGCATACAGTAGGCGCCCCATGTTTGT TCAATGAAGGAATGCAAGAGGACTTGAACTTTGCCCTCTCACCCCGGTCTTTGTCCCCAG GGCACTGCACTTGGCTGTGATTCATCAGCATGAACCCTTCCTGGATTTTCTTCTAGGCTT CTCGGCCGGCACTGAGTACATGGACCTGCAGAATGACCTAGGCCAGGTGAGCCACGAGGG ATGGTGTAGGGCTTGGGGTCCAGGGTTCCCAGTGTGACTCCCTACCGCCTGTCCTCTGCT TCTGCAGACAGCCCTGCACCTGGCAGCCATCCTGGGGGAGACATCCACGGTGGAGAAGCT GTACGCAGCAGGCGCCGGGCTGTGTGTGGCGGAGCGTAGGGGCCACACGGCGCTGCACCT GGCCTGCCGTGTGGGGGCACACGCCTGTGCCCGTGCCCTGCTTCAGCCCCGCCCCCGGCG CCCCAGGGAAGCCCCCGACACCTACCTCGCTCAGGGCCCTGACCGTACTCCCGACACCAA CCATACCCCTGTCGCCTTGTACCCCGATTCCGACTTGGAGAAGGAAGAAGAGGAGAGTGA GGAGGACTGGAAGCTGCAGCTGGAGGCTGAAAACTACGAGGGTGAGGGTCGTCACCAGGG AAGGACTCAGCTCCTGGGCTAGGCGAGAGCACCTGGCCCTGGGCTCAGCTTCCCTGATTT GAGACTGAGCTCCTTGGGAAATCATGCCTAGGCTTCAGGAGCCCACACATCGGGACCAGG GACCTCCACTCAGGGCCCAGATGATTGAGAATTGGATATGTAGGACCCAGGACCCCCACC TGGAGGCCCCAGGTCACTTGGGATGCAGACCTGTCACCCACAGACCCAGAGCTGCCAGGA TCCAGTTGTCGGGCCCCCGGGCTCCCCACCTGCAGAGTGTATTGCAGACCCCTACCCTAC CCAGGACCGGGGAATGCAGAGCTCAGGCCCTCTGTGAAACTCTGGCACCCCAGGCTCCCA GCAATGGGCAGCAGGGTTCAGAGACAGCCCTCCTCAGCCTCATGGGAAGAAGGGCTCATC TGCCCACAGCCCTGACATCCAAGTTTCTGCTCCCCTGCCTATAAGCCCAGCCACCTGAGA CCAGACCCCTCCTCAGATGGACTGACGTCATTCAGGACCCAGTGTTCAGGGCCTGCCTCT CGCCCCCAGGTCACAGGCTTTTCAGCTACTTGGTACCTTTTTTTTTTTTTTTTTTTTTTT TGAGACAGTCTCACTCTGTTGCCAGGTTGGAGTTCAGTGGCGTGATCTTGGCTCACTGCA ACCTCCACCTCCCAGGTTCAGGTGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTA CAGGGATTACAGGCACATGCTACCATGCCCAGCTTATTTTTGTATTTTTAGTAGAGACGG GGTTTTACCATGTTGACCAGGCTGGTCTTGAACTCCTGGCCTGGCCTTAGGTGATCTGCC CGCCATGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCGTGCCTGGGCAGGAAC CTTAATTTAAGGTTTTTTTTTTTTTTTTTTTTTGACATGGAGTCTCACTCTGTTGCCCAG GCTGGAGTGCAGTGGCGCCATCTCAGCTCACTGCAAGCTCCGCCTCCTGGGTTCACACCA TTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCGCCCGCCACCATGCCCAGCT AATTTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATGTTAGCCAGGATGGTCTCGATC TCCTGACCTCGTGATCCACCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGC CACTGTGCCTGGCCTTTATTTTTTATTTTTAGTAGAGACGTCTTGCCATGTTGCCCAGGC AGCTTCTTGAACTCCTGAGCTCAAGTGATCCTCTTGCTTTGGCCTCCCAAAGTGCTGGGA TTACAGGTGTGAAATAGCGTGCCAGCTCAGGTCCTTTGAGTGATAAGAGCAGAGACTTGG GTCTCCTCCTGGCCCCAAAATCCAGGCTCCCTGTCCACAGACCCCAGGCTGTTTACCCGC GGGCCCCAGGCTTCAAACAACTCAGGCACTAGCACTTGCCAGCAAGCTCAGGCCATCTGA GATAGGCATTTGGTACCCAGGTACCTCTTTGCCATACCCAAGAATTCAGGAACCAGCCCC CAAACCTAATCACCCTCACGCCACATGACCCTCCCCCAGGATCAAAGCACGGTGGGGTGG GGGGGGCCCTCACCTCATCATCTGACGCCAATCACTCTGTCCCCAGGCCACACCCCACTC CACGTGGCCGTTATCCACAAAGATGTGGAGATGGTCCGGCTGCTCCGAGATGCTGGAGCT GACCTTGACAAACCGGTGAGCCCCAACCTCGGGGAAGATGCCGTCGGCGGGAGGGGGCTT GTCCCCTCTTCGGGCCCTCTGACCTTTCTGTTGCACCCCCACAGGAGCCCACGTGCGGCC GGAGCCCCCTTCATTTGGCAGTGGAGGCCCAGGCAGCCGATGTGCTGGAGCTTCTCCTGA GGGCAGGCGCGAACCCTGCTGCCCGCATGTACGGTGGCCGCACCCCACTCGGCAGTGCCA TGCTCCGGCCCAACCCCATCCTCGCCCGCCTCCTCCGTGCACACGGAGCCCCTGAGCCCG AGGGCGAGGACGAGAAATCCGGCCCCTGCAGCAGCAGTAGCGACAGCGACAGCGGAGACG AGGGCGTGAGTCAGGAGGAGAGACAGGGCAGCCCAGCTGGGGGGTCAGGATAGACCGGCA GGCAAGAAGCCCAAGAAGATAATTAGGCACCGACCTTGGGCTGCTGTTAGAGAACTCAGG CAGCAGCGCCAGTGACACGGGGCACTAGTCAGGAGAGACCTGGACAGGGGTGGTGGGAAG AGCTTGGGCAGAAGTGGCTGAAAAACTAAGGCAGTGGCAAAGGTAGAACTCAGGCAGGGG TGGAGAAAAGGCGTTGGTCGCAGTGATTGGTGAACACAGCGGGGGTGGGTGGTAGCGCTG GGGGTGATTTTAGGCAGCAAGAATTGGAGAACTCACACTGCGAAAAGAAAACCTTGGGTG GCAGTGATTTGAACACCGGCAGTGCTGGGGCAGGACCCGAGCCAGCGGTGGGGAGAGATA TAGTCAGAGAACCCAGCAATACAGATCCGTCCTTGGGCAAGGCGCGGTGCTGGATGATGG GTGCGGAGGAATTTGGGTAAAGGCAGAGGGAAGGGGTGGAGGAGGGCCAGCTCAGTTGCC GAAACTCTGGAGTGGCGGCTGGCTAGAAATTGGTCTGTAGAAATGACCTTGAAAATGGAG TTCTGGCCAGGTGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGG CAGATCACGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGCAAGACCCTGTCTCTA CTAAAAATACAAAAATTAGCTGGGCGTGGTGGCGCATGCCTATAATCCCAGCTACTTGGG AGGCTGAGGTAGGAGAATTGCTTGAACCTGGGAGGTGGAGGTTGCAGTGAACCTAGATCA CGCCACTGCATTCCAGCCTGGGCAACAGAGCGAGACTCCATCTTAAAAAAAAAAAAAAAA AAAAGAAAGAAAAGAAAATGGAGTTCTGAGAGCTAGGAAACTGGGAGGTTGAGCCAGGAG CAGGGGAACTTGGGCTTTGAGGCGAGACCTAATTCTTAGGGTGCTCTATGAGGACATGGG TGGTGGGCAAAGTGACAGCCGCCTGAGCCCCTCTGCCTGGTCCCCTTTGCCCCCAGGATG AATACGACGACATTGTGGTTCACAGCAGCCGCAGCCAAACCCGGCTGCCTCCCACCCCAG CCTCAAAACCTCTTCCTGACGACCCCCGCCCCGTGTGATTTGTTTCATTGTTAATATAAT TTCCAGTTTAATAAACAAAACCCTAGTTCTGACAACCAGA OMIM ID 604495