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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for NCF4 (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 4689 Official gene symbol NCF4 Full name neutrophil cytosolic factor 4, 40kDa Aliases ,MGC3810,NCF,P40PHOX,SH3PXD4, Gene summary The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq] Location Chromosome: 22   Locus: 22q13.1 Gene position 37257030 - 37274059  Map Viewer Gene orientation plus Gene size 17030 bp Gene sequence >NCF4:16647599..16664628:Length=17030 GGAGGAGGAGCCTCTGCCAGACTGGAGAGAAGCAGGCCTGAGCCTCCCCAAAGGCAGCTC CTGGGGACTCCCAGGACCACAGGCTGAGACGAGACGCAGGGTGGCTGGAGGAAGTGAGAG GTGAACTCAGCCTGGGACTGGCTGGGCGAGACTCTCCACCTGCTCCCTGGGACCATCGCC CACCATGGCTGTGGCCCAGCAGCTGCGGGCCGAGAGGTGAGTGCCGGGGTGTGGCCGCCC CCGGGCCTTCTCACTGCTCCTCATAGGCCTTAGGGACAAAGGCCAGTCCTTCTGCAGTCC CTGATCAACATGAGAGGCTGGGGTTGAGTCAGAACCCAAATACTCAGAAATGCAACCTCT CAGAACTGCTTTAACGAAACTTTGAGCTGTGGCTCACCACCCTCAGACACAAATGAGAAC ACTGAGGCTCCAAGAGTGGGAGTGACTTGCCCACGGTCACACAACGAGTGACCGGCAGTG TCTGGAGAGGAATGCAGGTGTCCTGGGTCCCAGGCTGGGGCCCTTTGCTTCACATGGTGA TCAGCAATGACTTTCCATCTTCTGCGCAAACAGAATTCACAGAATCTGGCTTGTTCTTCC GCTAATCAGGGCTTGCCTCAAATGTCACCTCCTCCAAGAAGCCTTCCTGACAGCCCCTAC CTCATTGCTGTCTGACCCTTTGCCCTATTTCCCTTTTCTGCCTGGTTCTTATATTACAGG AATAATATTATATGCTCATTTATTATTTTTTCTTGAACGTTGGCTCCCCCATGAGAAGCA AGCTCCACGAGGCTGTGTCCGTTTTGATCGCTGCTGTATCACTAGGAGGTAGCTCATCCC TATTGAGCACCAGGACCAAGGGCTCAATAAATGTTGCTGAATGAATGAATAAATGAATGA ATGAATGGGTGGATCTTTGAGACGGAAAAGGTCTTAGATTCTTCTAGTCCAACCTTGCCA TTGTACAGATTGGAAATCTGAGGCCCAGGGAGGATAAGAGACTTACTCAGGGTCACAGAG AGTGACTGGCAAGGTTGGGGCTTGGAGCACGGCCTCACCAGCATCTAGCCTCGTCGCTTG GGAAGCATTTTCAGAATTTTTCCTCAGTAGCCAGGTCTGAGCTCTAAGCTGCGGGGGCCC TGAGGACGCAAAGCCTGGCCCCTGCACCCCCTGGATTGGAACAGCAGGTGACCTCTGTTA CCTACGTGGAGGCCACTCAGGGGGTCACCAGAGACAGGCCAGGCTGGTGTGTGCCTACGC GGGGAACAGAAGGCCCATGTTGGGGCCTGGGGCTGGAAGTAGAACCTGAAGCGTGGGTTG GGGCAAGGGCAGCAGAAGCAAATGCCTACAGGGGAGTCCACGTGGCCTTCCTGAGCCTCA GAGCGGGGTGCAGGAGCTGGGTAAGGCTGGCCGACCTGAATTCCTTCCTCCCCTCACATG CTCCTGGGGGACCCAGCCGCACGCAAACTCGAATCTTCCGGAAGCAGCAGCTGTTTGAGG CTTGGGCACTTCCTGCTTTCTGGGGTACAGGGTTCAGGGGATGACACGGAGAGCTGACCA GCAGGACTGTGCACTCCCTCCCCCACTCCCTGTCCCCTTTCAGCTGCCTTAGCCCTCAGA GGGGGAGGGACTGCTTTTCATGAGGCCTTGAGCCAGGTACTAGGGGCATGGGGGCTCCCT GTACCTCGAAGGTCTTATCTGAAAGCGAGCCTGGATTGTTCTGCTTAAGGTCAAAGCAGA GAGTACAAGGAGAGGGCGCAGGTTCGCGCAGCGGGGACTTTCTAGAACCCCAAGGTGAGA CATCCAAAGATGGGGAGGGCTGCCTTAGGGGTGGCAAGTTCGGTTCCAACAGACATGTTT TGAGCACCTACTATGTGCCAGGTGCCAGAAAACCTGCCCTGGCTGCCCTCCAAGGGTTCT TCCAACCTCGGCCTCCCCCAGGGCAGGCTCCAAAACCTCCCCCAGGCCAGGCTCCAAAGT CTGTGAACTGTGCGAGTGTGTCTTGAGCCAGAACATCCCGGCCCAGTAGGGCCTGGGTGA GGTCCCCAAGGGAGCGGATATTCCAGGGGACTTCCGGTTGGGTTTGCTGCTCTTCTTGCC CGCCCCACAGGCAGCCAGGCCATTCTCATGCTGCCCATCAAAAAACTCTATAATTGCAGA CGACGGTAGTGGCCGTGTATTGAGCAGTACTGAGCACCTACTGTATGCCGGGCTCTGTTC TGGGCACTGGGATGTAGGGTGAGCAGAGTCCTTGCCCTCATGGAGATTTTAGGGCTGTGT TTGTTACAGATGGGACTGCATGACCACCCGGAGACATAAGTACTTCTCCTGTCCCCATTT TACAGAGGAGGGAAGGAGCGGAGCACAGCTAGGAATCTTCCCAAGGGAGCTTGATCTTCT TGTCCCCAGTGCTGCGCCTATGCCTCGAGCATCTGCCAATGTCTGTCCTGCTTGACTCCT TCCTCAGCCCCCACCACCCCAGGGAAAACTCGAGGTCCCTCTGCGAGGCATCAAGGCACC TCGTGAGCGGGCCCTGCCTGTCTCTCCGACTGGTCTCTCATCACGTTCCACCTCCTGCTC TGTGCTCCAGCCATGCTCAGCAACCTGCGGTTCCCTGAACTGAGCAGCTCCATCCAGGGC ACATGTTGACTTTGTTTACATCTGTGACCCAGGGCCTAGGACAGGGCCTGGTATGGAGAT GTTTGATGCCTTATTCCCAGGTGAATCTGTGCAATTGACAGCAATGTGTTAGACTATAAT TTGGCTATTGCTATATGGTCACCAGCTTCCCATTCCTACACTCAATATGGCCACCAGCTT CCCATTCCTGCACTCAGTATGGCCGCCAGCTTCCCATTCCTGCACTCAAGGCCTGGGCTG TGTCTTGTTATCTCCGTATTCCCAGGGTCAGTGGCTGGACCTGGCCTGGGAAGGGGTGCT GAGAGACGAATGTTGGCTTCACAACATTAGTTTGCTTTGCACTCTACCTCATACCCGGTG GGCCCACAAAACACATCAGGGTGATAAGCAGGATCTCTTTTCCCCTCCTTCGCACAGTGA CTTTGAACAGCTTCCGGATGATGTTGCCATCTCGGCCAACATTGCTGACATCGAGGAGAA GAGAGGCTTCACCAGCCACTTTGTAAGACAGACTCCTAGTCCTTCACCCAACAACCTCTG AACTTCCACCCAGCTGACCTCTGAACCTTGCCCTCTGACCTCTGAACCTCCAATTCTCTG ATCTCTTAACTTCTATCTCAGTGGTTCTCAACAGGACCGATTTTGCCCATTTGACATTAC CCTGGGAGATTCTGATTATTGCATCTTGGGGCAGGTCTACTCCACATCTAGTGGGTAGAA TCCAGGGTGCTGCTAAACACCCCACTGTGCACATGACAGCCCTGTCCCCAGTAAAGAACT GTCCGGCCCCAGCATAATACTAAGATTGAGAAATCCTGATCGCGTCCTTTGACCTCAGAA CCTCCACCTGGAGAGTCGGGGGTGAGGGACTTTAGTGTTGCCCCCACAACACCCCTGTCA TATTCAGACACAGATGGAGGGGGCATCCTGCACCCACAGCACAGCCAGGGGCAGGTTCAC TCTGCACCATGACCTCCAAGGCATGGCTCCTCATTTCTTGGGCCTGAATGTGTGTTTGGC CTATTTCCAAGGGCTCTTGCCTCTAACACTAGGTCTCACTTCCTCTCTTTTTCCAGTTTT TTTTTTCTTTTCTTTTCTTTTTTTTTCGCAAAGCTCGTCTGCTTCTGGGGCGCCAGCCTT TTGACTTGACAGGGGTCTCCTTCTCCAGAGACCCTTCTGCATCCTTATCCTCATCATCTT CCTCCTCCTCCTCCTCCCCTTTTCCCTTCCACCTCTTTTTGGCTTGTGCTCCTGGCCCCT GAGCCCTCCCCACAACCTCTGTCCTCCTTAGGTTTTCGTCATCGAGGTGAAGACAAAAGG AGGATCCAAGTACCTCATCTACCGCCGCTACCGCCAGTTCCATGCTTTGCAGAGCAAGCT GGAGGAGCGCTTCGGGCCAGACAGCAAGAGCAGTGCCCTGGCCTGTACCCTGCCCACACT CCCAGGTAGGCGGCCACTCCCGTCCTGCTGCTGCAGAGCTGCTGACTCTCCTTCCTTCCA GGGCCCCTGACACTGTTCTGTGATTTGATCTCAACCCCAGTGAAAACTGTTCATGTAGTT TATAGCCCCCACTCCCGGCAGTTACAGGCTGCCAAGCCCTCCCTGCATGGCTCCCCCTGC CTCACGCCATGGCTTCCACCCCAAGCACTCTAGCCTCACAGCCCCGGAGCTCTGATGACC ATCGTGGCCACTCGCTCCTGCTGTCCACTACCAGGAGGCCACAGTCTGGAGCACTTCAGC ACCTGGCCTCCCTTCCTCAGAGACAGGAATCCCCCAGTCTGGTCCCTAAACACACTGACT CACCTCCCTGCCCACCCTCAGCTTCCTCCCACGAGACCAGCCCTCTGACTTCATGGTCTT GGCTTCCAGCGTCCCTGTGGCTCTCCTTCTTCTCCTGTCCCGCCAGGAAGCTGGGTGGCC TCAAGCCTCTGCTTGCAAACAGTCTCCCCGCCCCCTGGCCTCCTGGTCCTTCCTCCCCAG CTGGATCCTAACGCGCACCTTGGACAGCGCCAAGCCCTTAGCTGCTCAGCACCTGCCCCG CAGGAGGAAACCCCATCACGAATGGGTTACACGGGGGTGGTCTCAGCGGCGCCCTTCGTG CCCTGCAAGTTAGAGACAGGGACAATTGTCTCCCTTCCCCAAGCCTCAGGGACCCTTCCC CAAGCTCCAACCCCATCTCCAGTTTGTTTTTTCTGTCTCTGTTTCTGTCTCTCTCTGTCT CAGCATATGACCCCGCTCCTTCTCATCCAGCCCCACCAAGGAACTTGAAGCTCCCCCTAG GAGTCTTGCCTACTCTAAGCCAGCCTCCCCTCTCAGGCTCCATCATTTTCCCTCCTCTCT CTTTTGGGGCTCTCTCCTGACAATCTACCCCTCCTTTTCCTTGTATATTCATCTTCCTCT TGATATACCAACTCCCTCTGCTAAGCGTCTCCACAGCCTCAACCCTCTTCTGTCTTTAAA CAATCCTGAGCCATGAAACAGCATTCTTACAAGCCTCCCTGAGCCTCCGTGCCCCCAGGG CCCCCAAAGTTCTCTTTCTTCTTCCTTTGGCATCAAATTCACGCACTGTCTCACCTTGGC ATGGCCATCCTCTCCTTAACTCCTCAGCTTGGTTTAGCTCTGACTACTCCACTGAAATTC CTCTCGGTGAGGTGGGCCATGACCCATCAATTCTGGCTTCCATGGCCAGTGCCAAGCCTC ATCTTCACACCCCCACTCCTTCCTCTGTTAAGCTTTCTCCAACCTCCTGAGGCACCAGTG TCTCCCAATCCCCTTCCTAGCTTACTAGAGACTCCTTCAGCTTCTCTGTTACAGAATCAA CCTTCTCTGCTGCTCCTTGGAAGGTGGGGATCCTCTGAGCAGACATCCTCTCTCCCCTGC CTTGTCTTCTCATTCCAAACACTCACCCTGGCAAACTGACCCATGTCTGGGACTTAATTG TCACGTTTTTGCTCCTAACTCCCAATGTCTAGCTCTAGCCCAGACCCTCCTACCGCCGCC GCCATCACCTCTGTCCATCTCCTGGACACCAGGAGCCAGGCAGGTTTCAGACTTGCTTCC TCGTAGGGGTTCTCTTGGTGAATGGTTCCACCAGTGCGCCCACATGAAGGCACCTGGAGG GGACATTTGTCTCTTGGTAGCCCGTCATATTTCCTTTTCCTCCAGAACATCTGCCTTGAG CTTGAGGAATTGTTCATTCATCCACTTAACAAATGCTCATTCATCTGGGCATGATTCTAG ACCCATGGTTCTTAACTTTGGTGGTATGTGGACGTGCCTTGAGAGATGGAAAGAATCCTG GTTCCTGAGTCCTGCCCCCGGAGATTCTGATTTAATTGCTCTGGGGCAAGTGCTACACAG TGAGATATTTACAAGCTCCTTGGGTAGCTTGAATGTGCAGCCGGTGTTGCCACTGTCCTG GGTGATGGGGGTACAGCTGTGAGCCAAGCAGGTGAAAATCCTGCTCTCTTAGAACTAAGA GTCGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGCGCTTGGATGAACAGGCAGTAAAT AAAAAAGTAAGACAAGAAAAATATCAGCTGGTGATAGCACAACTGAGAGGATGAAAGTTG GATGGTGCCAGAGTGGCCACTTCAGTGCTGTGAAAAGATAACAGGGAAGAATGCTGAGCC ATCGGGAAGGGGCTCTGGCCAGGGTTCCTGGCCTGTAGGGGCAGCCCTGAGCCCCGGGGC CATGTTGGGCCAGGCTCCTAGGACAGCTCTTTGTCTCTTCTCAGCCAAAGTCTACGTGGG TGTGAAACAGGAGATCGCCGAGATGCGGATACCTGCCCTCAACGCCTACATGAAGGTACC AGTGGGCCTTGCCACCTTGGCACGTGGAAGGGCATGCAGTATTGGTGGGGGAGCCCACGT ACCATCCCTGGGTATGGCTTTGGGAACTGGGGCTGGCTCTCTGGCTCTGATGGCCCCATC TTCAATCCCTAAAGGCCTGGTCTGGGGAGTAAAACAGGATGCGTCCTTAGGGTTCCAGAG ATAGGAGCAGGAGCAACGGAGAAGGTAAAAGAGCCACACTAGGAATTGACAAGTCTTCAT TTAATGCTCCAAGCCCCACAGGTGAATGTCTATGCCAGGAGTTAAAATACAAAGGTGAAT TCCATCCAGTGTCTGCCCCCAAGGTACCCACTGTCCTATGGGAATGCCAACAGGTGGATC ATAAGATCACACGGAGACATATGTGTGCCTCCATCATGGGGGTGTGGCCAAGCAGGCCGC AGGTTGCTCATATAGCATCTTTGTGCAAACTAGAGTAGGCCTCCTCTGGGACAACTCACT CCCTTACGTGAACATGGGCTGGATTTTAGCTACACTCATGGGTCTTGGCTGGGGGCCCTT GTGTATTCTCCGACTTGCAAACTCTGCATCTCTATGAGATGGGAGCGTAGAGGAAGGAGC ATCTTAAAGGCAGAGGCCAAGGTGGTCAGGAAAGGACTTCCACCAGCCACAGCCATCCAG GAAAGGGGCAGTGTTCCTCATGAGGTGGCAGTGAGTGCACCGTCGCTAGAGACCTGATAG TGACCTCAGGAAGCTGGCAAGCGAAGCCCTCCTCCCAGCCCAGCGGCATCCTCACAGCTG GAGAGCGCTGGGCTAGGATCCTTTAGTCTTGACTCTGACACTGACTGGCTGGGTGATTTG GGGTGAGTTGCCCATCCTCTCTAGGCCTTGGTTTTCACACTTGTGAAATGGGGCAGTGCC CTCTAGTATCACAGGAGTGAAGTTGGGATCTGTCGAGAACAGGATGAGAAAGTGCTTTGT AAACTGTGAACCTGCTTCCAGAATGTGAGAGATCTTGACTCCTGATGGAGGGAAGGAGCA GATGGAGGGCAGAGGAGGTGGGAGGAAGGAGGAGAGAGCAGGTAGCTGCAGGAATCCTGG GCTCTGAGCAGGGAAGAGGGAGGGAGGGGAGCTGGGTGGGCTCCAGCTGCTCCTTCAGGG TGGCTGAGGCTCCACCCTTCTCCCCCTGGGCTAGAATAGGGGAGTGGGCTGTGAAGGGAG GGAGGGAGGGAAGGAGGAAGAGAAGGCAGGAGGCGAGGCTGGGGAACTGGGGCTCCTCAT TCCACACCTGGTCTTAGCAACCAGCAGCCCAGAGGATCCATCTCTGCCTCTTTGTGTCCA ATTGGGTTCCTGGAAGCCAGAGATCATTCAGGGCAGGAATCTCTGCCATGGCCACCCCAT CCTGTGCTTGCATACCCTCAGAGATGGGGAGCTCACTACCACTCCGCCCTGACCCAGGCT GCCTGTCCCATTGTTGGGCAGCTATGAGAAAAGCCCAACTCTCTGTAAGTCCTACCCACT GGTCTCACCCCGCCCTCATGAAGAATGTGAATCACATGATAATGACAACTGCCTGGAACT GCGTGAAGAGCTTTGACTGGCAACCAGGAGACTCTTGATACACGTTTATTGATAAATGAA TAATCTTATTTAATCCCCTCAATAACTTGTGAGTTAAGTGTGACAGAGCAGTTAGGTAGG TGGGATGAGATTTGAATTCACATCTCTGTGACTCCAGGGTTTGAGCTCTTACCCACTGTG CCTCGTTGTAATGAAAATCACAGTAACAATGATGACATCTAACTTTGATGGGCACCTGGT ATATGCCTGGTGTTGTTCTAAGGATTCTGCATGTATTTACTCATTTAATTCTCACACAAT CCCACGAGGGAGAGGCTATTATTGTCCCCATTTTATTAATGACCATCTGGAGCCAGGTTT GCCCAAAGCCACCCAGCTGGTGACAGGCAGAGCTGGGATTCGATCCCAGGAGCCCCTGGC TCCTTAAACACCTCCCAGGCTGTCCCCATATGACAGCCTTTTCCGGGCTCTGCATCCCCA GTTCCTCTCGGACAAAGTTCCCCGACCCCACCTCATCCTGCTGCCCCCATGGGATCCTCT GCAGGGCTCTGGGTGCCTCTGGAGCCTCAGCACCCAAAGCCAACCCTCAGTGTCCCCAGA CCTGTGCGCTTGGAGTTTGGTGAGATGACCCCGCCAGGCTCTGGGTGCTCGCGTCCTCAC AGCTTCAAAGTCTTTGCATCGTGGTGGGTGTAACCAGCTTGGATGAAACAAGGACACTAG GGCTCAAGTCCGGGCCCTGTCACTTAGCTCGGCTCCTCTGGGCCAGGTACTTTCCCTCTC CAAGCATCAGTTTCCTCAACTATGATATGAGATAAAGTATCAGGAAGCATTTTGTAGGCT ATAATGCCACCAACTGTTGTTAATTTGGGTTATTTTGGGAGCCCCCCACCCCCGCCAACT GTTGTCTCACCTTAAGCTTTGGGTAGCCTTTAGTGGCAGATGGCTCTGGGTGCCCCAGCT CTGTCCCTTGCTAGGCTTTGTGGCCTTGAGCATATCCCTTCACCTCTCTGATCCTAACTC AAGGGATGTCATGAGATGGAGCAAGGGCGCGCATGTGATACCCACCTGGTAAAGTCACCG CCGGGTCATGTTAGTTGTCATCACCATTACTGCTGTTTCTGGAGAACTTTAAGTCTTTTC CAAATGGACTCTTCTCAAGCCCCTGGTCCCTCTCCTGACCTTGGACCCAGGAGCAGAGCT TGTGAAGTGTTACCTTCAGCATGCTGAGTTTTCTTATTCTTTTAAACAACGCATTTCTGT TATCAGGCATCATGCATTAGTAAAGAGAGGAGGGCTGATGTCAGGGCTCGGGGACGGGAC ATCTAGGCTGGGGTGTCCAGATCTTTCTGCTGACTACCCCACCGGTTCTGCTGTCTCACC CACACAGAGCCTGCTCAGCCTGCCGGTCTGGGTGCTGATGGATGAGGACGTCCGGATCTT CTTTTACCAGTCGCCCTATGACTCAGAGCAGGTGCCCCAGGCACTCCGCCGGCTCCGCCC GCGCACCCGGAAAGTGTAAGTGACCAGCCCCTGGGCTTCCACATGGCCAGAGCCCTGGGT CCCTGCTGGAAAAGCATCTCTTTTCCCTGAAAGGAGAGAAGGAAAATACAGATCAGCCAT ATCCCTGGACACTCCAGGATGATTTGATTTATTAGATGGGTTTAGAAAGTCATGTTCAGG CTTGGAGGGACAGAGGGTGTGTGCCTTTCAATGTGATAATAAGGATTGGAAGACGAGGAC TGGGATATTGACTCCAGAGAGTTTGGTGCCACAGCAACTACTGGGGATAGCCCAGAAGCT CTGGGTGCCTGGAAAGAATTGGGGGCAGAGAGGAGGGAAAAGCTGCCCCATCCACAAACA TTCTCTGAGCATCTCTGGGAATGCCTTCTCCCTGGTGTGTTGGAGCTCCATGGGGCCAGC TATGGCTCTAGTTGTATCATGCTGGCCTCCAGAGCACACTGTTCCTCCCTTATTCCAAAA AGCCCATCCTTCCCACCAAAAATTCAAGCCACTCGTAGACTGCTGGGCTTCCAAAGCCCA GGTTGCTGCTACTAAGAATTCTGGGAAAAGCAGGACGGAGCTCCTGAGCTCCCCACCAGC TCCTCCCTCTGCTTCCTCCCACCAATGTCTCCAAGGGTCCTCTCCATGCCTGGCATCTCC CCTGTGCACACAGGCAGGTGTGTCTTAATTCCAGCTGTGCCATGTGGCAGCCGCAGGCCC CAGAGCAAGGCACTTCACCTCTCCAACCTTCAGTTTCCCTCAGCTGAAAAATTAGAAACA GTCACATTTACATCAGAGCTTGGTTGTAGGGAGCAGAGGAACAAACACATCTGAACACTT TGGCAAGTGAAAGGCACCGAATGAGCGTGTATCCCCTTCCCCACCTGCTTTCTGAGCCTG GCTTCCTGGTCCATAAAGAAGGGAGAACAATCCCACCTCCAAAGAGGTTGTGAGGATTTG GGGACAAGTGTGCCCGCCCAGAGGAGCAATTGCAGCCACATTTCAGCATCTTCTGTCTCC TCTGCCTTCCCTGCTCCTTGCAAGGGGCTCCTCTGGACACAGGAGCAGGAAGCTGGGCCC TGAGAGAATCACAGGGCTAACAAGCCCCTCTTCTCTCTCCACAGCAAGAGCGTGTCCCCA CAGGGCAACAGCGTTGACCGCATGGCAGCTCCGAGAGCAGAGGTAACCCCCGCCCCCACG CTGGCCAGGCTCTCACACTGTGGGCATCTGCCTTGGCCCACCTGCCAGCCACTGGGCCTC TCCTGCTGGGTGCTGCTGTGTGCCTGGGACAGTGCTGGGCACCAGGAGGAAGGAAGGGGT TACAGCCTCAGCCTCTGCCACTGGGGGTCCCCCGAGCCCAGCTAAGGGGAGGGCATGTGA CCAGCGTGCGGAGCCAGAGGAGAATGCTTCCATCCCTACGCTCATCCGGACAGTTTACCT GGGCCTCCTCTGAGTCAGCCCTGCCTTAGGCATGGAAGCTGCAGAGATGACTCAGACAAG GCCCAGCCCACGATGAAGCCTGGGGACCAGGGTGGGTGCTCAGCCCAGAGAGTTCGAACC CTTCCCTGTGTGCTCACCCCCACCAGGTTTGGAAGGAGCACCCATCCTGGAGTCAGGGAG ACCTGGGTTCAATTCCCAGCTCCTCCACTAAAAAATGGGGTGGCCTCAGAGAAGTCGCTT ATTCTCCCCAAGCCTCAGTTTCTACATCTGTAAAATGGGAGACTAAAGTATGTAAGGCAC TTCTATAGGAACTCAGTGAGTGTTCTCTCCTTCCCTCCTTACTGCACGCTTCTCCTCAGG CTCTATTTGACTTCACTGGAAACAGCAAACTGGAGCTGAATTTCAAAGCTGGAGATGTGA TCTTCCTCCTCAGTCGGATCAACAAAGACTGGCTGGAGGTGAGTTCAGAAGTGAGGATGG AGGTGAGATTGAAGGTGAGGTTGGAGGGAAATTAAAAGTGAAGATAGAGGTGAGGGTGGA AGTGCAATTGGAGGTGAGGATGAAGGTGAGGGTGGAGGTGAGATTGGAGGTGAGGATGGA GGTAAGAGTGGAGGTGAGGATGGAGGTGAGATTGGAGGTGAGGATGAAGGTGAGATTGGA GGTGAGGGTGGAGGTAAGAGTGGAGATGAGATTGGAGGTGAGGATGGAGGTGAGATTGGA GGTAAGGTTGGAGGTGAGATTGGAGGTGAGGTTGGAGGTGAGATTGGAGATGAGATTGGA GGTGAGGATGGAGGTGAGGGTGGAGATGAGGGTGAAGGTGAGGATGGAGATTGAGGGTGG AGATGAGGGTGAAGGTGAGGATGGAGGTAAGGGTGGACGTGAGGATGGGGGTGAGACTGG CAGTAAGGTTGGAGGTGAGGATGGAGGTGAGATTGGAGGTGAGGGTGGAGGTGAGACTGG AGGTGAGGATGGAGGTGAGATTGGAGGTGAGATTGGAGGTGAGGGTGGAGGTAAGGGTGG AGGCGAGAGTGGAGGTGAGGATGGAGGTGAGACTGGAGGTGAGATTGGAGGTGAGGATGG AGGTGAGATTGGAGGTAAGGTTGGAGGTGAGGATGGAGGTGAGATTGGAGGTGAGGATGG AGGTGAGCGTGGAGGTGAGATTGGAGGTAAGATTAGAGGTGAAGATAGAAATGAGAATGG AAGTGGGATTGGAGGTGAGTTTAGAGGTAAAGATGGAGGTGAGGATAGAGGTGAGGAAGG TGAGTTTGCAGGTAAGGATGGAGGTAAGATTAGAGGTGAGGATGGGGGTGAGTTTGGAGT TGAGGATGAAGGTGAGGTTGGAAGTGAGGTTAGAGATGAGGTTGGAGATGAGGTTGGGAA TAAGGATGGAGGTGAGGTTGGAGGTGAGGATGGAGGTGAGAATGCAGGTAAGGTTAGGCT GAGATTAGAGGTGAGGCTGGAGGTGAGGTTGCTTCAGGCATTGTATGCTTCAGAGACTGA GGATGGTCTCAGAAGGCCTCAGGGAAGAGATGCTATCTGAGGATAGCCCTGGAGATCCAG GCAGGTTGGGGAGCCTGCGGGAACAAAGCCTTTGGGGAGGCAGGTGTTCGGTGGCAGCAG AACATTCTTGGAGCTCATGCTTTGGTTCTGACCCTGAAAAATGGGTTGCTTAGGGCAAGT AAGTTAACCTACTGAGTTTAGTTTCTTGGTCTGTAATGGGTGTCTCAGCAGGGGCACTAT TGACATTGGGGCCAGATGGTCCCTTGTGGGGTTGTCCTGAGCATTGCAGGCTGTTCAGCA ATATCCCTGGCCTCTCCACTAGATGCCAGCAGCACTGCTAAATTGCACCAATCACATGGC TCTCCAGATATTTGCTCCTGAGGGGTGAAATCGCAACCACTTGTGTAATATGGGACAACA GTACATACCTTGCCCACAGCAGTAAAAGCTGCTGATGAAGAGTGTGAACTCAGAGTCAGC CTGTTTGGGCCATTTCCTAGCTCTGTTTTTCACTAGCTTTGTGGACCTTTGGAAACTTGC TCAAACTTGCGGTTTCCTTTTCTGTAAATGTTTCTTCATCGGCTTCCTGGAAAGGGTAAA GGAGGTGGTAGATGGCCAGGGCTCGCCCCAGAGCCTGGGTGTGCGGCGCCTGGCCAGGTA CTAGGGTCATTAGGAGACTTAAATGAAACTTCAAAGCCAGGGACTTTCCCAGTCACTGCT TTGTCCCTGTGTGGCCCACAGAAGGGCTGTGTTCTGACTCAGTGAGTGGAGGTGGGAAGT GGCTGTGTTGGGCCTTGGCCTGGGACCAGCCTTTTGTATTAGGTCCTGTCTTCAGACTTA GTGCTCCTGTGGGGAGTGTTGAAGGAGGTTCTGGGACAGGCCCAGAGGCAGGGTCAGCCC CCAGGGGTCCCAGGACCTTTAAGAGTTGGGTTGGGTCCCTAGCGTCCAGGCCCTGGAGAG GAGCTAGTAGTGACCACTGGTTTAGCCAGTTTAGCAGTTTCCATTTTACCCTAATCATAG ATCTCCATCTCAGGAACTCAGGGCTCTTACAGAGGCCTGAGGAGTATCTCTGGGCCACTT TCCAGAAATAGAAAACATGTATTGCCTTCCTGTTTTCCGGAAAGTCCTACTTATCAGTAT GCTGGCTAACTTCTGGCCTCAGGTTGAAGGTGGGGGCAGAGGGGCAGGGAGGGGACCACT TTGAGCCTTGGTTAATATGTTTGTAAAATGGCATGTAAATAATCCATGTTCCATAGGGTC GTTGTGAAGATGAACAGAACACGTGCCCAAAGCCCAGGCCATGGCCGGGTCTGGGTCTGA TTTCTGGCTACTTGGTCTAGAGTAGAGGCACAGTTGTATCTGATGAATGAATGAGTGAGT GAGCGGGATCAGCAGCAGGCCCTTCCTCACCCCTCATCCTCTTCCTCCCCTGTTCTATTT TCCTCTGTAACACCTGCTGCCATCTGACTCACTGGATAGGTCATTGTTCACAGCGCGCAC AGCGTGTCATTCCCCATCATACTGGAAACTCCGTGGGGGCAAGGACTTATTATTATTTTT TTATTATTATTTTTTCTTTGAGACAGAGTTTCACTCTGGTTGCCCAGGCTGGAGTGCAAT GGCGTGATCTCGGCTCACTGCAACCTCCACCTGCCAGGTTCAAGTGATTCTCCTGCTTCC GCCTCCCGAGTAGCTGGGATTACAGGCCCGCACCAACACGCTTGGCTAATTTGTATATGT TTAGTAGAGACAGGGTTTCACCAAGTTGGCCAGGCTGGTCTCGAACTACTGATCTCAAGT GATTCACCAGCTTCGGCCTCCCAAAGTGCTAGGATTACAGGTGTGAGCTACTGCGCCCGG CCCAAGGACTTTTATCTATTTTGAGAGCCCAGAGCCTGTCACGTGGCTGGTTCTCAAGAA GCCTTTGTTGAATGAATAAGTGAATGAGTGAGATAAAAGCAGCTTTCTATATAAATCCAG ATTCTGGCATATTGTAAAACCCAAATATAAGCCTTCTTAGAAGTGACCAGCTCAGCGAAC TTCCTCGCTTTCCCTCCTCCCTCTACAGAAGAAGACCCGGACCTCATCTGCCTTTCCCCA TCACTAGAACGGGGCTGAGGGCTCTGAGGCGTGGCTCTGCTGCCTCTCCTCTCACCAGCA TGGCATCCCTTCTCTTCCTCTGCAGGGCACTGTCCGGGGAGCCACGGGCATCTTCCCTCT CTCCTTCGTGAAGATCCTCAAAGACTTCCCTGAGGAGGACGACCCCACCAACTGGCTGCG TTGCTACTACTACGAAGACACCATCAGCACCATCAAGTCTGTGGCCTGGGAGGGAGGGGC CTGTCCAGCCTTCCTGCCATCCCTACGACCACTGCCCCTCACATCACCTTCTCATGGGTC CCTCTCCCACTCCAAAGCCCCCAGTGGCTCCCAGATGAGCCACAATGCTGTAACAAGCCA TCAACGTCCAGGGTGGCCTGGCCAGCCTCATTCCCCTTTCCCCCACCCCACACCCCACTT CCAGCCTGATGCCTCCTTACTCCAGCCTGTCACCCCCTTAGGGACATCGCGGTGGAGGAA GATCTCAGCAGCACTCCCCTATTGAAAGACCTGCTGGAGCTCACAAGGTGAGGGGCTGGG AATGGGGCTGGGGAGTTAGATACTCTGGAGAAGAGAGCGCAGGGAGAAATGTTAAGCACT AGTATTAAGGTGCTGGGGTTTTGCGTGTACTTTGTCTTCTCTTTTTATCCGCAGCCCAGC CCTGCAGGTTAGGCAGCATCTCCCCACTTTAGAGATGAGCGGGGAAGCTGCAGAGAGGTT AGGGGAACTGGTTGAGCTCACGCAGGTTGTGGGTTTAGATCCGGATCTGCAGCTGGAGCT AAAGTCTCTCTGGCTAAAAGCCTTGGACTTGAACCATCCACTCTCAGGGACTCACTACCC CCCCAGGTCCAGGACATTGCTGGACAGTTATTTTACAGAATGGTAACCGCATTGCTACAT TTCTGACTATAAAACTTGTACCAACTCATTATATATTAAAAAAGAAATGTCAGTAACCAT GTCAGAAAGATACAAAGAAGTGAAATCACCTCATATTTTTACTCCCCTCGTTATGTGACG TACACTCAGATTTCTTCAGTACTTACACCCCACACACACATGCACACACAAAAGTCACTT TGGCTGCACAAAACCTTTCAGTGGCTACATCATTAACATGGCCATGCGCTTTTGCTGGCC TCTTAGGATTTCTTCTGCTTTTTTACTACTCTAAACAACATTGTACAGACCATCTTAGTT AACCTATTTGATGACTTATCTGATCATTTCCTTTGAATGATTTTCAAGAAGTGGATTTGG GGATTAAAGCATTTGCAAGTCTCATAGGCTTCTGGCCCACACTGTGAAATTACTGGTAGA AAGCTCAGATCAATTTCTACGTACACCAGCCAAGTAGAAGGATGCGCATCTTCCCGCACC CAGGCCAGACAGTTCCTGTCCTTACAAGGTTCTCCTCAATAGCCTCACACAGGTGTCTCT CTGAGGCTTTATACAGCCCCACTCTGTGCCCAGTCAAACCCACTCTTCTTCACAACTCTT AATCCTTTAGCACATTTATACACGAGACATTTCAGGCTGTGCCACTAATTTCCGTGAAAG TCTCTTCTCCTTCTCCTTTTTTTTTTTGAGATGGAGTCTCACTCTGTTGCCCAGGCTGGA GTGCAGTGGTGCAATCTCAGCTCACTGCAACCTCTGCCTACTGTGTTCAAGTGATTCTCC TGCCTCAGCCTCCTGAGTGGCTGGGATCACAGGTGCATACTACCTCGCCCAGCTAATTTT TGTATTTTTAGTAGAGACAGGGTTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTAAC CTCAGGTAATCTGCCTGCCTCGGCCTCCCAAAATGCTGGAATTATAAGCGTGAGCCACCG CACCCAGCCTCTTCTCCCTTTTAGGCCTCGATATCCCCATCTGTACAATGGGAGGTTAGA TTACTTGGATGACACGGGCTTGTATCAGGCTCTGACTTTTTCTTACTCCTGGCTTCAGGA CATAAAACCCTTTTCACCCCCTCTCCCTACCCCTACCTTACGCTTAGGCCCTTTGATTAT CCCTGACTTTTCCCATGCAGGCGGGAGTTCCAGAGAGAGGACATAGCTCTGAATTACCGG GACGCTGAGGGGGATCTGGTTCGGCTGCTGTCGGATGAGGACGTAGCGCTCATGGTGCGG CAGGCTCGTGGCCTCCCCTCCCAGAAGCGCCTCTTCCCCTGGAAGCTGCACATCACGCAG AAGGACAACTACAGGGTCTACAACACGATGCCATGAGCTGACGGTGTCCCTGGAGCAGTG AGGGGACACCAGCAAAAACCTTCAGCTCTCAGAGGAGATTGGGACCAGGAAAACCTGGGA GGATGGGCAGACTTCCTGTCTTTGAGGCTAATGGACCCGTGGGGCTTGTAATCTGTCTCT TTCTACTATTTACATCTGATTTAAATAAACCATTCCATCTGAAAGGGGCA OMIM ID 601488