| Entrez gene ID | | 468 |
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| Official gene symbol | | ATF4 |
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| Full name | | activating transcription factor 4 (tax-responsive enhancer element B67) |
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| Aliases | | ,CREB-2,CREB2,TAXREB67,TXREB, |
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| Gene summary | | This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromsome at q28 in a region containing a large inverted duplication. [provided by RefSeq] |
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| Location | | Chromosome: 22 Locus: 22q13.1 |
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| Gene position | | 39916569 - 39918691 Map Viewer |
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| Gene orientation | | plus |
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| Gene size | | 2123 bp |
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| Gene sequence |
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| OMIM ID | | 604064 |
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