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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for MAP3K5 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID4217
Official gene symbolMAP3K5
Full namemitogen-activated protein kinase kinase kinase 5
Aliases,ASK1,MAPKKK5,MEKK5,
Gene summaryMitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not activate MAPK/ERK. [provided by RefSeq]
LocationChromosome: 6   Locus: 6q22.33
Gene position137113656 - 136878187  Map Viewer
Gene orientationminus
Gene size235470 bp
Gene sequence
OMIM ID602448