| Entrez gene ID | | 4145 |
| Official gene symbol | | MATK |
| Full name | | megakaryocyte-associated tyrosine kinase |
| Aliases | | ,CHK,CTK,DKFZp434N1212,HHYLTK,HYL,HYLTK,Lsk,MGC1708,MGC2101, |
| Gene summary | | The protein encoded by this gene has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer. Three alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq] |
| Location | | Chromosome: 19 Locus: 19p13.3 |
| Gene position | | 3801810 - 3777967 Map Viewer |
| Gene orientation | | minus |
| Gene size | | 23844 bp |
| Gene sequence |
| |
| OMIM ID | | 600038 |
|