| Entrez gene ID | | 4040 |
| Official gene symbol | | LRP6 |
| Full name | | low density lipoprotein receptor-related protein 6 |
| Aliases | | ,ADCAD2,FLJ90062,FLJ90421, |
| Gene summary | | This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined. |
| Location | | Chromosome: 12 Locus: 12p13.3-p11.2 |
| Gene position | | 12419811 - 12268959 Map Viewer |
| Gene orientation | | minus |
| Gene size | | 150853 bp |
| Gene sequence |
| |
| OMIM ID | | 603507 |