| Entrez gene ID | | 3683 |
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| Official gene symbol | | ITGAL |
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| Full name | | integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) |
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| Aliases | | ,CD11A,LFA-1,LFA1A, |
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| Gene summary | | ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] |
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| Location | | Chromosome: 16 Locus: 16p11.2 |
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| Gene position | | 30483983 - 30534506 Map Viewer |
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| Gene orientation | | plus |
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| Gene size | | 50524 bp |
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| Gene sequence |
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| OMIM ID | | 153370 |
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