| Entrez gene ID | | 361628 |
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| Official gene symbol | | Eif4g2 |
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| Full name | | eukaryotic translation initiation factor 4, gamma 2 |
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| Aliases | | - |
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| Gene summary | | Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F (eIF4F), which is a cap binding protein complex that consists of three subunits: eIF4A, eIF4E and eIF4G. The protein encoded by this gene shares similarity with the C-terminal region of eIF4G that contains the binding sites for eIF4A and eIF3; eIF4G, in addition, contains a binding site for eIF4E at the N-terminus. Unlike eIF4G, which supports cap-dependent and independent translation, this gene product functions as a general repressor of translation by forming translationally inactive complexes. In vitro and in vivo studies in human indicate that translation of this mRNA initiates exclusively at a non-AUG (GUG) codon. This also appears to be true for mouse and rat. [provided by RefSeq] |
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| Location | | Chromosome: 1 Locus: 1q33 |
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| Gene position | | 168829098 - 168841604 Map Viewer |
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| Gene orientation | | minus |
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| Gene size | | 12507 bp |
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| Gene sequence |
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