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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for IL10 (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 3586 Official gene symbol IL10 Full name interleukin 10 Aliases ,CSIF,IL-10,IL10A,MGC126450,MGC126451,TGIF, Gene summary The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. [provided by RefSeq] Location Chromosome: 1   Locus: 1q31-q32 Gene position 206945839 - 206940948  Map Viewer Gene orientation minus Gene size 4892 bp Gene sequence >IL10:complement(458727..463618):Length=4892 ACACATCAGGGGCTTGCTCTTGCAAAACCAAACCACAAGACAGACTTGCAAAAGAAGGCA TGCACAGCTCAGCACTGCTCTGTTGCCTGGTCCTCCTGACTGGGGTGAGGGCCAGCCCAG GCCAGGGCACCCAGTCTGAGAACAGCTGCACCCACTTCCCAGGCAACCTGCCTAACATGC TTCGAGATCTCCGAGATGCCTTCAGCAGAGTGAAGACTTTCTTTGTGAGTATGATTCCTT CCTGTCCTTTCTCTCTTCCTGGGACTGCCTGAACTAGACATTCTCCTGGAACTATAAGAA CCCTCCTCCTGCGCCTCCACCTCCATCCCCAACACCTATTCCCCCAAACTTAAATTCTTA AGAGAATCCTAGATCAAGCCATGGGTTTGGTGAGTTAAGCTAAGCCAGATGATACAGTAA ATGTGCAGGAAACCTGCCTTATAAAGTAAATGCGTTCTCTCTCGTGCTGAGAAACTTATA AGATCCTGCTGGCGCTCTATACTTTATTGGCTAGGAGAAGTAAAGAAATGTCTGATTCGA GGTGAAGATGCTCCCCATGCCTTGCAGCAGGGAAATTTAAATTGCCTCTGCTTAGAGCGT TTCCAGACCTGAAAGACCAGTGGTTTAGGGAAGCACTCTACATGAGGGAAACCTGCATTA GAAGGAGCTTCTTAATCCCTGGGATCTTTCCAAGCTAAACTGGATGTCTACAGTGGGGAG AAAGAAAAGCAGAGAACAGGACATGAGGGGGGCTCAAGGCCCCGAAGGGTTGACATAGGT GTCCCTTAAAGCCGAATGTAGCTCCGCAGAAAGAAGACCAGGACTGAGTCAAGCTTCTGC TTTCCCTTCAAAATCGGCCAGATTTTTTAAATAACTTGACTCTGAGGAGGAGGACCTGAT TTAAGTGATGGTCCCATCACTGTTGAATCCTCTGTTTTTAAAACTCCCCTTTTGATTTTT TTGGGCCAGAGCCAATTTTATTTAAAAAAAAAAATCTCTAAATGAAAGGGCATCAAAAAG ACCGCATTTCAGTTATTTCCCCAAACCTCAAGTTCATTCTCCTTTTGTTCTTCCTGCAGC AAATGAAGGATCAGCTGGACAACTTGTTGTTAAAGGAGTCCTTGCTGGAGGACTTTAAGG TGAGAGCAGGGGCGGGGTGCTGGGGGAGTGTGCAGCATGATTAAGGGAAGGGAGACTCTG CTTCCTGATTGCAGGGAATTGGGTTTGTTTCCTTCGCTTTGAAAAGGAGAAGTGGGAAGA TGTTAACTCAGCACATCCAGCAGCCAGAGGGTTTACAAAGGGCTCAGTCCCTTCGGGGAG GCTTCTGGTGAAGGAGGATCGCTAGAACCAAGCTGTCCTCTTAAGCTAGTTGCAGCAGCC CCTCCTCCCAGCCACCTCCGCCAATCTCTCACTCACCTTTGGCTCCTGCCCTTAGGGTTA CCTGGGTTGCCAAGCCTTGTCTGAGATGATCCAGTTTTACCTGGAGGAGGTGATGCCCCA AGCTGAGAACCAAGACCCAGACATCAAGGCGCATGTGAACTCCCTGGGGGAGAACCTGAA GACCCTCAGGCTGAGGCTACGGCGCTGTGTAAGTAGCAGATCAGTTTTTTCCCTTGCAGC TGCCCCCAAAATACCATCTCCTACAGACCAGCAGGGACACTCACATCCACAGACACAGCA AAGACACAGACTGGCAGAGCTAGCTGTAAATGAGGAAAGACTCCTGGAGTCAGATCTCTT GCTCATTTCTCTTTGAGCAGGCGTTGGGGGTGGCTGCTAGGCATTTACATGTGAAATTTG CAAACAGCTTTCCTGTTATTTGTGAGTCATTTGTGGGTTATTAACTACTCCCCTCTCTCT TCATAAAAGGAGCCCAGAGCTTCAGTCAGGCCTCCACTGCCTCTTTGTAACTAGACCCTG GGCGGGGAGCTAAGGTTCCCAAGCAGAGGAAACATCATTCACCTCTTTTAATCTCAATGT TTTGAAAGCAAAGCTCTAAGAAGGGCCCAATTGACTGACAGGATTTCCCCTGGCATTTTA GAAGGGACAAGGGGGCTATTCATCCCCAGGCTAGTGTCTATGAGTAATTCCTCCAGGTAA TTTATTTCTCCAACTGAAATGATGCCCTCACTACTAATGGTTTCCCCTGTTCTGTCACCA ATATTGGAAAATCAGTTGGTGTCTATTTGTAGGACAAGGCTATGTGAAGGGTTTGGTCCC AGTAGCTTCCCTCCTCAGATGCTTAGAAGTGTTCCTCGGTGGCTGTGACTGACGGGGAGG AACAGGAGAGAGAGGCAGAAAAGGACAGGCTGAAGAATGCCTCGCTCAGCACTGCAGGAG ATACTGTAGAGTTCTGGGGGAGGAAGGAATCCCAAGACCTGGGTTGTCATCCAAGCCTTG CAAACATCTTGGAGTGAGTCCTGGAGAAATACATTTAACTCCCAGGGCCATGGAAGCAGG GCTCAGTTCTCTCTGGGAGCTGTGAGGCAAGGCATTTGGATAAATCTGGCCTCCTCATGA TGCCACCAGCTTGTCCCCTAAGTGTGATGGACATGGAGCTGGAAGCCAGGATCACCAACA CTTTCTCTTTTCTTCCACAGCATCGATTTCTTCCCTGTGAAAACAAGAGCAAGGCCGTGG AGCAGGTGAAGAATGCCTTTAATAAGGTGAGCTTGGATGGTGGCAGAGAGGGTCTGCAGA GCACAACCCATGCCCACTCCCCAACCCCAAAGCATGGAAGGTGGTGGGGACTCAATAGGC CCCATTCTTCATTGGAGAGAGTGTGGGAACCTGACAGATGGTATGACCTGCTCAGCCAGT GAGGAGCTGCTGCCTTGATTGTATTTGTTTTCTGTTAAGTGTCTTTGGGGGTTTCTAAAT GACTGCTCGCTGCCTTTGCAGGCTTGCGGGTTAGGCTGGCCGGCCAGCCTGTGAACACAG TGAGCTGCATGCTGGGGAGAGTGACAAAGGAAACAGAAAGTACAGAAAGTAGCTTGTTGG GAATCTAGGCTGAACCCACACGTGCAGGAAGCTGGCACATAAATGTGCACATACAAATAC ACCTGGGGGTTCAGCCCAGACTCCCCAGAACTCAGAATGAGCAGGAAGCTGGATTCTCAC TTAACCTGGAGTTGGTTCAAGCCCGCTTTCCATCTGCCCTTCGCACCTGCGGAGGTGCCT GAGAATGTCAGTTCCCAAACGAAATGGGGTTTCACACTTCCAACTGTGCGTGAACTTTTT CAGTCTGATTTCCCAGAAACCGTGCGGCCTATGTCCTCCTCGTGGGCTGGGGACAGACAC TGCACAGAGTGCCAACATCAGGGGGTGTGAATTTCTCATAGTAGGTCAGGGCGGCAGGGC AGGGCCTGCTCAGTGTGTTGGTGGGAGAACACAGACATTTAAAAGGCTCCCTCCTCTCCT CTCACCGTCTTGCTTTCGAAGCGCTTCCTCTAATGTCTTTTCATCAAACTCTGCATAATC ATCATGTGAATACGTGACCTTTAAAATTGTTGAAAAGGCATCATTTTGAAGACAGTGCTT TGCAAAATGAATGCTCCCCTTGCTAGGGGGAGGCCTGGAGGAGATGAAGGTCAATGCACA GCCTTTCCCAAGGCAGCTAGGCCTATCCTCTGGTTTACTTCCCAGCGTGAGGGAGAACAA GCAACCTCTGCACTCAAGGTCATGCCCATCCATGAGCATGAGGGAGGGGAGCCTATTTAG TCCCCAGAAAGGATTTTAACTGTATGTTTCTTATCTCTCTGCACAGCTCCAAGAGAAAGG CATCTACAAAGCCATGAGTGAGTTTGACATCTTCATCAACTACATAGAAGCCTACATGAC AATGAAGATACGAAACTGAGACATCAGGGTGGCGACTCTATAGACTCTAGGACATAAATT AGAGGTCTCCAAAATCGGATCTGGGGCTCTGGGATAGCTGACCCAGCCCCTTGAGAAACC TTATTGTACCTCTCTTATAGAATATTTATTACCTCTGATACCTCAACCCCCATTTCTATT TATTTACTGAGCTTCTCTGTGAACGATTTAGAAAGAAGCCCAATATTATAATTTTTTTCA ATATTTATTATTTTCACCTGTTTTTAAGCTGTTTCCATAGGGTGACACACTATGGTATTT GAGTGTTTTAAGATAAATTATAAGTTACATAAGGGAGGAAAAAAAATGTTCTTTGGGGAG CCAACAGAAGCTTCCATTCCAAGCCTGACCACGCTTTCTAGCTGTTGAGCTGTTTTCCCT GACCTCCCTCTAATTTATCTTGTCTCTGGGCTTGGGGCTTCCTAACTGCTACAAATACTC TTAGGAAGAGAAACCAGGGAGCCCCTTTGATGATTAATTCACCTTCCAGTGTCTCGGAGG GATTCCCCTAACCTCATTCCCCAACCACTTCATTCTTGAAAGCTGTGGCCAGCTTGTTAT TTATAACAACCTAAATTTGGTTCTAGGCCGGGCGCGGTGGCTCACGCCTGTAATCCCAGC ACTTTGGGAGGCTGAGGCGGGTGGATCACTTGAGGTCAGGAGTTCCTAACCAGCCTGGTC AACATGGTGAAACCCCGTCTCTACTAAAAATACAAAAATTAGCCGGGCATGGTGGCGCGC ACCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAAGAGAATTGCTTGAACCCAGGAGATG GAAGTTGCAGTGAGCTGATATCATGCCCCTGTACTCCAGCCTGGGTGACAGAGCAAGACT CTGTCTCAAAAAATAAAAATAAAAATAAATTTGGTTCTAATAGAACTCAGTTTTAACTAG AATTTATTCAATTCCTCTGGGAATGTTACATTGTTTGTCTGTCTTCATAGCAGATTTTAA TTTTGAATAAATAAATGTATCTTATTCACATC OMIM ID 124092