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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for IL1B (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 3553 Official gene symbol IL1B Full name interleukin 1, beta Aliases ,IL-1,IL1-BETA,IL1F2, Gene summary The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq] Location Chromosome: 2   Locus: 2q14 Gene position 113594356 - 113587337  Map Viewer Gene orientation minus Gene size 7020 bp Gene sequence >IL1B:complement(3336000..3343019):Length=7020 ACCAAACCTCTTCGAGGCACAAGGCACAACAGGCTGCTCTGGGATTCTCTTCAGCCAATC TTCATTGCTCAAGTATGACTTTAATCTTCCTTACAACTAGGTGCTAAGGGAGTCTCTCTG TCTCTCTGCCTCTTTGTGTGTATGCATATTCTCTCTCTCTCTCTCTTTCTTTCTCTGTCT CTCCCTCTCCTTCCCTCTCTGCCTCCCTCTCTCAGCTTTTTGCAAAAATGCCAGGTGTAA TATAATGCTTATGACTCGGGAAATATTCTGGGAATGGATACTGCTTATCTAACAGCTGAC ACCCTAAAGGTTAGTGTCAAAGCCTCTGCTCCAGCTCTCCTAGCCAATACATTGCTAGTT GGGGTTTGGTTTAGCAAATGCTTTTCTCTAGACCCAAAGGACTTCTCTTTCACACATTCA TTCATTTACTCAGAGATCATTTCTTTGCATGACTGCCATGCACTGGATGCTGAGAGAAAT CACACATGAACGTAGCCGTCATGGGGAAGTCACTCATTTTCTCCTTTTTACACAGGTGTC TGAAGCAGCCATGGCAGAAGTACCTGAGCTCGCCAGTGAAATGATGGCTTATTACAGGTC AGTGGAGACGCTGAGACCAGTAACATGAGCAGGTCTCCTCTTTCAAGAGTAGAGTGTTAT CTGTGCTTGGAGACCAGATTTTTCCCCTAAATTGCCTCTTTCAGTGGCAAACAGGGTGCC AAGTAAATCTGATTTAAAGACTACTTTCCCATTACAAGTCCCTCCAGCCTTGGGACCTGG AGGCTATCCAGATGTGTTGTTGCAAGGGCTTCCTGCAGAGGCAAATGGGGAGAAAAGACT CCAAGCCCACAATACAAGGAATCCCTTTGCAAAGTGTGGCTTGGAGGGAGAGGGAGAGCT CAGATTTTAGCTGACTCTGCTGGGCTAGAGGTTAGGCCTCAAGATCCAACAGGGAGCACC CAGGGTGCCCACCTGCCAGGCCTAGAATCTGCCTTCTGGACTGTTCTGCGCATATCACTG TGAAACTTGCCAGGTGTTTCAGGCAGCTTTGAGAGGCAGGCTGTTTGCAGTTTCTTATGA ACAGTCAAGTCTTGTACACAGGGAAGGAAAAATAAACCTGTTTAGAAGACATAATTGAGA CATGTCCCTGTTTTTATTACAGTGGCAATGAGGATGACTTGTTCTTTGAAGCTGATGGCC CTAAACAGATGAAGGTAAGACTATGGGTTTAACTCCCAACCCAAGGAAGGGCTCTAACAC AGGGAAAGCTCAAAGAAGGGAGTTCTGGGCCACTTTGATGCCATGGTATTTTGTTTTAGA AAGACTTTAACCTCTTCCAGTGAGACACAGGCTGCACCACTTGCTGACCTGGCCACTTGG TCATCATATCACCACAGTCACTCACTAACGTTGGTGGTGGTGGCCACACTTGGTGGTGAC AGGGGAGGAGTAGTGATAATGTTTCCCATTTCATAGTAGGAAGACAACCAAGTCTTCAAC ATAAATTTGATTATCCTTTTAAGAGATGGATTCAGCCTATGCCAATCACTTGAGTTAAAC TCTGAAACCAAGAGATGATCTTGAGAACTAACATATGTCTACCCCTTTTGAGTAGAATAG TTTTTTGCTACCTGGGGTGAAGCTTATAACAACAAGACATAGATGATATAAACAAAAAGA TGAATTGAGACTTGAAAGAAAACCATTCACTTGCTGTTTGACCTTGACAAGTCATTTTAC CCGCTTTGGACCTCATCTGAAAAATAAAGGGCTGAGCTGGATGATCTCTGAGATTCCAGC ATCCTGCAACCTCCAGTTCTGAAATATTTTCAGTTGTAGCTAAGGGCATTTGGGCAGCAA ATGGTCATTTTTCAGACTCATCCTTACAAAGAGCCATGTTATATTCCTGCTGTCCCTTCT GTTTTATATGATGCTCAGTAGCCTTCCTAGGTGGCCCAGCCATCAGCCTAGCTAGGTCAG TTGTGCAGGTTGGGAGGCAGCCACTTTTCTCTGGCTTTATTTTATTCCAGTTTGTGATAG CCTCCCCTAGCCTCATAATCCAGTCCTCAATCTTGTTAAAAACATATTTCTTTAGAAGTT TTAAGACTGGCATAACTTGTTGGCTGCAGCTGTGGGAGGAGCCCATTGGCTTGTCTGCCT GGCCTTTGCCCCCATTGCCTCTTCCAGCAGCTTGGCTCTGCTCCAGGCAGGAAATTCTCT CCTGCTCAACTTTCTTTTGTGCACTTACAGGTCTCTTTAACTGTCTTTCAAGCCTTTGAA CCATTATCATGCCTTAAGGCAACCTCAGTGAAGCCTTAATACGGAGCTTCTCTGAATAAG AGGAAAGTGGTAACATTTCACAAAAAGTACTCTCACAGGATTTGCAGAATGCCTATGAGA CAGTGTTATGAAAAAGGAAAAAAAAGAACAGTGTAGAAAAATTGAATACTTGCTGAGTGA GCATAGGTGAATGGAAAATGTTATGGTCATCTGCATGAAAAAGCAAATCATAGTGTGACA GCATTAGGGATACAAAAAGATATAGAGAAGGTATACATGTATGGTGTAGGTGGGGCATGT ACAAAAAAGATGAACAAAGTAGAAATGGGATTTATTCTAAAAGAATAGCCTGTAAGGTGT CAGAAAGCCCACATTCTAGTCTTGAGTCTGCCTCTAACCTGCTGTGTGCCCTTGAGTACA CACTTAACCTCCTTGAGCTTCAGAGAGGGATAATCTTTTTATTTTATTTTATTTTATTTT GTTTTGTTTTGTTTTGTTTTGTTTTATGAGACAGAGTCTCACTCTGTTGCCCAGGCTGGA GTGCAGTGGTACAATCTTGGCTTACTGCATCCTCCACCTCCTGAGTTCAAGCGATTCTCC TTCCTCAGTCTCCTGAATAGCTAGGATTACAGGTGCACCCCACCACACCCAGCTAATTTT TGTATTTTTAGTAGAGAAGGGGTTTCGCCATGTTGGCCAGGCTGGTTTTGAAGTCCTGAC CTAAATGATTCATCCACCTCGGCTTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCAC GCCTGGCCCAGAGAGGGATGATCTTTAGAAGCTCGGGATTCTTTCAAGCCCTTTCCTCCT CTCTGAGCTTTCTACTCTCTGATGTCAAAGCATGGTTCCTGGCAGGACCACCTCACCAGG CTCCCTCCCTCGCTCTCTCCGCAGTGCTCCTTCCAGGACCTGGACCTCTGCCCTCTGGAT GGCGGCATCCAGCTACGAATCTCCGACCACCACTACAGCAAGGGCTTCAGGCAGGCCGCG TCAGTTGTTGTGGCCATGGACAAGCTGAGGAAGATGCTGGTTCCCTGCCCACAGACCTTC CAGGAGAATGACCTGAGCACCTTCTTTCCCTTCATCTTTGAAGAAGGTAGTTAGCCAAGA GCAGGCAGTAGATCTCCACTTGTGTCCTCTTGGAAGTCATCAAGCCCCAGCCAACTCAAT TCCCCCAGAGCCAAAGCCCTTTAAAGGTAGAAGGCCCAGCGGGGAGACAAAACAAAGAAG GCTGGAAACCAAAGCAATCATCTCTTTAGTGGAAACTATTCTTAAAGAAGATCTTGATGG CTACTGACATTTGCAACTCCCTCACTCTTTCTCAGGGGCCTTTCACTTACATTGTCACCA GAGGTTCGTAACCTCCCTGTGGGCTAGTGTTATGACCATCACCATTTTACCTAAGTAGCT CTGTTGCTCGGCCACAGTGAGCAGTAATAGACCTGAAGCTGGAACCCATGTCTAATAGTG TCAGGTCCAGTGTTCTTAGCCACCCCACTCCCAGCTTCATCCCTACTGGTGTTGTCATCA GACTTTGACCGTATATGCTCAGGTGTCCTCCAAGAAATCAAATTTTGCCGCCTCGCCTCA CGAGGCCTGCCCTTCTGATTTTATACCTAAACAACATGTGCTCCACATTTCAGAACCTAT CTTCTTCGACACATGGGATAACGAGGCTTATGTGCACGATGCACCTGTACGATCACTGAA CTGCACGCTCCGGGACTCACAGCAAAAAAGCTTGGTGATGTCTGGTCCATATGAACTGAA AGCTCTCCACCTCCAGGGACAGGATATGGAGCAACAAGGTAAATGGAAACATCCTGGTTT CCCTGCCTGGCCTCCTGGCAGCTTGCTAATTCTCCATGTTTTAAACAAAGTAGAAAGTTA ATTTAAGGCAAATGATCAACACAAGTGAAAAAAAATATTAAAAAGGAATATACAAACTTT GGTCCTAGAAATGGCACATTTGATTGCACTGGCCAGTGCATTTGTTAACAGGAGTGTGAC CCTGAGAAATTAGACGGCTCAAGCACTCCCAGGACCATGTCCACCCAAGTCTCTTGGGCA TAGTGCAATGTCAATTCTTCCACAATATGGGGTCATTTGATGGACATGGCCTAACTGCCT GTGGGTTCTCTCTTCCTGTTGTTGAGGCTGAAACAAGAGTGCTGGAGCGATAATGTGTCC ATCCCCCTCCCCAGTCTTCCCCCCTTGCCCCAACATCCGTCCCACCCAATGCCAGGTGGT TCCTTGTAGGGAAATTTTACCGCCCAGCAGGAACTTATATCTCTCCGCTGTAACGGGCAA AAGTTTCAAGTGCGGTGAACCCATCATTAGCTGTGGTGATCTGCCTGGCATCGTGCCACA GTAGCCAAAGCCTCTGCACAGGAGTGTGGGCAACTAAGGCTGCTGACTTTGAAGGACAGC CTCACTCAGGGGGAAGCTATTTGCTCTCAGCCAGGCCAAGAAAATCCTGTTTCTTTGGAA TCGGGTAGTAAGAGTGATCCCAGGGCCTCCAATTGACACTGCTGTGACTGAGGAAGATCA AAATGAGTGTCTCTCTTTGGAGCCACTTTCCCAGCTCAGCCTCTCCTCTCCCAGTTTCTT CCCATGGGCTACTCTCTGTTCCTGAAACAGTTCTGGTGCCTGATTTCTGGCAGAAGTACA GCTTCACCTCTTTCCTTTCCTTCCACATTGATCAAGTTGTTCCGCTCCTGTGGATGGGCA CATTGCCAGCCAGTGACACAATGGCTTCCTTCCTTCCTTCCTTCAGCATTTAAAATGTAG ACCCTCTTTCATTCTCCGTTCCTACTGCTATGAGGCTCTGAGAAACCCTCAGGCCTTTGA GGGGAAACCCTAAATCAACAAAATGACCCTGCTATTGTCTGTGAGAAGTCAAGTTATCCT GTGTCTTAGGCCAAGGAACCTCACTGTGGGTTCCCACAGAGGCTACCAAATTACATGTAT CCTACTCATGGGGCCTAGGGGTTGGGGTGACCCTGCACTGCTGTGTCCCTAACCACAAGA CCCCCTTCTTTCTTCAGTGGTGTTCTCCATGTCCTTTGTACAAGGAGAAGAAAGTAATGA CAAAATACCTGTGGCCTTGGGCCTCAAGGAAAAGAATCTGTACCTGTCCTGCGTGTTGAA AGATGATAAGCCCACTCTACAGCTGGAGGTAAGTGAATGCTATGGAATGAAGCCCTTCTC AGCCTCCTGCTACCACTTATTCCCAGACAACCACCTTCTCCCCGCCCCCATCCCTAGGAA AAGCTGGGAACAGGTCTATTTGACAATTTTGCATTAATGTAAATAAATTTAACATAATTT TTAACTGCGTGCAACCTTCAATCCTGCTGCAGAAAATTAAATCATTTTGCCGATGTTATT ATGTCCTACCATAGTTACAACCCCAACAGATTATATATTGTTAGGGCTGCTCTCATTTGA TAGACACCTTGGGAAATAGATGACTTAAAGGGTCCCATTATCATGTCCACTCCACTCCCA AAATTACCACCACTATCACCTCCAGCTTTCTCAGCAAAAGCTTCATTTCCAAGTTGATGT CATTCTAGGACCATAAGGAAAAATACAATAAAAAGCCCCTGGAAACTAGGTACTTCAAGA AGCTCTAGCTTAATTTTCACCCCCCCAAAAAAAAAAAATTCTCACCTACATTATGCTCCT CAGCATTTGGCACTAAGTTTTAGAAAAGAAGAAGGGCTCTTTTAATAATCACACGGAAAG TTGGGGGCCCAGTTACAACTCAGGAGTCTGGCTCCTGATCATGTGACCTGCTCGTCAGTT TCCTTTCTGGCCAACCCAAAGAACATCTTTCCCATAGCATCTTTGTCCCTTGCCCCACAA AAATTCTTCTTTCTCTTTCGCTGCAGAGTGTAGATCCCAAAAATTACCCAAAGAAGAAGA TGGAAAAGCGATTTGTCTTCAACAAGATAGAAATCAATAACAAGCTGGAATTTGAGTCTG CCCAGTTCCCCAACTGGTACATCAGCACCTCTCAAGCAGAAAACATGCCCGTCTTCCTGG GAGGGACCAAAGGCGGCCAGGATATAACTGACTTCACCATGCAATTTGTGTCTTCCTAAA GAGAGCTGTACCCAGAGAGTCCTGTGCTGAATGTGGACTCAATCCCTAGGGCTGGCAGAA AGGGAACAGAAAGGTTTTTGAGTACGGCTATAGCCTGGACTTTCCTGTTGTCTACACCAA TGCCCAACTGCCTGCCTTAGGGTAGTGCTAAGAGGATCTCCTGTCCATCAGCCAGGACAG TCAGCTCTCTCCTTTCAGGGCCAATCCCCAGCCCTTTTGTTGAGCCAGGCCTCTCTCACC TCTCCTACTCACTTAAAGCCCGCCTGACAGAAACCACGGCCACATTTGGTTCTAAGAAAC CCTCTGTCATTCGCTCCCACATTCTGATGAGCAACCGCTTCCCTATTTATTTATTTATTT GTTTGTTTGTTTTATTCATTGGTCTAATTTATTCAAAGGGGGCAAGAAGTAGCAGTGTCT GTAAAAGAGCCTAGTTTTTAATAGCTATGGAATCAATTCAATTTGGACTGGTGTGCTCTC TTTAAATCAAGTCCTTTAATTAAGACTGAAAATATATAAGCTCAGATTATTTAAATGGGA ATATTTATAAATGAGCAAATATCATACTGTTCAATGGTTCTGAAATAAACTTCACTGAAG OMIM ID 147720