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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for IKBKB (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID3551
Official gene symbolIKBKB
Full nameinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
Aliases,FLJ40509,IKK-beta,IKK2,IKKB,MGC131801,NFKBIKB,
Gene summaryNFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008, or NFKBIB, MIM 604495), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).[supplied by OMIM]
LocationChromosome: 8   Locus: 8p11.2
Gene position42128820 - 42190171  Map Viewer
Gene orientationplus
Gene size61352 bp
Gene sequence
OMIM ID603258