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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for IDH3B (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 3420 Official gene symbol IDH3B Full name isocitrate dehydrogenase 3 (NAD+) beta Aliases ,FLJ11043,H-IDHB,MGC903,RP46, Gene summary Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the beta subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase. Three alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq] Location Chromosome: 20   Locus: 20p13 Gene position 2644843 - 2639041  Map Viewer Gene orientation minus Gene size 5803 bp Gene sequence >IDH3B:complement(2579041..2584843):Length=5803 GCGGGAAACATGGCGGCATTGAGCGGAGTCCGCTGGCTGACCCGAGTGAGGCCCCGGGAC ATGTCGGGCAGGGGCGGGCGAAGGAGCGGAGAGTTTGTCCTAGGGTTTCCTAAACAGGGC AAAGTCAACTGTAGTGTTCGGGGTCTGGATGTCTCAAAGCTGACCTTACAGGCTTGTGTG TCCCTGTTGCAGGCGCTGGTCTCCGCCGGGAACCCTGGGGCATGGAGAGGTCTGAGTACC TCGGCCGCGGCGCACGCTGCATCGCGGAGCCAGGTATGCACGAATCTGGCTGGGGTCTCT CTTACGACCCTGTCCCTTCCTCGCTGCTCCCTCCCCTGGCTTTTCCCCACCCCTCCCGGG TCTCCCTACTTCTCTACTCCCAGGATCCGTGCTCCCGCCCCAGCTCTATCTTTACTTCTC CCCTCTTCCCCCAATTGAGGCCGAGGACGTGAGGGTGGAGGGCTCCTTTCCCGTGACCAT GCTTCCGGGAGACGGTGTGGGGCCTGAGCTGATGCACGCCGTCAAGGAGGTGTTCAAGGT GAGTGGCCTCGGGGATCAGACAGTAGAGGACAGTAGTGTGTTGGAAAGGACTTGGCCTTG ACTGTGATGTTTTGGGAACCTGTCTCTGAAGGCTGCCGCTGTCCCAGTGGAGTTCCAGGA GCACCACCTGAGTGAGGTGCAGAATATGGCATCTGAGGAGAAGCTGGAGCAGGTGCTGAG TTCCATGAAGGAGAACAAAGTGGCCATCATTGGTATGTGTGCCCTCTTGCCACTTGTCCA TGTGCCATTTAAAATCAAATGACCAAATGTTTATTAAGCCCTTCTCCCCACATGCTATGC AATTATATTAACTCCAGGGCAACCACCATTGGTATTTGGACATTTGTTCCTTCCCATTGG GAGCCCAGGAGTTGAGAGATCATGTCAGCTGTCTATGCAGAAAAGTTCCAGGGGTTCTGA GTCTGTCCTGAGGCTACATCAACTGTCATCAAATCTTATTCATTGCATTTCTGGAATACC ACTTTTAGCTGCCCCTTTTCTTTTTTTTTTTTTCCCCTCCCTTCCTTCCTCTTTGTTTCT TCTTGCTCTGTCGCCCAGGCTGGAGTGCAGTGGCGCGATCTCGGCTCACTGCAACCTCCC CGTCCCTGGTTCAAGCAATTCTCCTGCCTCAGCCTCCTGAGTAGCTGCGACTACAGGTGT GCACCACCACACCCAGCTAATTTTTGTGTTTGTTTTGTTTTAAGACAGAGTCTCGCTCTG TCGCCCAGGCTGGAGTGCAATGTTGCCATCTCAGCTCACTGCAACCTCTGCCTCCCGGGT TCAAGTGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGCTGGTATTACAGGAGCGTGCCA CCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATGTTGGTCAGGC TGGTCTCGAACTCCTGACCTTGTGATCTGCCCGCCTTGGCCTCCCACAGTGCTGGGATTA CAAGTGTGAGCCACCATGCCCAGGCTAATTTTTGTATTTTTAGTAGAGAGAGGGTTTTAC CATGTTGGCCAGGCTGGTCTCGAACTCTTGACCTCAAGTGATCCACCCACCTCTGCATCC CAAACTGCTGCGATTATAGGCGTGAGCCACCGTGCCTAGCTGCCCCTTTTCTTTTGTCTT CCGCGCTTTAATCTCCTCATTTGATTTTTTTGGCTTCTAGTTCTGCCCCTATAGTTCATC TTCCATATCTCTTCTTGGAAAGAACAGCCTGATTTTCCAGGCCCAGCCTTACCATAGGAA AGTCAGTACTTTATAAGTTGGCCCTTAATTTTCTGCCTTGGTTCCACAACTCTTGTTCTG TGCTTCAATCACACTAGATTGTGTGTTAGATTCCAAATATGTACTACCTGACTTATATTG TTCCCTCCACCCAGAACGTTCTTTCTTTGGTGCTACCTGTTAGAGTCCTTCTCACTCATT CACTGTATTAGTTTCCCATAGCTGCCGTAACACACTACCATGAACCTGGTGGCTTATCAT TAACAGAAATGTATTCTCTCACAGTGCTGGAGGCCATCAGTCTGAAATTAAGGTGTTGGC AGGGCCCTGCTCCCTCTGAAGGTTTAGGGGAGAAACCTTTCTTGCCTCTTCTGGTGGCTC TTGCTGTTTTTTGACTTGTAGATGCATCACTCCAATATCTGTGGTTTTCTTCCCTCTCTG TCTCGGTATCATTTTTCTCCTCAAATATTTAGCCCTGGATGGGACGATTTTTTCTCAAGA TCCTTAACTTAATTACATCTGCAAAGCCTCTTTTCCCAAATAAGGTCACATACATAGGTT CTGGGGCTCAAGGCATGGCTGAAGTGCCAGCTCTTCTGTGCTGTATCCTGATATTACTGG AGAGGATTTCCTCTTTGTGTTGCTATGCAAGTTTCCCATGGTACTTATCATGTCTTTCAT ATTTTCTGTCTTTCCCAGTGTACCGTTTGCTTCTCAAGGGCAGGAGTTGTATGGTTTTAG TTGTTATCCTTATTGCCTGACATATAATTGATATTCATCAGTAGGTGTTGGGTTAAAAAA TGTCAAATAAGGAGAAGGCACAGATAAAAAGATCACAGATCTGCTAGCATTGTTTTTCAA CTTGTTGTTAAACCCAGGCTCTTTTTTGATAAATAGAAAAAATCTGTTCTCCGTTTTGAA GTTTCAACATAAATTAAATATGTTGACTAAAAATAAAGCATTAAGGCCGGGGCGGGTGGA TCACTTGAGGTCAGGAGTTTGAGACCAGCCTGGCCAACATGGTGAGACACTGCCTCTACT AAAAATACAAAAAATTAGCCAGGTGTGGTGGCACATGCCTGTAATCCCAGCTACTGGGGA GGCTGAGGCAGGAGAATTGCTTGAACCTGGGAGGCAGAGGTTGCAGTGAGCCCAGGTCGT GCCACTGCACTCCAGCCTGGGCGACAGAGTGAGACCCTGTGTCTCTCACACACGCACACA CACACACACACACACACACAGAAAATGCAATAGATGAAATGTTTCTGGCTTTAACTACAT TATTCTCTTTTGTCCCTTGCCCCCAGAGACAATTTAAAAGTTTACTGATGTGGGAATGGG AGATGGGAGTCTGGGTTACATGATGTTCCTAAGGGGGTTAGACACTGGTCTGAGTTCCCT TGGGCTTGGCCTGTGGCTGACACTCCTTTTCCCACTTTGTTTTCACAGGAAAGATTCATA CCCCGATGGAGTATAAGGGGGAGCTAGCCTCCTATGATATGCGGCTGAGGTAGGTGGTCT GGGTGGGGTGAATGGTTGAGAGGTGCCAGGGCACCAGGAGCAGAGCTGATGGCCCTGCCC ACCCTCAGGCGTAAGTTGGACTTATTTGCCAACGTAGTCCATGTGAAGTCACTTCCTGGG TATATGACTCGGCACAACAATCTAGACCTGGTGATCATTCGAGAGCAGACAGAAGGGGAG TACAGCTCTCTGGAACATGAGGTGAGGCCCCAGAAACTGGGGGAGGGCAAGGATGAAGAT GGGAGAGAGGTGGAGCTCCTTGTTTCCCTTCCCAGTGTCACCTAGCTGCTGCTTTCTTCT TACCCAGAGTGCAAGGGGTGTGATTGAGTGTTTGAAGATTGTCACACGAGCCAAGTCTCA GCGGATTGCAAAGTTCGCCTTTGACTATGCCACCAAGAAGGGGCGGGGCAAGGTCACTGC TGTCCACAAGGCCAACATCATGTGAGGGGCATGGCTTTGTGTAGGATGGGTTCCTGGGAA GGTAGCCCCTGTACTTTCTTGGCTGATTCTGTCCCCTTTGGCCCATGGACAGGAAACTTG GGGATGGGTTGTTCCTGCAGTGCTGTGAGGAAGTTGCTGAACTGTACCCCAAAATCAAAT TTGAGACAATGATCATAGACAACTGCTGCATGCAGGTGAGGCCTCCCCACATCTCTACTC ATGGGGCGGAGGAGGAGGGTGGGGAGTGGAATTTACTTCATGCCTGCATCTCACCCTCTA GCTGGTGCAGAATCCTTACCAGTTTGATGTGCTTGTGATGCCCAATCTCTATGGGAACAT TATTGACAATCTGGCTGCTGGCCTGGTTGGGGGAGCTGGTGTGGTCCCTGGTGAGAGCTA TAGTGCAGAATACGCAGTCTTTGAGACGGTGAGGCTGCTTTCTCCCTCGGCCCTTCCTCT GACCTCAAGTCCGCCATTCCTCTCCCATCCCAATATCTCCACTTCCTAAGTGATCTTGGC CTGTTCTTCCCCCACGCTGCCCACCATGCCTCTTTTCAGTGACCCTGGCCTGAGCTCCCC CTCCCATAATGTCCTTTTCCAACCTAAGCCTCTGCATACCCCTCCTGCCTCCTCCCAGTG TCTAGCCTGCCCCTCTCTCCACAGGGTGCCCGGCACCCATTTGCCCAGGCAGTGGGCAGG AATATAGCCAATCCCACGGCCATGCTGCTGTCGGCTTCCAACATGCTGCGGCATCTTAAG TAGGTCATGGGAGGCTGTCGGCAGAGGTTGGGTGTCGTGAGGAGGAGCAGGTGGGGAAAT TAGCGGGAGGTGTCTTGGGGGAGTCACAGTTTCTTCCTGTCCATATCCACAGTCTTGAGT ATCACTCCAGCATGATCGCAGATGCGGTGAAGAAGGTGATCAAAGTTGGCAAGGTGAGTT GAGAAGAGTAGTGCTGGCTTCAGGATTTAGAGTAGTTCTGGTGTCAGCACCTCGGCACTA CCCTCTGGGGAACCTGAATGGGGGTCTCCTTTCCCCCCAGGTCCCCAGAACATCTGCTCC CTGACATCCCTGCATCCCTCTCAGGGCTGTTCTTCATCTCCCTTCTCTTGGCTGTTTCAT CCTCTTGATCTCTTTTGCCTCTTAGATCCCATCTGCTGTTCCCTCTTTCCTGCTCCATCC ACTGCCCTTTTCATGGGCCATCTGAATGCAGAACTTGCAGCTCTCCTTGGGGGTGGAACA GCAAGGGATACAGGCAGGCTGAAGCATCAGCTTCACCTTCACGCCCCATCTCCTTTTCGC TGTGATTCTTTCCTTCCACCTGGTCTTGTCTCTATTTCTTCCAAGGAAGGTAGCCACATC CTGCCTCTGATCTGCGTTTCCCATCATCTTTGCCTGCTCAGCCTCCTGTCCTGCCCTGGC TGCAGCACAGCTAATAGTGGCTTAAGAGGAGTGGCAGGTCCATGTGCTTCCCATCCTGGC TCCTCCTTCCATTCCTGTGCATTGCCTTTTTTCTGGCTGTCACGCATTCTTGGCTTCCAT TTCCTCAATCACATTGCCCTACCTCCCTTCATGGGCTCTCTTTTCTCCCTCCCCACGGCT GTTGCCGGTGGTGGCTGTAGGTGCGGACTCGAGACATGGGCGGCTACAGCACCACAACCG ACTTCATCAAGTCTGTCATCGGTCACCTGCAGACTAAAGGGAGCTAGAGCCCTTTATTTC TTCCAACCTTGCAAGGACCACACTCCCCATACCCTTCAGTGCAGTGTACCAGGGAAGAGA CCTTGTGCCTCTAAGCAGTGGACCATGGTCACCTTGCTGGGTAGAGCCTAGGTTGTCCTT GGGCCGGCTTCCTTAGGGGACAGACTGTTGGGTGGTGATGGGGATTGTTAGGATGGAGCC CAGGCCACATGGATGATGATGATTCTCCCCCACAGGTTCGAACCTCTGACATGGGTGGCT ATGCTACTTGCCATGACTTCACTGAGGCTGTCATTGCTGCCTTGCCCCACCCATAGGCCC TGTCCATACCCATGTAAGGTGTTCAATAAAGAACATGAACCAA OMIM ID 604526