| Entrez gene ID | | 31 |
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| Official gene symbol | | ACACA |
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| Full name | | acetyl-CoA carboxylase alpha |
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| Aliases | | ,ACAC,ACC,ACC1,ACCA, |
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| Gene summary | | Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene. [provided by RefSeq] |
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| Location | | Chromosome: 17 Locus: 17q21 |
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| Gene position | | 35766902 - 35441927 Map Viewer |
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| Gene orientation | | minus |
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| Gene size | | 324976 bp |
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| Gene sequence |
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| OMIM ID | | 200350 |
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