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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for PILRA (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID29992
Official gene symbolPILRA
Full namepaired immunoglobin-like type 2 receptor alpha
Aliases,FDF03,
Gene summaryCell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This particular gene encodes the ITIM-bearing member of the receptor pair, which functions in the inhibitory role. Alternative splicing has been observed at this locus and three variants, each encoding a distinct isoform, are described. [provided by RefSeq]
LocationChromosome: 7   Locus: 7q22.1
Gene position99971068 - 99997722  Map Viewer
Gene orientationplus
Gene size26655 bp
Gene sequence
OMIM ID605341