| Entrez gene ID | | 29992 |
| Official gene symbol | | PILRA |
| Full name | | paired immunoglobin-like type 2 receptor alpha |
| Aliases | | ,FDF03, |
| Gene summary | | Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This particular gene encodes the ITIM-bearing member of the receptor pair, which functions in the inhibitory role. Alternative splicing has been observed at this locus and three variants, each encoding a distinct isoform, are described. [provided by RefSeq] |
| Location | | Chromosome: 7 Locus: 7q22.1 |
| Gene position | | 99971068 - 99997722 Map Viewer |
| Gene orientation | | plus |
| Gene size | | 26655 bp |
| Gene sequence |
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| OMIM ID | | 605341 |
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