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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for GUSB (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 2990 Official gene symbol GUSB Full name glucuronidase, beta Aliases ,BG,FLJ39445,MPS7, Gene summary This gene encodes a hydrolase that degrades glycosaminoglycans, including heparan sulfate, dermatan sulfate, and chondroitin-4,6-sulfate. The enzyme forms a homotetramer that is localized to the lysosome. Mutations in this gene result in mucopolysaccharidosis type VII. There are many pseudogenes of this locus in the human genome. Location Chromosome: 7   Locus: 7q21.11 Gene position 65447301 - 65425671  Map Viewer Gene orientation minus Gene size 21631 bp Gene sequence >GUSB:complement(3458514..3480144):Length=21631 GTCCTCAACCAAGATGGCGCGGATGGCTTCAGGCGCATCACGACACCGGCGCGTCACGCG ACCCGCCCTACGGGCACCTCCCGCGCTTTTCTTAGCGCCGCAGACGGTGGCCGAGCGGGG GACCGGGAAGCATGGCCCGGGGGTCGGCGGTTGCCTGGGCGGCGCTCGGGCCGTTGTTGT GGGGCTGCGCGCTGGGGCTGCAGGGCGGGATGCTGTACCCCCAGGAGAGCCCGTCGCGGG AGTGCAAGGAGCTGGACGGCCTCTGGAGCTTCCGCGCCGACTTCTCTGACAACCGACGCC GGGGCTTCGAGGAGCAGTGGTACCGGCGGCCGCTGTGGGAGGTGCGATCTCGGGGCAGGG CCGGGAGGCGCCCGAAAGCCCGGCGGTGGGAGTAGGGGAGCCCGGGCCCCCCGCAGACTT CTTCCCCTGGGCGTCTCCGAGCTGGGGCCCGCAGGAGGTTAAAGGTCAACGGGCTTGGGG GCGCCGGCTTGGGGGACGGGGGAACAGGAGCACCCTGGAGGGCCGGGGCGGATTAGGCAG GAGGAGAAAAGGCTCTTGCCGAGCCCTTTCCCGAGGTAAAGGCTGAGTCTGTGCAGTATC CTTCCTTTCAATATTTATTTTTAATTTTTAAAAATTTTTTTGAGACTGGGTTTGCACCTG TTTCCCAGGCTGGGGCGGAGTGGCGCCAGCCTAACTTCTGAGCTCAAGCGATTCTCCCGC CCCAGCCTTGCAATTTAGGGGGTGCCAACACGCCTGGCTAATTGAAAAAAAAAAAATTAT CTGGGCTCGGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGTGGAGGCGGGCGAATC GCCTGAGGCCAGGAGTTTGAGACCAGGCTGGCCAACATAACAGGGTGAAACCTCATCTCT ACTAAAAATATAAAAATTAGCCAAGTGTGGTGGTTCATGCCTGTAATCCCAGCTACTTGG GAGGCTGAGTCAGGAGAATTGCTTGAACCCGGGAGTAGAGGTTGCAGTGAGCTGAGATCA GGATGCCACTGCACTCCAACTTGGGCGACATAGTGAGACTACGTCTCCAAAAAAAAAAAA AAGGCAAAAAAACTTAAAAAAAAAAAAAAGATACAGGGTGTCACTATTTACCCAGGGTGG TCTCGAACTCCTGGCCTCAAGCCATCCTCCCACGTTGACCTCCCAAAGCGCTGATTACTG GCATGAGCCACCCACACACTCTGGCCACAGCGGCATGCACTGCACAGAGCTGGGCCCGGG GATCGGGAGAAGGTGACAGTTTAGATGTCCTGAGGTCAGCTCTGCCGAGGCAGGAAGTCC CTTGGTTTTCAAGGTTCACATAGAGGACAGGACATGACATCAGGCCCAGGACGCCACCCC TGTTCCCCTCCTGACTTGGATGTGATCTGCAGAGAAGTGGAACTGGGTGAGGTCTGGGCG GCTTTTGCCTGGTCTACATCCTCTTATTCTGACTTTGCAGCATTCAGTACAGGAGGGAAA GAGGAGGGGGCTGGGTGCCAGTGTGCACCCCACTCACAGTGTCCTAAGCAAAGCTCCCCC CATTCCTCCAACCAGCCTTCCTCCCTGTGACAGGCAGTGGCCATCTGCCTCTTAGTCACA GGTCTGAACCTTCTTGCCTCTGGCTGGGATGTGGCCCTGGGCTTGCTCCTGTCTCAGGAG ATATTGTGCCCCATCCACTCTGAGGAGGAACTCCTGGCCCCACTGGCCCAGGTGCACAGA TCGCCCTGGCAGTTGACCTGTCATCAGCAAGTTATCTGTCCTTTCTGCCAAGAATCCCCG CTATGTGTCAGGGCTTGTGCTAGGCCTGGGGGCACAGCCGTGCAGCACACTGGTCCTGGA CCCTTTTGGGGGCCTAGGAGCTGAGCCCGGCTCTTCTCTCCACAGTCAGGCCCCACCGTG GACATGCCAGTTCCCTCCAGCTTCAATGACATCAGCCAGGACTGGCGTCTGCGGCATTTT GTCGGCTGGGTGTGGTACGAACGGGAGGTGATCCTGCCGGAGCGATGGACCCAGGACCTG CGCACAAGAGTGGTGCTGAGGATTGGCAGTGCCCATTCCTATGCCATCGTGGTCAGTGCG GCCAGGAGCAGGCAGGGCGGGTGGGGGGGCACGGCTGCTGAACAGCATGGGACCTCCAGC TGCCACCCACGGCATGTATGCTGGGGTGGGATGGTGGGGGGTCCTGCCCTGCCCTGCCCT GGGGGCTGTGCCCTGTATAGGGGGATAGGTAGCCTGATCTACCCCATTGGGATGTCATTC TTCCCGTCTGGCTGGAAGGCCCCGGAGCCCCATGCTGCAGGTTATGTGAGGGAGTGCCCG ATAGTAGGGCGCCTCCTCATGCCCTGACCTGCAGCCCCCTCCCCGTATCTCCTGTGTCTG CAGTGGGTGAATGGGGTCGACACGCTAGAGCATGAGGGGGGCTACCTCCCCTTCGAGGCC GACATCAGCAACCTGGTCCAGGTGGGGCCCCTGCCCTCCCGGCTCCGAATCACTATCGCC ATCAACAACACACTCACCCCCACCACCCTGCCACCAGGGACCATCCAATACCTGACTGAC ACCTCCAAGTGGGTACCATCCTGCCTCCATTGCACACACCCACCTTCCCGCCCCACCCTG TGGTCTTCCTGGTAGGGACTGGGTGGCCTTCACAGAGTGGAGGCCTTGGATCTGGGGAGG CCAGGGAGGCCTGTGAGCTGAGGTCAGGGGACCCAGAGCAAGGGCCCAGCAAACCACAGT CCTCCCATCCTAGGTATCCCAAGGGTTACTTTGTCCAGAACACATATTTTGACTTTTTCA ACTACGCTGGACTGCAGCGGTCTGTACTTCTGTACACGACACCCACCACCTACATCGATG ACATCACCGTCACCACCAGCGTGGAGCAAGACAGTGGTGAGGGCTTCTGGTAGGATCCTC TCAGCGGGGCCCAGGGTGGCTCTGTTTGTTCCCTGTTTGGAAAGCTCTCCCAGGAAAAAG GTGCTCCCAGCATCTCTACACCCTCACAGATTCCCTTCCACCTATGAAGCTAAAATTCAG CCTGTGTGAGCGGATACGGGCTCCCAAAATCACCCGTGTGGTTGACCTCGCTAGGAGAAG AGGGGTCTGGCCTAACGTCACACAGCTCGGGGTGGCAATCCTGTCCCTTCTCTATGGTGC TACTCTCACTCCATCTCCCCTTGCTACACATCGTGCTCAAGGAACAGGCAGCTTCGGTGG GGGGGGCGCCGGGCATGGTGGCTTATGCCTGTCATCCAGCACTTTGCAAGGAGGCCCTGG TATAAGGATCACTTGAGGCCAGTAGTTCAAGAGCAGCCTGGGCAACATAGTGAGGCCATC ACCACAAAAAATTAAAAAATTAGCCAGGGATGGTGATGTGTGCCGGTAGTCCCAGCTGCT GAGGCAGGAGAATCACTTGAGCCTGGGATGTCAAGGGTGCAGTGAGCTATGACCACACCA CTGCACTCTGGTCTGGGCAACAGACGCAGACCCTGTCTTTCTTTTTTTCTTCTTTTTTTT TTTTGAGCTGGAGTCTCGCTCTGTCGCCAGGCTGGAGTGCGATGGCGTGATCTTGGCTCA CTGCAACCTCTGCCTCCCGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCGAGTAACTGG GATTATAGGCACCCGCCACCACGCCCGGCTAATTTTTCTATTTTTTTTTAGTAGAGACAG GGTTTCACTCTATTGGCCTGACTGGTCTTGAACTCCTAACCTCAGGTGATCCACCCTCCT CGGCCTGCCAAAATGCAAGGGTTACAGGCGTGAGCCACTGTGCCCAGCTGGGATACCCTG TTTTTTTTGTTTTTGTTTTTTGTTTTTGAGATGGAGTCTTGCTCTGTTGTCCAGGCTGGA GTGCTGTGGCGTGTTCTTGGCTCACTGCAACCTCCGCCTCCCGGGTTCAAACAATTCTCT TGCCTCAGCCTCCTGAGCAGCTGGGATTACAGGCGTGTGCCACCACGTCCAGCTAATTTT TGTATTTTTAGTAGAGATGGGGTTTCACCATGTTGGCCAGGCTGGTTCAACTCCTGACTT CGGGATCCACCCGCCTCAGTCTCCCAAAATGCTGGGATTACAGGAATGAGCCACAGCGCT CGGTCTGTATTTAAGAAAAATTTTTGTTTTAAGTTTTTTTTCTTTTTAAAAATATATCTT TTTCAGGGCGGGCGCGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGG GGGGATCACGAGGTCAGGAGATCGCGACCATCCTGACTAACATGGTGAAACTCCGTCTCT ACTAAAAATGCAAAAAATTAGCCGGGCATGGTGGCAGGGGCCTGTAGTCCCAGCGACTCG GGAGGCTGAGGCAGGAGAATGGCGTGAACCTGGGAGGCAGAGCTTGCAGTGAGCTGAGAT TGCATCACTGCACTCCAGCCTAGGGGACAGAGCGAGACTCCATGTCAAAAAATAAAAATA AAAAAATATATATATATCTTTTTCTTTTTCTGAGATGAGGCTTGCACTGTGGCCCAGGCT GGAGTGCAGTGGTGAGATTATTGACAGCCGTTGTGGGGCCGCGGTTCTAAGTTTAAAAGA ATTTAGGCTGGGTGTGGTGGCTAATGCCTGTCATCCCAGCACTTTGGGAGTCCAAGGTGG ATGGATCGCTTTAGCTGCAAAGTTTGAGACCAGCCTGGGCAACATACTGAGACCCTATCT AAGAAAAAAATAAATAAATAAAATAAAATAAATGAATAAAAAAGAATTTAAAAAAGAATC CCACAGCAAAGACAATGCACCATAGAGCAATTTATTGCCAAGGAAAGGTATTTTGGAAGT TAAGTTTAGAACAGCCTGGGTGCACTGGCTCATGCCTGTAATCCCAGCACTTTTGGAGGC CGAGATGGGTGGATCACTTGAGCTCAGAAGTTCAAACCAGCTTAGCCAACATTAGCTGGA CATTGTGGTGTGAGCCTGCAATCCCGGCTACTCAGGAGGTTGAGATGGGAGAATTGTTTG AACCCGGGAGGTGGAGGTTGCAGTCAGCTGAGATTGCAACACTGCACTCCAGCCTAGGTG ACAGAGTGACACCCCCATCTCAAAAAAAATAGTGAAGTGCAAAATGCACAGTTCACCCTG AGACACAGAATTCAGGACAGGCTGCTCGTAAGGATGAGACAGCACCGATTATTACTGGGG AAACTCCCTTTCTGGGAGTCTTCCGTGATGAATTCCTAAGGAGCTGGGAAGAGGTGTTAC TGTAAGCACGTTCTGGGCCGTCCTCTGGTTGCACATGCGTAGTAGCTGTACATGCTTGTT CACACGTCACGTGTCTCAGTGCCGTGGTTGGCATGTCTGAGGGACACGGTCACTTCCTTG ACTACCTATCCTGCCTCAAGATCATAGCTCACTGCAGCCCCGAACTCCTGGCTCAAGCAA TCCTCCCACTTCAGCCTCCCAAGTAGCTGGGGCTGCCGGGGCTGCAAGCACGCACCACCA CGACCGGCTGATTGTTTGTATTTTTAGGGAAGAAGTGGTTTCCCTATGTTACCCAGGCTG GTCTTGAACTCCTGGTCTCAAGCGATCCTCCCACCCCAGCCTCCTCAAGTGTTGGGATTA CAGGTGTGACCACTGCACCTGGCCAAAATCTTTTTTTAAATTAAAAAAAGCACCGGGTGC GGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCCAAGGCGGGTGGATCACCTGAGG TCAGGGGTTCAAGACCAGCCTGGCCAATATGACAAAACCCATCTCTACTAAAAATATAAA AATTCGCCAAGCATGGTGGTGCACGTCTATAATCCCAGGTACTTGGGAGGCTGAGACAGG AGAATCACCTGAACCCCAGAGGTGGAGGTTGCAGTGAGCCGAGATCATGCCACTGCACTC CAGCCTGGGGGACAGAGTGAGACTCCGTCTCAAAAAAAAAAAATAAGAAATTAAATTTAA AAAAAGCAACAGAAACAAATGGCTGCCTGGCAGCGGTGGCTGCAGGGCGCTCCTGTTTGT GTGACTCAGGTCGTGTCCCTCCCTCAGCCCTGGTCTCTCTTGTTTCTTGCAGGGCTGGTG AATTACCAGATCTCTGTCAAGGGCAGTAACCTGTTCAAGTTGGAAGTGCGTCTTTTGGAT GCAGAAAACAAAGTCGTGGCGAATGGGACTGGGACCCAGGGCCAACTTAAGGTGCCAGGT GTCAGCCTCTGGTGGCCGTACCTGATGCACGAACGCCCTGCCTATCTGTATTCATTGGAG GTAATGGTGGTTTGGGACATGCCTAAGGGAGGTCTTTTGCCCCCATGTGGTGACCCTGGC TTCAGCAGGAGCCCAAGACAGGTGGATGGGCAGGCATGGTCCTCTGAGCTTTCTGATGTT TCTCACCCTTGGTGGGAGGCCCATTTTCTTTTTTTTTTTTTTTTTTGAGATGGTCTCACT CTGTCACCCAGGCTGGAGTGCAATGGCCTGATCACAGCTCACTGCAGCCTTGAACTCTCA GCCTGCAGCAGTCCTCCTGCCTTGGCCTCCTGAGTAGCTGGGACTACAGGCACATGCCAC CATGTCTGGCTAAATAAAAAAAATTTTGTAGCCTGGGCAGAGTGACTCATGCCTGTAATC TCAGCATTTTGGGAGGCTGAGGTGGGTGGATCACTTGAGGCCAAGAGTTCAAGACCAGCC TGGCCAACATGGTGAAACCCCATCTCTACTAAAAATATGAAAATTTGCTGGGCATGGTGG CGAACACCTGTAATTCCAGCCACTCGGGAGGCTGAGGCAGGAGAATTGCTTGAACTCAGG AGGCAGAGGCTGCAGTGAGCTGAGATCACACCACTGCACTCCAGCCTGGGGGACAGACTG AGACTGTCTCAGAAGAAAAACATTTTTTTTTTATAGAGATGGGGTCTCAGTCTGTCAGCA GGCTGGTCTTCAACTCCTGGACTCAAGTGATCCTCCTGCCTTAGCCTCCCAAAGTGTGGG AACTCCAGGCATGAGCCACCTTGTCTTGTCAAAGGGAAGGCCATGTTTTGAAGGGCAGGT TCCCAGGGTCAGCCAGGGTAGGGCAGAACCTCTGATTGCTGCATCTCTGCTTACAGGCCC AGAGGCAGCTGCTGGGGTGCACGAGGGGCCTTCCTGCTGGAGGGCAGGCCGGATGGGGCT CAGGCTGTCGGGGTGCTCACACCTGGTGCTTTGGCTGTCATAGGTGCAGCTGACTGCACA GACGTCACTGGGGCCTGTGTCTGACTTCTACACACTCCCTGTGGGGATCCGCACTGTGGC TGTCACCAAGAGCCAGTTCCTCATCAATGGGAAACCTTTCTATTTCCACGGTGTCAACAA GCATGAGGATGCGGACGTGTGTTGGGGCTCCTGGGTCCTTGTCGGGGCTGCTTCTGGTCA CCCTCCACTTTCGCCTTCCCTGTGTCCTGCAGTTGAGGGCAGCTCAGGGCAATGAGGCAA ATGGCTCCAAATGGAGAGGGGGCTCATGGGGTGGCTCTCCAGGGTCCTGGCTCTCAGAGG AAGTGCAGCTTCGACAGGGACAGGGGTCACTTGGCTCTGCTATCTCCTAGATCCGAGGGA AGGGCTTCGACTGGCCGCTGCTGGTGAAGGACTTCAACCTGCTTCGCTGGCTTGGTGCCA ACGCTTTCCGTACCAGCCACTACCCCTATGCAGAGGAAGTGATGCAGATGTGTGACCGCT ATGGGATTGTGGTCATCGATGAGTGTCCCGGCGTGGGCCTGGCGCTGCCGTGAGTCTCTG CTGTGCACCTGCTCCGCCTGCCCAGCCCGGGGGCGTCACCGTGACCCTCTGTCCCTTCCC TCCTGGCCCGCAGGCAGTTCTTCAACAACGTTTCTCTGCATCACCACATGCAGGTGATGG AAGAAGTGGTGCGTAGGGACAAGAACCACCCCGCGGTCGTGATGTGGTCTGTGGCCAACG AGCCTGCGTCCCACCTAGAATCTGCTGGCTACTACTTGAAGTGAGTGCTCCCTCCCTGCC CTCGGCTAGAGTGGGAAGGAGACCCTGGCAGGTGGCTGGCCTCGGTGGGCATGTGCTGTT CAAGATCGGCCTCGTGTCCAGCCCAATGGGAAGGCCGTCCATACCCAGATAGTTCAGGGG ACCAAATATCTACCCACCCAAATTGTGGTTTTCTTTTTTGTTCTTTTTTTTTCTTTTTGA GATGGAGTCTCACTATATGGCCCAGGCTGGAGTGCAGTGGGGTGATCTCCGCTCATTACA ACCTCTGCCTCCTGGGTTCAAGTGATTCTCCTGCCTCAGTCTCCTGAGTAGCTAGGATTA CAGGCACCCATGAACCACTGTGCTGGGGCTGTTTTTTTTTTTCAAAATGGGTTCTCACTC TGGTTGCCCAGGTTGGAGTGCAGCGGTGCAGTTTTGGCTTACTGCAGCCTTGACTTCCCA GGCTCAGGTGATCCTCCTGTCTCAGCCTCCCAAGTAGCTGGGATTCTAGATGTGTGTCAT CACGCCCAGCTAATTTTTGCTTTATTTTTTATTTTTTGGATATGCAGTCTCCCTCTATTG CCCAGGATGGAGTGCAGGGGCATGATCTCAGCTCACTGCAACCTCTGCCGCTCAGGTTCA AGTGATTCTCCAGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCACATGCCACCACGCC CAGCTAAGTTTTCCTTTTTTCCTTTTTATGAGATGGAGTCTCACTCCGTGGCCAGGCTGG AGTGCAGTGGCGCAATCTCGTCTCACTGCAACCTTCACCTTCCAGGTTCAAGTGATTCTC CTGCCTCAGCCTCCTGAGGAGTTGGGATTACAGGCACACGCCAACATACCCTGCTAATTT TTGTATTTTTAGCAGAGACGGGGTTTCACCATTTTGGCTAGGATGGTCTCGATCTCTTGA ACTCATGATCCGCCTGCCTCGGCCTCCTGAAGTGCTCGGATTACAGGCGTGAGCTACCAC GCCTGGCCAACTTTTGCATTTTTCAGTAGAGACGGGGTTTCACTATGTTGGGCCAGGCTG GTCTTGGACTACTGACCTCAGGAGATCCACTTACCTCGGCCTCCCAGAGTGCTGGGATTA CAGGCGTGAGCCACCGTGCCCGGCTAATTAGAGACTGGGTTTCACCATGTTTGCCAGGCT GGCGTGGAACTCCTGGCCTCTAGTGATCCTCCTGCCTCACCTTCCCAAAGTGCTGGGATT ACAGGTGTGAACCACCACACCTGGCCCCCTTTTCTTCCTTACAATCGTGCAGTTCTAACT CAGCGTTCAGAGTTGGATTTTTCACTTGGGGTAGAAGCAGGAGAGGTGGTAGAAATGCCT CTTGACTCATACAGCACACCCCAATTTCATGCAGTGCTTTGGGCTGAGCCAAGTCTGCAG CAGGCAGAAGGCTCTGAGAAGTTGTTGCAGCCTGGGCCAAGGACAATTCAGAGCTTGGGG GCACAGGGGTGTGCTCAGCAGGACTGGGTGGACAGGCCCTTTGTTGCGAAGGGGAAGAGT ACAGGCTTCCAGGAGCAGGTGTTTGAGGCTTCTTTGGGAGGTGGCCAGAGGAGATGCCTG TTTTCTGGGGCAGGATTTGGAGGGAGCCACCCAGGCTGGAGAGGTTCAGCCAGGCTGTCA CAGGCTTTGAAGTTTCCCATCTGAGAGCCTGGCTGTTGGAGAGTGTGGGTTTGGAACTTG AGGCTAGGGGGTTCTTTTCTGATCTGTGCCAGCCACAGCCTTCGGATAGGCAGAGCAATG ATGGGGGAGGGCGTAAAAGAAGAAATGAACTGAGGAAAGAGAAGAGGAAAACAGGCTTCA ACAACAGTCTAGGCTGGGTGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCA AGGTGGGTGGATCACCTGAGGTCAGGAGTTTGAGACCGGCGTGGCCAACAGATATTGAAA CCCTGTCTCTACTAAAAATAAAACAATTAGCGGAACACAGAGGTGGGCGTCTGTAATCCC AGCTACTTGGGAGGCTGAGGCAGGAGAATTGCTTGAGCCCAGGAGGTGGAGGTTGCAGTG AGCCAAGATCATGTCATTGCACTCCAGCCTGGGCTACAGAGTGAGATTCTGTCTCTCAAA AAAACAAAAACAAAAACAGTCTGTACTGTGGAGGCCTCGGGCAGGTGCCAGGAGCTCTGA GCACAGACGGGTCCCTCTGTTGGGTTTTTCTTCCCTTCTAAGGGCCATTTCTTCTTATTT ATTTATTTATTTTTTGAGATGGAGTTTTGCACTTGTTGCCCAGGCTGGAGTGCAATGGCA CAATCTCGGCTCACCACAACCTCTGCCTCCTGGGTTCAAGTGATTCTCCCGCCTCAGCCT CCCGAGTAGCTGGGATTACAGGCATGCGCCACCACGCCCAGCTAATTTGTATTTTTAGTA GATATGGGGTTTCTCCGTGTTGGTCAGGCTGGTCTCGAACTCCCAACCTCAGGTTATCTG CCTGCCTCAGCCTCCCAAATAGCTGGGGCCACAGGTGTGTGCGGCCATGTCAGGCTAAGT TTAAATTTTTTTTTTTTTTTCCGCAAGATGGAGTCTTGCTTGTTGCCCAGGCTGGAGAGC ACTGGTGCAATTTTGGCTCACTACAACCTCTACCTCCTGGGTTCAGGCAATTCTTCTGCC TCAGCCTCATGAGTAGCTGGGATTCCAGGCGCATGCCACCATGCCCAGCTAGGTTTTTTT TGTATTTTTTTGTAGAGATAGACTTTTACCATGTTGACCAGGCTGGTCTCAAACTCTTGA CCTCATGATCCACCCGCCTCGGCCTCCCAAAGTGTTGGGATTACAGGCGTGAGCCACCAT GCCCGCCCCTAATTTTTAAATTTGTTGTAGAAACAAGGTCTTGCTATGTTGCCCAGGCTG GTCTTGAACTCCTGGTCTCTGGTAAAACTCCCAAAGTGCTGGGATTCTAGGCGTGAGCCG CCTTGCCCGGCACTTGCACCATTTCTCTGCATGCGTCTCCACTCCCACTGCCCAGGACCT GTGGACTTAGATTTGAGTCACTGCTGAGCACCTCGCACCTAGCCCCATGCCTGCCTCCCA GCCTGCACTCCGTTTGCTTGATGCATTAATAAATATCCCTCCCAAATCTGCATCCATCCA CCTCCTGTGTTCAAGAGCTGTTTCAGGGCGTCAACCTCATTTTTGCCAGTGTCCAGCCTA GTGACCTCAGCTCTGTGTACCTGGAAGAGTGGCTGCTCCTCTGGGGGTATAGGATTCGGA GATGGGGGTAGAAGGAGTGATGTTAGAGAGCTCGGTCTAGGACTAGAGGATCATATGCCC TTATGTAAAATACATCTCAAGTTAGGGAAGAAAGCAGCGGCTCCATGCTTTTTTTTTTTT CCCCTTTGTTTTTGTTTGTTTGTTTTGAGACAGGGTCTTGCTCTGTGGACCAGGCTGGAG TGCAGTGGCATGATCTTGGCCCACTGCAGACTCCTCCTTCTGGGTTCACGCCATTCTTCT GCCTCAGCCTCCTGAGTAGCTCAGACTATAGGCGCCGGCCACCACGCCCGGCTAATTTTT TGTATTTTTAGTAGAGACGGGGTTTCACCGTGTTAGGATGGTATCGATCTCCTGACCTTG TGATCTGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTGCGCCTG GCCGCTAATTTTTGTATTTGTAGTAGATAGAGTTGGGGTTTCACCATGTTGGCCAGGCTG ATCTTGAACTCCTGACCTCAAGTGATCCACCCACCTCGGCCTCCCAAAGTGCTGGGATTA CAGGTGTGAACCATCGTGCCTGGCCCCGTGTTGTGTTCTGGCGGTGGAAGATGGGACAGA GAGGATGGGAGGGTGTCTGAGCCATTCCTGGACTGATGGAACCTGTTTCTTCTGCCTTTT GTGGACAGGATGGTGATCGCTCACACCAAATCCTTGGACCCCTCCCGGCCTGTGACCTTT GTGAGCAACTCTAACTATGCAGCAGACAAGGGGGTGAGCCTGGGGGTCCCCACCCCACTT CTCCCTGCCTTTGCCTGGGCTTGTCCTGAAGCCTGGTCATGGGAACAGCCAGGAAGAACC ATGCGCTGCCAGTCTGGGTTTTATTTCATTTTCTTTTTTACTTAAAAAGATAGAGACAGG GTCTTGCCATGTTGCCCAGGCTGGTCTCCAACTCCTGGGCTCAAGCAATCCTCCTGCCTT GGCCTCCCAAAGGGCTGGGGTTACAGGTGTGGGCCACCACACCCCGGCCGCAGCCAGTCT GTTTTCACAGATGGTCTTTGGGTTAATGAGAATTCTCCCCCTGCTTACTCGCCAGGCAGT GTGGCTTTCTCAATCCAAGGAGGCTGGGCATAGGGAGATGGGATTTGTTTGCTCAGTTTG GACTCAGCATTTTTTGCACTTCGATTTAATAGACTCATAAAACATCAAAGATTTAAGGGA GCTTAGAGTTCATCTGGCCCACACCTGGCTGATGAGAATCTCTAGGGGAAGTTTTTATGA AATGCCAGATCTCTGCATTCTGAGGTCCTGATTTAGTACGTCCAGGGTTGGAACTTGAGT TTTTCTTTTTCTTTTGTAGAGGCAAGGTCTTACTCTCTTGCCCTGGCTGGAGTGCAGTGG TGCAATCACAGCTCACTGCAGCCTTGAATTCCTGAGCCCAAGTGATCCTCCTGCCTCAGC CTCCCGAGTAGCTGGGACTCCAGGTTTTCACCACTGCGCCTAGCTAATTTTATATCTTTT TGTAGAGGTGGCATCTCTCTATGTTGCCCAGGCTGGTCTCAAAGTCTTGAGCTCAAGTGA TCTCCTGCCTTGGCCTCCCAAAGTGCTGTGATTACAGGCATGAGTTGCAGTGCCTGGCTG ACATTAGCATTCTTTATTTATTTATTTATTTATTTTGAGATGGAATCTTGCTCTGTTGCC CAGGCTTGAGTGAAATGGTGCAATCTCAGCTCGCTGCAACCTCGTCCTCCCAGGTTCAAG CAATTCTGCCTCGGCCTCCTGAGTAGCTGGGATTACAGGTGCATGCCACCACACCCAGCT AATTTTTGTATTTTTTAGTAGAGATGGGGTTTTGCCATGTTAGCCAGGCTGGTCTCAAAC TGCTGATCTCAGGTGATCTGCCCACTTTGGCCTCCCAACGTGCTGGGATTACAGGCGTGA GCCACCACACCCGGCCAGCATTTTTACTAGAAAGAAATGTGTTCAGGACGCATTAGAAAC TAGCCAGTTGGACACAGAAGCCCCTGCTGCTCAGCTGTAAGCACCGCTATGCTGAAGCTT GGGGTGGTCCTACTCGGTCGTCACCGCCCTGCTCCTTGGAGTGACTTTTCTGGCCCTCTG CAGTCCACAGTGCTGCCTTGTGAAAGCTCCCTCAAGATCCTCTGTGACAGCCGGGCATGG TGGCTTACACCTATCATCCCAGCACTTTGGGAGGCCGAGGCAGGCAGATTACTTGAGATC AGGAGTTCAAGACCAGCCCAGCCAACTGGTGAAACTTCATTTCTACCAAAAATACAAAAA ATTAGCTGGGCGTGGTGGCGCACGCCTGTAATCCTAGCTACTCGGGAGACTGAGGCATGA GAAGCACCTGATGGTGGGAGGCAGAGGTTGCAGTGAGCTGAGATCGCACCACTAACATTC TAGCCTGGGCGACAGAGCGAGACTCTGTCTCCAAAACAAAACAAAAGATTTTCTGTGAGA ATGACTGCATCGGCCCCTCGGGTGGCAGCGCTTCTCCAGGGCAAGGTGAGGGGAAGCCCA GTGATGGGAGTGCTGCCTGGAGAGGAGTCAGTTCCAGTGGTGGGGGCCCTGGGCTTTGGC TGAGGGCTGTGCGTTGGCAGCTGCTGTGCCTCTCACAGCCCTTCCCAGCGGCGCACGTCA TGAGTGTCAGTGTGGAGTCCCAGGCCTACCTCCTCTGGGCCACTTTGTGACCATGTTTCT TGCCTATGGCAGGGTAATTTCAGGATCTAAATTGGTACACTTGGACGTTCTCAGCCCCAG GAGGCAGCTGTTCCCGTTCTAGGTTTTTTTTTTTTTTTTTTTTTGGTAGAAATGGGGGCT TGTGATGTTGCCCAGGCTGGTCTCGAACTCCTGGGATCAAGTGATCCTCCCATCTTGGCC TCCCAATGTGCTGGGATTACAGGCATGAGCCACCGTGCCCTGCTAATTTTCTTACTACTA TTTTTTGTAATGCTGCAGTCTTGCTGTGTTGCCCAGGCTGGTCTTAAGCCATCCTCCTGC CTCAGCCTCCCAGAGTGCTGGGATTACATCCCCCTTACCTTCTCTGCCAGAGGAGCCCCC GCAGTGTGTGAATGCTGAGTCATGCTGTCTACTGAGTGCTGAACGGGCTCTGCTGCTCTG GTCCTAGGCTCCGTATGTGGATGTGATCTGTTTGAACAGCTACTACTCTTGGTATCACGA CTACGGGCACCTGGAGTTGATTCAGCTGCAGCTGGCCACCCAGTTTGAGAACTGGTATAA GAAGTATCAGAAGCCCATTATTCAGAGCGAGTATGGAGCAGAAACGATTGCAGGGTTTCA CCAGGTAAGCAGTGTTGAGCTTTCTGCTTGTGTGTTCTCTCAGGGCAGAGATGTCACTCA CCTCCTCCAGCCTGACCTGCGCCCACTGCACTGCTCCCCTCGCTTCAGCTTTGGGCTCTC CTCCCACGGCCCCGTCCACGTTCCCTCACCGCCAACAGCCAGGCCTGTGCCCCACTCACT TGGTCCTCAGAGGTGGCCTCCTTACTGGCTTTGTTTCCAGATAGCCTCCTATCACCCGTG CCCAAGTGGTCTTTCTAACAGATCCAAATTTGTATTTGTTTTTGAGACCGGATCTCTCTG TCACCCAGGCTGGAGTGTGGTGGTGCGATCACTGCTCACTGCAGCCTTAACCTCCTGGGC TCAAGTGATCCTCCCACCTCAGCCTCCTGAGTAGCTGGGACCATAGGCACATGCCAACAC GCCTGGCTAATTTTTTTACTTTTGTAGAGATGGGGTCTTGCCATGTTGCCCAGACTGGTC TTGAACTCCTGGCCTCAAGTGATCTGCCTCAGGCTCCCAAAGTGCTGGGATTACAGGTGT GAGCCTCTGCACCAGCCACAGTTGAAAATTTTGGGAGTCCTGTCATTGGCTCCCCCAGGC CCACAGGACAAAGCCCTAACCTCTGGTCAGGACACTCAGTGTCCTCTGCTCTCTCCTGGG TTTTCATCCCCTTCTCCCCTCTATCCCAGCCACTGATCTGTTTCCACTGCCCTCGCTTGC TCTCCTGCTCTTGCTTGAGCTGTTTCTTCTGCCTGGAATGCCCATGTTGGCACCATAATC ACCAACTAAAATATCCTTTTTCTTAATTTTCATATTTTAGATATAGGGTCTTGCTATGTT GTCCAGGCTGGTCTCAAACTCCTGGACTCAATTGATCTTCCTGCCTTGGCCTCCAAAAGT GCTGGAATTACAGGCATGATCCACTGTGCTAGCCTTTTTTTCTTTTTCTTTTTTTCAGGG TCTTGTTGTGTTGCCCAGGCTGGAGTGCAGTGGTGTCATCATAGCTCACTGCAGCCTTGA ACTAAAGGGCTGAAGTAATTCTTCCACCTCAGCCTCCTGAGTAGCTGGGACGACAGGCAT GAACCACCATGTGCAGCCTATTTTTAAATTTTTTTGTAAAGATGGAGTCTATCAGGCTGG TCTAGAACTCCTGGCCTTACGTGATTGTCCTGCCTCAGACTCCCAAAGTGCTGGGAATCC AGGCATGAGACACCATGCCCAGCCTGTCGTCATTTTTTTAATCTATCTCATTTTTTTGTC CTCCTCACCAAAGATATGTTGGTTTGTCTTGTGAGGTTTTTTTTTTCCTGTGGATTCCTG AACCCCATCCAGCCCCTCATTCCCACCCCAGCCAGCTCACACTTGTTTGTCACAGCTCCT GGTTGACACACAGGGAACAGCCACCCACAGTGGACTGCGCTGTTCTGTTTGCACCCTTAA ATTTATCGTGCTTACAGAATGCCACTTCTGCAAACTAGTCAAGTAGGGGAAGTGGCTCTT GGATATATTTGCTTGCGCATCCTCTTTGAAAAGGTAACCAGCTCTGAATTCTTTTTTTTT TTTTGACACAGAGTTTCGCTCTCGTTGCCTAGGCTGGAGTGCAGTGGCGCGATCTCGGCT CACTGCAATGTCCACCTCCCTGGTTCAAGCGATTCTCATGCCTCAGCCTCCCGAGTAGCT GGGATTACAGGCATGCGCCACCACGCCCACCTCATTTTGTATTTTTAGTAGAGATGAGGT TTCACCATGTTGGTCAGGCTGGTCTTGAACTCCTGACCTCAAGTGATCCGCCCGCCTTGG CCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGTGCCAAGCCCTAGCTCTGAATTC TTAAGAAACTCTTGAGAGGGTCTAGGTCAGTGCTGATAGAACCTCTGCAGTGCTGGGCAT GGTGGCTCACACCTGGAATGCTGGCACTTTGGGAGGCCAAGGTCAGAGGATCTCTTGAGC CCAGGAGTTTGAGACCAGTCTGTGCAACATAGACCCCATCTCTACAAAAAATTTAAAATT AGTTGGGCATGGTTATGAGTGCTTGTAGTCCAAGCCACTTGGGAGGCTGAGGTGGGAGGA TTGTTTGAGCCCAGTAGGTCAAGGCTGCATTCAGCTATGATTGCACCACTGTACTCCCAC CTGGGTGACAGAGTGAGACCTTGTTTCAAAAAATAAAAAAAAACAAACTTGCAATGATGG AAATGTTCTATATTTGCACTGTCTGAAATGGTACACACTAGCTACACATGGCTACTGAGG TCTTGATATATGACTAGGATAACTGAATTGATTTAGTTTAATTAAATAAATTTTTTTGAG ACAGCCTCACTCTGTTGCCCAGGCTGGAGTGCAGTGGCATAATCACAGCTCACTGCTCAA CCTCCTGGGCTCAAGCGATCCTCCCTCCTTAGCCCCAAGTAGCTTGAACTGCAGGCGTGC GCCACCACACCTGGCTAATATTTTGACTTTTTGTAGAGACTGGGTCTCACTGTGTTGCCT AGACTAGTCTTGAAATCCTGGGCTGAAGTGATCCTCCTGTCTCGACCTCCAAAAGTGCTG GCATTACAGACCTGAGGTACCATGCCCAGCCTGGTTTGGTTGAGTTTAATTTAATTTAAT TTTTATATATATATATATATTTATTAGAGACAGGGTCTCACTGTGTCACCCAAACTGGAG TGCAGTGGTGTGAACACAGCTCACTGTCGCTTTGATCTCTGGGGCTCAAGCAGTCCTCCA ACCTCAGCCTCCCAAGTAGCTGGGACCACAGATGTGTGCCACTAGGCTTGGCTAATTTTT GTACTTTTTGTAGAGATGGGGTCTTGCTATGTTGCCCAGGCTGGTCTTGAACACCTGGGC TCAAGCAGTCCTCCCACCTCAGCCTCCCAAATTGCTGGGATGACAGACATGAGCCACTGC ACCTGACTGAAAGACATATTTTTGCCTGTAGTGTAGTTTAGCCTTAAGACTGTACCAGCA GATAGAGGTGGAAAAGTAATGTGAAACGAATGTCAAATTACGTTTATAAATAAAGCAGCT GCTCATTAAGGTTGTTTTTTTTTTTAAACCTCCTTTTTTATTCTGGGTTACATCATTCCC TGGCTGTCTTTACCCCAGCATCAGTGAGTCCTGCAGTCACTATAGCCCCCTGTGAAGACA GATATTTTGGTCACCATCAAGTGGATCTTTATTTTTATCTAACATTTACAATTCTGCCAG TTCTGACTCTTACATTCTCTTTGCCTTGAATCCTAGGATCCACCTCTGATGTTCACTGAA GAGTACCAGAAAAGTCTGCTAGAGCAGTACCATCTGGGTCTGGATCAAAAACGCAGAAAA TACGTGGTTGGAGAGCTCATTTGGAATTTTGCCGATTTCATGACTGAACAGTGTAAGTGG CAGTTTGGCTCATGGGATAACGTACCCGTCCTCATTTTTTCAGGTTGCCTTTCCAATTCT GGCCATTTCAATTGTAAGAATATTGGAAACAAAGTTGGGGAAGCTGGTTTAATCCATGTA GGTTGCGTTGAGAATTTTCTAGGAAAAGTAAGTTGTGTTTAGGAAGTAGGAAAGCAATCA GGCCCCCGCCTCCCAAATACGGTCAAAAAGCAAACAGGAGAGTCAGCTATAGTGAATCGG AAATGGCTGGCTTGCCTTTTCCTTGTCTATTTTGTAGCCAAGGAGGAACGAAAAACGGGA CCTCATCATGGATTTACTTTTGGGATACACTCATTATTCCATAGAAGGGTACAAAGCCTG AGAAACTTAAGGTATTTCAGTCTGTTGTATATTACTTGCGAAAAGCAGGCTTATCAAATA CAGGTGAGTTTCAACGCATCTTGAATTTGGCAGCATTTACAAGTCTTCAGGCCAGGTGTA GTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGTCAGGGTGGGAGGATCGCTTGAGGC CAGGAGTTCAAGACCAGCCTGTTCAGCATAGCAAGACCCCATCTCTACAAAAAATAAACA GATTAGCTAGGCGTGGTGGTGTGTGCCTGTAGTCTCAGCTGCTTGGGAGGCTGAGGCAGG CGGATAACCTGAGCACAGGAGTTGGAGGCTGCAGTGAACTATGATTGCACCACTGCACAA GAGCCTGGACAACAGAGTGAGACTTGTCTTTAAAACACAAGATTGGTCTTCAAAGAGAAT AACATCTGCGGTGTCTTGTGAGGATGGATGAGGGGCTGCCAAGTTCGCAATGAATGTGTC CCATTTCTTCTTAGTTTATGGACTTACCATAAACTGAAGATAGCAGTTTGGTGGGTTGGA GAAGCATGTGGTAATGGTGGGAATTATAATACATTACTTACAGGGAAAGACAGGCCTTTG AAAGGTAAAGCGTAAGAGTGAGAATGGAATACGGATGAATGAATGAACAAGATGAGGTGA GAAGGAAGAGGTAAAGGGAAAAGGAGAACAGGAAGCTGTCCTCTGCGTGGCACCTGTGAT AAATGGTTTCTGGGGACATCCCTGATGGCAGTTTTGTGGAGAGGTGCGAGGCTTTATGCG GTAAGAAATGAGCTGCAGGCTGGGCGCAGTGGCTCAAGCCTGTGATCCCAGCACTTTGGG AGGCCAAGGTGGACAGATCACCTGAGGTCAGGAGTTTGAGACCAGCATGGCCAACATGGA GAAACCCCATCTCTACTAAAAATACAAAATTAGCCGGGTGTGGTAGCGCATGCCTGTAAT GCCAGCCACTTGGGAGACTGAGGCATGAGAATCTGTTGAACCTGGGAGATGGAGGTTGCA ATGAGCTAAGATCACAGCACTGTACTCCAGCTTGAGCAATAGAGTGAGACTCTTTTTTTT TTTTGAGACGGAGTTTTGCTCGTTTCCCAGGCTGGAGTGCAGTGGCGCTATCTCAGCCTA CTGCAACCTCCACCTCCCAGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCGATTAACTGG GATTGCAGGCATGCGCCACCACACCCGGCTAATTTTGTATTTTTAGTAGAGACGGGGTTT CTCCATGTTGGTCAGGCTGGGCTTGAACTACCGACCTCAGGTGATCCGCACATCTGGGCC TCCCAAAGTGCTGGGATTACAGGCATGAGCCACCATGGCCAGCTGAAACTCGGTCTTAAA AAGAAAAAAGAAATGAGCTGCATCACGTTGGGCAAGTCACCTAAGCTTTTCATAAGCCTG TCCAGTGGGGATAATGCCACCTCCTTGTTGGTGTCGTAAGGGCTGCATTTGATGAAGTAC TTGGCGATGCCTGTGTTCACTTATGGAAGAAACAGTCTTGAACCTTTTGGTGGGGAAAGC CCCCTTTCCATTTAACATTTCCATTTAGTGGTGGTCTTACTGGGGACAGAGAATGTCCTG AGAGCACAGCCCTGACAGGTCGTTGCCAGCTGTGCTCCTCCACCAGGCTCAGCTCAGGCC TAATGACCACCAGTGGTGGGTGCTGCCAAGCTGGACGTCAGCCCCGGCGGACTTTGAACT CCATGAGTAGGTCCCACGCAGGGACCTGTGGCTGGTCAGGACCCTGGCTCCCACTAGGCG CTATCTCTTCAGAAAGGCCCAAGGCTTTTCAAGGGTAACTGTCCCAGATACCCCTAGCCC TCTGCCTACCCAGTTACCAGACAGCTGGGTACCCAGCATGTAAACCTTAGTTTGCAAATA AAAGATAAACTTTTAGTGCTTTTTTTTTTTTTGGAGATGGAGTCTCACTCTGTCGCCCAG GCTGGAGTGCAGTGGCACAATCTCAGCTCACTGCAACCTCTGCGTCCTGGGTTCAAGCGA TTCTCCTGCCCCAGCCTCCTGAGTAGCTGGGACCACAGGCACCCACCACCATGCCTGTAT AATTTTTGTATTTTTAGTAGAGATGAGGTTTCACCATATTGTCCAGGCTGGTCTTAATCT CCTGACCTTGTGATCCGCCTGCTTTGTCCTCCCAGAGTGCTGGGATTACAGGCATGAGCC AATGTGCCCAGCCAGTTTTTGTATTTTTAATAGAGGCGGGTTTCCTCATGTTGGCCAGGC TGATCTTGAACTCCTGACCTCAGGTGATCCACCTGCCTCAGCCTCCCAAAGCACTGGGAT TACAGGCGTTGGCCACCACACCTGGCCACTGTTTTGGGTTTTTTTCCCCTAACAGACTAG AAAACTAGAAATTAACACACCAGGGAACCTGGGTGTTTGGGCAGAGCAGTGGTATTTAAA TATTTCAACCCATAAATTGTCACTTCAGAGCAAGCATCCTGAAACTGTAAGAGGACATTT GGCTGAGCATGGTGGCTTGTGCTTATAATCCCAGCACTTTAGGGAGGCTAAGGAGGGCAG ATTGCTTGAGCCCAGTAGTTTGAGACCAGCCTGGACAACATAATGAGACCTTGTCTTTAC TAAAAAATAAAAATAAAAGATTACCGGGCATGGTGGTGCTGGAGAGGCTGAGGCAGGAGG ATTGCCTGAGCCCAGGAGGTTGAGGCTGCAGTGAGCTATGATTGTGTCACCGCATTCCAG CCTGGGCAACAGGGAGAAAAAAGAAAAAAAAAGACATTTCTATTTAGTGCCTACCTTAGC TCCAGACTGGTTCTAACTTGACCCATCAGAAGACATCTGAATCGCTTTGTGTCTTTTTTT TTTTTTTGTAGCACCGACGAGAGTGCTGGGGAATAAAAAGGGGATCTTCACTCGGCAGAG ACAACCAAAAAGTGCAGCGTTCCTTTTGCGAGAGAGATACTGGAAGATTGCCAATGAAAC CAGGTATCCCCACTCAGTAGCCAAGTCACAATGTTTGGAAAACAGCCTGTTTACTTGAGC AAGACTGATACCACCTGCGTGTCCCTTCCTCCCCGAGTCAGGGCGACTTCCACAGCAGCA GAACAAGTGCCTCCTGGACTGTTCACGGCAGACCAGAACGTTTCTGGCCTGGGTTTTGTG GTCATCTATTCTAGCAGGGAACACTAAAGGTGGAAATAAAAGATTTTCTATTATGGAAAT AAAGAGTTGGCATGAAAGTGGCTACTGAAAA OMIM ID 611499