| Entrez gene ID | | 29128 |
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| Official gene symbol | | UHRF1 |
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| Full name | | ubiquitin-like with PHD and ring finger domains 1 |
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| Aliases | | ,FLJ21925,ICBP90,MGC138707,Np95,RNF106,hNP95, |
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| Gene summary | | This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] |
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| Location | | Chromosome: 19 Locus: 19p13.3 |
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| Gene position | | 4909510 - 4962165 Map Viewer |
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| Gene orientation | | plus |
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| Gene size | | 52656 bp |
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| Gene sequence |
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| OMIM ID | | 607990 |
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