| Entrez gene ID | | 2875 |
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| Official gene symbol | | GPT |
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| Full name | | glutamic-pyruvate transaminase (alanine aminotransferase) |
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| Aliases | | ,AAT1,ALT1,GPT1, |
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| Gene summary | | This gene encodes cytosolic alanine aminotransaminase 1 (ALT1); also known as glutamate-pyruvate transaminase 1. This enzyme catalyzes the reversible transamination between alanine and 2-oxoglutarate to generate pyruvate and glutamate and, therefore, plays a key role in the intermediary metabolism of glucose and amino acids. Serum activity levels of this enzyme are routinely used as a biomarker of liver injury caused by drug toxicity, infection, alcohol, and steatosis. A related gene on chromosome 16 encodes a putative mitochondrial alanine aminotransaminase. |
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| Location | | Chromosome: 8 Locus: 8q24.3 |
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| Gene position | | 145729465 - 145732555 Map Viewer |
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| Gene orientation | | plus |
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| Gene size | | 3091 bp |
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| Gene sequence |
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| OMIM ID | | 138200 |
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