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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for GPS2 (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 2874 Official gene symbol GPS2 Full name G protein pathway suppressor 2 Aliases ,AMF-1,MGC104294,MGC119287,MGC119288,MGC119289, Gene summary This gene encodes a protein involved in G protein-mitogen-activated protein kinase (MAPK) signaling cascades. When overexpressed in mammalian cells, this gene could potently suppress a RAS- and MAPK-mediated signal and interfere with JNK activity, suggesting that the function of this gene may be signal repression. The encoded protein is an integral subunit of the NCOR1-HDAC3 (nuclear receptor corepressor 1-histone deacetylase 3) complex, and it was shown that the complex inhibits JNK activation through this subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP1 (activator protein 1) function. [provided by RefSeq] Location Chromosome: 17   Locus: 17p13 Gene position 7218658 - 7215978  Map Viewer Gene orientation minus Gene size 2681 bp Gene sequence >GPS2:complement(6819352..6822032):Length=2681 AGAAGGCGGGTAGGAAGGGCAGTCGTCCGCGCTGGCTGGGCAGGGAGCGGCAGCAGCGAG CCGGGGACCCCGGCGCCGCCCGCGCGCGGTGGGACTGGGGCTGCGGTCCCGGCCGGGTGG CGGGCTCCTGGGACACGTGACCGGGGCGGCGAGCGGGCCGGGCGGACGGGCTTCCGCCTG GGCCGGGCGCGGCCCCCTCTGAGCGCCCGCCTCCCCGCAGGCCCCGTCTGAGGTCTGGCA GTCAGAGACAGCCGGGCGCCCACGGCCCGAGCGCCCACGGCAGCACCATGCCCGCACTCC TGGAGCGCCCCAAGCTTTCCAACGCCATGGCCAGGGCGCTGCACCGGCACATTATGATGG AGCGGGAGCGCAAGCGGCAGGGTGAGCCGGGGCCATAGCAGGGGGACGCACGGCCCAGAA TGGCTCCTGTACCTCAAGGCTGGCCTCAACCCACCGGCCAACCAGCGCGCCCGCTGCCGA GCGCAGAGGAGGGAAGGAATAGCCCCGTTGTGGTGGGATTTAAGCGTCCTGTTCCACGCT CCAGAACCCTTGAGATGGGAAGGACCTTGGAGAGCACCTGATAAAGCCTTTCCGTTCCCT ATTGCCGCGATGGGGAGCTTGTCCCCTCGAGGCAAAGAGCATACAGGCGTGTTGGGATGA CTGGGTTTTGCTGGTCTTCAATCTGTAACGTTGGAATTGTTTTCACTACCCTGCCTCTTC TTCATTCTGCCTGATTCTCCAGAGGAAGAAGAGGTGGATAAGATGATGGAACAGAAGATG AAGGAAGAACAGGAGAGAAGGAAGAAAAAGGAGATGGAAGAGAGAATGTCATTAGAGGAG ACCAAGGAACAAGTAAGCAGTCCCTTGAACTTTCCCAGCTTTGATTTCTTCGTTTGACTC TCCCTGCCTTCATCTTCTTTTCCCACCCCATCCCAGATTCTGAAGTTGGAGGAGAAGCTT TTGGCTCTACAGGAAGAGAAGCACCAGCTTTTCCTGCAGCTCAAGAAAGTTTTACATGAG GAAGAAAAACGGAGGCGAAAGGAACAGAGGTGGGATCAGAGTGCTAAAAACTGAAATGGG GGCCAAGTGGAACTGGGATCAGGTAGTAAAAGAACCAGTGTTTAATGGCAAAAGAGAAGG CATCTGTCCTTGACTTTGACCTGTCTTCCTTTCACTCCAGTGACCTGACCACCCTAACAT CAGCTGCATACCAGCAGAGCCTGACTGTTCACACAGGAACTCATCTCCTCAGCATGCAGG GTGAGGACTAAAGAAACCACCAGATGGAACCGGCCTTCTTGGAGGTCACAGCCTCCCATT TCAGCATCATGAAGCCCTTCTCCCTTTCTAGGGAGCCCTGGAGGACACAATCGCCCAGGC ACCCTCATGGCAGCTGACAGAGCCAAACAAATGTTTGGACCCCAAGTGCTTACGGTGAGA GTAGGATTGGATGCCTAGCCCCTAGTACTTCCATCCATGCATCCTTGCCACCAGTATTCA AGTCACAAACATATCAAGCACTTAAGTTTAGGGGGAAACGGGGCATACAGATACACACAA GTCACTGGGTTTCAGCTTTCAAGGAGTTTGTAGGCGAGTTCTCATTCTCCTTCCTTAGAC CCGGCACTACGTGGGCTCAGCAGCTGCTTTTGCAGGGACACCAGAGCATGGACAATTCCA AGGCAGTCCTGGTGGTGCCTATGGGACTGCTCAGCCCCCACCTCACTATGGGCCCACACA GCCAGCTTATAGTCCTAGTCAGCAGCTCAGAGGTGAGTAATAGGAGGGATGGGGCTTGGC CTTCCTCAAGGTCAAAGGAGGAATGCCATTCAGTAAAAGATTTTAATGGCTCTGTCTTTT CCTTTCTCAGCTCCTTCGGCATTCCCTGCAGTGCAGTACCTATCTCAGCCACAGCCACAG CCCTATGCTGTGCATGGCCACTTTCAGCCCACTCAGACAGGTGATAACATCCCATGCAGG AGCTCTAGCTCTCAGGTCCTCCCCTCCCTGTTTCATTCTCATCTCACATGCCCCTCTTCC CCACCTAGGTTTCCTCCAGCCTGGTGGTGCCCTGTCCTTGCAAAAGCAGATGGAACATGC TAACCAGCAGACTGGCTTCTCCGACTCAGTGAGTATGGCACCTTGGGAGGTCAGGGTTAG GGATATGTTAAGGGGAGCTTCAGTATGCCTCAGGCCCTGACTCTGTTCTCTGCAGTCCTC TCTGCGCCCCATGCACCCCCAGGCTCTGCATCCAGCCCCTGGACTCCTTGCTTCCCCCCA GCTCCCTGTGCAGATGCAGCCAGCAGGAAAGGTAAGAATGGTAATAGAATTTACCTGTCA GAATCCCTACACTAGGGATCCGGAAAAGCAGGATTAGGTAGGACAGGTGGCCCACATCAT CTGGTTTTTCCTTCCTCTTTGGGGGTGGTTATCAGTAGGGTATTAAGTGGAAGGGAGAGT ATGCCCAGTGACAAAGCCCTCTTTTCATCACCACCACCAGTCGGGCTTTGCAGCTACCAG CCAACCTGGCCCTCGGCTCCCCTTCATCCAACACAGCCAGAACCCGCGATTCTACCACAA GTGACCATCAGATTATATCTTCAACACCACACCCCCCACCCCATCGTGGGTGAGGGTATC CCCTGTGTGTCCCAGGCCAATAAAATCTACCTGCCACTGCC OMIM ID 601935