| Entrez gene ID | | 27413 |
| Official gene symbol | | Abcb11 |
| Full name | | ATP-binding cassette, sub-family B (MDR/TAP), member 11 |
| Aliases | | ABC16,Bsep,Lith1,PFIC2,PGY4,SPGP |
| Gene summary | | The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is the major canalicular bile salt transporter in humans and mice. Mutations in the human gene cause a form of progressive familial intrahepatic cholestases which are a group of inherited disorders with severe cholestatic liver disease from early infancy. [provided by RefSeq] |
| Location | | Chromosome: 2 Locus: 2 C2|2 38.4 cM |
| Gene position | | 69180673 - 69076339 Map Viewer |
| Gene orientation | | minus |
| Gene size | | 104335 bp |
| Gene sequence |
| |
|