| Entrez gene ID | | 24896 |
|
| Official gene symbol | | Gnas |
|
| Full name | | GNAS complex locus |
|
| Aliases | | Gnas1,Gnpas,Nesp55 |
|
| Gene summary | | This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5' exons. Some transcripts contain a differentially methylated region (DMR) at their 5' exons, and this DMR is commonly found in imprinted genes and correlates with transcript expression. In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants have been found for this gene. [provided by RefSeq] |
|
| Location | | Chromosome: 3 Locus: 3q42 |
|
| Gene position | | 165213398 - 165214550 Map Viewer |
|
| Gene orientation | | plus |
|
| Gene size | | 1153 bp |
|
| Gene sequence |
| |
|
|
