| Entrez gene ID | | 22859 |
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| Official gene symbol | | LPHN1 |
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| Full name | | latrophilin 1 |
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| Aliases | | ,CIRL1,CL1,LEC2, |
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| Gene summary | | This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. Latrophilin-1 has been shown to recruit the neurotoxin from black widow spider venom, alpha-latrotoxin, to the synapse plasma membrane. Alternative splicing results in multiple variants encoding distinct isoforms. |
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| Location | | Chromosome: 19 Locus: 19p13.2 |
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| Gene position | | 14316997 - 14258549 Map Viewer |
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| Gene orientation | | minus |
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| Gene size | | 58449 bp |
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| Gene sequence |
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