| Entrez gene ID | | 2066 |
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| Official gene symbol | | ERBB4 |
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| Full name | | v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) |
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| Aliases | | ,HER4,MGC138404,p180erbB4, |
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| Gene summary | | This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq] |
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| Location | | Chromosome: 2 Locus: 2q33.3-q34 |
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| Gene position | | 213403352 - 212240442 Map Viewer |
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| Gene orientation | | minus |
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| Gene size | | 1162911 bp |
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| Gene sequence |
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| OMIM ID | | 600543 |
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