| Entrez gene ID | | 2017 |
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| Official gene symbol | | CTTN |
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| Full name | | cortactin |
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| Aliases | | ,EMS1,FLJ34459, |
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| Gene summary | | This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene. [provided by RefSeq] |
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| Location | | Chromosome: 11 Locus: 11q13 |
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| Gene position | | 70244612 - 70282690 Map Viewer |
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| Gene orientation | | plus |
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| Gene size | | 38079 bp |
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| Gene sequence |
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| OMIM ID | | 164765 |
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