| Entrez gene ID | | 1871 |
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| Official gene symbol | | E2F3 |
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| Full name | | E2F transcription factor 3 |
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| Aliases | | ,DKFZp686C18211,E2F-3,KIAA0075,MGC104598, |
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| Gene summary | | The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F2, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner. [provided by RefSeq] |
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| Location | | Chromosome: 6 Locus: 6p22 |
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| Gene position | | 20402137 - 20493945 Map Viewer |
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| Gene orientation | | plus |
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| Gene size | | 91809 bp |
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| Gene sequence |
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| OMIM ID | | 600427 |
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