| Entrez gene ID | | 18669 |
|
| Official gene symbol | | Abcb1b |
|
| Full name | | ATP-binding cassette, sub-family B (MDR/TAP), member 1B |
|
| Aliases | | Abcb1,Mdr1,Mdr1b,Pgy-1,Pgy1,mdr |
|
| Gene summary | | The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This gene encodes a membrane glycoprotein which confers a multidrug-resistance phenotype. The protein encoded by the human gene is an ATP-dependent drug efflux pump for xenobiotic compounds which is responsible for decreased drug accumulation in multidrug-resistant cells and mediates the development of resistance to anticancer drugs. [provided by RefSeq] |
|
| Location | | Chromosome: 5 Locus: 5 1.0 cM |
|
| Gene position | | 8798147 - 8866314 Map Viewer |
|
| Gene orientation | | plus |
|
| Gene size | | 68168 bp |
|
| Gene sequence |
| |
|
|
