| Entrez gene ID | | 18301 |
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| Official gene symbol | | Fxyd5 |
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| Full name | | FXYD domain-containing ion transport regulator 5 |
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| Aliases | | EF-8,Oit2,RIC |
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| Gene summary | | This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. This gene product, FXYD5, has not been characterized as a protein. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq] |
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| Location | | Chromosome: 7 Locus: 7 B1 |
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| Gene position | | 31827341 - 31817742 Map Viewer |
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| Gene orientation | | minus |
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| Gene size | | 9600 bp |
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| Gene sequence |
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