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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for CSE1L (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID1434
Official gene symbolCSE1L
Full nameCSE1 chromosome segregation 1-like (yeast)
Aliases,CAS,CSE1,MGC117283,MGC130036,MGC130037,XPO2,
Gene summaryProteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation. [provided by RefSeq]
LocationChromosome: 20   Locus: 20q13
Gene position47662838 - 47713486  Map Viewer
Gene orientationplus
Gene size50649 bp
Gene sequence
OMIM ID601342