| Entrez gene ID | | 1434 |
| Official gene symbol | | CSE1L |
| Full name | | CSE1 chromosome segregation 1-like (yeast) |
| Aliases | | ,CAS,CSE1,MGC117283,MGC130036,MGC130037,XPO2, |
| Gene summary | | Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation. [provided by RefSeq] |
| Location | | Chromosome: 20 Locus: 20q13 |
| Gene position | | 47662838 - 47713486 Map Viewer |
| Gene orientation | | plus |
| Gene size | | 50649 bp |
| Gene sequence |
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| OMIM ID | | 601342 |
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