| Entrez gene ID | | 1361 |
| Official gene symbol | | CPB2 |
| Full name | | carboxypeptidase B2 (plasma) |
| Aliases | | ,CPU,PCPB,TAFI, |
| Gene summary | | Carboxypeptidases are enzymes that hydrolyze C-terminal peptide bonds. The carboxypeptidase family includes metallo-, serine, and cysteine carboxypeptidases. According to their substrate specificity, these enzymes are referred to as carboxypeptidase A (cleaving aliphatic residues) or carboxypeptidase B (cleaving basic amino residues). The protein encoded by this gene is activated by trypsin and acts on carboxypeptidase B substrates. After thrombin activation, the mature protein downregulates fibrinolysis. Polymorphisms have been described for this gene and its promoter region. Available sequence data analyses indicate splice variants that encode different isoforms. [provided by RefSeq] |
| Location | | Chromosome: 13 Locus: 13q14.11 |
| Gene position | | 46679211 - 46627322 Map Viewer |
| Gene orientation | | minus |
| Gene size | | 51890 bp |
| Gene sequence |
| |
| OMIM ID | | 603101 |
|