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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for TPP1 (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 1200 Official gene symbol TPP1 Full name tripeptidyl peptidase I Aliases ,CLN2,GIG1,LPIC,MGC21297, Gene summary This gene encodes a member of the sedolisin family of serine proteases. The protease functions in the lysosome to cleave N-terminal tripeptides from substrates, and has weaker endopeptidase activity. It is synthesized as a catalytically-inactive enzyme which is activated and auto-proteolyzed upon acidification. Mutations in this gene result in late-infantile neuronal ceroid lipofuscinosis, which is associated with the failure to degrade specific neuropeptides and a subunit of ATP synthase in the lysosome. [provided by RefSeq] Location Chromosome: 11   Locus: 11p15 Gene position 6640692 - 6633997  Map Viewer Gene orientation minus Gene size 6696 bp Gene sequence >TPP1:complement(6573997..6580692):Length=6696 GGTGGTGGAATATAGAGCTCATGTGATCCGTCACATGACAGCAGATCCGCGGAAGGGCAG AATGGGACTCCAAGCCTGGTGAGAAATTGAGAGGGCTCGGGAGAAAGGGATCACGTTGGA GGGAGCACACATTGGGAGGGTGGGAACACAAGGACAACGTAGCTCCCACTGAAACCCACC TGCTGCCCCTACAGCCTCCTAGGGCTCTTTGCCCTCATCCTCTCTGGCAAATGCAGTTAC AGCCCGGAGCCCGACCAGCGGAGGACGTGAGTTGACTTAGCACAGACTGCCCCCTTCCCC ATACCCTGTTCTGCCTCCCACTGTCCTGGTCCTAGCTTCTCTCACCCCCGTGCCAGCTCC TAGTACGCACTCCATAGCTTCATCTCTATGTTCCTAGCCTCAGTCCCCTATCATTCACCT CATGTGATCTGTATCTGCTCCTAGGATCCTCCCCAAGGTCTCAGCTCCTAATCTGGAACC TTCCATGACCAATATTTTCCATCTCCACCCTAACCAAAGCCATGTCCCTGACCCCTGACC CTACAGGCTGCCCCCAGGCTGGGTGTCCCTGGGCCGTGCGGACCCTGAGGAAGAGCTGAG TCTCACCTTTGCCCTGAGACAGCAGAATGTGGAAAGACTCTCGGAGCTGGTGCAGGCTGT GTCGGATCCCAGCTCTCCTCAATACGGTGCCTTTTGGGACTGAGGACAGGATGTGGGATG CGGTGGAGGGACACAGGGCTGGGTTGGGCATGGGATGGCGATCATGTCAGAGCCTGCCAA GACACTTGTGTTCCTCAGGCTAGAAACCTAAAAGGGGATGTGGTTCAGTATACAGGCTTT ATGATCAAATACGAACTCAAATTCTGACTCTGCTACTTACTAGCTACCAGGCATCTAGTA CAACTTACGTTCCTTCCCCTACCCTCAAATCCATTCTAATTTCCTCTTTTGTTCACATAC TAAGGCTGCCAGTTCTAACTCCCAAAGAGCCTTTGGATTAATCTCCTTCTTGCCGTCTTT TGTTACGACCAACTCCGTTATTTATTCCCACTCCTGGACTACTGCCCAGCTCCCCAGCTG ATCTGCAGTCTCCTCCCTCCACCCCACCCCTCACTGTACTCCCCCACTCTGCTTCAAAAC AGTCTCTCCAACAGTCAAAATGGATTGGTTCCTTCTCCTGGTTAAAGCCCTTCACAGCAG GGGGAGTGTGTGCTTGTGAACTGCAGAGGCTGGGGACGGGGCAGTGTGACACTAGTGTGC ATGGCAGGAAACAGTGACTCACCATCGTGTTAAGCTTAAAATCAACAAGTATGCAAATTT GAGCTAAACTGAATAACTGGTACCGAAAGATTTGAAAACATTTACCGGACATAAGCTTAA AATTAAAATGGAAAATTTATATGTATTAACCTCATTCATTTTCATGATCATGGCAATACA TGCTGTGGTGCGACATTTGCAACTTACTGGCCTTTAGGGTAAATCCATATTATTGGCCAT GGCATTTCAAGTCTCTCCAGCCTTTTCTTCCTCTGCTTCCCAAGTACACCCTACACCTGC ACACATAGCCCTCCTTTACCCTGTTCCAGGCTTTGGGAAGTCCTGATGTCTCATAGTTGA GGTCCAAAAGGGGGAGTTTGGGAAAGCAATGAATGAGGGCAAGTGCCTCTTCTGAATCCC TGCAGGAAAATACCTGACCCTAGAGAATGTGGCTGATCTGGTGAGGCCATCCCCACTGAC CCTCCACACGGTGCAAAAATGGCTCTTGGCAGCCGGAGCCCAGAAGTGCCATTCTGTGAT CACACAGGACTTTCTGACTTGCTGGCTGAGCATCCGGTGAGAGGAAATGATTGCTCCATG GAGGGCACCAGTCATCCCATCAGTGAGATGGATGGGAGGGAGTTGAGAGCTTGCTGGGGC TTGTGGGTGGGAGCTAATGCATGGGGAGACAGTGACTGACTGCCCAGGGATGCTCAGAGG TAGCTTCTTCTGTTCCGTTTTGAGCTTTCTGACCTCTGTTCTCTGACCTCCAGACAAGCA GAGCTGCTGCTCCCTGGGGCTGAGTTTCATCACTATGTGGGAGGACCTACGGAAACCCAT GTTGTAAGGTCCCCACATCCCTACCAGCTTCCACAGGCCTTGGCCCCCCATGTGGACTTT GGTAACACCTATGGGGTGAATGGGGGTTGGGGCACACAGATCCAGGGGCTGAGGAAGTTT AGATGCCATTGGGGACTGGGGGTGGGGTGAGTTGTAAGGTGGGCATTACAGTCTATAAGA TCTCCTCAAGCCTGACTTCTCCCTACAGTGGGGGGACTGCACCGTTTTCCCCCAACATCA TCCCTGAGGCAACGTCCTGAGCCGCAGGTGACAGGGACTGTAGGCCTGCATCTGGGGGTA ACCCCCTCTGTGATCCGTAAGCGATACAACTTGACCTCACAAGACGTGGGCTCTGGCACC AGCAATAACAGCCAAGCCTGTGCCCAGGTGAGCCAAGCAAAGAGCCCCAGGGTCCTCATA GCCTCCCCACAGTGTCCTCAATTCCTTACCACCCTGGGACTCACCCTCGGACCCACGATC TCTGCTCTGACTCCCTCCATAGTTCCTGGAGCAGTATTTCCATGACTCAGACCTGGCTCA GTTCATGCGCCTCTTCGGTGGCAACTTTGCACATCAGGCATCAGTAGCCCGTGTGGTTGG ACAACAGGGCCGGGGCCGGGCCGGGATTGAGGCCAGTCTAGATGTGCAGTACCTGATGAG TGCTGGTGCCAACATCTCCACCTGGGTCTACAGTAGCCCTGGTACTACCAAGAGGACTGG ACAGTGGGGAAGGGGGTGGGAGATGGGTGTTGATCCCTGCTCCCTCAAGGGAATGCTATA AGCTGGAGAGAGATCCTGACAACCCCCAGTGACTATCTTTGTGCCCATCCCTCAAAAAAA AAAAAAAAAAAAATCCAGGCCGGCATGAGGGACAGGAGCCCTTCCTGCAGTGGCTCATGC TGCTCAGTAATGAGTCAGCCCTGCCACATGTGCATACTGTGAGCTATGGAGATGATGAGG ACTCCCTCAGCAGCGCCTACATCCAGCGGGTCAACACTGAGCTCATGAAGGCTGCCGCTC GGGGTCTCACCCTGCTCTTCGCCTCAGGTGACCTCCTACCCTAAACTTAGACAATGCTTA CACCTCTGCAGCCTGGGAGCTTTGACTCCACAGTGATCCCTGAGCCTGGTCTCTGACTCA TAATCTGAACTCAGACCTTCCAGTAGGGACCACTGACCTGACCTCTACACTCTGACCTCC TACAGTAACAAATTTCCCCTCTGACATCCGAACCCACATACTAAGCCCTAACCAATTAAT ATGAATGCTACACTTGGTCTCTCTCAGGTGACAGTGGGGCCGGGTGTTGGTCTGTCTCTG GAAGACACCAGTTCCGCCCTACCTTCCCTGCCTCCAGGTAAGTACTCTAGCCTACCACTC AGGTATAACCACCACCTTTCACTTGTGATCTCATGATGTAGAACCTTTGTCTTGACCCCA CCATGTGCTCCTGTGGTTCAGCCTTAAGCTTTGCCTGCCCTGGTTGCTGTACTCCTGTCT CTTCTTCCTGCAGGTCCCAGGCCCCAAATCTCTTGTGTGGGATACAGCTCCCATTGTTCC TTTTCGTCAGTTCCCAGGCATTTTAGTGGAAGATTTGGTGGGTGTTCTGTAGAGAAAAGT GTGCACAGTCACCTCGGGCCATGCCTTGAAGGCTCAAAATCTCTTAGTCAATCCCATATA CATGCTTCCCCACAGAGTCTAGTTCCTCCAGCAAGACCTGGGCTATACTCACCCCTCCCC ACATATCTTGGAGGTCCCCTTGGGTCCCCTACTATCCAAATGCTGTCTTCTCCCCTCAGC CCCTATGTCACCACAGTGGGAGGCACATCCTTCCAGGAACCTTTCCTCATCACAAATGAA ATTGTTGACTATATCAGTGGTGGTGGCTTCAGCAATGTGTTCCCACGGCCTTCATACCAG GTACGTGTGTTTGTGTGGATGGATGCAGGGTAAGAGTGAGGATGGGGGATCCTCAGTTCA GCTGACTGCTGGGCAGGCCACATGCCAATACTCACTCAAAAATGCCTTTCAGGAGGAAGC TGTAACGAAGTTCCTGAGCTCTAGCCCCCACCTGCCACCATCCAGTTACTTCAATGCCAG TGGCCGTGCCTACCCAGATGTGGCTGCACTTTCTGATGGCTACTGGGTGGTCAGCAACAG AGTGCCCATTCCATGGGTGTCCGGAACCTCGGTGAGAATCAGCCCATCTCCAAACTCTCA CTCAGGAACTACCCTTACCCCCTAACACCTTGAACACCTTGCACCTAGAACCCCTGACTC CTTAGAGATGTCTGATACTTTAAAGCATCACTCCCAAAAAGTCCAATCACTCAGAACCCC TGACCTCTACTTGCACCTTCACTCTTGTAGGCCTCTACTCCAGTGTTTGGGGGGATCCTA TCCTTGATCAATGAGCACAGGATCCTTAGTGGCCGCCCCCCTCTTGGCTTTCTCAACCCA AGGCTCTACCAGCAGCATGGGGCAGGACTCTTTGATGTAAGTATGGAAGGGAAGGGTGTG GACGTTTTCAAACAACTATGGGGAGTGCTAAGGGGGACTTGGGGGCAGTTAGGGTGGTGT GGAATAGCCTTTGAAATGTGAGTACAGGGTGAGGAGATATACTCTTTAAGTACTGGTACT AGTAGGCCCAGATCTGATGCCAGCCTCCTCCCTAGGTAACCCGTGGCTGCCATGAGTCCT GTCTGGATGAAGAGGTAGAGGGCCAGGGTTTCTGCTCTGGTCCTGGCTGGGATCCTGTAA CAGGCTGGGGAACACCCAACTTCCCAGCTTTGCTGAAGACTCTACTCAACCCCTGACCCT TTCCTATCAGGAGAGATGGCTTGTCCCCTGCCCTGAAGCTGGCAGTTCAGTCCCTTATTC TGCCCTGTTGGAAGCCCTGCTGAACCCTCAACTATTGACTGCTGCAGACAGCTTATCTCC CTAACCCTGAAATGCTGTGAGCTTGACTTGACTCCCAACCCTACCATGCTCCATCATACT CAGGTCTCCCTACTCCTGCCTTAGATTCCTCAATAAGATGCTGTAACTAGCATTTTTTGA ATGCCTCTCCCTCCGCATCTCATCTTTCTCTTTTCAATCAGGCTTTTCCAAAGGGTTGTA TACAGACTCTGTGCACTATTTCACTTGATATTCATTCCCCAATTCACTGCAAGGAGACCT CTACTGTCACCGTTTACTCTTTCCTACCCTGACATCCAGAAACAATGGCCTCCAGTGCAT ACTTCTCAATCTTTGCTTTATGGCCTTTCCATCATAGTTGCCCACTCCCTCTCCTTACTT AGCTTCCAGGTCTTAACTTCTCTGACTACTCTTGTCTTCCTCTCTCATCAATTTCTGCTT CTTCATGGAATGCTGACCTTCATTGCTCCATTTGTAGATTTTTGCTCTTCTCAGTTTACT CATTGTCCCCTGGAACAAATCACTGACATCTACAACCATTACCATCTCACTAAATAAGAC TTTCTATCCAATAATGATTGATACCTCAAATGTAAGATGCGTGATACTCAACATTTCATC GTCCACCTTCCCAACCCCAAACAATTCCATCTCGTTTCTTCTTGGTAAATGATGCTATGC TTTTTCCAACCAAGCCAGAAACCTGTGTCATCTTTTCACCCCACCTTCAATCAACAAGTC CTCAATCAACAAGTCCTACTGACTGCACATCTTAAATATATCTTTATCAGTCCACAAGTC CTTCCAATTATATTTCCCAAGTATATCTAGAACTTATCCACTTATATCCCCACTGCTACT ACCTTAGTTTAGGGCTATATTCTCTTGAAAAAAAGTGTCCTTACTTCCTGCCAATCCCCA AGTCATCTTCCAGAGTAAAATGCAAATCCCATCAGGCCACTTGGATGAAAACCCTTCAAG GATTACTGGATAGAATTCAGGCTTTCCCCTCCAGCCCCCAATCATAGCTCACAAACCTTC CTTGCTATTTGTTCTTAAGTAAAAAATCATTTTTCCTCCTCCCTCCCCAAACCCCAAGGA ACTCTCACTCTTGCTCAAGCTGTTCCGTCCCCTTACCACCCCTGATACAACTGCCAGGTT AATTTCCAGAATTCTTGCAAGACTCAGTTCAGAAGTCACCTTCTTTCGTGAATGTTTTGA TTCCCTGAGGCTACTTTATTTTGGTATGGCTGAAAAATCCTAGATTTTCTAAACAAAACC TGTTTGAATCTTGGTTCTGATATGGACTAGGAGAGAGACTGGGTCAAGTAAGCTTATCTC CCTGAGGCTGTTTCCTCGTCTGTTAAGTGTGAATATCAATACCTGCCTTTCATAATCACC AGGGAATAAAGTGGAATAATGTTGATAACAGTGCTTGGCACCTGGAAGTAGGTGGCAGAT GTTAACGCCCTTCCTCCCTTGCACTGCGCCCCCTGTGCCTACCTCTAGCATTGTAACGAC CACGTAGTATTGAAATGGCCAGTTTACTTGTCTGCCTTCCTTTCCAAGACCGTTGGTGCC TAGAGGACTAGAATCGTGTCCTATTTAACTTTGTGTTCCCAGGTCCTAGCTCAGGAGTTG GCAAATAAGAATTAAATGTCTGCTACACCGAAAACC OMIM ID 607998